Folic acid in early pregnancy: a public health success story

No abstract is available for this paper.

• Publication year

  2010

• Venue

  The FASEB Journal

• Publication date

  2010-11-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1096/fj.10-165084PMID 20631328PMCID PMC2974421
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Folic acid to reduce neonatal mortality from neural tube disorders

  2010cited by this paper
• Higher serum folate levels are associated with a lower risk of atopy and wheeze.

  2009cited by this paper
• Preconceptional Folate Supplementation and the Risk of Spontaneous Preterm Birth: A Cohort Study

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• Mitochondrial C1-Tetrahydrofolate Synthase (MTHFD1L) Supports the Flow of Mitochondrial One-carbon Units into the Methyl Cycle in Embryos*

  2009cited by this paper
• Regulation of folate receptor 1 gene expression in the visceral endoderm.

  2009cited by this paper
• Cancer incidence and mortality after treatment with folic acid and vitamin B12.

  2009cited by this paper
• Development of the vertebrate central nervous system: formation of the neural tube

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• Folate-related birth defects: Embryonic consequences of abnormal folate transport and metabolism

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• Colon cancer in Chile before and after the start of the flour fortification program with folic acid

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  2008cited by this paper
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  2008cited by this paper
• Cytoplasmic Serine Hydroxymethyltransferase Regulates the Metabolic Partitioning of Methylenetetrahydrofolate but Is Not Essential in Mice*

  2008cited by this paper
• Folic acid supplementation in early second trimester and the risk of preeclampsia.

  2008cited by this paper
• Maternal exposure to folic acid antagonists and placenta-mediated adverse pregnancy outcomes

  2008cited by this paper
• Review of the Magnitude of Folate and Vitamin B12 Deficiencies Worldwide

  2008cited by this paper
• Embryonic development in the reduced folate carrier knockout mouse is modulated by maternal folate supplementation.

  2008cited by this paper
• Trends in wheat-flour fortification with folic acid and iron--worldwide, 2004 and 2007.

  2008cited by this paper
• Cardiovascular abnormalities in Folr1 knockout mice and folate rescue.

  2007cited by this paper
• A Temporal Association between Folic Acid Fortification and an Increase in Colorectal Cancer Rates May Be Illuminating Important Biological Principles: A Hypothesis

  2007cited by this paper
• Folic acid for the prevention of colorectal adenomas: a randomized clinical trial.

  2007cited by this paper
• Preliminary Evidence Shows That Folic Acid Fortification of the Food Supply Is Associated with Higher Methotrexate Dosing in Patients with Rheumatoid Arthritis

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• Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase.

  2007cited by this paper
• Trends of selected malformations in relation to folic acid recommendations and fortification: an international assessment.

  2006cited by this paper
• March of Dimes: global report on birth defects, the hidden toll of dying and disabled children.

  2005cited by this paper
• High folic acid levels and failure of single‐dose methotrexate treatment in ectopic pregnancy

  2005cited by this paper
• Changes in the birth prevalence of selected birth defects after grain fortification with folic acid in the United States: findings from a multi-state population-based study.

  2005cited by this paper
• Periconceptional folate intake by supplement and food reduces the risk of nonsyndromic cleft lip with or without cleft palate.

  2004cited by this paper
• Embryonic development of folate binding protein‐1 (Folbp1) knockout mice: Effects of the chemical form, dose, and timing of maternal folate supplementation

  2004cited by this paper
• Low vitamin B-12 concentrations in patients without anemia: the effect of folic acid fortification of grain.

  2003influential reference
• Reduced folate carrier polymorphism (80A→G) and neural tube defects

  2003cited by this paper
• Prevalence of spina bifida and anencephaly during the transition to mandatory folic acid fortification in the United States

  2003cited by this paper
• Cytoplasmic Serine Hydroxymethyltransferase Mediates Competition between Folate-dependent Deoxyribonucleotide andS-Adenosylmethionine Biosyntheses*

  2002cited by this paper
• Mitochondrial NAD-Dependent Methylenetetrahydrofolate Dehydrogenase-Methenyltetrahydrofolate Cyclohydrolase Is Essential for Embryonic Development

  2002cited by this paper
• Prevalence of spina bifida and anencephaly during the transition to mandatory folic acid fortification in the United States.

  2002cited by this paper
• Rescue of Embryonic Lethality in Reduced Folate Carrier-deficient Mice by Maternal Folic Acid Supplementation Reveals Early Neonatal Failure of Hematopoietic Organs*

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• Oral clefts and vitamin supplementation.

