Toward a pluri-component, multimodal, and dynamic organization of the ventral semantic stream in humans: lessons from stimulation mapping in awake patients

For many decades, neural basis underlying cognitive functions was conceived in a localizationist framework. Owing to the development of connectomics, an alternative hodotopical account was proposed, in which brain functions are sub-served by the interactions of large-scale distributed and parallel subnetworks (Catani, 2007; de Benedictis and Duffau, 2011). In this setting, the processing of visual information is divided in a dorsal stream dedicated to the analysis of the spatial position (“where”) and in a ventral stream specialized in object identification (“what”; Underleider and Haxby, 1994). By analogy, a dual-stream model for auditory language processing was suggested, with a dorsal stream involved in mapping sound to articulation and a ventral stream involved in mapping sound to meaning (Hickok and Poeppel, 2004). Nonetheless, the neural structures supporting the ventral route is still controversial. We have recently proposed a new model of language, in which the subcortical anatomical constraints have been incorporated (Duffau et al., 2013): beyond a well-recognized dorsal phonological/articulatory stream underlain by the superior longitudinal fascicle, the neuroanatomy subserving a parallel ventral stream involved in multimodal semantics was described. Here, our purpose is to detail the dynamic functional anatomy of this multi-component ventral route, constituted by direct and indirect pathways (explaining a possible compensation following brain injury) and implied in pluri-modal semantic processes—i.e., in verbal and non-verbal comprehension, control and noetic consciousness.

• Publication year

  2013

• Venue

  Frontiers in Systems Neuroscience

• Publication date

  2013-08-26

• Fields of study

  Biology, Medicine, Computer Science

• Identifiers
  DOI 10.3389/fnsys.2013.00044PMID 23986661PMCID 3752437
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A re-examination of neural basis of language processing: proposal of a dynamic hodotopical model from data provided by brain stimulation mapping during picture naming.

  2014cited by this paper
• Mapping the connectivity underlying multimodal (verbal and non-verbal) semantic processing: a brain electrostimulation study.

  2013cited by this paper
• Middle longitudinal fasciculus delineation within language pathways: a diffusion tensor imaging study in human.

  2013cited by this paper
• Brain Mapping: From Neural Basis of Cognition to Surgical Applications

  2012cited by this paper
• Brain Hodotopy: From Esoteric Concept to Practical Surgical Applications

  2011cited by this paper
• The structure and connectivity of semantic memory in the healthy older adult brain

  2011cited by this paper
• What is the role of the uncinate fasciculus? Surgical removal and proper name retrieval.

  2011cited by this paper
• Does the left superior longitudinal fascicle subserve language semantics? A brain electrostimulation study

  2011cited by this paper
• Is the human left middle longitudinal fascicle essential for language? A brain electrostimulation study

  2011cited by this paper
• Frontal terminations for the inferior fronto-occipital fascicle: anatomical dissection, DTI study and functional considerations on a multi-component bundle

  2011cited by this paper
• Anatomic dissection of the inferior fronto-occipital fasciculus revisited in the lights of brain stimulation data.

  2010cited by this paper
• The Neural Organization of Semantic Control: TMS Evidence for a Distributed Network in Left Inferior Frontal and Posterior Middle Temporal Gyrus

  2010cited by this paper
• The anterior temporal lobe semantic hub is a part of the language neural network: selective disruption of irregular past tense verbs by rTMS.

  2010cited by this paper
• The extreme capsule in humans and rethinking of the language circuitry

  2009influential reference
• Does post-lesional subcortical plasticity exist in the human brain?

  2009cited by this paper
• Is the left uncinate fasciculus essential for language?

  2009cited by this paper
• Evidence for an occipito-temporal tract underlying visual recognition in picture naming.

  2009cited by this paper
• White matter functional connectivity as an additional landmark for dominant temporal lobectomy

  2008cited by this paper
• Does the left inferior longitudinal fasciculus play a role in language? A brain stimulation study.

  2007cited by this paper
• From hodology to function.

