The roles of evolutionarily conserved functional modules in cilia-related trafficking

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Nature Cell Biology

• Publication date

  2013-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/ncb2888PMID 24296415PMCID PMC4016715
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Centriole distal appendages promote membrane docking, leading to cilia initiation.

  2013cited by this paper
• Single molecule imaging reveals a major role for diffusion in the exploration of ciliary space by signaling receptors

  2013cited by this paper
• NDR2‐mediated Rabin8 phosphorylation is crucial for ciliogenesis by switching binding specificity from phosphatidylserine to Sec15

  2013cited by this paper
• Molecular Basis of Tubulin Transport Within the Cilium by IFT74 and IFT81

  2013cited by this paper
• Exome sequencing identifies mutations in LZTFL1, a BBSome and smoothened trafficking regulator, in a family with Bardet–Biedl syndrome with situs inversus and insertional polydactyly

  2012cited by this paper
• Live-Cell Imaging Evidence for the Ciliary Transport of Rod Photoreceptor Opsin by Heterotrimeric Kinesin-2

  2012cited by this paper
• Primary cilia and coordination of receptor tyrosine kinase (RTK) signalling

  2012cited by this paper
• IFT25 links the signal-dependent movement of Hedgehog components to intraflagellar transport.

  2012cited by this paper
• The emerging role of Arf/Arl small GTPases in cilia and ciliopathies

  2012cited by this paper
• The X-linked retinitis pigmentosa protein RP2 facilitates G protein traffic.

  2012cited by this paper
• Cep164 mediates vesicular docking to the mother centriole during early steps of ciliogenesis

  2012cited by this paper
• The base of the cilium: roles for transition fibres and the transition zone in ciliary formation, maintenance and compartmentalization

  2012cited by this paper
• Inversin, Wnt signaling and primary cilia.

  2012cited by this paper
• Scoring a backstage pass: Mechanisms of ciliogenesis and ciliary access

  2012cited by this paper
• Who drives the ciliary highway?

  2012cited by this paper
• Arl3 and RP2 mediated assembly and traffic of membrane associated cilia proteins.

  2012cited by this paper
• Structural Studies of Ciliary Components

  2012cited by this paper
• RAB-Like 2 Has an Essential Role in Male Fertility, Sperm Intra-Flagellar Transport, and Tail Assembly

  2012cited by this paper
• BBS proteins interact genetically with the IFT pathway to influence SHH-related phenotypes

  2012cited by this paper
• Endocytosis genes facilitate protein and membrane transport in C. elegans sensory cilia.

  2012cited by this paper
• A Proteome-wide screen for mammalian SxIP motif-containing microtubule plus-end tracking proteins.

  2012cited by this paper
• The BBSome controls IFT assembly and turnaround in cilia

  2012cited by this paper
• The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis.

  2012cited by this paper
• The centrosome regulates the Rab11- dependent recycling endosome pathway at appendages of the mother centriole.

  2012cited by this paper
• Small molecule inhibitors of Smoothened ciliary localization and ciliogenesis

  2012cited by this paper
• The Arf GAP ASAP1 provides a platform to regulate Arf4‐ and Rab11–Rab8‐mediated ciliary receptor targeting

  2012cited by this paper
• The GTPase TcRjl of the human pathogen Trypanosoma cruzi is involved in the cell growth and differentiation.

  2012cited by this paper
• Architecture and function of IFT complex proteins in ciliogenesis.

  2012cited by this paper
• The Centrosome in Cells and Organisms

  2012influential reference
• IFT20 is required for opsin trafficking and photoreceptor outer segment development

  2011cited by this paper
• The structure of the nuclear pore complex.

  2011cited by this paper
• Rab23 is a flagellar protein in Trypanosoma brucei

  2011cited by this paper
• A Transition Zone Complex Regulates Mammalian Ciliogenesis and Ciliary Membrane Composition

  2011cited by this paper
• Rabs and other small GTPases in ciliary transport

  2011cited by this paper
• An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium.