  2001cited by this paper
• Folic acid antagonists during pregnancy and risk of birth defects.

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• Targeted Disruption of the Methionine Synthase Gene in Mice

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  2001cited by this paper
• A case-control study of nonsyndromic oral clefts in Maryland.

  2001cited by this paper
• Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition.

  2001cited by this paper
• Impact of folic acid fortification of the US food supply on the occurrence of neural tube defects.

  2001cited by this paper
• Arsenic-induced congenital malformations in genetically susceptible folate binding protein-2 knockout mice.

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• Mice lacking the folic acid-binding protein Folbp1 are defective in early embryonic development

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• Correction: Prevention of Neural-Tube Defects with Folic Acid in China.

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• Serum Total Homocysteine Concentrations in the Third National Health and Nutrition Examination Survey (19911994): Population Reference Ranges and Contribution of Vitamin Status to High Serum Concentrations

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• Multivitamin Use, Folate, and Colon Cancer in Women in the Nurses' Health Study

  1998cited by this paper
• A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity.

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• Altered folate and vitamin B12 metabolism in families with spina bifida offspring.

  1997cited by this paper
• Orofacial clefts in Hungary. Epidemiological and genetic data, primary prevention.

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• Molecular Cloning, Characterization, and Regulation of the Human Mitochondrial Serine Hydroxymethyltransferase Gene*

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• Population-based case control study of folic acid supplementation during pregnancy.

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• Periconceptional multivitamin use and the occurrence of conotruncal heart defects: results from a population-based, case-control study.

  1996cited by this paper
• Maternal periconceptional use of multivitamins and reduced risk for conotruncal heart defects and limb deficiencies among offspring.

  1995cited by this paper
• Risks of orofacial clefts in children born to women using multivitamins containing folic acid periconceptionally.

  1995cited by this paper
• PERICONCEPTIONAL VITAMIN USE, DIETARY FOLATE, AND THE OCCURRENCE OF NEURAL TUBE DEFECTS

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• The methylfolate axis in neural tube defects: in vitro characterisation and clinical investigation.

  1994cited by this paper
• Maternal plasma folate and vitamin B12 are independent risk factors for neural tube defects.

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• Investigation of factors influencing folate status in women who have had a neural tube defect‐affected infant

  1993cited by this paper
• Periconceptional folic acid exposure and risk of occurrent neural tube defects.

  1993cited by this paper
• Folate and vitamin B12 concentrations in maternal and fetal blood, and amniotic fluid in second trimester pregnancies complicated by neural tube defects

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• Identification of genes using oligonucleotides corresponding to splice site consensus sequences.

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• Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation.

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• Prevention of neural tube defects : Results of the Medical Research Council Vitamin Study MRC VITAMIN STUDY RESEARCH GROUP

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• Primary prevention of neural tube defects with folic acid supplementation: Cuban experience

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• Multivitamin/folic acid supplementation in early pregnancy reduces the prevalence of neural tube defects.

  1989cited by this paper
• Dietary folate as a risk factor for neural‐tube defects: evidence from a case‐control study in Western Australia

  1989cited by this paper
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  1989cited by this paper
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  1988cited by this paper
• Is disordered folate metabolism the basis for the genetic predisposition to neural tube defects?

  1987cited by this paper
• Periconceptional vitamin supplementation and the prevention of neural tube defects in south-east England and Northern Ireland.

  1984cited by this paper
• VITAMIN SUPPLEMENTATION AND NEURAL TUBE DEFECTS

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• Further experience of vitamin supplementation for prevention of neural tube defect recurrences.

  1983cited by this paper
• Vitamin supplementation and neural tube defects.

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• HLA-DR3, DR4 increase in chronic stage of Spanish oil disease.

  1982cited by this paper
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  1981cited by this paper
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• Apparent prevention of neural tube defects by periconceptional vitamin supplementation.

  1981cited by this paper
• Vitamin dificiencies and neural tube defects.

  1976cited by this paper
• American Journal of Epidemiology Original Contribution Effect of Supplemental Folic Acid in Pregnancy on Childhood Asthma: a Prospective Birth Cohort Study

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• Department of Health and Human Services Food and Drug Administration Food Standards: Amendment of Standards of Identity for Enriched Grain Products to Require Addition of Folic Acid

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• Altered Pax6 and gga-miR-365-3P expression in the cerebral cortex of chicken embryo in response to in ovo administration of folic acid; real-time PCR and Western blot analysis

  2025cites this paper
• Dietary Supplements in the Perinatal Period.

