SHH propagates distal limb bud development by enhancing CYP26B1-mediated retinoic acid clearance via AER-FGF signalling

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Development

• Publication date

  2011-05-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/dev.063966PMID 21471156PMCID PMC3082298
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• FGF9 suppresses meiosis and promotes male germ cell fate in mice.

  2010cited by this paper
• Neuronal regulation of the spatial patterning of neurogenesis.

  2010cited by this paper
• Short limbs, cleft palate, and delayed formation of flat proliferative chondrocytes in mice with targeted disruption of a putative protein kinase gene, Pkdcc (AW548124)

  2009cited by this paper
• Ectopic Meis1 expression in the mouse limb bud alters P-D patterning in a Pbx1-independent manner.

  2009cited by this paper
• Vertebrate limb development: moving from classical morphogen gradients to an integrated 4-dimensional patterning system.

  2009cited by this paper
• Removal of maternal retinoic acid by embryonic CYP26 is required for correct Nodal expression during early embryonic patterning.

  2009cited by this paper
• Vertebrate limb bud development: moving towards integrative analysis of organogenesis

  2009cited by this paper
• Ectopic Meis 1 expression in the mouse limb bud alters PD patterning in a Pbx 1-independent manner

  2009cited by this paper
• Growing models of vertebrate limb development

  2009cited by this paper
• Sall genes regulate region-specific morphogenesis in the mouse limb by modulating Hox activities

  2009cited by this paper
• Progressive interdigital cell death: regulation by the antagonistic interaction between fibroblast growth factor 8 and retinoic acid

  2009cited by this paper
• The role of stromal-derived factor-1--CXCR7 axis in development and cancer.

  2009cited by this paper
• Retinoic acid promotes limb induction through effects on body axis extension but is unnecessary for limb patterning.

  2009influential reference
• A Self-Regulatory System of Interlinked Signaling Feedback Loops Controls Mouse Limb Patterning

  2009influential reference
• Uncoupling Sonic hedgehog control of pattern and expansion of the developing limb bud.

  2008influential reference
• Genetic evidence that FGFs have an instructive role in limb proximal–distal patterning

  2008influential reference
• Integration of growth and specification in chick wing digit-patterning

  2008cited by this paper
• A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb.

  2008cited by this paper
• An Fgf/Gremlin inhibitory feedback loop triggers termination of limb bud outgrowth

  2008cited by this paper
• Sharp developmental thresholds defined through bistability by antagonistic gradients of retinoic acid and FGF signaling

  2007cited by this paper
• Rethinking the proximodistal axis of the vertebrate limb in the molecular era.

  2007cited by this paper
• The role of Hox genes during vertebrate limb development.

  2007cited by this paper
• Differential regulation of gene expression in the digit forming area of the mouse limb bud by SHH and gremlin 1/FGF-mediated epithelial-mesenchymal signalling

  2006cited by this paper
• Faculty Opinions recommendation of Opposing FGF and retinoid pathways control ventral neural pattern, neuronal differentiation, and segmentation during body axis extension.

  2004cited by this paper
• Regulation of retinoic acid distribution is required for proximodistal patterning and outgrowth of the developing mouse limb.

  2004influential reference
• Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression.

  2004cited by this paper
• Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities.

  2004cited by this paper
• Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis

  2004cited by this paper
• Cellular anomalies underlying retinoid-induced phocomelia.

  2004cited by this paper
• Regulation of segmental patterning by retinoic acid signaling during Xenopus somitogenesis.

  2004cited by this paper
• Opposing FGF and retinoid pathways control ventral neural pattern, neuronal differentiation, and segmentation during body axis extension.

  2003cited by this paper
• Embryonic retinoic acid synthesis is required for forelimb growth and anteroposterior patterning in the mouse.

  2002cited by this paper
• Functions of FGF signalling from the apical ectodermal ridge in limb development

  2002cited by this paper
• Progression of Vertebrate Limb Development Through SHH-Mediated Counteraction of GLI3

  2002cited by this paper
• Gene expression pattern Cloning of a novel retinoic-acid metabolizing cytochrome P 450 , Cyp 26 B 1 , and comparative expression analysis with Cyp 26 A 1 during early murine development

  2001cited by this paper
• Gene and cluster-specific expression of the Iroquois family members during mouse development.

  2001cited by this paper
• Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiation.

