Stepwise degradations and deamidation of the eye lens protein α-crystallin in ageing

No abstract is available for this paper.

• Publication year

  1975

• Venue

  Nature

• Publication date

  1975-11-20

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/258264A0
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Cataract and abnormalities of the lens

  1976cited by this paper
• The maturation of the lens cell: a morphologic study.

  1975cited by this paper
• Intracellular Degradation of α-Crystallin

  1974cited by this paper
• Intracellular Carboxy-Terminal Degradation of the αA Chain of α-Crystallin

  1974cited by this paper
• Intracellular protein degradation in mammalian and bacterial cells.

  1974cited by this paper
• The Amino-Acid Sequence of the αA2 Chain of Bovine α-Crystallin

  1973cited by this paper
• Population character and variety in subunit structure of high-molecular-weight proteins from the bovine eye lens.

  1973cited by this paper
• Characteristics of -crystallin related to fiber cell development in calf eye lenses.

  1973cited by this paper
• Aging of alpha-crystallins during development of the lens.

  1969cited by this paper
• Subunits of Alpha-Crystallin from Adult and Embryonic Cattle Lens

  1968cited by this paper

• Insights into the biochemical and biophysical mechanisms mediating the longevity of the transparent optics of the eye lens

  2022cites this paper
• 1D continuous gel electrophoresis composition for the separation of deamidated proteins.

  2021cites this paper
• Modifications of Long‐Lived Proteins that Affect Protein Solubility

  2021cites this paper
• The pH dependent mechanisms of non-enzymatic peptide bond cleavage reactions.

  2019cites this paper
• Chemical Strategies to Glycoprotein Analysis

  2019cites this paper
• The Proteome of Cataract Markers: Focus on Crystallins.

  2018cites this paper
• Recent advances in mass spectrometric analysis of protein deamidation.

  2017cites this paper
• Structure and function of α-crystallins: Traversing from in vitro to in vivo.

  2016cites this paper
• Non-enzymatic glycation of α-crystallin as an in vitro model for aging, diabetes and degenerative diseases

  2015cites this paper
• Investigating the relationship between glutamine deamidation and collagen breakdown in bone

  2015cites this paper
• Lens β-crystallins: the role of deamidation and related modifications in aging and cataract.

  2014influential citation
• 12.10 – Organic Nitrogen: Sources, Fates, and Chemistry

  2014cites this paper
• Extensive deamidation at asparagine residue 279 accounts for weak immunoreactivity of tau with RD4 antibody in Alzheimer’s disease brain

  2013cites this paper
• Phosphoproteomics characterization of novel phosphorylated sites of lens proteins from normal and cataractous human eye lenses

  2011cites this paper
• Clinical proteomics: Current status, challenges, and future perspectives

  2011cites this paper
• Localization of low molecular weight crystallin peptides in the aging human lens using a MALDI mass spectrometry imaging approach.

  2010cites this paper
• Ubiquitin proteasome pathway-mediated degradation of proteins: effects due to site-specific substrate deamidation.

  2010cites this paper
• “Toxic memory” via chaperone modification is a potential mechanism for rapid mallory‐denk body reinduction

  2008cites this paper
• Decreased association of aged alpha crystallins with gamma crystallins.

  2006cites this paper
• Stereochemically altered noncollagenous protein from human dentin

  2006cites this paper
• Subunit Exchange of Polydisperse Proteins

  2005cites this paper
• Multiple sclerosis

  2005cites this paper
• Phosphorylation of αB-Crystallin Alters Chaperone Function through Loss of Dimeric Substructure*

  2004cites this paper
• Multiple Sclerosis

  2003cites this paper
• Posttranslational modification of human alphaA-crystallin: correlation with electrophoretic migration.

  2002cites this paper
• Does post-translational modification influence chaperone-like activity of alpha-crystallin? I. Study on phosphorylation.