  2025cites this paper
• Biological, dietetic and pharmacological properties of vitamin B9

  2025cites this paper
• Präventive Neurologie – nie zu früh und nie zu spät

  2025cites this paper
• Fundamental origins of neural tube defects with a basis in genetics and nutrition

  2025cites this paper
• Folate as solution, folate as problem: some reflections on problem formation in public health through the lens of Neural Tube Defects

  2025cites this paper
• Biomarkers for the Diagnosis of Perinatal Mood and Anxiety Disorders: Existing Landscapes and Emerging Frontiers.

  2025cites this paper
• A quest for genetic causes underlying signaling pathways associated with neural tube defects

  2023cites this paper
• Examining the relationship between autism spectrum disorder and neural tube defects

  2023cites this paper
• Global neurosurgery: Reflections on myelomeningocele in the Zanzibar archipelago (Tanzania)

  2023cites this paper
• Nutrición y embarazo

  2023cites this paper
• Periconceptional maternal folate supplementation impacts a diverse range of congenital malformations

  2023cites this paper
• Awareness of folic acid supplimentation in pregnancy questionnaire-based study

  2023cites this paper
• The roles of JAK2/STAT3 signaling in fusion of the secondary palate

  2023cites this paper
• Periconceptional Mediterranean diet during pregnancy on children’s health

  2022cites this paper
• Effect of folic acid supplementation on diminished ovarian reserve: study protocol of a single-centre, open-label, randomised, placebo-controlled clinical trial

  2022cites this paper
• Maternal MTHFR 677C>T, 1298A>C gene polymorphisms and risk of offspring aneuploidy

  2022cites this paper
• A review of transglycosylated compounds as food additives to enhance the solubility and oral absorption of hydrophobic compounds in nutraceuticals and pharmaceuticals

  2022cites this paper
• Folic acid to prevent spina bifida and anencephaly

  2021cites this paper
• Physical Activity Promotion and the United Nations Sustainable Development Goals: Building Synergies to Maximize Impact.

  2021cites this paper
• Degradation of vitamins

  2021cites this paper
• Methionine synthase supports tumor tetrahydrofolate pools

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• Effect of folic acid on animal models, cell cultures, and human oral clefts: a literature review

  2020cites this paper
• Methionine synthase supports tumor tetrahydrofolate pools

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• Folic acid consumption based on the theory of planned behaviour in pregnant women

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• On the Potential Role of the Neural Crest Cells in Integrating Pigmentation Into Behavioral and Physiological Syndromes

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• Anterior cleft palate due to Cbfb deficiency and its rescue by folic acid

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  2019cites this paper
• MicroRNA-655-3p and microRNA-497-5p inhibit cell proliferation in cultured human lip cells through the regulation of genes related to human cleft lip

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• Considerations for Studying Folate Beyond the Typical Range of Exposure.

  2018cites this paper
• Prevalent genotypes of methylenetetrahydrofolate reductase (MTHFR) in recurrent miscarriage and recurrent implantation failure

  2018cites this paper
• Effects of Folic Acid and Homocysteine on the Morphogenesis of Mouse Cephalic Neural Crest Cells In Vitro

  2017cites this paper
• Environnement, génétique et épigénétique

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• 171 – Pathophysiology of Neural Tube Defects

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• Genetic or nutritional disturbances in folate‐related pathways and epigenetic interactions

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• Factors Influencing Adherence to Folic Acid and Ferrous Sulphate Nutritional Intake among Pregnant Teenagers in Buffalo City Municipality, South Africa

  2017cites this paper
• The Role of Hedgehog Signalling in the Formation of the Ventricular Septum

  2017cites this paper
• Sequence variation in folate pathway genes and risks of human cleft lip with or without cleft palate

  2016cites this paper
• Maternal and postweaning folic acid supplementation interact to influence body weight, insulin resistance, and food intake regulatory gene expression in rat offspring in a sex-specific manner.

  2016cites this paper
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• Polymorphisms in the MTHFR gene influence embryo viability and the incidence of aneuploidy

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• High levels of iron supplementation prevents neural tube defects in the Fpn1ffe mouse model.

  2016cites this paper
• Safe use of high intakes of folic acid: research challenges and paths forward.

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• Paternal transmission of MTHFD1 G1958A variant predisposes to neural tube defects in the offspring

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• [Cleft lip/palate and flour fortification with folic acid in Chile].

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• Diet and Common Mental Disorders: The Imperative to Translate Evidence into Action

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