Role of CD4 receptor down-regulation during HIV-1 infection.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Current HIV Research

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.2174/1570162043485086PMID 15053340
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Solution structure of the hydrophilic region of HIV-1 encoded virus protein U (Vpu) by CD and 1H NMR spectroscopy.

  2009cited by this paper
• Solution structure of the cytoplasmic domain of the human immunodeficiency virus type 1 encoded virus protein U (Vpu).

  2009cited by this paper
• Signals for sorting of transmembrane proteins to endosomes and lysosomes.

  2003cited by this paper
• Human Immunodeficiency Virus Type 1 Nef-Mediated Downregulation of CD4 Correlates with Nef Enhancement of Viral Pathogenesis

  2003cited by this paper
• Enhanced CD4 Down-modulation by Late Stage HIV-1 nef Alleles Is Associated with Increased Env Incorporation and Viral Replication*

  2003cited by this paper
• The presence of the casein kinase II phosphorylation sites of Vpu enhances the CD4(+) T cell loss caused by the simian-human immunodeficiency virus SHIV(KU-lbMC33) in pig-tailed macaques.

  2003cited by this paper
• Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase.

  2003cited by this paper
• Vpu Exerts a Positive Effect on HIV-1 Infectivity by Down-modulating CD4 Receptor Molecules at the Surface of HIV-1-producing Cells*

  2003cited by this paper
• Downregulation of CD4 is required for maintenance of viral infectivity of HIV-1.

  2003cited by this paper
• Inefficient Enhancement of Viral Infectivity and CD4 Downregulation by Human Immunodeficiency Virus Type 1 Nef from Japanese Long-Term Nonprogressors

  2002cited by this paper
• Nef-Mediated Downregulation of CD4 Enhances Human Immunodeficiency Virus Type 1 Replication in Primary T Lymphocytes

  2002cited by this paper
• Cell Surface CD4 Interferes with the Infectivity of HIV-1 Particles Released from T Cells*

  2002cited by this paper
• Subunit H of the V-ATPase Binds to the Medium Chain of Adaptor Protein Complex 2 and Connects Nef to the Endocytic Machinery*

  2002cited by this paper
• Characterization of a Novel Simian Immunodeficiency Virus with a vpu Gene from Greater Spot-Nosed Monkeys (Cercopithecus nictitans) Provides New Insights into Simian/Human Immunodeficiency Virus Phylogeny

  2002cited by this paper
• Structure–function relationships in HIV‐1 Nef

  2001cited by this paper
• Nef-Induced CD4 Downregulation: a Diacidic Sequence in Human Immunodeficiency Virus Type 1 Nef Does Not Function as a Protein Sorting Motif through Direct Binding to β-COP

  2001cited by this paper
• Dynamic Nef and Nef dynamics: how structure could explain the complex activities of this small HIV protein.

  2001cited by this paper
• Plasma membrane rafts play a critical role in HIV-1 assembly and release

  2001cited by this paper
• Direct In Vitro Binding of Full-Length Human Immunodeficiency Virus Type 1 Nef Protein to CD4 Cytoplasmic Domain

  2001cited by this paper
• CD4 Down-Modulation by Human Immunodeficiency Virus Type 1 Nef Correlates with the Efficiency of Viral Replication and with CD4+ T-Cell Depletion in Human Lymphoid Tissue Ex Vivo

  2001cited by this paper
• Modulation of Different Human Immunodeficiency Virus Type 1 Nef Functions during Progression to AIDS

  2001cited by this paper
• Interactions of HIV-1 nef with the mu subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based sorting motif.

  2000cited by this paper
• Membrane interactions and alignment of structures within the HIV‐1 Vpu cytoplasmic domain: effect of phosphorylation of serines 52 and 56

  2000cited by this paper
• Evidence for Budding of Human Immunodeficiency Virus Type 1 Selectively from Glycolipid-Enriched Membrane Lipid Rafts

  2000cited by this paper
• Disrupting Surfaces of Nef Required for Downregulation of CD4 and for Enhancement of Virion Infectivity Attenuates Simian Immunodeficiency Virus Replication In Vivo

  2000cited by this paper
• The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro.

  1999cited by this paper
• Cluster of differentiation antigen 4 (CD4) endocytosis and adaptor complex binding require activation of the CD4 endocytosis signal by serine phosphorylation.

