Smad4 is required to induce digit ray primordia and to initiate the aggregation and differentiation of chondrogenic progenitors in mouse limb buds

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Development

• Publication date

  2012-11-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/dev.084822PMID 23034633
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Dermis isolated adult stem cells for cartilage tissue engineering.

  2012cited by this paper
• Recruitment of 5′ Hoxa genes in the allantois is essential for proper extra-embryonic function in placental mammals

  2012cited by this paper
• Smad1/Smad5 signaling in limb ectoderm functions redundantly and is required for interdigital programmed cell death.

  2012cited by this paper
• GLI3 constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesis.

  2012cited by this paper
• SHH propagates distal limb bud development by enhancing CYP26B1-mediated retinoic acid clearance via AER-FGF signalling

  2011cited by this paper
• Defining the Earliest Transcriptional Steps of Chondrogenic Progenitor Specification during the Formation of the Digits in the Embryonic Limb

  2011cited by this paper
• Recapitulation of endochondral bone formation using human adult mesenchymal stem cells as a paradigm for developmental engineering

  2010cited by this paper
• Extracellular regulation of BMP signaling.

  2010cited by this paper
• The Inductive Effect of Bone Morphogenetic Protein-4 on Chondral-Lineage Differentiation and In Situ Cartilage Repair

  2010cited by this paper
• Receptor tyrosine kinase-like orphan receptor 2 (ROR2) and Indian hedgehog regulate digit outgrowth mediated by the phalanx-forming region

  2010influential reference
• Regulation of BMP-dependent chondrogenesis in early limb mesenchyme by TGFβ signals

  2010cited by this paper
• The origin of digits: expression patterns versus regulatory mechanisms.

  2010cited by this paper
• In the limb AER Bmp2 and Bmp4 are required for dorsal-ventral patterning and interdigital cell death but not limb outgrowth.

  2009cited by this paper
• A Self-Regulatory System of Interlinked Signaling Feedback Loops Controls Mouse Limb Patterning

  2009influential reference
• Vertebrate limb bud development: moving towards integrative analysis of organogenesis

  2009cited by this paper
• Wnt and FGF signals interact to coordinate growth with cell fate specification during limb development

  2008cited by this paper
• Unique SMAD1/5/8 activity at the phalanx-forming region determines digit identity

  2008influential reference
• Uncoupling Sonic hedgehog control of pattern and expansion of the developing limb bud.

  2008cited by this paper
• An Fgf/Gremlin inhibitory feedback loop triggers termination of limb bud outgrowth

  2008cited by this paper
• Sox9, a key transcription factor of bone morphogenetic protein‐2‐induced chondrogenesis, is activated through BMP pathway and a CCAAT box in the proximal promoter

  2008cited by this paper
• Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism.

  2008influential reference
• The role of Hox genes during vertebrate limb development.

  2007cited by this paper
• Visualization of cartilage formation: insight into cellular properties of skeletal progenitors and chondrodysplasia syndromes.

  2007cited by this paper
• Multiplicity of BMP Signaling in Skeletal Development

  2007cited by this paper
• BMP signals control limb bud interdigital programmed cell death by regulating FGF signaling

  2007cited by this paper
• Deletion of Tgfbr2 in Prx1-cre expressing mesenchyme results in defects in development of the long bones and joints.

  2007cited by this paper
• BMP receptor type IA in limb bud mesenchyme regulates distal outgrowth and patterning.

  2006cited by this paper
• Genetic Analysis of the Roles of BMP2, BMP4, and BMP7 in Limb Patterning and Skeletogenesis

  2006cited by this paper
• Regulation of Gremlin expression in the posterior limb bud.

  2006cited by this paper
• Differential regulation of gene expression in the digit forming area of the mouse limb bud by SHH and gremlin 1/FGF-mediated epithelial-mesenchymal signalling

  2006cited by this paper
• SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS

  2005cited by this paper
• Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors.

  2005cited by this paper
• BMP signaling stimulates cellular differentiation at multiple steps during cartilage development.

  2005cited by this paper
• Fjx1: A notch‐inducible secreted ligand with specific binding sites in developing mouse embryos and adult brain

  2005cited by this paper
• Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo.

  2005cited by this paper
• Specificity and versatility in tgf-beta signaling through Smads.

  2005cited by this paper
• Levels of Gli3 repressor correlate with Bmp4 expression and apoptosis during limb development

  2004cited by this paper
• Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis

  2004cited by this paper
• Differential requirements for Smad4 in TGFβ-dependent patterning of the early mouse embryo

  2004cited by this paper
• The Limb Bud Shh-Fgf Feedback Loop Is Terminated by Expansion of Former ZPA Cells

  2004cited by this paper
• Regulation of retinoic acid distribution is required for proximodistal patterning and outgrowth of the developing mouse limb.

  2004cited by this paper
• Bmp4 in limb bud mesoderm regulates digit pattern by controlling AER development.

  2004cited by this paper
• Regulation of myogenic differentiation in the developing limb bud

  2003cited by this paper
• Expression of Cre recombinase in the developing mouse limb bud driven by a Prxl enhancer

  2002cited by this paper
• SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7.

