Interleukin 1 receptor antagonist (IL-1ra) prevents or cures pulmonary fibrosis elicited in mice by bleomycin or silica.

No abstract is available for this paper.

• Publication year

  1993

• Venue

  Cytokine

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1016/1043-4666(93)90024-YPMID 7683505
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Fibroproliferative disorders.

  1991cited by this paper
• A recombinant human receptor antagonist to interleukin 1 improves survival after lethal endotoxemia in mice

  1991cited by this paper
• Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro.

  1991cited by this paper
• The intratracheal administration of endotoxin and cytokines. III. The interleukin-1 (IL-1) receptor antagonist inhibits endotoxin- and IL-1-induced acute inflammation.

  1991cited by this paper
• Fibrogenic cytokines: the role of immune mediators in the development of scar tissue.

  1991cited by this paper
• Pro- and anti-inflammatory roles of interleukin-1 in recurrence of bacterial cell wall-induced arthritis in rats

  1991cited by this paper
• Interleukin-1 receptor antagonist reduces mortality from endotoxin shock

  1990cited by this paper
• Regulation of alloreactivity in vivo by a soluble form of the interleukin-1 receptor.

  1990cited by this paper
• Requirement of tumour necrosis factor for development of silica-induced pulmonary fibrosis

  1990cited by this paper
• Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist

  1990cited by this paper
• Interleukin 1 (IL-1) gene expression, synthesis, and effect of specific IL-1 receptor blockade in rabbit immune complex colitis.

  1990cited by this paper
• Role for T lymphocytes in silica-induced pulmonary inflammation.

  1989cited by this paper
• Macrophage production of transforming growth factor beta and fibroblast collagen synthesis in chronic pulmonary inflammation

  1989cited by this paper
• Role for T lymphocytes in silica-induced pulmonary inflammation.

  1989cited by this paper
• Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis

  1989cited by this paper
• Phagocytosis and inflammatory stimuli induce GM-CSF mRNA in macrophages through posttranscriptional regulation.

  1987cited by this paper
• Tumour necrosis factor as immunomodulator and mediator of monocyte cytotoxicity induced by itself, γ-interferon and interleukin-1

  1986cited by this paper
• Patterns of pulmonary fibrosis.

  1986cited by this paper
• Gamma interferon enhances macrophage transcription of the tumor necrosis factor/cachectin, interleukin 1, and urokinase genes, which are controlled by short-lived repressors

  1986cited by this paper
• Patterns of pulmonary fibrosis.

  1986cited by this paper
• Tumour necrosis factor as immunomodulator and mediator of monocyte cytotoxicity induced by itself, gamma-interferon and interleukin-1.

  1986cited by this paper
• Interleukin 1 increases collagen type IV production by murine mammary epithelial cells.

  1985cited by this paper
• The effects of the nude (nu/nu) mutation on bleomycin-induced pulmonary fibrosis. A biochemical evaluation.

  1983cited by this paper
• Interleukin 1, a potential regulator of fibroblast proliferation.

  1982cited by this paper
• Bleomycin-induced pulmonary fibrosis in the rat: inhibition by indomethacin.

  1979cited by this paper
• The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid.

  1961cited by this paper

• “Immunomodulatory nanoparticles elicit antifibrotic monocyte activation to resolve murine pulmonary fibrosis”

  2025cites this paper
• Emergence of inflammatory fibroblasts with aging in Hermansky-Pudlak syndrome associated pulmonary fibrosis

  2025cites this paper
• NLRP3 deficiency abrogates silica-induced neutrophil infiltration, pulmonary damage and fibrosis

  2025cites this paper
• IL-1RA autoantibodies: insights into mechanisms and associated diseases.

  2024cites this paper
• A recombinant IL-1β vaccine attenuates bleomycin-induced pulmonary fibrosis in mice.

  2024cites this paper
• Inflammatory Markers Involved in the Pathogenesis of Dupuytren's Contracture.