  2001cites this paper
• Age-Related Nuclear Cataract: A Lens Transport Problem

  2000cites this paper
• Cysteine Is the Initial Site of Modification of α-Crystallin by Kynurenine

  2000cites this paper
• Chapter 2 – Posttranslational Modifications

  1998cites this paper
• Age-related changes in human lens crystallins identified by two-dimensional electrophoresis and mass spectrometry.

  1998cites this paper
• The effects of ageing on the chaperone-like function of rabbit alpha-crystallin, comparing three methods of assay.

  1997cites this paper
• Cleavage of Amino Acid Residue(s) from the N-Terminal Region of αA- and αB-Crystallins in Human Crystalline Lens during Aging

  1997cites this paper
• Chapter 1 The covalent structure of proteins

  1997cites this paper
• Structural basis of eye lens transparency: light scattering by concentrated solutions of bovine alpha-crystallin proteins.

  1996cites this paper
• Loss of the C-terminal serine residue from bovine βB2-crystallin

  1995cites this paper
• Oxidative stress‐induced cataract: mechanism of action

  1995cites this paper
• Identification of the in vivo truncation sites at the C-terminal region of alpha-A crystallin from aged bovine and human lens.

  1995cites this paper
• Analysis of normal human fetal eye lens crystallins by high‐performance liquid chromatography/mass spectrometry

  1995cites this paper
• Age-dependent cleavage at the C-terminal region of lens βB2 crystallin

  1995cites this paper
• Effect of cross-linking on the chaperone-like function of alpha crystallin.

  1995cites this paper
• Immunolocalization of the C-terminal and N-terminal regions of alpha-A and alpha-B crystallins.

  1994cites this paper
• Alpha-A crystallin: quantitation of C-terminal modification during lens aging.

  1994cites this paper
• Aging of Long‐Lived Proteins: Extracellular Matrix (Collagens, Elastins, Proteoglycans) and Lens Crystallins

  1994cites this paper
• Age‐dependent deamidation of αB‐crystallin

  1993cites this paper
• Primary structure of rabbit lens α-crystallins

  1993cites this paper
• Post-translational modification of proteins.

  1993cites this paper
• Biogeochemistry of brachiopod intracrystalline proteins and amino acids

  1992cites this paper
• Structural organization and stability of a thermoresistant domain generated by in vivo hydrolysis of the alpha-crystallin B chain from calf lens.

  1992cites this paper
• Age-dependent loss of the C-terminal amino acid from alpha crystallin.

  1992cites this paper
• Binding of actin to lens alpha crystallins.

  1992cites this paper
• Wide range of racemization of amino acids in peptides from human fossil bone and its implications for amino acid racemization dating

  1992cites this paper
• The ability of lens alpha crystallin to protect against heat-induced aggregation is age-dependent.

  1992cites this paper
• α-Crystallin exists in a non-spherical form

  1992cites this paper
• Identification by 1H NMR spectroscopy of flexible C‐terminal extensions in bovine lens α‐crystallin

  1992cites this paper
• Elucidation of the primary structures of proteins by mass spectrometry.

  1991cites this paper
• Amino Acid Cosmogeochemistry

  1991cites this paper
• Triosephosphate isomerase deficiency: Haemolytic anaemia, myopathy with altered mitochondria and mental retardation due to a new variant with accelerated enzyme catabolism and diminished specific activity

  1991cites this paper
• Structural properties of polydisperse biopolymer solutions: A light scattering study of bovine α‐crystallin

  1991cites this paper
• Site‐specific racemization in aging α‐crystallin

  1990cites this paper
• Synthesis of α-crystallin by a cell line derived from the lens of a transgenic animal

  1990cites this paper
• A dynamic quaternary structure of bovine alpha-crystallin as indicated from intermolecular exchange of subunits.

  1990cites this paper
• Loss of high-affinity membrane binding of bovine nuclear α-crystallin

  1989cites this paper
• The effect of phosphorylation on the structure of α-crystallin

  1989cites this paper
• Stability of Protein Pharmaceuticals

  1989cites this paper
• Age-related increase in concentration and aggregation of degraded polypeptides in human lenses.

