Cardiac-Specific YAP Activation Improves Cardiac Function and Survival in an Experimental Murine MI Model

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Circulation Research

• Publication date

  2014-05-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1161/CIRCRESAHA.115.303632PMID 24833660PMCID PMC4104149
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Legionella Kinase LegK2 Targets the ARP2/3 Complex To Inhibit Actin Nucleation on Phagosomes and Allow Bacterial Evasion of the Late Endocytic Pathway

  2015cited by this paper
• YAP and TAZ regulate skin wound healing.

  2014cited by this paper
• The Hippo Pathway Is Activated and Is a Causal Mechanism for Adipogenesis in Arrhythmogenic Cardiomyopathy

  2014cited by this paper
• Macrophages are required for neonatal heart regeneration.

  2014cited by this paper
• Remodeling and dedifferentiation of adult cardiomyocytes during disease and regeneration

  2013cited by this paper
• Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2

  2013cited by this paper
• Targeting inflammatory pathways in myocardial infarction

  2013cited by this paper
• Macrophages are required for adult salamander limb regeneration

  2013cited by this paper
• Hippo pathway effector Yap promotes cardiac regeneration

  2013cited by this paper
• Hippo signaling impedes adult heart regeneration

  2013cited by this paper
• Clonally dominant cardiomyocytes direct heart morphogenesis

  2012cited by this paper
• C/EBP Transcription Factors Mediate Epicardial Activation During Heart Development and Injury

  2012cited by this paper
• YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy

  2012cited by this paper
• Mammalian Myocardial Regeneration

  2012cited by this paper
• Muscle : fundamental biology and mechanisms of disease

  2012cited by this paper
• Control of mitochondrial structure and function by the Yorkie/YAP oncogenic pathway.

  2012cited by this paper
• Hippo Pathway Inhibits Wnt Signaling to Restrain Cardiomyocyte Proliferation and Heart Size

  2011cited by this paper
• Yap 1 Acts Downstream of a-Catenin to Control Epidermal Proliferation

  2011cited by this paper
• Regulation of Insulin-Like Growth Factor Signaling by Yap Governs Cardiomyocyte Proliferation and Embryonic Heart Size

  2011cited by this paper
• The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version.

  2010cited by this paper
• TWEAK is a positive regulator of cardiomyocyte proliferation.

  2010cited by this paper
• Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells.

  2010cited by this paper
• Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury.

  2009influential reference
• Gene Therapy Using Adeno-Associated Virus Vectors

  2008cited by this paper
• TEAD mediates YAP-dependent gene induction and growth control.

  2008cited by this paper
• Analysis of AAV serotypes 1-9 mediated gene expression and tropism in mice after systemic injection.

  2008cited by this paper
• Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

  2008cited by this paper
• Lats2 Is a Negative Regulator of Myocyte Size in the Heart

  2008cited by this paper
• YAP1 increases organ size and expands undifferentiated progenitor cells.

  2007cited by this paper
• Elucidation of a universal size-control mechanism in Drosophila and mammals.

  2007cited by this paper
• Production and characterization of adeno-associated viral vectors

  2006cited by this paper
• Anillin localization defect in cardiomyocyte binucleation.

  2006cited by this paper
• Myocardial gene transfer and long‐term expression following intracoronary delivery of adeno‐associated virus

  2005cited by this paper
• Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline induction

  2005cited by this paper
• Mouse cardiac surgery: comprehensive techniques for the generation of mouse models of human diseases and their application for genomic studies.

  2004cited by this paper
• IL-6 levels in acute and post myocardial infarction: their relation to CRP levels, infarction size, left ventricular systolic function, and heart failure.

  2004cited by this paper
• Targeted Expression of Cyclin D2 Results in Cardiomyocyte DNA Synthesis and Infarct Regression in Transgenic Mice

  2004cited by this paper
• Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy.

  2003cited by this paper
• Telomerase reverse transcriptase promotes cardiac muscle cell proliferation, hypertrophy, and survival

  2001cited by this paper
• Apoptotic versus autophagic cell death in heart failure.

  2001cited by this paper
• Gene recombination in postmitotic cells. Targeted expression of Cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in vivo.

  1997cited by this paper

• NMRK2-YAP-NADK axis preserves redox protection against myocardial ischemia/reperfusion injury.