  2002influential reference
• The Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal development.

  2002cited by this paper
• Optical Projection Tomography as a Tool for 3D Microscopy and Gene Expression Studies

  2002influential reference
• Generation of Smad4/Dpc4 conditional knockout mice

  2002influential reference
• BMP controls proximodistal outgrowth, via induction of the apical ectodermal ridge, and dorsoventral patterning in the vertebrate limb.

  2001cited by this paper
• BMPR-IA signaling is required for the formation of the apical ectodermal ridge and dorsal-ventral patterning of the limb.

  2001cited by this paper
• Analysis of the tendon cell fate using Scleraxis, a specific marker for tendons and ligaments.

  2001cited by this paper
• Interdigital regulation of digit identity and homeotic transformation by modulated BMP signaling.

  2000influential reference
• BMPs are required at two steps of limb chondrogenesis: formation of prechondrogenic condensations and their differentiation into chondrocytes.

  2000cited by this paper
• Sox9 is required for cartilage formation

  1999cited by this paper
• Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds

  1999cited by this paper
• Control of digit formation by activin signalling.

  1999cited by this paper
• Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton.

  1998cited by this paper
• Targeted Disruption of Decorin Leads to Abnormal Collagen Fibril Morphology and Skin Fragility

  1997cited by this paper
• SOX9 directly regulates the type-ll collagen gene

  1997cited by this paper
• TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes.

  1997cited by this paper
• SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene

  1997cited by this paper
• Scleraxis: a basic helix-loop-helix protein that prefigures skeletal formation during mouse embryogenesis.

  1995cited by this paper
• Transforming growth factor‐β and bone morphogenetic protein‐2 act by distinct mechanisms to promote chick limb cartilage differentiation in vitro

  1994influential reference
• Article Wnt5a/jnk and Fgf/mapk Pathways Regulate the Cellular Events Shaping the Vertebrate Limb Bud

  year unknowncited by this paper

• Single-cell profiling of penta- and tetradactyl mouse limb buds identifies mesenchymal progenitors controlling digit numbers and identities

  2025cites this paper
• WNT signaling coordinately controls mouse limb bud outgrowth and establishment of the digit-interdigit pattern

  2025cites this paper
• Cardio-Respiratory Complications in Adult Monozygotic Twins With Myhre Syndrome.

  2025cites this paper
• CXXC Finger Protein 1 drives BMP signaling and progenitor cell differentiation during limb development.

  2025cites this paper
• Spatio-temporal reconstruction of gene expression patterns in developing mice

  2024cites this paper
• Harnessing mesenchymal aggregation for engineered organ‐level regeneration: Recent progress and perspective

  2023cites this paper
• Characterization of Fibrodysplasia Ossificans Progessiva relevant Acvr1/Acvr2 Activin receptors in medaka (Oryzias latipes)

  2023cites this paper
• SMAD4 contributes to chondrocyte and osteocyte development

  2021cites this paper
• Spatial regulation by multiple Gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity

  2021cites this paper
• SMAD4 target genes are part of a transcriptional network that integrates the response to BMP and SHH signaling during early limb bud patterning

  2021influential citation
• Molecular and cellular regulation of intramembranous and endochondral bone formation during embryogenesis

  2020cites this paper
• Stem Cells for the Regeneration of Tendon and Ligament: A Perspective

  2020cites this paper
• Ten‐m/Odz3 regulates migration and differentiation of chondrogenic ATDC5 cells via RhoA‐mediated actin reorganization

  2020influential citation
• Smad4-dependent morphogenic signals control the maturation and axonal targeting of basal vomeronasal sensory neurons to the accessory olfactory bulb

  2020cites this paper
• Dynamic and self-regulatory interactions among gene regulatory networks control vertebrate limb bud morphogenesis.

  2020cites this paper
• Mathematical modeling of chondrogenic pattern formation during limb development: Recent advances in continuous models.

  2020cites this paper
• Mechanisms of synovial joint and articular cartilage development

  2019cites this paper
• The Development and Evolution of Cartilage

  2019cites this paper
• Molecular signatures identify immature mesenchymal progenitors in early mouse limb buds that respond differentially to morphogen signaling

  2019cites this paper
• Smad4 signaling establishes the somatosensory map of basal vomeronasal sensory neurons

  2019cites this paper
• Models of tendon development and injury

  2019influential citation
• Dynamic mechanical loading and growth factors influence chondrogenesis of induced pluripotent mesenchymal progenitor cells in a cartilage-mimetic hydrogel.

  2019cites this paper
• Spatial and Quantitative Detection of BMP Activity in Mouse Embryonic Limb Buds.

  2018cites this paper
• Optimizing a 3D model system for molecular manipulation of tenogenesis

  2018cites this paper
• Developmentally inspired programming of adult human mesenchymal stromal cells toward stable chondrogenesis

  2018cites this paper
• Smad4 deficiency impairs chondrocyte hypertrophy via the Runx2 transcription factor in mouse skeletal development

  2018cites this paper
• The BMP Pathway and Its Inhibitors in the Skeleton.