  1999cited by this paper
• Two elements target SIV Nef to the AP‐2 clathrin adaptor complex, but only one is required for the induction of CD4 endocytosis

  1999cited by this paper
• CD4 segregates into specific detergent-resistant T-cell membrane microdomains.

  1999cited by this paper
• HIV: a new role for Nef in the spread of HIV.

  1999cited by this paper
• A family of mammalian F-box proteins.

  1999cited by this paper
• Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes.

  1999cited by this paper
• Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein.

  1999cited by this paper
• Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner.

  1999cited by this paper
• Mechanism of Nef‐induced CD4 endocytosis: Nef connects CD4 with the μ chain of adaptor complexes

  1998cited by this paper
• Structural and functional analysis of the membrane-spanning domain of the human immunodeficiency virus type 1 Vpu protein.

  1998cited by this paper
• Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice.

  1998cited by this paper
• A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif.

  1998cited by this paper
• A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor.

  1998cited by this paper
• Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity.

  1998cited by this paper
• Mutational Analysis of the Human Immunodeficiency Virus Type 1 Vpu Transmembrane Domain That Promotes the Enhanced Release of Virus-Like Particles from the Plasma Membrane of Mammalian Cells

  1998cited by this paper
• CD4 Glycoprotein Degradation Induced by Human Immunodeficiency Virus Type 1 Vpu Protein Requires the Function of Proteasomes and the Ubiquitin-Conjugating Pathway

  1998cited by this paper
• Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4.

  1998cited by this paper
• A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4.

  1998cited by this paper
• Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules.

  1998cited by this paper
• Co‐localization of HIV‐1 Nef with the AP‐2 adaptor protein complex correlates with Nef‐induced CD4 down‐regulation

  1997cited by this paper
• Co-receptors for HIV-1 entry.

  1997cited by this paper
• Putative alpha-helical structures in the human immunodeficiency virus type 1 Vpu protein and CD4 are involved in binding and degradation of the CD4 molecule

  1997cited by this paper
• Secondary structure and tertiary fold of the human immunodeficiency virus protein U (Vpu) cytoplasmic domain in solution.

  1997cited by this paper
• The HIV-1 Nef protein acts as a connector with sorting pathways in the Golgi and at the plasma membrane.

  1997cited by this paper
• Rapid degradation of CD4 in cells expressing human immunodeficiency virus type 1 Env and Vpu is blocked by proteasome inhibitors.

  1997cited by this paper
• Functional rafts in cell membranes

  1997cited by this paper
• Nef-mediated Clathrin-coated Pit Formation

  1997cited by this paper
• The CD4 determinant for downregulation by HIV-1 Nef directly binds to Nef. Mapping of the Nef binding surface by NMR.

  1996cited by this paper
• The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol.

  1996cited by this paper
• Sec6l-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

  1996cited by this paper
• CD4 down-modulation during infection of human T cells with human immunodeficiency virus type 1 involves independent activities of vpu, env, and nef

  1996cited by this paper
• An endosomal beta COP is involved in the pH-dependent formation of transport vesicles destined for late endosomes

  1996cited by this paper
• SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box.

  1996cited by this paper
• Nef-CD4 physical interaction sensed with the yeast two-hybrid system.

  1996cited by this paper
• Interference to human immunodeficiency virus type 1 infection in the absence of downmodulation of the principal virus receptor, CD4

  1996cited by this paper
• The two biological activities of human immunodeficiency virus type 1 Vpu protein involve two separable structural domains

  1996cited by this paper
• The human immunodeficiency virus type 1 Vpu protein: a potential regulator of proteolysis and protein transport in the mammalian secretory pathway.

  1995cited by this paper
• Human immunodeficiency virus type 1 Nef induces accumulation of CD4 in early endosomes

  1995cited by this paper
• The human immunodeficiency virus type 1 Vpu protein specifically binds to the cytoplasmic domain of CD4: implications for the mechanism of degradation

  1995cited by this paper
• The human immunodeficiency virus type 1 (HIV-1) CD4 receptor and its central role in promotion of HIV-1 infection

  1995cited by this paper
• Degradation of CD4 induced by human immunodeficiency virus type 1 Vpu protein: a predicted alpha-helix structure in the proximal cytoplasmic region of CD4 contributes to Vpu sensitivity.