  2011cited by this paper
• Ultrastructure of cilia and flagella – back to the future!

  2011cited by this paper
• A conserved signal and GTPase complex are required for the ciliary transport of polycystin-1

  2011cited by this paper
• Ciliopathies.

  2011cited by this paper
• Intraflagellar transport delivers tubulin isotypes to sensory cilium middle and distal segments

  2011cited by this paper
• Tracing the origins of centrioles, cilia, and flagella

  2011cited by this paper
• Rab8 GTPase as a regulator of cell shape

  2011cited by this paper
• Polycystin-2 takes different routes to the somatic and ciliary plasma membrane

  2011cited by this paper
• Remodelling of Cortical Actin Where Lytic Granules Dock at Natural Killer Cell Immune Synapses Revealed by Super-Resolution Microscopy

  2011cited by this paper
• Intraflagellar transport proteins in ciliogenesis of photoreceptor cells

  2011cited by this paper
• Crystal structure of the intraflagellar transport complex 25/27

  2011cited by this paper
• Dopamine receptor 1 localizes to neuronal cilia in a dynamic process that requires the Bardet-Biedl syndrome proteins

  2011cited by this paper
• Faculty of 1000 evaluation for Evolution: On a bender--BARs, ESCRTs, COPs, and finally getting your coat.

  2011cited by this paper
• Mutations in SDCCAG8/NPHP10 Cause Bardet-Biedl Syndrome and Are Associated with Penetrant Renal Disease and Absent Polydactyly

  2011cited by this paper
• Ciliogenesis: building the cell's antenna

  2011influential reference
• The Retrograde IFT Machinery of C. elegans Cilia: Two IFT Dynein Complexes?

  2011cited by this paper
• Thousands of Rab GTPases for the Cell Biologist

  2011cited by this paper
• MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis

  2011cited by this paper
• Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome

  2011cited by this paper
• Mutations in a Guanylate Cyclase GCY-35/GCY-36 Modify Bardet-Biedl Syndrome–Associated Phenotypes in Caenorhabditis elegans

  2011cited by this paper
• ARF family G proteins and their regulators: roles in membrane transport, development and disease

  2011cited by this paper
• On a bender—BARs, ESCRTs, COPs, and finally getting your coat

  2011cited by this paper
• A Novel Protein LZTFL1 Regulates Ciliary Trafficking of the BBSome and Smoothened

  2011cited by this paper
• BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly

  2010cited by this paper
• Coordination of Rab8 and Rab11 in primary ciliogenesis

  2010cited by this paper
• Planar Cell Polarity Acts Through Septins to Control Collective Cell Movement and Ciliogenesis

  2010cited by this paper
• TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia.

  2010cited by this paper
• cAMP and cGMP signaling: sensory systems with prokaryotic roots adopted by eukaryotic cilia.

  2010cited by this paper
• The small GTPases ARL-13 and ARL-3 coordinate intraflagellar transport and ciliogenesis

  2010cited by this paper
• Intraflagellar transport molecules in ciliary and nonciliary cells of the retina

  2010cited by this paper
• Identification and Functional Analysis of the Vision-Specific BBS3 (ARL6) Long Isoform

  2010cited by this paper
• The cell biology of vision

  2010cited by this paper
• A molecular network for de novo generation of the apical surface and lumen

  2010cited by this paper
• Ofd1, a human disease gene, regulates the length and distal structure of centrioles.

  2010cited by this paper
• The conserved Bardet-Biedl syndrome proteins assemble a coat that traffics membrane proteins to cilia.