  2024cites this paper
• Animal models of silicosis: fishing for new therapeutic targets and treatments

  2023cites this paper
• Theroleofinterleukin-1familyinfibroticdiseases.

  2023cites this paper
• Dasatinib suppresses particulate-induced pyroptosis and acute lung inflammation

  2023cites this paper
• Toward targeted treatments for silicosis

  2023cites this paper
• Relationship between systemic inflammation and lung injury induced by chromate exposure: A cross-sectional study in workers.

  2023cites this paper
• Think Beyond Particle Cytotoxicity: When Self-Cellular Components Released After Immunogenic Cell Death Explain Chronic Disease Development

  2022cites this paper
• Another One Fights the Dust - Targeting the NLRP3 Inflammasome for the Treatment of Silicosis.

  2022cites this paper
• Effects of the Cytoplasm and Mitochondrial Specific Hydroxyl Radical Scavengers TA293 and mitoTA293 in Bleomycin-Induced Pulmonary Fibrosis Model Mice

  2021cites this paper
• The Roles of Type 2 Cytotoxic T Cells in Inflammation, Tissue Remodeling, and Prostaglandin (PG) D2 Production Are Attenuated by PGD2 Receptor 2 Antagonism

  2021cites this paper
• Genetic Risk Factors for Idiopathic Pulmonary Fibrosis: Insights into Immunopathogenesis

  2021cites this paper
• Evaluation of aromatase inhibitor on radiation induced pulmonary fibrosis via TGF- β/Smad 3 and TGF- β/PDGF pathways in rats

  2021cites this paper
• New Insights into Pathomechanisms and Treatment Possibilities for Lung Silicosis

  2021influential citation
• The Role of the Interleukin 1 Family in Lung Disease

  2021cites this paper
• Ferulic Acid Ameliorates the Progression of Pulmonary Fibrosis Via Inhibition of TGF-β/Smad Signalling.

  2021cites this paper
• Is individual genetic susceptibility a link between silica exposure and development or severity of silicosis? A systematic review

  2020cites this paper
• NLRP inflammasome as a key role player in the pathogenesis of environmental toxicants.

  2019cites this paper
• Coelonin, an Anti-Inflammation Active Component of Bletilla striata and Its Potential Mechanism

  2019cites this paper
• Comparison of cytokine/chemokine levels in aqueous humor of primary open-angle glaucoma patients with positive or negative outcome following trabeculectomy

  2019cites this paper
• Increased SLAMF7high monocytes in myelofibrosis patients harboring JAK2V617F provide a therapeutic target of elotuzumab.

  2019cites this paper
• Comorbidity associated to Ascaris suum infection during pulmonary fibrosis exacerbates chronic lung and liver inflammation and dysfunction but not affect the parasite cycle in mice

  2019influential citation
• Bleomycin use in the treatment of Hodgkin lymphoma (HL): toxicity and outcomes in the modern era

  2019cites this paper
• Pathogenesis of Fibrosis—The Lung as a Model

  2019cites this paper
• Interleukin 1α and 1β gene variations are associated with tuberculosis in silica exposed subjects.

  2019cites this paper
• Drug-Induced Interstitial Lung Disease

  2019cites this paper
• Fucoidan Inhibits Radiation-Induced Pneumonitis and Lung Fibrosis by Reducing Inflammatory Cytokine Expression in Lung Tissues

  2018cites this paper
• Role of Infiltrating Monocytes in the Development of Radiation-Induced Pulmonary Fibrosis

  2018cites this paper
• Inflammasome in the Pathogenesis of Pulmonary Diseases

  2018cites this paper
• Respiratory Toxicity of Polyhexamethylene Guanidine Phosphate Exposure in Zebrafish

  2018cites this paper
• The involvement of the NLRP3 inflammasome in donor lung injury

  2018cites this paper
• Veno-Venous Extracorporeal Membrane Oxygenation Use in the Treatment of Bleomycin Pulmonary Toxicity

  2017cites this paper
• Hypoxia and sterile inflammation in cystic fibrosis airways: mechanisms and potential therapies

  2017cites this paper
• Neuro-immune interactions during development of pulmonary fibrosis

  2017cites this paper
• Muc1 deficiency exacerbates pulmonary fibrosis in a mouse model of silicosis.