  2001cited by this paper
• Some distal limb structures develop in mice lacking Sonic hedgehog signaling.

  2001cited by this paper
• Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function.

  2001cited by this paper
• Opposing RA and FGF signals control proximodistal vertebrate limb development through regulation of Meis genes.

  2000influential reference
• Fgf8 signalling from the AER is essential for normal limb development

  2000cited by this paper
• Conserved regulation of proximodistal limb axis development by Meis1/Hth

  1999cited by this paper
• Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed.

  1999cited by this paper
• A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo.

  1999cited by this paper
• Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds

  1999cited by this paper
• Embryonic retinoic acid synthesis is essential for early mouse post-implantation development

  1999cited by this paper
• Developmental expression of Mab21l2 during mouse embryogenesis.

  1999influential reference
• Control of vertebrate limb outgrowth by the proximal factor Meis2 and distal antagonism of BMPs by Gremlin.

  1999cited by this paper
• Sonic hedgehog signaling is essential for hair development.

  1998cited by this paper
• Expression of the mouse Gli and Ptc genes is adjacent to embryonic sources of hedgehog signals suggesting a conservation of pathways between flies and mice.

  1997cited by this paper
• The mesenchymal factor, FGF10, initiates and maintains the outgrowth of the chick limb bud through interaction with FGF8, an apical ectodermal factor.

  1997cited by this paper
• Retinoic acid changes the proximodistal developmental competence and affinity of distal cells in the developing chick limb bud.

  1997cited by this paper
• Enhanced LTP in mice deficient in the AMPA receptor GluR2.

  1996cited by this paper
• Analysis of Hox gene expression in the chick limb bud.

  1996cited by this paper
• Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand

  1995cited by this paper
• Retinoic acid application to chick wing buds leads to a dose-dependent reorganization of the apical ectodermal ridge that is mediated by the mesenchyme.

  1989cited by this paper

• AmeloD regulates cell proliferation and differentiation process of ameloblasts through modulation of the sonic hedgehog (shh) signaling pathway

  2026cites this paper
• Environmental yin-yang: how external cues are processed at the level of cells and at the level of an organism.

  2025cites this paper
• Early retinoic acid signaling organizes the body axis and defines domains for the forelimb and eye.

  2025cites this paper
• Retinoic acid breakdown is required for proximodistal positional identity during axolotl limb regeneration

  2025cites this paper
• Engineered thoracic spinal cord organoids for transplantation after spinal cord injury.

  2025cites this paper
• Retinoic acid breakdown is required for proximodistal positional identity during amphibian limb regeneration

  2024cites this paper
• Cell 3D Positioning by Optical encoding (C3PO) and its application to spatial transcriptomics

  2024cites this paper
• TBX3 is essential for establishment of the posterior boundary of anterior genes and upregulation of posterior genes together with HAND2 during the onset of limb bud development

  2024cites this paper
• 3D reconstruction of the mouse cochlea from scRNA-seq data suggests morphogen-based principles in apex-to-base specification.

  2024cites this paper
• Fgf signalling triggers an intrinsic mesodermal timer that determines the duration of limb patterning

  2023cites this paper
• Mesenchyme-derived vertebrate lonesome kinase controls lung organogenesis by altering the matrisome

  2023cites this paper
• A single-cell census of mouse limb development identifies complex spatiotemporal dynamics of skeleton formation.

  2023cites this paper
• KIF3B promotes a PI3K signaling gradient causing changes in a Shh protein gradient and suppressing polydactyly in mice.

  2022cites this paper
• GLI transcriptional repression is inert prior to Hedgehog pathway activation

  2022cites this paper
• Am80-Encapsulated Lipid Nanoparticles, Developed with the Aim of Achieving Alveolar Regeneration, Have an Improvement Effect on Pulmonary Emphysema

  2022cites this paper
• Integrated multi-omics reveals minor spliceosome inhibition causes molecular stalling and developmental delay of the mouse forelimb

  2022cites this paper
• Retinoic acid, RARs and early development.