  2010cited by this paper
• Differential role of Rab proteins in ciliary trafficking: Rab23 regulates Smoothened levels

  2010cited by this paper
• The cytoplasmic tail of fibrocystin contains a ciliary targeting sequence

  2010cited by this paper
• The AP-1 clathrin adaptor facilitates cilium formation and functions with RAB-8 in C. elegans ciliary membrane transport

  2010cited by this paper
• The Compartmentalized Bacteria of the Planctomycetes-Verrucomicrobia-Chlamydiae Superphylum Have Membrane Coat-Like Proteins

  2010cited by this paper
• Functional genomic screen for modulators of ciliogenesis and cilium length

  2010cited by this paper
• Predation and eukaryote cell origins: a coevolutionary perspective.

  2009influential reference
• Apical trafficking in epithelial cells: signals, clusters and motors

  2009cited by this paper
• Mechanistic insights into Bardet-Biedl syndrome, a model ciliopathy.

  2009cited by this paper
• A novel function for the atypical small G protein Rab-like 5 in the assembly of the trypanosome flagellum

  2009cited by this paper
• Primary Cilia and Signaling Pathways in Mammalian Development, Health and Disease

  2009cited by this paper
• Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium

  2009cited by this paper
• First and last ancestors: reconstructing evolution of the endomembrane system with ESCRTs, vesicle coat proteins, and nuclear pore complexes.

  2009cited by this paper
• Intraflagellar transport and the generation of dynamic, structurally and functionally diverse cilia.

  2009cited by this paper
• The exocyst protein Sec10 is necessary for primary ciliogenesis and cystogenesis in vitro.

  2009cited by this paper
• Motile Cilia of Human Airway Epithelia Are Chemosensory

  2009cited by this paper
• Primary ciliogenesis defects are associated with human astrocytoma/glioblastoma cells

  2009cited by this paper
• Electron-tomographic analysis of intraflagellar transport particle trains in situ

  2009cited by this paper
• Making sense of cilia in disease: The human ciliopathies

  2009cited by this paper
• The Chlamydomonas reinhardtii BBSome is an IFT cargo required for export of specific signaling proteins from flagella

  2009cited by this paper
• Ciliary targeting motif VxPx directs assembly of a trafficking module through Arf4

  2009cited by this paper
• Intraflagellar transport is required for polarized recycling of the TCR/CD3 complex to the immune synapse

  2009cited by this paper
• The motile cilium in development and disease: emerging new insights

  2009cited by this paper
• Intraflagellar Transport (IFT) Protein IFT25 Is a Phosphoprotein Component of IFT Complex B and Physically Interacts with IFT27 in Chlamydomonas

  2009cited by this paper
• Uncoordinated 119 Protein Controls Trafficking of Lck via the Rab11 Endosome and Is Critical for Immunological Synapse Formation1

  2009cited by this paper
• The RJL family of small GTPases is an ancient eukaryotic invention probably functionally associated with the flagellar apparatus.

  2009cited by this paper
• Hypomorphic mutations in syndromic encephalocele genes are associated with Bardet-Biedl syndrome

  2008cited by this paper
• Identification of ciliary localization sequences within the third intracellular loop of G protein-coupled receptors.

  2008cited by this paper
• Bardet–Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia

  2008cited by this paper
• Chapter Two Intraflagellar Transport (IFT)

  2008cited by this paper
• A BBSome subunit links ciliogenesis, microtubule stability, and acetylation.

  2008cited by this paper
• Intraflagellar transport motors in cilia: moving along the cell's antenna

  2008cited by this paper

• NDR2 kinase: A review of its physiological role and involvement in carcinogenesis.

