The molecular biology of mammalian lipoxygenases and the quest for eicosanoid functions using lipoxygenase-deficient mice.

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Biochimica et Biophysica Acta

• Publication date

  1996-11-11

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/S0005-2760(96)00107-5PMID 8944751
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity [published erratum appears in J Exp Med 1997 May 5;185(9):1715]

  1996cited by this paper
• Functional Expression and Cellular Localization of a Mouse Epidermal Lipoxygenase*

  1996cited by this paper
• Disruption of 12/15-Lipoxygenase Expression in Peritoneal Macrophages

  1996cited by this paper
• Sorting out the cytokines of asthma

  1996cited by this paper
• Structure conservation in lipoxygenases: Structural analysis of soybean lipoxygenase‐1 and modeling of human lipoxygenases

  1996cited by this paper
• Tyrosine Kinase Activity Modulates Catalysis and Translocation of Cellular 5-Lipoxygenase (*)

  1996cited by this paper
• Constitutive activation of 5-lipoxygenase in the lungs of patients with idiopathic pulmonary fibrosis.

  1996cited by this paper
• Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model

  1996cited by this paper
• Lipoxygenases: structural principles and spectroscopy.

  1996cited by this paper
• cDNA Cloning, Expression, Mutagenesis, Intracellular Localization, and Gene Chromosomal Assignment of Mouse 5-Lipoxygenase (*)

  1995cited by this paper
• Cloning and characterization of a murine macrophage lipoxygenase.

  1995cited by this paper
• A possible role for 15-lipoxygenase in atherogenesis.

  1995cited by this paper
• Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II

  1995cited by this paper
• The transcriptional regulation of human arachidonate 12-lipoxygenase gene by NF kappa B/Rel.

  1995cited by this paper
• Translocation and Leukotriene Synthetic Capacity of Nuclear 5-Lipoxygenase in Rat Basophilic Leukemia Cells and Alveolar Macrophages (*)

  1995cited by this paper
• Enhanced Levels of Lipoperoxides in Low Density Lipoprotein Incubated with Murine Fibroblasts Expressing High Levels of Human 15-Lipoxygenase (*)

  1995cited by this paper
• Differential Activation of Peroxisome Proliferator-activated Receptors by Eicosanoids (*)

  1995cited by this paper
• Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse.

  1995cited by this paper
• Tissue-specific regulation of the rabbit 15-lipoxygenase gene in erythroid cells by a transcriptional silencer.

  1995cited by this paper
• Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration.

  1995cited by this paper
• The RXR heterodimers and orphan receptors.

  1995cited by this paper
• 15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ

  1995cited by this paper
• Eosinophil recruitment into the respiratory epithelium following antigenic challenge in hyper-IgE mice is accompanied by interleukin 5-dependent bronchial hyperresponsiveness.

  1995cited by this paper
• Subcellular localization of 12(S)-hydroxy-5,8,10,14-eicosatetraenoic acid binding sites in Lewis lung carcinoma cells.

  1995cited by this paper
• Genomic and cDNA cloning of a novel mouse lipoxygenase gene.

  1995cited by this paper
• Induction of 15-lipoxygenase mRNA and protein in early atherosclerotic lesions.

  1995cited by this paper
• 5-Lipoxygenase is located in the euchromatin of the nucleus in resting human alveolar macrophages and translocates to the nuclear envelope upon cell activation.

  1995cited by this paper
• 5-Oxo-6,8,11,14-eicosatetraenoic acid is a potent stimulator of human eosinophil migration.

  1995cited by this paper
• 12-Lipoxygenase in Lewis lung carcinoma cells: molecular identity, intracellular distribution of activity and protein, and Ca(2+)-dependent translocation from cytosol to membranes.

  1995cited by this paper
• Ribozyme-mediated inhibition of expression of leukocyte-type 12-lipoxygenase in porcine aortic vascular smooth muscle cells.

  1995cited by this paper
• 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma.