  2022cites this paper
• Single-cell atlas of mouse limb development reveals a complex spatiotemporal dynamics of skeleton formation

  2022cites this paper
• Loss of Vlk in Prx1+ Cells Delays the Initial Steps of Endochondral Bone Formation and Fracture Repair in the Limb

  2022cites this paper
• Highlighting the gaps in hazard and risk assessment of unregulated Endocrine Active Substances in surface waters: retinoids as a European case study

  2021cites this paper
• Role of Retinoic Acid Signaling, FGF Signaling and Meis Genes in Control of Limb Development

  2021cites this paper
• THREE-DIMENSIONAL COMPUTATIONAL MODEL OF EARLY UPPER LIMB DEVELOPMENT

  2021cites this paper
• Human Stem Cell-Derived Thymic Epithelial Cells Enhance Human T Cell Development in a Xenogeneic Thymus.

  2021cites this paper
• Conserved and species-specific chromatin remodeling and regulatory dynamics during mouse and chicken limb bud development

  2021cites this paper
• SMAD4 target genes are part of a transcriptional network that integrates the response to BMP and SHH signaling during early limb bud patterning

  2021influential citation
• GLI transcriptional repression is inert prior to Hedgehog pathway activation

  2021cites this paper
• Erf Affects Commitment and Differentiation of Osteoprogenitor Cells in Cranial Sutures via the Retinoic Acid Pathway

  2021cites this paper
• Species-specific developmental timing dictates expansion of the avian wing skeletal pattern

  2021influential citation
• Developmental timing scales wing patterning between avian species

  2021influential citation
• Gene Regulatory and Expression Differences between Mouse and Pig Limb Buds Provide Insights into the Evolutionary Emergence of Artiodactyl Traits

  2020cites this paper
• Regulating Retinoic Acid Availability during Development and Regeneration: The Role of the CYP26 Enzymes

  2020cites this paper
• Mathematical modeling of chondrogenic pattern formation during limb development: Recent advances in continuous models.

  2020cites this paper
• The Biochemistry of Retinoid Signaling III: Vitamin A and Retinoic Acid in Embryonic Development

  2020cites this paper
• Retinoid Signaling in Skeletal Development: Scoping the System for Predictive Toxicology.

  2020cites this paper
• Dynamic and self-regulatory interactions among gene regulatory networks control vertebrate limb bud morphogenesis.

  2020cites this paper
• Cyp26b1 is an essential regulator of distal airway epithelial differentiation during lung development

  2020cites this paper
• Mesoderm patterning by a dynamic gradient of retinoic acid signalling

  2020cites this paper
• Sonic Hedgehog is not a limb morphogen but acts as a trigger to specify all digits

  2020cites this paper
• RA Signaling in Limb Development and Regeneration in Different Species.

  2020cites this paper
• Molecular signatures identify immature mesenchymal progenitors in early mouse limb buds that respond differentially to morphogen signaling

  2019cites this paper
• GLI transcriptional repression regulates tissue-specific enhancer activity in response to Hedgehog signaling

  2019cites this paper
• Cyp26b1 is required for proper airway epithelial differentiation during lung development

  2019cites this paper
• Sonic Hedgehog Signaling Is Required for Cyp26 Expression during Embryonic Development

  2019cites this paper
• A Sprouty4 reporter to monitor FGF/ERK signaling activity in ESCs and mice.

  2018cites this paper
• Variant PRC1 competes with retinoic acid-related signals to repress Meis2 in the mouse distal forelimb bud

  2018influential citation
• LHX2 Mediates the FGF-to-SHH Regulatory Loop during Limb Development

  2018cites this paper
• Coordination of limb development by crosstalk among axial patterning pathways.

  2017influential citation
• Retinoic acid in developmental toxicology: Teratogen, morphogen and biomarker.

  2017cites this paper
• Fin-fold development in paddlefish and catshark and implications for the evolution of the autopod

  2017cites this paper
• Transcriptional changes in chick wing bud polarization induced by retinoic acid

  2017cites this paper
• John Saunders' ZPA, Sonic hedgehog and digit identity - How does it really all work?

  2017cites this paper
• Pitx1 directly modulates the core limb development program to implement hindlimb identity

  2017cites this paper
• RING 1 proteins contribute to early proximal-distal specification of the forelimb bud by restricting Meis 2 expression

  2016influential citation
• T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number

  2016cites this paper
• Mechanisms of vertebrate embryo segmentation: Common themes in trunk and limb development.

  2016cites this paper
• The chick embryo as a model for the effects of prenatal exposure to alcohol on craniofacial development.