  2025cites this paper
• G Protein‐Coupled Receptor Signal Intersection at the Primary Cilium

  2025cites this paper
• The role of IFT20 mediated by neuropeptide FILa1 in ciliary activity during larval settlement of Urechis unicinctus

  2025cites this paper
• The primary cilium as a multifunctional organelle: emerging roles and unanswered questions

  2025cites this paper
• Design principles of ciliary signaling

  2025cites this paper
• Intraflagellar transport-20 coiled-coil domain mediates the channelrhodopsins trafficking to the cilia in Chlamydomonas reinhardtii

  2025cites this paper
• Label-free proteomic comparison reveals ciliary and nonciliary phenotypes of IFT-A mutants

  2024cites this paper
• Patient-derived and gene-edited pluripotent stem cells lacking NPHP1 recapitulate juvenile nephronophthisis in abnormalities of primary cilia and renal cyst formation

  2024cites this paper
• C. elegans PPEF-type phosphatase (Retinal degeneration C ortholog) functions in diverse classes of cilia to regulate nematode behaviors

  2024cites this paper
• Insights into degradation and targeting of the photoreceptor channelrhodopsin-1.

  2024cites this paper
• The relationship between intraflagellar transport and upstream protein trafficking pathways and macrocyclic lactone resistance in Caenorhabditis elegans

  2024cites this paper
• ARL3 GTPases facilitate ODA16 unloading from IFT in motile cilia

  2024cites this paper
• Cilia and Cancer: From Molecular Genetics to Therapeutic Strategies

  2023cites this paper
• Label-free proteomic comparison reveals ciliary and non-ciliary phenotypes of IFT-A mutants

  2023cites this paper
• Effects of Sesquiterpene Lactones on Primary Cilia Formation (Ciliogenesis)

  2023cites this paper
• MAST4 promotes primary ciliary resorption through phosphorylation of Tctex-1

  2023cites this paper
• Knockout of the BRAP homolog in mice leads to abnormal tracheal cilia

  2023cites this paper
• Primary cilia in skeletal development and disease.

  2023cites this paper
• Arl3 regulates ODA16-mediated intraflagellar transport in motile cilia biogenesis

  2023cites this paper
• The Arf family GTPases: Regulation of vesicle biogenesis and beyond

  2023cites this paper
• Trisomy 21 induces pericentrosomal crowding delaying primary ciliogenesis and mouse cerebellar development

  2023cites this paper
• Evidence for intraflagellar transport in butterfly spermatocyte cilia

  2023cites this paper
• Composition, organization and mechanisms of the transition zone, a gate for the cilium

  2022influential citation
• Evidence for intraflagellar transport in butterfly spermatocyte cilia

  2022cites this paper
• Male infertility‐associated Ccdc108 regulates multiciliogenesis via the intraflagellar transport machinery

  2022cites this paper
• Structural diversity in a stereotypic organelle — Sensory cilia of Caenorhabditis elegans

  2022cites this paper
• Cytoskeletal Protein 4.1G Is Essential for the Primary Ciliogenesis and Osteoblast Differentiation in Bone Formation

  2022cites this paper
• Shedding of ciliary vesicles at a glance.

  2022cites this paper
• Intraflagellar transport 1 20 cilia-dependent and cilia-independent signaling pathways in cell development and tissue homeostasis.

  2022cites this paper
• KLC3 Regulates Ciliary Trafficking and Cyst Progression in CILK1 Deficiency–Related Polycystic Kidney Disease

  2022cites this paper
• Aromatic patterns: Tryptophan aromaticity as a catalyst for the emergence of life and rise of consciousness.

  2022cites this paper
• Evolutionarily conserved genetic interactions between nphp-4 and bbs-5 mutations exacerbate ciliopathy phenotypes

  2021cites this paper
• The exocyst complex and intracellular vesicles mediate soluble protein trafficking to the primary cilium

  2021cites this paper
• Rab‐like small GTPases in the regulation of ciliary Bardet‐Biedl syndrome (BBS) complex transport

  2021cites this paper
• The uptake of avermectins in Caenorhabditis elegans is dependent on Intra-Flagellar Transport and other protein trafficking pathways

  2021cites this paper
• TALPID3/KIAA0586 Regulates Multiple Aspects of Neuromuscular Patterning During Gastrointestinal Development in Animal Models and Human

  2021cites this paper
• Trisomy 21 increases microtubules and disrupts centriolar satellite localization

  2021cites this paper
• Evolutionarily conserved genetic interactions between nphp-4 and bbs-5 mutations exacerbate ciliopathy phenotypes.

