Cloning of a novel somatostatin receptor, SSTR3, coupled to adenylylcyclase.

No abstract is available for this paper.

• Publication year

  1992

• Venue

  Journal of Biological Chemistry

• Publication date

  1992-10-05

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 1328199
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.

  1992cited by this paper
• Pharmacological properties of two cloned somatostatin receptors.

  1992cited by this paper
• Sequence Alignment of the G-Protein Coupled Receptor Superfamily

  1992cited by this paper
• Gi alpha 1 selectively couples somatostatin receptors to adenylyl cyclase in pituitary-derived AtT-20 cells.

  1992cited by this paper
• The effect of baclofen and somatostatin on neuronal activity in the rat ventromedial hypothalamic nucleus in vitro.

  1992cited by this paper
• Development of antibodies against the rat brain somatostatin receptor.

  1992cited by this paper
• Nigropedunculopontine projection in the rat: An Anterograde tracing study with phaseolus vulgaris‐leucoagglutinin (PHA‐L)

  1991cited by this paper
• The role of somatostatin and its analogs in the diagnosis and treatment of tumors.

  1991cited by this paper
• Model systems for the study of seven-transmembrane-segment receptors.

  1991cited by this paper
• Subtypes of brain somatostatin receptors couple to multiple cellular effector systems.

  1991cited by this paper
• Cholinergic nigrotectal projections in the rat.

  1991cited by this paper
• Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases.

  1991cited by this paper
• The interaction between cAMP-dependent and cAMP-independent mechanisms in mediating the somatostatin inhibition of insulin secretion in isolated rat pancreatic islets.

  1991cited by this paper
• Differential distribution of somatostatin receptor subtypes in rat brain revealed by newly developed somatostatin analogs.

  1991cited by this paper
• Structural analysis and functional role of the carbohydrate component of somatostatin receptors.

  1991cited by this paper
• Human dopamine D1 receptor encoded by an intronless gene on chromosome 5

  1990cited by this paper
• Differential effects of somatostatin on adenylate cyclase as functional correlate for different brain somatostatin receptor subpopulations.

  1989cited by this paper
• Analogs of somatostatin selectively label distinct subtypes of somatostatin receptors in rat brain.

  1989cited by this paper
• Direct inhibitory effects of a somatostatin analog, SMS 201-995, on AR4-2J cell proliferation via pertussis toxin-sensitive guanosine triphosphate-binding protein-independent mechanism.

  1989cited by this paper
• Somatostatin-14 and somatostatin-28 induce opposite effects on potassium currents in rat neocortical neurons.

  1989cited by this paper
• Beta-adrenergic and somatostatin receptors regulate Na-H exchange independent of cAMP.

  1989cited by this paper
• Pertussis toxin modifies the characteristics of both the inhibitory GTP binding proteins and the somatostatin receptor in anterior pituitary tumor cells.

  1988cited by this paper
• Chimeric alpha 2-,beta 2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity.

  1988cited by this paper
• Somatostatin pretreatment increases the number of somatostatin receptors in GH4C1 pituitary cells and does not reduce cellular responsiveness to somatostatin.

  1988cited by this paper
• Characteristics of somatostatin desensitization in the pituitary tumor cell line AtT-20.

  1988cited by this paper
• Sequence, tissue distribution, and chromosomal localization of mRNA encoding a human glucose transporter-like protein.

  1988cited by this paper
• Pertussis toxin blocks the inhibitory effects of somatostatin on cAMP-dependent vasoactive intestinal peptide and cAMP-independent thyrotropin releasing hormone-stimulated prolactin secretion of GH3 cells.

  1986cited by this paper
• Somatostatin in the central nervous system: physiology and pathological modifications.

  1986cited by this paper
• Chemistry and pharmacology of SMS 201-995, a long-acting octapeptide analogue of somatostatin.

  1986cited by this paper
• Somatostatin desensitization in rat anterior pituitary cells.

  1984cited by this paper
• A super active cyclic hexapeptide analog of somatostatin.

  1984cited by this paper
• Characterization of pallidonigral neurons in the rat by a combination of Golgi impregnation and retrograde transport of horseradish peroxidase: their monosynaptic input from the neostriatum

  1984cited by this paper
• Somatostatin desensitization: loss of the ability of somatostatin to inhibit cyclic AMP accumulation and adrenocorticotropin hormone release.