  2026cites this paper
• TEAD-independent mechanisms of YAP function in cardiomyocyte cell cycle reentry

  2026cites this paper
• Mechanisms and Therapeutic Potential of Human Cardiomyocyte Proliferation.

  2026cites this paper
• Fungal commensal promotes intestinal repair via its secreted peptide in mice

  2026cites this paper
• Neonatally-derived multipotent Islet-1+ Mesp1+FOXA2+ stem cell clones restore cardiac function in sheep

  2026cites this paper
• Functional Restoration of Uterine Architecture and Fertility via a 3D-Printed Biomimetic Scaffold: The Role of Macrophage-Driven Immunomodulation

  2026cites this paper
• Insights into Cardiomyocyte Regeneration from Screening and Transcriptomics Approaches

  2026cites this paper
• Cross-species comparison reveals that Hmga1 reduces H3K27me3 levels to promote cardiomyocyte proliferation and cardiac regeneration

  2025cites this paper
• The drug-elicitable alternative splicing module for tunable vector expression in the heart

  2025cites this paper
• The Role of Yes‐Associated Protein in Inflammatory Diseases and Cancer

  2025cites this paper
• Geometrically controlled cardiac microtissues promote vascularization and reduce inflammation in vitro and in vivo.

  2025cites this paper
• Molecular gatekeepers of endogenous adult mammalian cardiomyocyte proliferation

  2025cites this paper
• Gene therapy in cardiac and vascular diseases: a review of approaches to treat genetic and common cardiovascular diseases with novel gene-based therapeutics

  2025cites this paper
• The effects of YAP/TAZ in cardiomyocytes: a scoping review

  2025cites this paper
• Network Modeling Predicts How DYRK1A Inhibition Promotes Cardiomyocyte Cycling after Ischemic/Reperfusion Injury

  2025cites this paper
• Exploring Hippo YAP/TAZ Signaling: A Novel Avenue for Cardiovascular Disorders

  2025cites this paper
• Expression of foetal gene Pontin is essential in protecting heart against pathological remodelling and cardiomyopathy

  2025cites this paper
• Cell type specificity of hippo-YAP signaling in cardiac development and disease.

  2025cites this paper
• Targeting the Hippo pathway for cardiac regeneration.

  2025cites this paper
• Cardiomyocyte YAP represses myocardial inflammation and fibrosis and restrains MEF2 regulated gene expression.

  2025cites this paper
• Cell cycle arrest of cardiomyocytes in the context of cardiac regeneration

  2025cites this paper
• The immune system in cardiovascular diseases: from basic mechanisms to therapeutic implications

  2025cites this paper
• Heart Regeneration and Repair: Molecular Mechanism and Therapeutic Targets

  2025cites this paper
• YAP1 reactivation in cardiomyocytes following ECM remodelling contributes to the development of contractile force and sarcomere maturation

  2025cites this paper
• Messenger RNA (mRNA) based therapeutics in transforming cardiovascular care: Progress, regulatory challenges and future perspectives.

  2025cites this paper
• Fatty acid metabolism suppresses neonatal cardiomyocyte proliferation by increasing PDK4 and HMGCS2 expression through PPARδ

  2025cites this paper
• Crosstalk between MST1-Hippo and Wnt/β-Catenin, Notch, and PI3K/Akt pathways in cardiac physiology and pathology

  2025influential citation
• PTMA controls cardiomyocyte proliferation and cardiac repair by enhancing STAT3 acetylation

  2025cites this paper
• Transient overexpression of hPKM2 in porcine cardiomyocytes prevents heart failure after myocardial infarction

  2025cites this paper
• METTL1‐Mediated M7G tRNA Modification Promotes Residual Liver Regeneration After Hepatectomy via Translational Control

  2025cites this paper
• Phosphoserine aminotransferase 1 promotes serine synthesis pathway and cardiac repair after myocardial infarction

  2025cites this paper
• Protein Phosphatase 1 Regulatory Subunit 17 (PPP1R17) Regulates Cerebral Ischemia and Ischemia–Reperfusion Brain Injury by Suppressing YAP1-Mediated Mitophagy

  2025cites this paper
• Cardiac Development, Cellular Composition and Function: From Regulatory Mechanisms to Applications

  2025cites this paper
• DWORF Gene Therapy Improves Cardiac Calcium Handling and Mitochondrial Function.