  1988cites this paper
• Definition and comparison of the phosphorylation sites of the A and B chains of bovine alpha-crystallin.

  1988cites this paper
• Covalent change in alpha crystallin during human senile cataractogenesis.

  1988cites this paper
• Post-translational modifications of eye lens crystallins: crosslinking, phosphorylation and deamidation.

  1988cites this paper
• Rat lens gamma-crystallins. Characterization of the six gene products and their spatial and temporal distribution resulting from differential synthesis.

  1988cites this paper
• Biochemical and histochemical evidence for lysosomal proteases in rodent lenses.

  1987cites this paper
• Ontogeny of αA and αB crystallin polypeptides during Rana temporaria lens development

  1987cites this paper
• Age‐dependent deamidation of chicken αA‐crystallin

  1987cites this paper
• Structural changes in bovine lens crystallins induced by ascorbate, metal, and oxygen.

  1986cites this paper
• Immunological comparison of heat-shock proteins and alpha-crystallin.

  1986cites this paper
• Amino acid racemization dating: Evidence of apparent reversal in aspartic acid racemization with time in shells of Ostrea

  1986cites this paper
• Some aspects of the phosphorylation of α-crystallin A

  1986cites this paper
• Aminopeptidase III activity in normal and cataractous lenses.

  1986cites this paper
• Molecular basis of the accumulation of abnormal proteins in progeria and aging fibroblasts.

  1985cites this paper
• Domain structure and evolution in α‐crystallins and small heat‐shock proteins

  1985cites this paper
• Age-related changes of calpain II and alpha-crystallin in the lens of hereditary cataract (Nakano) mouse.

  1985cites this paper
• Acetylation of lens crystallins: a possible mechanism by which aspirin could prevent cataract formation.

  1985cites this paper
• Biochemistry of human alpha amylase isoenzymes.

  1985cites this paper
• Chapter 3 – The Lens: Development, Proteins, Metabolism and Cataract

  1984cites this paper
• Accelerator mass spectrometry radiocarbon ages of amino acid extracts from Californian palaeoindian skeletons

  1984cites this paper
• Limited proteolysis of bovine lens alpha-crystallin by calpain, a Ca2+-dependent cysteine proteinase, isolated from the same tissue.

  1984cites this paper
• Soluble exopeptidases of bovine and human lens: characterization by electrophoresis.

  1984cites this paper
• Structural homology of lens crystallins. III. Secondary structure estimation from circular dichroism and prediction from amino acid sequences.

  1983cites this paper
• Premature Aging Diseases: Cellular and Molecular Changes

  1983cites this paper
• Senile Cataracts and Aging Changes in Human Proteins

  1983cites this paper
• Physicochemical characterization of high-molecular-weight α-crystallin subpopulations from the calf lens nucleus

  1983cites this paper
• Loss of free amino groups in the water-insoluble fraction of nuclear senile cataracts.

  1983cites this paper
• Structural homology of lens crystallins. II. Homology expressed by correlation coefficients and hydropathy profiles.

  1983cites this paper
• Structural studies on soluble lens proteins related to aging

  1982cites this paper
• 4 – Ontogeny and Localization of the Crystallins in Eye Lens Development and Regeneration

  1982cites this paper
• The measurement and interpretation of Brillouin scattering in the lens of the eye

  1982cites this paper
• Physicochemical characterization of lens proteins of the squid Nototodarus gouldi and comparison with vertebrate crystallins.

  1982cites this paper
• Reflections on the internal primary, secondary and tertiary structure homology of the eye lens proteins α‐,β‐ and γ‐crystallin

  1981cites this paper
• The molecular structure and stability of the eye lens: X-ray analysis of γ-crystallin II

  1981cites this paper
• Molecular basis for the accumulation of acidic isozymes of triosephosphate isomerase on aging.

  1981cites this paper
• Analysis of the origin of charge heterogeneity of Rauscher murine leukaemia virus p30.

  1980cites this paper