  1984cited by this paper
• Somatostatin (second of two parts).

  1983cited by this paper
• Somatostatin.

  1983cited by this paper
• A nucleotide regulatory site for somatostatin inhibition of adenylate cyclase in S49 lymphoma cells

  1983cited by this paper
• Somatostatin hyperpolarizes hippocampal pyramidal cells in vitro.

  1981cited by this paper
• Isolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activity.

  1980cited by this paper
• DNA sequencing with chain-terminating inhibitors.

  1977cited by this paper
• Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone

  1973cited by this paper

• Somatostatin receptors in GtoPdb v.2025.3

  2025cites this paper
• Smoothened inhibition of PKA at cilia transduces Hedgehog signals

  2025cites this paper
• Octreotide

  2025cites this paper
• Somatostatin receptors in GtoPdb v.2023.1

  2023cites this paper
• Neuropathological Examinations in the Mouse Brain-Investigation of a New Pharmaceutical Target in the Cuprizone Model and Comparative Histological Analyses of Primary Cilia in the Physiological Central Nervous System

  2021cites this paper
• Signaling in the primary cilium through the lens of the Hedgehog pathway

  2020cites this paper
• Neurochemistry of the Kölliker‐Fuse nucleus from a respiratory perspective

  2020cites this paper
• Biological and Biochemical Basis of the Differential Efficacy of First and Second Generation Somatostatin Receptor Ligands in Neuroendocrine Neoplasms

  2019cites this paper
• Somatostatin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

  2019cites this paper
• The human brain somatostatin interactome: SST binds selectively to P-type family ATPases

  2019cites this paper
• Exploring the Role of Somatostatin in the Pathogenesis of Alzheimer’s disease

  2018cites this paper
• Quantitative Comparison of Primary Cilia Marker Expression and Length in the Mouse Brain

  2018cites this paper
• International Union of Basic and Clinical Pharmacology. CV. Somatostatin Receptors: Structure, Function, Ligands, and New Nomenclature

  2018cites this paper
• Regulation of Endogenous (Male) Rodent GLP-1 Secretion and Human Islet Insulin Secretion by Antagonism of Somatostatin Receptor 5

  2017cites this paper
• BBSome trains remove activated GPCRs from cilia by enabling passage through the transition zone

  2017cites this paper
• Somatostatin in the rat rostral ventrolateral medulla: Origins and mechanism of action

  2016cites this paper
• UTILITY OF SOMATOSTATIN ANALOGS IN NEUROENDOCRINE GASTROENTEROPANCREATIC TUMORS NONGH SECRETING - AND PITUITARY TUMORS

  2016cites this paper
• Somatostatin Analogs: Future Perspectives and Preclinical Studies-Pansomatostatins

  2015cites this paper
• Rôle des acides biliaires et de leur récepteur TGR5 dans la régulation de la somatostatine pancréatique et intestinale : conséquences fonctionnelles sur les îlots pancréatiques humains

  2015cites this paper
• The somatostatin receptor in human pancreatic β-cells.

  2014cites this paper
• Down-regulation of pancreatic and duodenal homeobox-1 by somatostatin receptor subtype 5: a novel mechanism for inhibition of cellular proliferation and insulin secretion by somatostatin

  2014cites this paper
• Tc-p829 99m of a Novel Tumor Tracer, Binding in Vivo Somatostatin Receptor Subtype Specificity and Updated Version Citing Articles E-mail Alerts Somatostatin Receptor Subtype Specificity and in Vivo Binding of a Novel Tumor Tracer, 99mtc-p8291

  2013cites this paper
• Somatostatin receptors: from signaling to clinical practice.

  2013cites this paper
• Somatostatin receptor pathophysiology in the neuroendocrine system

  2013cites this paper
• Somatostatin receptor-3 mediated intracellular signaling and apoptosis is regulated by its cytoplasmic terminal.

  2011cites this paper
• The Hypofunctional Effect of P335L Single Nucleotide Polymorphism on SSTR5 Function

  2011cites this paper
• gastric and colonic smooth muscle cells Expression of somatostatin receptor subtypes on guinea pig

  2011cites this paper
• The somatostatin analogue octreotide inhibits capsaicin‐mediated activation of nociceptive primary afferent fibres in spinal cord lamina II (substantia gelatinosa)

  2011cites this paper
• Relative expression of mRNA for the somatostatin receptors in the caudate putamen of C57BL/6J and 129P3/J mice: strain and heroin effects.