  2017cites this paper
• Strategies to Enhance the Therapeutic Ratio of Radiation as a Cancer Treatment

  2016cites this paper
• Myofibroblasts and lung fibrosis induced by carbon nanotube exposure

  2016cites this paper
• The IL-1 cytokine family and its role in inflammation and fibrosis in the lung

  2016cites this paper
• CaMKII inhibition in type II pneumocytes protects from bleomycin-induced pulmonary fibrosis by preventing Ca2+-dependent apoptosis.

  2016cites this paper
• Novel Strategies to Prevent, Mitigate or Reverse Radiation Injury and Fibrosis

  2016cites this paper
• Pulmonary toxicity of indium‐tin oxide production facility particles in rats

  2016cites this paper
• Mesenchymal Stromal Cell-Based Therapies for Chronic Lung Disease of Prematurity

  2016cites this paper
• Immunostimulation During and After R-CHOP Therapy for B-Cell Lymphoma

  2016influential citation
• Biologic treatments for pulmonary involvement in rheumatic disease

  2016cites this paper
• Cell-Based Therapy for Silicosis

  2016cites this paper
• [Genetic Features of Factors of Inflammation and Fibrosis Possible Common Pathway of Formation of Predisposition to Atrial Fibrillation and Chronic Obstructive Pulmonary Disease].

  2015cites this paper
• Switch regulation of interleukin-1 beta in downstream of inflammatory cytokines induced by two micro-sized silica particles on differentiated THP-1 macrophages.

  2015cites this paper
• Extracellular cathepsin S and intracellular caspase 1 activation are surrogate biomarkers of particulate-induced lysosomal disruption in macrophages

  2015cites this paper
• Interleukin-1 as a Common Denominator from Autoinflammatory to Autoimmune Disorders: Premises, Perils, and Perspectives

  2015cites this paper
• Pathobiology of wound healing after glaucoma filtration surgery

  2015cites this paper
• The exacerbating roles of CCAAT/enhancer-binding protein homologous protein (CHOP) in the development of bleomycin-induced pulmonary fibrosis and the preventive effects of tauroursodeoxycholic acid (TUDCA) against pulmonary fibrosis in mice.

  2015cites this paper
• Nano-risk Science: application of toxicogenomics in an adverse outcome pathway framework for risk assessment of multi-walled carbon nanotubes

  2015cites this paper
• Silica-induced NLRP3 inflammasome activation in vitro and in rat lungs

  2014cites this paper
• Pathogenesis and Mechanisms of Asbestosis and Silicosis

  2014cites this paper
• Asbestos‐Induced Chronic Inflammation and Cancer

  2014cites this paper
• Regulation of silica-induced pulmonary inflammation

  2014cites this paper
• The role of the inflammasome in fibrotic respiratory diseases.

  2014cites this paper
• Alternative strategies to manipulate fibrocyte involvement in the fibrotic tissue response: pharmacokinetic inhibition and the feasibility of directed-adipogenic differentiation.

  2014cites this paper
• Host responses in tissue repair and fibrosis.

  2013cites this paper
• Изменения в легких вследствие лекарственной терапии больных лимфомой Ходжкина

  2013cites this paper
• Therapeutic effect of exogenous bone marrow‑derived mesenchymal stem cell transplantation on silicosis via paracrine mechanisms in rats.

  2013cites this paper
• WNT/β-catenin signaling induces IL-1β expression by alveolar epithelial cells in pulmonary fibrosis.