  1995cited by this paper
• Genomic Structure of an Attenuated Quasi Species of HIV-1 from a Blood Transfusion Donor and Recipients

  1995cited by this paper
• Functional analysis of the phosphorylation sites on the human immunodeficiency virus type 1 Vpu protein.

  1995cited by this paper
• Differential activities of the human immunodeficiency virus type 1-encoded Vpu protein are regulated by phosphorylation and occur in different cellular compartments

  1994cited by this paper
• Association of p56lck with the cytoplasmic domain of CD4 modulates HIV‐1 expression.

  1994cited by this paper
• The cytoplasmic domain of CD4 plays a critical role during the early stages of HIV infection in T‐cells.

  1994cited by this paper
• Intracellular membrane traffic of human immunodeficiency virus type 1 envelope glycoproteins: vpu liberates Golgi-targeted gp160 from CD4-dependent retention in the endoplasmic reticulum.

  1994cited by this paper
• Myristoylation-dependent binding of HIV-1 Nef to CD4.

  1994cited by this paper
• Cell surface CD4 downregulation and resistance to superinfection induced by a defective provirus of HIV-1.

  1994cited by this paper
• Vpu-mediated proteolysis of gp160/CD4 chimeric envelope glycoproteins in the endoplasmic reticulum: requirement of both the anchor and cytoplasmic domains of CD4.

  1994cited by this paper
• Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain.

  1994cited by this paper
• Physical interaction of the HIV-1 Nef protein with beta-COP, a component of non-clathrin-coated vesicles essential for membrane traffic.

  1994cited by this paper
• Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4

  1994cited by this paper
• Sequences present in the cytoplasmic domain of CD4 are necessary and sufficient to confer sensitivity to the human immunodeficiency virus type 1 Vpu protein

  1994cited by this paper
• Stimulation of heterologous protein degradation by the Vpu protein of HIV-1 requires the transmembrane and cytoplasmic domains of CD4.

  1994cited by this paper
• The human immunodeficiency virus type 1 encoded Vpu protein is phosphorylated by casein kinase-2 (CK-2) at positions Ser52 and Ser56 within a predicted alpha-helix-turn-alpha-helix-motif.

  1994cited by this paper
• Vpu-induced degradation of CD4: requirement for specific amino acid residues in the cytoplasmic domain of CD4

  1993cited by this paper
• Human immunodeficiency virus type 1 Vpu protein is an oligomeric type I integral membrane protein

  1993cited by this paper
• Role of CD4 and CD8 in T cell activation and differentiation.

  1993cited by this paper
• Human immunodeficiency virus type 1 Vpu protein induces degradation of chimeric envelope glycoproteins bearing the cytoplasmic and anchor domains of CD4: role of the cytoplasmic domain in Vpu-induced degradation in the endoplasmic reticulum

  1993cited by this paper
• Phorbol ester-induced downregulation of CD4 is a multistep process involving dissociation from p56lck, increased association with clathrin- coated pits, and altered endosomal sorting

  1993cited by this paper
• Human immunodeficiency virus type 1 Vpu protein induces degradation of CD4 in vitro: the cytoplasmic domain of CD4 contributes to Vpu sensitivity

  1993cited by this paper
• Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infection

  1993cited by this paper
• MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8

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• Dissociation of unintegrated viral DNA accumulation from single-cell lysis induced by human immunodeficiency virus type 1

  1992cited by this paper
• Human-immunodeficiency-virus-type-1-encoded Vpu protein is phosphorylated by casein kinase II.

  1992cited by this paper
• Identification of a CD4 binding site on the beta 2 domain of HLA-DR molecules.

  1992cited by this paper
• Human immunodeficiency virus type 1 Vpu protein regulates the formation of intracellular gp160-CD4 complexes

  1992cited by this paper
• Human immunodeficiency virus type 1 Vpu protein induces rapid degradation of CD4

  1992cited by this paper
• Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface.

  1992cited by this paper
• Importance of the nef gene for maintenance of high virus loads and for development of AIDS.

  1991cited by this paper
• Serine phosphorylation-independent downregulation of cell-surface CD4 by nef

  1991cited by this paper
• Inhibition of gp160 and CD4 maturation in U937 cells after both defective and productive infections by human immunodeficiency virus type 1

  1991cited by this paper
• Kinetics of expression of multiply spliced RNA in early human immunodeficiency virus type 1 infection of lymphocytes and monocytes.

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