  2016cites this paper
• Getting a handle on embryo limb development: Molecular interactions driving limb outgrowth and patterning.

  2016cites this paper
• Gradients, waves and timers, an overview of limb patterning models.

  2016cites this paper
• Xenopus Limb bud morphogenesis

  2016cites this paper
• Retinoic acid signalling in the development of the epidermis, the limbs and the secondary palate.

  2016cites this paper
• Characterization of transcription factors and LncRNAs involved in the development of the bat wing

  2016cites this paper
• The many lives of SHH in limb development and evolution.

  2016cites this paper
• RING1 proteins contribute to early proximal-distal specification of the forelimb bud by restricting Meis2 expression

  2016cites this paper
• A study of the regulatory role of retinoic acid receptor gamma in Zebrafish development

  2015cites this paper
• Spatiotemporal regulation of GLI target genes in the mammalian limb bud.

  2015influential citation
• An intrinsic timer specifies distal structures of the vertebrate limb

  2015cites this paper
• Mechanisms of retinoic acid signalling and its roles in organ and limb development

  2015cites this paper
• Data-driven modelling of a gene regulatory network for cell fate decisions in the growing limb bud

  2015cites this paper
• Investigation of the SHH gradient during limb development through quantitation of transcriptional regulation, expression, and protein distribution.

  2015cites this paper
• eview etting a handle on embryo limb development : Molecular nteractions driving limb outgrowth and patterning

  2015cites this paper
• Next generation limb development and evolution: old questions, new perspectives

  2015cites this paper
• Image-based Modelling of Organogenesis

  2015cites this paper
• Genetic Interactions Between Shox2 and Hox Genes During the Regional Growth and Development of the Mouse Limb

  2014cites this paper
• To BMP or not to BMP during vertebrate limb bud development.

  2014cites this paper
• Simulating Organogenesis

  2014cites this paper
• Towards in silico Organogenesis: A Data-based Computational Model for Limb Bud Patterning

  2014influential citation
• Image-based Parameter Inference for Spatio-temporal models of Organogenesis

  2014cites this paper
• How do digits emerge? - mathematical models of limb development.

  2014influential citation
• Adverse effects of high glucose levels on somite and limb development in avian embryos.

  2014cites this paper
• Limb patterning: from signaling gradients to molecular oscillations.

  2014cites this paper
• Limb Patterning : From Signaling Gradients to Molecular Oscillations eba

  2014cites this paper
• Diffusible signals and epigenetic timing cooperate in late proximo-distal limb patterning

  2014influential citation
• Sonic hedgehog-expressing cells in the developing limb measure time by an intrinsic cell cycle clock

  2014cites this paper
• “Self‐regulation,” a new facet of Hox genes' function

  2014cites this paper
• HOXA13 regulates Aldh1a2 expression in the autopod to facilitate interdigital programmed cell death

  2013cites this paper
• An investigation into two photostable retinoids and their use as tools to study retinoid function in vivo

  2013influential citation
• The Sonic hedgehog gradient in the developing limb

  2013cites this paper
• Antagonism between retinoic acid and fibroblast growth factor signaling during limb development.

  2013cites this paper
• A Hh-driven gene network controls specification, pattern and size of the Drosophila simple eyes

  2013cites this paper
• Simulating Organogenesis in COMSOL: Parameter Optimization for PDE-based models

  2013cites this paper
• Simulating Organogenesis in COMSOL: Cell-based Signaling Models

  2013cites this paper
• Molecular analysis of regulative events in the developing chick limb

  2013influential citation
• Simulating tissue morphogenesis and signaling.

  2013cites this paper
• The hedgehog target Vlk genetically interacts with Gli3 to regulate chondrocyte differentiation during mouse long bone development.

  2013cites this paper
• Gradients of signalling in the developing limb.

  2012cites this paper
• Digit patterning during limb development as a result of the BMP-receptor interaction

  2012cites this paper
• Three new patients with FATCO: Fibular agenesis with ectrodactyly

  2012cites this paper
• Smad4 is required to induce digit ray primordia and to initiate the aggregation and differentiation of chondrogenic progenitors in mouse limb buds

  2012cites this paper
• Encoding and decoding of positional information in morphogen-dependent patterning.

  2012cites this paper
• Simulation Organogenesis in COMSOL: Deforming and Interacting Domains

  2012cites this paper