  2007influential reference
• Meta-analyzing left hemisphere language areas: Phonology, semantics, and sentence processing

  2006cited by this paper
• New insights into the anatomo-functional connectivity of the semantic system: a study using cortico-subcortical electrostimulations.

  2005cited by this paper
• Dorsal and ventral streams: a framework for understanding aspects of the functional anatomy of language.

  2004cited by this paper
• 'What' and 'where' in the human brain.

  1994cited by this paper

• Enhancing Verb Naming with Anodal tDCS Over the Left Inferior Frontal Gyrus: Insights from Lesion Mapping and Structural Connectivity Estimation

  2026cites this paper
• [Surgical treatment of intracerebral frontal lobe tumors. Part II: speech functional system].

  2025cites this paper
• Language neuroscience in the operating room: neurosurgical considerations for multilingual brain tumor patients

  2025cites this paper
• Impact of air pollution on Neurite Orientation Dispersion and Density metrics (NODDI) in 10–13-year-old children with and without ADHD diagnosis

  2025cites this paper
• Networks for proper versus common name retrieval: insights from causal mapping and new hypotheses

  2025cites this paper
• Loss of microstructural integrity in left hemispheric white matter tracts is associated with poorer digits in noise understanding.

  2025cites this paper
• Multiple brain activation patterns underlying successful visual short-term memory across the adult lifespan

  2025cites this paper
• Identifying proximity to white matter language tracts with gradient-based intraoperative electrical mapping.

  2025cites this paper
• White matter microstructural plasticity associated with educational intervention in reading disability

  2024cites this paper
• Individual differences of white matter characteristic along the anterior insula-based fiber tract circuit for pain empathy in healthy women and women with primary dysmenorrhea

  2024cites this paper
• Function-guided differences of arcuate fascicle and inferior fronto-occipital fascicle tractography as diagnostic indicators for surgical risk stratification

  2024cites this paper
• Aberrant White Matter Development in Cerebral Visual Impairment: A Proposed Mechanism for Visual Dysfunction Following Early Brain Injury

  2024cites this paper
• Impact of white matter networks on risk for memory decline following resection versus ablation in temporal lobe epilepsy

  2024influential citation
• Anatomo-functional profile of white matter tracts in relevance to language: A systematic review

  2024cites this paper
• Right hemisphere and metaphor comprehension: A connectionist perspective.

  2023cites this paper
• Application of diffusion tensor imaging in the diagnosis of post-stroke aphasia: a meta-analysis and systematic review

  2023cites this paper
• Ventral and dorsal aspects of the inferior frontal-occipital fasciculus support verbal semantic access and visually-guided behavioural control

  2023influential citation
• Understanding Language Reorganization With Neuroimaging: How Language Adapts to Different Focal Lesions and Insights Into Clinical Applications

  2022cites this paper
• Exploring the ventral white matter language network in bimodal and unimodal bilinguals.

  2022cites this paper
• Atypical structural connectivity of language networks in autism spectrum disorder: A meta‐analysis of diffusion tensor imaging studies

  2022cites this paper
• Segregated circuits for phonemic and semantic fluency: A novel patient-tailored disconnection study

  2022cites this paper
• Structural Connectivity in Down Syndrome and Alzheimer’s Disease

  2022cites this paper
• Profiling morphologic MRI features of motor neuron disease caused by TARDBP mutations

  2022cites this paper
• Functional network and structural connections involved in picture naming.

  2022cites this paper
• Converting sounds to meaning with ventral semantic language networks: integration of interdisciplinary data on brain connectivity, direct electrical stimulation and clinical disconnection syndromes

  2022cites this paper
• The importance of basal-temporal white matter to pre- and post-surgical naming ability in temporal lobe epilepsy

  2022cites this paper
• Fixel-based evidence of microstructural damage in crossing pathways improves language mapping in Post-stroke aphasia

  2021cites this paper
• Impairment and Plasticity of Language-Related White Matter in Patients With Brain Arteriovenous Malformations

  2021cites this paper
• Benefit of Action Naming Over Object Naming for Visualization of Subcortical Language Pathways in Navigated Transcranial Magnetic Stimulation-Based Diffusion Tensor Imaging-Fiber Tracking

  2021influential citation
• Semantic Cognition

  2021cites this paper
• Reading

  2021cites this paper
• The Relevant Role of Navigated Tractography in Speech Eloquent Area Glioma Surgery: Single Center Experience

  2021cites this paper
• Naming: Nouns and Verbs

  2021cites this paper
• Anatomical aspects of the insula, opercula and peri-insular white matter for a transcortical approach to insular glioma resection

  2021cites this paper
• The inferior longitudinal fasciculus: anatomy, function and surgical considerations.