  2018cites this paper
• Tendon stem progenitor cells: Understanding the biology to inform therapeutic strategies for tendon repair

  2018cites this paper
• Theory of mechanochemical patterning in biphasic biological tissues

  2018cites this paper
• SMAD 3 and SMAD 4 have a more dominant role than SMAD 2 in TGF β-induced chondrogenic differentiation of bone marrow-derived mesenchymal stem cells

  2017cites this paper
• Differential involvement of Wnt signaling in Bmp regulation of cancellous versus periosteal bone growth

  2017cites this paper
• Long noncoding RNA DANCR regulates miR-1305-Smad 4 axis to promote chondrogenic differentiation of human synovium-derived mesenchymal stem cells

  2017cites this paper
• Coordinated development of the limb musculoskeletal system: Tendon and muscle patterning and integration with the skeleton.

  2017cites this paper
• SMAD3 and SMAD4 have a more dominant role than SMAD2 in TGFβ-induced chondrogenic differentiation of bone marrow-derived mesenchymal stem cells

  2017cites this paper
• A dive into TGFβ signaling components during generation and degeneration of cartilage

  2017cites this paper
• BMP signalling in skeletal development, disease and repair

  2016cites this paper
• MicroRNAs in osteoarthritis and chondrogenesis

  2016influential citation
• PRMT5 is essential for the maintenance of chondrogenic progenitor cells in the limb bud

  2016cites this paper
• Learn, simplify and implement: developmental re-engineering strategies for cartilage repai.

  2016cites this paper
• The fin-to-limb transition as the re-organization of a Turing pattern

  2016cites this paper
• Dual function of Bmpr1a signaling in restricting preosteoblast proliferation and stimulating osteoblast activity in mouse

  2016cites this paper
• Cell Signaling in Tenocytes: Response to Load and Ligands in Health and Disease.

  2016cites this paper
• SIMULATION TECHNIQUES FOR MECHANO-CHEMICAL INTERACTIONS IN MORPHOGENESIS

  2016cites this paper
• An orphan gene is necessary for preaxial digit formation during salamander limb development

  2015cites this paper
• Wdpcp affects skeletogenesis via the hedgehog pathway

  2015cites this paper
• Control of Arabidopsis vein-network formation by cell proliferation

  2015cites this paper
• Molecular regulation of tendon cell fate during development

  2015cites this paper
• Next generation limb development and evolution: old questions, new perspectives

  2015cites this paper
• BMP-Smad4 signaling is required for precartilaginous mesenchymal condensation independent of Sox9 in the mouse.

  2015influential citation
• Dysregulation of the Transforming Growth Factor β Pathway in Induced Pluripotent Stem Cells Generated from Patients with Diamond Blackfan Anemia

  2015cites this paper
• Re-engineering development to instruct tissue regeneration.

  2014cites this paper
• TGFβ signaling in cartilage development and maintenance.

  2014cites this paper
• The chondrocytic journey in endochondral bone growth and skeletal dysplasia.

  2014cites this paper
• In Turing's hands—the making of digits

  2014cites this paper
• Aggrecan- and COMP-Loaded Poly-(Lactic-Co-Glycolic Acid) Nanoparticles Stimulate Chondrogenic Differentiation of Human Mesenchymal Stem Cells

  2014cites this paper
• Dynamics of BMP signaling in limb bud mesenchyme and polydactyly.

  2014influential citation
• Digit patterning is controlled by a Bmp-Sox9-Wnt Turing network modulated by morphogen gradients

  2014cites this paper
• Ligand‐ and Stage‐Dependent Divergent Functions of BMP Signaling in the Differentiation of Embryonic Skeletogenic Progenitors In Vitro

  2014cites this paper
• To BMP or not to BMP during vertebrate limb bud development.

  2014cites this paper
• Decorin gene expression in the differentiation of the skeletal connective tissues of the developing limb.

  2014cites this paper
• Smad4 Regulates Ureteral Smooth Muscle Cell Differentiation during Mouse Embryogenesis

  2014cites this paper
• Towards in silico Organogenesis: A Data-based Computational Model for Limb Bud Patterning

  2014influential citation
• How do digits emerge? - mathematical models of limb development.

  2014influential citation
• Activin/BMP2 chimeric ligands direct adipose-derived stem cells to chondrogenic differentiation.

  2013cites this paper
• Expression and Functional Study of Extracellular BMP Antagonists during the Morphogenesis of the Digits and Their Associated Connective Tissues

  2013cites this paper
• Autopodial development is selectively impaired by misexpression of chordin-like 1 in the chick limb.

  2013cites this paper
• Inter-dependent tissue growth and Turing patterning in a model for long bone development

  2013cites this paper
• Dual requirement of ectodermal Smad4 during AER formation and termination of feedback signaling in mouse limb buds

  2013cites this paper
• Digit patterning during limb development as a result of the BMP-receptor interaction

  2012cites this paper
• Making sense-data-based simulations of vertebrate limb development.

  2012cites this paper