  2013cites this paper
• Neutralization of interleukin-1 beta attenuates silica-induced lung inflammation and fibrosis in C57BL/6 mice

  2013cites this paper
• Bleomycin-Induced Lung Injury

  2013cites this paper
• IL1RN genetic variations and risk of IPF: a meta-analysis and mRNA expression study

  2012cites this paper
• Effect of Resveratrol on Treatment of Bleomycin-Induced Pulmonary Fibrosis in Rats

  2012cites this paper
• Th17 peripheral cells are increased in diffuse cutaneous systemic sclerosis compared with limited illness: a cross-sectional study

  2012cites this paper
• Comparison of non-crystalline silica nanoparticles in IL-1β release from macrophages

  2012cites this paper
• Inflammation and Pulmonary Fibrosis

  2012cites this paper
• Apoptotic and immunological markers in idiopathic pulmonary fibrosis: evolving concepts of pathogenesis

  2012cites this paper
• Pathogenesis and treatment of chemical-induced lung injury

  2012cites this paper
• IL-36α Exerts Pro-Inflammatory Effects in the Lungs of Mice

  2012cites this paper
• Association Between Proinflammatory Responses of Respirable Silica Dust and Adverse Health Effects Among Dust-Exposed Workers

  2012cites this paper
• Genetic variability in the IL1RN gene and the balance between interleukin (IL)‐1 receptor agonist and IL‐1β in idiopathic pulmonary fibrosis

  2011cites this paper
• Treatment with imatinib results in reduced IL-4-producing T cells, but increased CD4(+) T cells in the broncho-alveolar lavage of patients with systemic sclerosis.

  2011cites this paper
• Potential Role of the Inflammasome-Derived Inflammatory Cytokines in Pulmonary Fibrosis

  2011cites this paper
• Inflammasome and Lung Pathologies

  2011cites this paper
• Environment and the Role of Inflammation in Chronic Pulmonary Diseases: The Silent Mediator

  2011cites this paper
• Pathophysiological relevance of PDE inhibition in lung fibroblasts for the treatment of pulmonary diseases

  2010cites this paper
• Inflammasome and IL-1β-Mediated Disorders

  2010cites this paper
• Alternatively activated alveolar macrophages in pulmonary fibrosis-mediator production and intracellular signal transduction.

  2010cites this paper
• Proinflammatory responses triggerd by ricin toxin require macrophages and IL-1[beta] signaling through the NALP3 inflammasome

  2010cites this paper
• Cytokine‐dependent balance of mitogenic effects in primary human lung fibroblasts related to cyclic AMP signaling and phosphodiesterase 4 inhibition

  2010cites this paper
• Titanium dioxide induces different levels of IL-1beta production dependent on its particle characteristics through caspase-1 activation mediated by reactive oxygen species and cathepsin B.

  2010cites this paper
• The effect of surface modification of amorphous silica particles on NLRP3 inflammasome mediated IL-1beta production, ROS production and endosomal rupture.

  2010cites this paper
• IL-1RI deficiency ameliorates early experimental renal interstitial fibrosis.

  2009influential citation
• Corticosteroid resistance in pulmonary neutrophilic inflammatory disorders and rationale for adjunct IL-1beta targeted therapy.

  2009cites this paper
• IL-1 RI deficiency ameliorates early experimental renal interstitial fibrosis

  2009influential citation
• Pulmonary fibrosis: pathogenesis, etiology and regulation

  2009cites this paper
• N-acetylcysteine inhibits TNF-alpha, sTNFR, and TGF-beta1 release by alveolar macrophages in idiopathic pulmonary fibrosis in vitro.

  2009cites this paper
• 16,16-Dimethyl prostaglandin E2 efficacy on prevention and protection from bleomycin-induced lung injury and fibrosis.

  2009cites this paper
• ROLE OF INFL AMMATION IN THE DEVELOPMENT OF LUNG FIBROSIS AND IN THE PATHOGENESIS OF PULMONARY HYPERTENSION

  2009cites this paper
• How Frustration Leads to Inflammation

  2008cites this paper
• Association of cytokine gene polymorphisms in CWP and its severity in Turkish coal workers.

  2008cites this paper
• The Nalp3 inflammasome is essential for the development of silicosis

  2008cites this paper
• Long-term continuous exposure to static magnetic field reduces popolysaccharide-induced cytotoxicity of fibroblasts

  2008cites this paper