  2021cites this paper
• Anatomy and White Matter Connections of the Lingual Gyrus and Cuneus.

  2021cites this paper
• Prediction of Aphasia Severity in Patients with Stroke Using Diffusion Tensor Imaging

  2021cites this paper
• Correlations between Dual-Pathway White Matter Alterations and Language Impairment in Patients with Aphasia: A Systematic Review and Meta-analysis

  2021cites this paper
• New Philosophy, Clinical Pearls, and Methods for Intraoperative Cognition Mapping and Monitoring "à la carte" in Brain Tumor Patients.

  2021cites this paper
• A Review of Cortical and Subcortical Stimulation Mapping for Language.

  2021cites this paper
• Revisiting the functional anatomy of the human brain: Toward a meta-networking theory of cerebral functions.

  2020cites this paper
• Towards a tractography-based risk stratification model for language area associated gliomas

  2020cites this paper
• Effects of vocal music on verbal learning and long-term recovery after stroke

  2020cites this paper
• Relation Between Reading Performance and White-Matter Alteration and Reorganization in Neurosurgical Patients

  2020cites this paper
• Intraoperative Direct Stimulation Identification and Preservation of Critical White Matter Tracts During Brain Surgery.

  2020cites this paper
• Bundle analytics, a computational framework for investigating the shapes and profiles of brain pathways across populations

  2020cites this paper
• What do we know about pre- and postoperative plasticity in patients with glioma? A review of neuroimaging and intraoperative mapping studies

  2020cites this paper
• Microsurgical anatomy of language

  2020cites this paper
• Altered brain structures in the dorsal and ventral language pathways in individuals with and without developmental language disorder (DLD)

  2020influential citation
• A case of aphasia due to temporobasal edema: Contemporary models of language anatomy are clinically relevant

  2020cites this paper
• The cortical organization of language: distilling human connectome insights for supratentorial neurosurgery.

  2020cites this paper
• Structural white matter connectometry of word production in aphasia: an observational study.

  2020cites this paper
• Changes in white matter microstructure related to non-linguistic cognitive impairment in post-stroke aphasia

  2020cites this paper
• Transcortico-subcortical approach for left posterior mediobasal temporal region gliomas: a case series and anatomical review of relevant white matter tracts.

  2020cites this paper
• Translational Neuroscience of Aphasia and Adult Language Rehabilitation

  2020cites this paper
• Structural properties of the ventral reading pathways are associated with morphological processing in adult English readers.

  2019cites this paper
• Beyond Language: Mapping Cognition and Emotion.

  2019cites this paper
• Awake Craniotomy and Bedside Cognitive Mapping in Neurosurgery

  2019cites this paper
• Awake Craniotomies for Neoplasms Involving Language Networks

  2019cites this paper
• White matter integrity in brain structures supporting semantic processing is associated with value-directed remembering in older adults.

  2019cites this paper
• Grey and white matter substrates of action naming.

  2019cites this paper
• Association Between White Matter Microstructure and Verbal Fluency in Patients With Multiple Sclerosis

  2019cites this paper
• Cognitive and neural mechanisms underlying the mnemonic effect of songs after stroke

  2019cites this paper
• Disruption of the Frontal Aslant Tract is Not Associated with Long-Term Postoperative Language Deficits: A Case Report.

  2019cites this paper
• The impact of expressive language development and the left inferior longitudinal fasciculus on listening and reading comprehension

  2019cites this paper
• The link between structural connectivity and neurocognition illustrated by focal epilepsy.