  1995cited by this paper
• Leukotriene-deficient mice generated by targeted disruption of the 5-lipoxygenase gene.

  1995cited by this paper
• Arachidonate 15-hpoxygenase

  1995cited by this paper
• The transcriptional regulation of human arachidonate 12‐lipoxygenase gene by NFκB/Rel

  1995cited by this paper
• Arachidonate 15-lipoxygenase.

  1995cited by this paper
• Evidence that a leukocyte type of 12-lipoxygenase is expressed and regulated by angiotensin II in human adrenal glomerulosa cells.

  1994cited by this paper
• 5-Lipoxygenase.

  1994cited by this paper
• Targeted gene disruption by homologous recombination. Toward an understanding of specific blood cell functions.

  1994cited by this paper
• 12-Lipoxygenases and 12(S)-HETE: role in cancer metastasis

  1994cited by this paper
• Translation of 15‐lipoxygenase mRNA is inhibited by a protein that binds to a repeated sequence in the 3′ untranslated region.

  1994cited by this paper
• Neutrophils are essential for early anti-Listeria defense in the liver, but not in the spleen or peritoneal cavity, as revealed by a granulocyte-depleting monoclonal antibody

  1994cited by this paper
• Prostaglandin H Synthase and Lipoxygenase Gene Families in the Epithelial Cell Barrier a

  1994cited by this paper
• The structure and function of lipoxygenase.

  1994cited by this paper
• cDNA cloning, expression, mutagenesis of C-terminal isoleucine, genomic structure, and chromosomal localizations of murine 12-lipoxygenases.

  1994cited by this paper
• Altered inflammatory responses in leukotriene-deficient mice.

  1994cited by this paper
• Calcium promotes membrane association of reticulocyte 15-lipoxygenase.

  1994cited by this paper
• The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.

  1994cited by this paper
• 5-Lipoxygenase contains a functional Src homology 3-binding motif that interacts with the Src homology 3 domain of Grb2 and cytoskeletal proteins.

  1994cited by this paper
• Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene

  1994cited by this paper
• Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4.

  1994cited by this paper
• Localization of 5-lipoxygenase to the nucleus of unstimulated rat basophilic leukemia cells.

  1994cited by this paper
• Regio- and stereochemistry of the dioxygenation reaction catalyzed by (S)-type lipoxygenases or by the cyclooxygenase activity of prostaglandin H synthases.

  1994cited by this paper
• Arachidonate 12-lipoxygenase of rat pineal glands: catalytic properties and primary structure deduced from its cDNA.

  1994cited by this paper
• Lipoxygenase Deficiency in Primary Thrombocythemia Is not a True Deficiency

  1994cited by this paper
• Fibronectin-induced cell spreading and down-regulation of 12-lipoxygenase expression in megakaryocytic DAMI cells.

  1994cited by this paper
• Induction of 15-lipoxygenase by interleukin-13 in human blood monocytes.

  1994cited by this paper
• Targeted Gene Disruption by Homologous Recombination

  1994cited by this paper
• Redistribution of 5-lipoxygenase and cytosolic phospholipase A2 to the nuclear fraction upon macrophage activation.

  1993cited by this paper
• Molecular cloning of a 12-lipoxygenase cDNA from rat brain.

  1993cited by this paper
• Elevated glucose and angiotensin II increase 12-lipoxygenase activity and expression in porcine aortic smooth muscle cells.

  1993cited by this paper
• Molecular biology in the eicosanoid field.

  1993cited by this paper
• 5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes

  1993cited by this paper
• Arachidonate 12-lipoxygenase is localized in neurons, glial cells, and endothelial cells of the canine brain.

  1993cited by this paper
• 5‐lipoxygenase‐activating protein is an arachidonate binding protein

  1993cited by this paper
• The three-dimensional structure of an arachidonic acid 15-lipoxygenase.

  1993cited by this paper
• Human alveolar macrophages have 15-lipoxygenase and generate 15(S)-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid and lipoxins.