  2021cites this paper
• Trisomy 21 induces pericentrosomal crowding disrupting early stages of primary ciliogenesis and mouse cerebellar development

  2021cites this paper
• CDKL kinase regulates the length of the ciliary proximal segment.

  2021cites this paper
• Phosphorylation and Ubiquitylation Regulate Protein Trafficking, Signaling, and the Biogenesis of Primary Cilia

  2021cites this paper
• Protein turnover dynamics suggest a diffusion-to-capture mechanism for peri-basal body recruitment and retention of intraflagellar transport proteins

  2021cites this paper
• Molecular basis of ciliary defects caused by compound heterozygous IFT144/WDR19 mutations found in cranioectodermal dysplasia.

  2021cites this paper
• A Model for Primary Cilium Biogenesis by Polarized Epithelial Cells: Role of the Midbody Remnant and Associated Specialized Membranes

  2021cites this paper
• Neutrophil degranulation interconnects over-represented biological processes in atrial fibrillation

  2021cites this paper
• Identification of the TTC26 Splice Variant in a Novel Complex Ciliopathy Syndrome with Biliary, Renal, Neurological, and Skeletal Manifestations

  2021cites this paper
• Ciliary GPCR‐based transcriptome as a key regulator of cilia length control

  2021cites this paper
• Propulsive nanomachines: the convergent evolution of archaella, flagella, and cilia.

  2020cites this paper
• Sub-Ciliary Segregation of Two Drosophila Transient Receptor Potential Channels Begins at the Initial Stage of Their Pre-Ciliary Trafficking

  2020cites this paper
• Protein turnover dynamics suggest a diffusion to capture mechanism for peri-basal body recruitment and retention of intraflagellar transport proteins

  2020cites this paper
• WD40-Repeat Proteins in Ciliopathies and Congenital Disorders of Endocrine System

  2020cites this paper
• Anterograde trafficking of ciliary MAP kinase–like ICK/CILK1 by the intraflagellar transport machinery is required for intraciliary retrograde protein trafficking

  2020cites this paper
• Loss of polycystins suppresses deciliation via the activation of the centrosomal integrity pathway

  2020cites this paper
• Architecture of the IFT ciliary trafficking machinery and interplay between its components

  2020cites this paper
• New perspectives on GPCRs: GPCR heterodimer formation (melanocortin receptor) and GPCR on primary cilia (melanin concentrating hormone receptor).

  2020cites this paper
• Dissecting the Vesicular Trafficking Function of IFT Subunits

  2020cites this paper
• A Ciliary View of the Immunological Synapse

  2019cites this paper
• HDAC3 and HDAC8 are required for cilia assembly and elongation

  2019cites this paper
• Novel insights into the genetic landscape of congenital heart disease with systems genetics.

  2019cites this paper
• Requirement of IFT-B–BBSome complex interaction in export of GPR161 from cilia

  2019cites this paper
• [Selective signaling pathway via feeding-related ciliary GPCR, melanin-concentrating hormone receptor 1].

  2019cites this paper
• [Current situation of researches on a sensor organelle, primary cilium, to understand the pathogenesis of ciliopathy].

  2019cites this paper
• The Late Endosomal Pathway Regulates the Ciliary Targeting of Tetraspanin Protein Peripherin 2

  2019cites this paper
• Cellular signalling by primary cilia in development, organ function and disease

  2019cites this paper
• Atoh1 Controls Primary Cilia Formation to Allow for SHH-Triggered Granule Neuron Progenitor Proliferation.

