Rab8 GTPase as a regulator of cell shape

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Cytoskeleton

• Publication date

  2011-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/cm.20529PMID 21850707
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Retinal Degeneration and Failure of Photoreceptor Outer Segment Formation in Mice with Targeted Deletion of the Joubert Syndrome Gene, Ahi1

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• Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice

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• A molecular network for de novo generation of the apical surface and lumen

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• RhoA Regulates Peroxisome Association to Microtubules and the Actin Cytoskeleton

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• Rab8 Interacts with Distinct Motifs in α2B- and β2-Adrenergic Receptors and Differentially Modulates Their Transport*

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• Coordination of Rab8 and Rab11 in primary ciliogenesis

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• Collapsin Response Mediator Protein-2 (Crmp2) Regulates Trafficking by Linking Endocytic Regulatory Proteins to Dynein Motors*

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• Alternative Splicing in Class V Myosins Determines Association with Rab10*

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• ARF6-Mediated Endosome Recycling Reverses Lipid Accumulation Defects in Niemann-Pick Type C Disease

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• Membrane organization and dynamics in cell polarity.

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• Ahi1, whose human ortholog is mutated in Joubert syndrome, is required for Rab8a localization, ciliogenesis and vesicle trafficking.

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• Myosin Vc is a molecular motor that functions in secretory granule trafficking.

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• Myosin Vc, a Member of the Actin Motor Family Associated with Rab8, Is Involved in the Release of DV2 from HepG2 Cells

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• Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.

  2009cited by this paper
• MICAL-L1 links EHD1 to tubular recycling endosomes and regulates receptor recycling.

  2009cited by this paper
• Mutant huntingtin impairs post-Golgi trafficking to lysosomes by delocalizing optineurin/Rab8 complex from the Golgi apparatus.

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• The primary cilium as a cellular signaling center: lessons from disease.

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• Negative Guidance Factor-Induced Macropinocytosis in the Growth Cone Plays a Critical Role in Repulsive Axon Turning

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• EphA2 engages Git1 to suppress Arf6 activity modulating epithelial cell-cell contacts.

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• Rab8 Regulates ABCA1 Cell Surface Expression and Facilitates Cholesterol Efflux in Primary Human Macrophages

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• MYO5B mutations cause microvillus inclusion disease and disrupt epithelial cell polarity

  2008cited by this paper
• Rab8 is Involved in Zymogen Granule Formation in Pancreatic Acinar AR42J Cells

  2008cited by this paper
• The Parkinson's disease protein α-synuclein disrupts cellular Rab homeostasis

  2008cited by this paper
• The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis.

  2008cited by this paper
• Involvement of Rab13 and JRAB/MICAL-L2 in epithelial cell scattering

  2008cited by this paper
• Muscle cells engage Rab8A and myosin Vb in insulin-dependent GLUT4 translocation.

  2008cited by this paper
• elipsa is an early determinant of ciliogenesis that links the IFT particle to membrane-associated small GTPase Rab8

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• Rab8b GTPase, a protein transport regulator, is an interacting partner of otoferlin, defective in a human autosomal recessive deafness form.

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• Roles for the recycling endosome, Rab8, and Rab11 in hantavirus release from epithelial cells

  2008cited by this paper
• CEP290 interacts with the centriolar satellite component PCM-1 and is required for Rab8 localization to the primary cilium.

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• GLUT4 Vesicle Recruitment and Fusion Are Differentially Regulated by Rac, AS160, and Rab8A in Muscle Cells*

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• Rab8 regulates basolateral secretory, but not recycling, traffic at the recycling endosome.

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• CP110 suppresses primary cilia formation through its interaction with CEP290, a protein deficient in human ciliary disease.

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• Substrate specificity and effect on GLUT4 translocation of the Rab GTPase-activating protein Tbc1d1.

  2007cited by this paper
• High-precision mapping of protein–protein interfaces: an integrated genetic strategy combining en masse mutagenesis and DNA-level parallel analysis on a yeast two-hybrid platform

  2007cited by this paper
• Myosin Vb interacts with Rab8a on a tubular network containing EHD1 and EHD3.

  2007cited by this paper
• MT1‐MMP proinvasive activity is regulated by a novel Rab8‐dependent exocytic pathway

  2007cited by this paper
• EHD1 regulates cholesterol homeostasis and lipid droplet storage.

  2007cited by this paper
• Functional dissection of Rab GTPases involved in primary cilium formation

  2007influential reference
• Functional Compartmentalization of Endosomal Trafficking for the Synaptic Delivery of AMPA Receptors during Long-Term Potentiation

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• A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis.

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• Rab GTPases Containing a CAAX Motif Are Processed Post-geranylgeranylation by Proteolysis and Methylation*

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• Purification and functional properties of a Rab8-specific GEF (Rabin3) in action remodeling and polarized transport.

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• Inhibition of Metabotropic Glutamate Receptor Signaling by the Huntingtin-binding Protein Optineurin*

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• Recycling Endosomes Supply AMPA Receptors for LTP

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• Mutant presenilin (A260V) affects Rab8 in PC12D cell.

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• Abnormal α‐Synuclein Interactions with Rab Proteins in α‐Synuclein A30P Transgenic Mice

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• A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport.

  2002influential reference
• Ypt32 recruits the Sec4p guanine nucleotide exchange factor, Sec2p, to secretory vesicles; evidence for a Rab cascade in yeast

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• GRAB: a physiologic guanine nucleotide exchange factor for Rab3A, which interacts with inositol hexakisphosphate kinase.

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• Rab8b and Its Interacting Partner TRIP8b Are Involved in Regulated Secretion in AtT20 Cells*

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• Protein quality control machinery supports primary ciliogenesis by eliminating GDP-bound Rab8-family GTPases

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• Crosstalk between the Rho and Rab family of small GTPases in neurodegenerative disorders

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• Rab8A promotes breast cancer progression by increasing surface expression of Tropomyosin-related kinase B.

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