  2018cites this paper
• Objective analysis of the topological organization of the human cortical visual connectome suggests three visual pathways

  2018cites this paper
• Beyond the word and image: II‐ Structural and functional connectivity of a common semantic system

  2018influential citation
• Microsurgical Anatomy of the Vertical Rami of the Superior Longitudinal Fasciculus: An Intraparietal Sulcus Dissection Study.

  2018cites this paper
• Functional compensation of the left inferior longitudinal fasciculus for picture naming

  2018cites this paper
• Electrical stimulation of the dorsolateral prefrontal cortex impairs semantic cognition

  2018cites this paper
• Multifunctional Roles of the Ventral Stream in Language Models: Advanced Segmental Quantification in Post-Stroke Aphasic Patients

  2018influential citation
• One tract, two tract, old tract, new tract: A pilot study of the structural and functional differentiation of the inferior fronto-occipital fasciculus

  2018cites this paper
• Rostro‐caudal organization of the human posterior superior temporal sulcus revealed by connectivity profiles

  2018cites this paper
• Surgical Anatomy of the Insula

  2018cites this paper
• Value-Directed Remembering and Aging: Examination of Supporting Mechanisms and Effects on Memory Quality

  2018cites this paper
• A Connectomic Atlas of the Human Cerebrum-Chapter 12: Tractographic Description of the Middle Longitudinal Fasciculus.

  2018cites this paper
• Functional Anatomy of the Inferior Longitudinal Fasciculus: From Historical Reports to Current Hypotheses

  2018cites this paper
• Association of excessive social media use with abnormal white matter integrity of the corpus callosum.

  2018cites this paper
• Sigmund Freud—early network theories of the brain

  2018cites this paper
• From blueprints to brain maps: the status of the Lemma Model in cognitive neuroscience

  2018cites this paper
• In Reply: Microsurgical Anatomy of the Vertical Rami of the Superior Longitudinal Fasciculus: An Intraparietal Sulcus Dissection Study.

  2018cites this paper
• A Role for the Frontal Aslant Tract in Speech Planning: A Neurosurgical Case Study

  2018cites this paper
• Toward a functional neuroanatomy of semantic aphasia: A history and ten new cases.

  2017cites this paper
• Interactions Between Diffuse Low-Grade Glioma (DLGG), Brain Connectome and Neuroplasticity

  2017cites this paper
• Language, Cognitive and Emotional Evaluations

  2017cites this paper
• A graded tractographic parcellation of the temporal lobe

  2017cites this paper
• Neuronavigated Fiber Dissection with Pial Preservation: Laboratory Model to Simulate Opercular Approaches to Insular Tumors.

  2017cites this paper
• Neural pathways subserving face-based mentalizing

  2017cites this paper
• Individual differences in social desirability are associated with white-matter microstructure of the external capsule

  2017cites this paper
• Laterality of anterior temporal lobe repetitive transcranial magnetic stimulation determines the degree of disruption in picture naming

  2017cites this paper
• The tract terminations in the temporal lobe: Their location and associated functions

  2017influential citation
• The error of Broca: From the traditional localizationist concept to a connectomal anatomy of human brain.

  2017cites this paper
• Mapping Domain-Selective and Counterpointed Domain-General Higher Cognitive Functions in the Lateral Parietal Cortex: Evidence from fMRI Comparisons of Difficulty-Varying Semantic Versus Visuo-Spatial Tasks, and Functional Connectivity Analyses

  2017cites this paper
• Mapping the connectome in awake surgery for gliomas: an update.

  2017cites this paper
• Distinct contributions of the fornix and inferior longitudinal fasciculus to episodic and semantic autobiographical memory

  2017cites this paper
• Hodotopy, neuroplasticity and diffuse gliomas.

  2017cites this paper
• Peri- and intraoperative cognitive and language assessment for surgical resection in brain eloquent structures.

  2017cites this paper
• A surgical approach to the anatomo-functional structure of language.

  2017cites this paper
• Diffusion Magnetic Resonance Imaging in Diffuse Low-Grade Gliomas

  2017cites this paper