  2019cites this paper
• Rab7 regulates primary cilia disassembly through cilia excision

  2019cites this paper
• Defining the layers of a sensory cilium with STORM and cryoelectron nanoscopy

  2019cites this paper
• Key roles of Arf small G proteins and biosynthetic trafficking for animal development

  2019cites this paper
• Ciliogenesis Control Mechanisms in Cerebellar Neuron Progenitors

  2019cites this paper
• Deficiency of calpain-6 inhibits primary ciliogenesis

  2019cites this paper
• Roles for IFT172 and Primary Cilia in Cell Migration, Cell Division, and Neocortex Development

  2019cites this paper
• A null allele of Dnaaf2 displays embryonic lethality and mimics human ciliary dyskinesia.

  2019cites this paper
• Length-dependent disassembly maintains four different flagellar lengths in Giardia

  2019cites this paper
• Cilium Length and Intraflagellar Transport Regulation by Kinases PKG-1 and GCK-2 in Caenorhabditis elegans Sensory Neurons

  2018cites this paper
• Cell polarity: having and making sense of direction—on the evolutionary significance of the primary cilium/centrosome organ in Metazoa

  2018cites this paper
• The Joubert syndrome protein ARL13B binds tubulin to maintain uniform distribution of proteins along the ciliary membrane

  2018cites this paper
• Targeted deletion of the AAA-ATPase Ruvbl1 in mice disrupts ciliary integrity and causes renal disease and hydrocephalus

  2018cites this paper
• Trisomy 21 Represses Cilia Formation and Function.

  2018cites this paper
• Ciliary signalling in cancer

  2018cites this paper
• CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function

  2018cites this paper
• Biochemische und strukturelle Einsichten der proteolytischen Modifikation kleiner GTPasen durch bakterielle Effektoren aus Salmonella enterica und Vibrio vulnificus

  2018cites this paper
• BBS1 is involved in retrograde trafficking of ciliary GPCRs in the context of the BBSome complex

  2018cites this paper
• Regulation of ciliary membrane protein trafficking and signalling by kinesin motor proteins

  2018cites this paper
• Myosin-Va is required for preciliary vesicle transportation to the mother centriole during ciliogenesis

  2018cites this paper
• Dysfunction of ciliary vesicle trafficking in ciliopathies

  2018cites this paper
• The unusual flagellar-targeting mechanism and functions of the trypanosome ortholog of the ciliary GTPase Arl13b

  2018cites this paper
• Ciliopathy-associated mutations of IFT122 impair ciliary protein trafficking but not ciliogenesis

  2018cites this paper
• The role of RFX transcription factors in neurons and in the human brain

  2018cites this paper
• C11ORF74 interacts with the IFT-A complex and participates in ciliary BBSome localization

  2018cites this paper
• Retromer associates with the cytoplasmic amino-terminus of polycystin-2

  2018cites this paper
• Role for intraflagellar transport in building a functional transition zone

  2018cites this paper
• Ciliary protein trafficking mediated by IFT and BBSome complexes with the aid of kinesin-2 and dynein-2 motors.

  2018cites this paper
• Regulator of calcineurin-2 is a centriolar protein with a role in cilia length control

  2018cites this paper
• Regulator of calcineurin-2 is a ciliary protein with a role in cilia length control

  2017cites this paper
• The Cilium: Cellular Antenna and Central Processing Unit

  2017cites this paper
• Intraflagellar transport velocity is governed by the number of active KIF17 and KIF3AB motors and their motility properties under load

  2017cites this paper
• Export of membrane proteins from the Golgi complex to the primary cilium requires the kinesin motor, KIFC1

  2017cites this paper
• TGF-β receptor I/II trafficking and signaling at primary cilia are inhibited by ceramide to attenuate cell migration and tumor metastasis

  2017cites this paper
• Crystal structure of tetrameric human Rabin8 GEF domain

  2017cites this paper
• Localization of Protein Kinase NDR2 to Peroxisomes and Its Role in Ciliogenesis*

  2017cites this paper