Why are tumour blood vessels abnormal and why is it important to know?

Tumour blood vessels differ from their normal counterparts for reasons that have received little attention. We report here that they are of at least six distinct types, we describe how each forms, and, looking forward, encourage the targeting of tumour vessel subsets that have lost their vascular endothelial growth factor-A (VEGF-A) dependency and so are likely unresponsive to anti-VEGF-A therapies.

• Publication year

  2009

• Venue

  British Journal of Cancer

• Publication date

  2009-02-24

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.bjc.6604929PMID 19240721PMCID 2661770
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Tumor blood vessels

  2011cited by this paper
• Vascular Endothelial Growth Factor: Basic Biology and Clinical Applications

  2009cited by this paper
• Neutralizing VEGF decreases tortuosity and alters endothelial cell division orientation in arterioles and veins in a rat model of ROP: relevance to plus disease.

  2008cited by this paper
• Blood vessel maturation and response to vascular-disrupting therapy in single vascular endothelial growth factor-A isoform-producing tumors.

  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2006cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2004influential reference
• Rous-Whipple Award Lecture. How tumors make bad blood vessels and stroma.

  2003cited by this paper
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  2003cited by this paper
• Blood vessels and nerves: common signals, pathways and diseases

  2003cited by this paper
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  2002cited by this paper
• Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis.

  2002cited by this paper
• Prognostic importance of glomeruloid microvascular proliferation indicates an aggressive angiogenic phenotype in human cancers.

  2002cited by this paper
• Unorthodox angiogenesis in skeletal muscle.

  2001cited by this paper
• Glomeruloid microvascular proliferation follows adenoviral vascular permeability factor/vascular endothelial growth factor-164 gene delivery.

  2001cited by this paper
• Vasculogenic mimicry and tumor angiogenesis.

  2000cited by this paper
• Heterogeneity of the Angiogenic Response Induced in Different Normal Adult Tissues by Vascular Permeability Factor/Vascular Endothelial Growth Factor

  2000influential reference
• Isoforms of Vascular Endothelial Growth Factor Act in a Coordinate Fashion To Recruit and Expand Tumor Vasculature

  2000cited by this paper
• Vascular endothelial growth factor C induces angiogenesis in vivo.

  1998cited by this paper
• Pathology of the Skin With Clinical Correlation

  1997cited by this paper
• Vascular endothelial growth factor: basic biology and clinical implications.

  1997cited by this paper
• The vesiculo‐vacuolar organelle (VVO): a distinct endothelial cell structure that provides a transcellular pathway for macromolecular extravasation

  1996cited by this paper
• Pathogenesis of ascites tumor growth: angiogenesis, vascular remodeling, and stroma formation in the peritoneal lining.

  1995cited by this paper
• First steps of tumor-related angiogenesis.

  1991cited by this paper
• Pathology of the Skin With Clinical Correlations

  1990cited by this paper
• Distensibility of single capillaries and venules in the rat and frog mesentery.

  1989cited by this paper
• Intermittent blood flow in a murine tumor: radiobiological effects.

  1987cited by this paper
• Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing.

  1986cited by this paper
• Transplacental carcinogenesis by stilbestrol.

  1971cited by this paper
• Tumor angiogenesis: therapeutic implications.

  1971cited by this paper

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