  2025cites this paper
• Harnessing mRNA technology for ischemic heart disease: a review of regenerative and protective therapies

  2025cites this paper
• The Role of Mechanosignaling in the Control of Myocardial Mass.

  2024cites this paper
• YAP Alleviates Pulmonary Fibrosis Through Promoting Alveolar Regeneration via Modulating the Stemness of Alveolar Type 2 Cells

  2024cites this paper
• A Drug-Elicitable Alternative-Splicing Module (DreAM) for Tunable AAV Expression and Controlled Myocardial Regeneration

  2024cites this paper
• Silencing DOCK2 Attenuates Cardiac Fibrosis Following Myocardial Infarction in Mice Via Targeting PI3K/Akt and Wnt/β-Catenin Pathways

  2024cites this paper
• Tudor-SN promotes cardiomyocyte proliferation and neonatal heart regeneration through regulating the phosphorylation of YAP

  2024cites this paper
• Dual Mechanism of Action: Exosomes from Human iPSC-Cardiomyocytes and Mesenchymal Stem Cells Restore Injured Myocardium

  2024cites this paper
• MBNL1 Regulates Programmed Postnatal Switching Between Regenerative and Differentiated Cardiac States

  2024cites this paper
• Cell Polyploidy. Cardiac Muscle. Liver. Ontogenesis and Regeneration

  2024cites this paper
• MicroRNA205: A Key Regulator of Cardiomyocyte Transition from Proliferative to Hypertrophic Growth in the Neonatal Heart

  2024cites this paper
• Cardiomyocyte‐Specific Overexpression of Activated Yes‐Associated Protein Modified‐RNA Promotes Cardiomyocyte Proliferation and Myocardial Regeneration

  2024cites this paper
• The genetics of cardiomyocyte polyploidy.

  2024cites this paper
• The roles of Hippo/YAP signaling pathway in physical therapy

  2024cites this paper
• Decoding the Impact of the Hippo Pathway on Different Cell Types in Heart Failure.

  2024cites this paper
• Engineered bone marrow mesenchymal stem cell-derived exosomes loaded with miR302 through the cardiomyocyte specific peptide can reduce myocardial ischemia and reperfusion (I/R) injury

  2024cites this paper
• Targeting cardiomyocyte cell cycle regulation in heart failure

  2024cites this paper
• YAP/TAZ as mechanobiological signaling pathway in cardiovascular physiological regulation and pathogenesis

  2024cites this paper
• The Hippo signaling pathway in development and regeneration.

  2024cites this paper
• Signaling Pathways Governing Cardiomyocyte Differentiation

  2024cites this paper
• Prostaglandin E2 Induces YAP1 and Agrin Through EP4 in Neonatally-Derived Islet-1+ Stem Cells

  2024cites this paper
• The potential role of hippo pathway effector yap1/yap1b in female-biased sexual size dimorphism of Chinese tongue sole (Cynoglossus semilaevis)

  2024cites this paper
• Yap is a Nutrient Sensor Sensitive to the Amino Acid L-Isoleucine and Regulates Expression of Ctgf in Cardiomyocytes

  2024cites this paper
• Role of transcriptional cofactors in cardiovascular diseases.

  2024cites this paper
• YAP K236 Acetylation Facilitates its Nucleic Export and Deprived the Protection against Cardiac Hypertrophy in Mice.

  2024cites this paper
• The role of the extracellular matrix in cardiac regeneration

  2024cites this paper
• The Hippo pathway: Organ size control and beyond.

  2024cites this paper
• Engineered Cardiac Tissues as a Platform for CRISPR‐Based Mitogen Discovery

  2024cites this paper
• The Hippo Signaling Pathway, Reactive Oxygen Species Production, and Oxidative Stress: A Two-Way Traffic Regulation

  2024cites this paper
• Transition from fetal to postnatal state in the heart: Crosstalk between metabolism and regeneration

  2024cites this paper
• Apelin‐13's Actions in Controlling Hypertension‐Related Cardiac Hypertrophy and the Expressions of Inflammatory Cytokines

  2024cites this paper
• Lats-IN-1 protects cardiac function and promotes regeneration after myocardial infarction by targeting the hippo pathway

  2024cites this paper
• HDAC7 promotes cardiomyocyte proliferation by suppressing myocyte enhancer factor 2

  2024cites this paper
• Yap Is a Nutrient Sensor Sensitive to the Amino Acid L-Isoleucine and Regulates the Expression of Ctgf in Cardiomyocytes