  2010cites this paper
• Somatostatin Signaling in Neuronal Cilia Is Criticalfor Object Recognition Memory

  2010cites this paper
• Developmental changes in frequency of the ciliary somatostatin receptor 3 protein.

  2009cites this paper
• C H A N G E IN SOMATOSTATIN RECEPTOR EXPRESSION AFTER V A S C U L A R INJURY

  2009cites this paper
• Microarray Analysis of Somatostatin Receptor 5-Regulated Gene Expression Profiles in Murine Pancreas

  2009cites this paper
• Intraoperative Scintigraphic Detection of Abdominal Endocrine Tumors

  2009cites this paper
• Role of radiopharmaceuticals in the diagnosis and treatment of neuroendocrine tumours.

  2009cites this paper
• Synthesis and biologic activity of conformationally constrained analogs of L-363,301.

  2008cites this paper
• The diffuse neuroendocrine system and its immuno-modulatory roles in chicken T-cell immunity

  2007cites this paper
• INVOLVEMENT OF SOMATOSTATIN RECEPTOR SUBTYPES IN MEMBRANE ION CHANNEL MODIFICATION BY SOMATOSTATIN IN PITUITARY SOMATOTROPES

  2007cites this paper
• Somatostatin Receptors in Human Neuroblastoma Cell Lines Identification , Characterization , and Biological Activity of Updated

  2007influential citation
• Guiding principles applied in the design of GPCR-selective hypothalamic hormone agonists and antagonists

  2006cites this paper
• Novel Insights from Clinical Experience

  2006cites this paper
• Proceedings of the Australian Physiological and Pharmacological Society Symposium: Second Messengers Go2 AND Gi3 PROTEINS MEDIATE THE ACTION OF SOMATOSTATIN ON MEMBRANE Ca2+

  2006cites this paper
• Alterations in glucose homeostasis in SSTR1 gene-ablated mice.

  2006cites this paper
• Somatostatin and its Receptors in the Development of the Endocrine Pancreas

  2006cites this paper
• Desensitization of somatostatin-induced inhibition of low extracellular magnesium concentration-induced calcium spikes in cultured rat hippocampal neurons.

  2006cites this paper
• Regulation of Neuronal Nitric-oxide Synthase Activity by Somatostatin Analogs following SST5 Somatostatin Receptor Activation*

  2006cites this paper
• Expression pattern of somatostatin receptor subtypes 1–5 in human skin: an immunohistochemical study of healthy subjects and patients with psoriasis or atopic dermatitis

  2006cites this paper
• Somatostatin receptors and autoimmune‐mediated diabetes

  2005cites this paper
• Somatostatin

  2005cites this paper
• SSTR5 ablation in islet results in alterations in glucose homeostasis in mice

  2005cites this paper
• Role of Protein kinase C in Desensitization of Somatostatin-induced Calcium Signalling in NG108-15 Cells

  2005cites this paper
• Molecular control of peptide hormone and receptor expression RCgulation molCculaire des hormones

  2005cites this paper
• Novel modalities of somatostatin actions.

  2004cites this paper
• Receptor-Mediated Tumor Targeting with Radiopeptides. Part 1. General Concepts and Methods: Applications to Somatostatin Receptor-Expressing Tumors

  2004cites this paper
• Somatostatin Receptor Gene Family - Subtype Selectivity for Ligand Binding

  2004cites this paper
• Somatostatin-mRNA expression in brainstem projections into the medial preoptic nucleus

  2004cites this paper
• The effect of global SSTR5 gene ablation on the endocrine pancreas and glucose regulation in aging mice.

  2004cites this paper
• Untersuchungen zur Dimerisierung von Somatostatin-Rezeptoren mit anderen G-Protein-gekoppelten Rezeptoren

  2004cites this paper
• Double-gene ablation of SSTR1 and SSTR5 results in hyperinsulinemia and improved glucose tolerance in mice.

  2004cites this paper
• Expression and Function of Somatostatin and its Receptors in Immune Cells

  2004cites this paper
• Orbital scintigraphy with the somatostatin receptor tracer 99mTc-P829 in patients with Graves' disease.