  1993cited by this paper
• Regulation of 5-lipoxygenase and 5-lipoxygenase-activating protein expression in HL-60 cells.

  1993cited by this paper
• Activity and protein distribution of 12-lipoxygenase in HEL cells: induction of membrane-association by phorbol ester TPA, modulation of activity by glutathione and 13-HPODE, and Ca(2+)-dependent translocation to membranes.

  1993cited by this paper
• Induction of arachidonate 12-lipoxygenase mRNA by epidermal growth factor in A431 cells.

  1993cited by this paper
• Decreased messenger RNA of arachidonate 12-lipoxygenase in platelets of patients with myeloproliferative disorders.

  1993cited by this paper
• A cryptic, microsomal-type arachidonate 12-lipoxygenase is tonically inactivated by oxidation-reduction conditions in cultured epithelial cells.

  1993cited by this paper
• Arachidonate 12-lipoxygenase of platelet-type in human epidermal cells.

  1993cited by this paper
• Differential expression of arachidonate 5-lipoxygenase transcripts in human brain tumors: evidence for the expression of a multitranscript family.

  1992cited by this paper
• Cellular oxidative modification of low density lipoprotein does not require lipoxygenases.

  1992cited by this paper
• Cloning of the guinea pig 5-lipoxygenase gene and nucleotide sequence of its promoter.

  1992cited by this paper
• Structure and chromosomal localization of human arachidonate 12-lipoxygenase gene.

  1992cited by this paper
• The role of the epidermal 12-hydroxyeicosatetraenoic acid receptor in the skin.

  1992cited by this paper
• Cloning and expression of an airway epithelial 12-lipoxygenase.

  1992cited by this paper
• Scoring a technical knockout in mice.

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• Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase.

  1992cited by this paper
• Localization of Arachidonate 12‐Lipoxygenase in Canine Brain Tissues

  1992cited by this paper
• Characterization of human 12-lipoxygenase genes.

  1992cited by this paper
• 15-Hydroxyeicosatetraenoic acid (15-HETE) receptors. Involvement in the 15-HETE-induced stimulation of the cryptic 5-lipoxygenase in PT-18 mast/basophil cells.

  1992cited by this paper
• Leukotriene B4 in the immune system.

  1992cited by this paper
• Mammalian lipoxygenases: molecular structures and functions.

  1992cited by this paper
• Altering genes in animals by gene targeting.

  1992cited by this paper
• Leukotriene C4 uses a probenecid-sensitive export carrier that does not recognize leukotriene B4.

  1992cited by this paper
• Cloning of human airway 15-lipoxygenase: identity to the reticulocyte enzyme and expression in epithelium.

  1992cited by this paper
• Molecular structure and function of the porcine arachidonate 12-lipoxygenase gene.

  1992cited by this paper
• Interleukin 4 is important in protective immunity to a gastrointestinal nematode infection in mice.

  1991cited by this paper
• Arachidonate 15-lipoxygenase; characteristics and potential biological significance.

  1991cited by this paper
• "Enzymatic" lipid peroxidation: reactions of mammalian lipoxygenases.

  1991cited by this paper
• Localization of arachidonate 12-lipoxygenase in canine brain tissues.

  1991cited by this paper
• The molecular biology of mammalian arachidonic acid metabolism.

  1991cited by this paper
• Gene expression in macrophage-rich human atherosclerotic lesions. 15-lipoxygenase and acetyl low density lipoprotein receptor messenger RNA colocalize with oxidation specific lipid-protein adducts.

  1991cited by this paper
• Arachidonate 15-lipoxygenase; characteristics and potential biological significance.

  1991cited by this paper
• Cloning and sequence analysis of the cDNA for arachidonate 12-lipoxygenase of porcine leukocytes.

  1990cited by this paper
• Characterization of the human 5-lipoxygenase gene promoter.

  1990cited by this paper
• Molecular cloning and expression of human arachidonate 12-lipoxygenase.

  1990cited by this paper
• Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions.

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