  2024cites this paper
• Untangling the role of RhoA in the heart: protective effect and mechanism

  2024cites this paper
• Virally delivered CMYA5 enhances the assembly of cardiac dyads

  2024cites this paper
• The Multifaceted Roles of Hippo-YAP in Cardiovascular Diseases

  2024cites this paper
• HAX1-Overexpression Augments Cardioprotective Efficacy of Stem Cell-Based Therapy Through Mediating Hippo-Yap Signaling

  2024cites this paper
• Another-regulin regulates cardiomyocyte calcium handling via integration of neuroendocrine signaling with SERCA2a activity

  2024cites this paper
• Leveraging chromatin state transitions for the identification of regulatory networks orchestrating heart regeneration

  2024cites this paper
• Redifferentiated cardiomyocytes retain residual dedifferentiation signatures and are protected against ischemic injury

  2023cites this paper
• Cardiomyocyte Ploidy, Metabolic Reprogramming and Heart Repair

  2023cites this paper
• TMEM11 regulates cardiomyocyte proliferation and cardiac repair via METTL1-mediated m7G methylation of ATF5 mRNA

  2023cites this paper
• Integrated metabolic and epigenetic mechanisms in cardiomyocyte proliferation.

  2023cites this paper
• Genetic recording of in vivo cell proliferation by ProTracer

  2023cites this paper
• Integrative transcriptomics and cell systems analyses reveal protective pathways controlled by Igfbp‐3 in anthracycline‐induced cardiotoxicity

  2023cites this paper
• Are There Hopeful Therapeutic Strategies to Regenerate the Infarcted Hearts?

  2023cites this paper
• Drug Discovery for Adult Cardiomyocyte Regeneration: Opportunities and Challenges

  2023influential citation
• Regeneration of the heart: from molecular mechanisms to clinical therapeutics

  2023cites this paper
• Mechanosensation to inflammation: Roles for YAP/TAZ in innate immune cells

  2023cites this paper
• β-catenin ameliorates myocardial infarction by preventing YAP-associated apoptosis

  2023cites this paper
• Regulation of endogenous cardiomyocyte proliferation: The known unknowns

  2023cites this paper
• Neonatal Cardiovascular-Progenitor-Cell-Derived Extracellular Vesicles Activate YAP1 in Adult Cardiac Progenitor Cells

  2023cites this paper
• Altered coronary artery function, arteriogenesis and endothelial YAP signaling in postnatal hypertrophic cardiomyopathy

  2023cites this paper
• Jmjd4 Facilitates Pkm2 Degradation in Cardiomyocytes and Is Protective Against Dilated Cardiomyopathy

  2023cites this paper
• The Hippo Pathway Effectors YAP/TAZ-TEAD Oncoproteins as Emerging Therapeutic Targets in the Tumor Microenvironment

  2023cites this paper
• Yes-Associated Protein and Transcriptional Coactivator with PDZ-Binding Motif in Cardiovascular Diseases

  2023cites this paper
• The circular RNA circHelz enhances cardiac fibrosis by facilitating the nuclear translocation of YAP1.

  2023cites this paper
• Hippo signaling and histone methylation control cardiomyocyte cell cycle re-entry through distinct transcriptional pathways

  2023cites this paper
• Fusogenic Coiled-Coil Peptides Enhance Lipid Nanoparticle-Mediated mRNA Delivery upon Intramyocardial Administration

  2023cites this paper
• MBNL1 regulates programmed postnatal switching between regenerative and differentiated cardiac states

  2023cites this paper
• Neuregulin-1 regulates cardiomyocyte dynamics, cell cycle progression, and maturation during ventricular chamber morphogenesis

  2023cites this paper
• Genome Editing and Cardiac Regeneration.

  2023cites this paper
• An updated review of YAP: A promising therapeutic target against cardiac aging?

  2023cites this paper
• The critical role of miR-130b-5p in cardiomyocyte proliferation and cardiac repair in mice after myocardial infarction.

  2023cites this paper
• Systematic in vivo candidate evaluation uncovers therapeutic targets for LMNA dilated cardiomyopathy and risk of Lamin A toxicity

  2023cites this paper
• Nrg1 Regulates Cardiomyocyte Migration and Cell Cycle in Ventricular Development

  2023cites this paper