Farnesyl diphosphate synthase; regulation of product specificity.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Acta Biochimica Polonica

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.18388/ABP.2005_3485PMID 15827605
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Branch-point reactions in the biosynthesis of cholesterol, dolichol, ubiquinone and prenylated proteins.

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• Identification of farnesol as the non-sterol derivative of mevalonic acid required for the accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

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• Thermostable farnesyl diphosphate synthase of Bacillus stearothermophilus: crystallization and site-directed mutagenesis.

  1994influential reference
• Yeast farnesyl-diphosphate synthase: site-directed mutagenesis of residues in highly conserved prenyltransferase domains I and II.

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• Crystallization and preliminary X-ray diffraction studies of Bacillus stearothermophilus farnesyl diphosphate synthase expressed in Escherichia coli.

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• 3-Hydroxy-3-methylglutaryl-coenzyme A reductase. The difference in the mechanism of the in vitro modulation by phosphorylation and dephosphorylation to modulation of enzyme activity by non-esterified cholesterol.

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• Human liver prenyltransferase and its characterization.

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• Purification and properties of pig liver prenyltransferase: interconvertible forms of the enzyme.

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• Prenyltransferase: the mechanism of the reaction.

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• Crystallization and partial characterization of prenyltransferase from avian liver.

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• Prenyltransferase from Saccharomyces cerevisiae. Purification to homogeneity and molecular properties.

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• Studies on the biosynthesis of cholesterol. XX. Steric course of decarboxylation of 5-pyrophosphomevalonate and of the carbon to carbon bond formation in the biosynthesis of farnesyl pyrophosphate.

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