  2003cites this paper
• Somatostatin and somatostatin receptor physiology

  2003cites this paper
• Somatostatin receptors.

  2003cites this paper
• Expression of IGFBP-3 by human retinal endothelial cell cultures: IGFBP-3 involvement in growth inhibition and apoptosis.

  2003cites this paper
• Novel sst(4)-selective somatostatin (SRIF) agonists. 1. Lead identification using a betide scan.

  2003cites this paper
• Localization of Messenger Ribonucleic Acids for Somatostatin Receptor Subtypes (sstr1–5) in the Rat Adrenal Gland

  2003cites this paper
• Conserved Motifs in Somatostatin, D2-dopamine, and α2B-Adrenergic Receptors for Inhibiting the Na-H Exchanger, NHE1*

  2003cites this paper
• Novel sst(4)-selective somatostatin (SRIF) agonists. 3. Analogues amenable to radiolabeling.

  2003cites this paper
• Endogenous somatostatin receptors mobilize calcium from inositol 1,4,5-trisphosphate-sensitive stores in NG108-15 cells.

  2003cites this paper
• Pegvisomant in the treatment of acromegaly.

  2003cites this paper
• Recent advances in cerebellar granule cell migration

  2003cites this paper
• Identification of somatostatin receptors controlling growth hormone and thyrotropin secretion in the chicken using receptor subtype-specific agonists.

  2003cites this paper
• Cholangiocarcinoma cells express somatostatin receptor subtype 2 and respond to octreotide treatment.

  2002cites this paper
• Cellular and molecular mechanisms of cerebellar granule cell migration

  2002cites this paper
• In- and Y-DOTA-lanreotide: results and implications of the MAURITIUS trial.

  2002cites this paper
• A comparison of the effects of pegvisomant and octreotide on glucose, insulin, gastrin, cholecystokinin, and pancreatic polypeptide responses to oral glucose and a standard mixed meal.

  2002cites this paper
• Exploration of the DTrp-NMeLys motif in the search for potent somatostatin antagonists.

  2002cites this paper
• Antiangiogenic effects of somatostatin analogues

  2002cites this paper
• Somatostatin analogs and radiopeptides in cancer therapy.

  2002cites this paper
• Results and Implications of the MAURITIUS Trial

  2002cites this paper
• 111In- and 90Y-DOTA-Lanreotide: Results and implications of the MAURITIUS trial

  2002cites this paper
• Expression changes of somatostatin receptor subtypes sst2A, sst2B, sst3 and sst4 after a cortical contusion trauma in rats.

  2002cites this paper
• Drug design at peptide receptors

  2002cites this paper
• Somatostatin (SRIF) and SRIF receptors in the mouse retina.

  2002cites this paper
• Somatostatin sst2 receptor knock-out mice: localisation of sst1-5 receptor mRNA and binding in mouse brain by semi-quantitative RT-PCR, in situ hybridisation histochemistry and receptor autoradiography.

  2002cites this paper
• Drug design at peptide receptors: somatostatin receptor ligands.

  2002cites this paper
• Inhibition of experimental angiogenesis of cornea by somatostatin

  2002cites this paper
• Growth hormone receptor antagonists: discovery, development, and use in patients with acromegaly.

  2002cites this paper
• Experience with indium-111 and yttrium-90-labeled somatostatin analogs.

  2002cites this paper
• High-throughput receptor-binding methods for somatostatin receptor 2.

  2002cites this paper
• Sulfonylurea Receptor Knockout Causes Glucose Intolerance in Mice That is Not Alleviated by Concomitant Somatostatin Subtype Receptor 5 Knockout

  2002cites this paper
• Small molecule somatostatin receptor subtype-2 antagonists.

  2001cites this paper
• Influence of the somatostatin receptor sst2 on growth factor signal cascades in human glioma cells.

  2001cites this paper
• Identification of potent non-peptide somatostatin antagonists with sst(3) selectivity.

  2001cites this paper
• The place of pegvisomant in the management of acromegaly

  2001cites this paper
• 111In-DOTA-lanreotide scintigraphy in patients with tumors of the lung.

  2001cites this paper
• Highly potent and subtype selective ligands derived by N-methyl scan of a somatostatin antagonist.

  2001cites this paper
• Utilidad de los análogos de somatostatina en tumores neuroendocrinos gastroenteropancreáticos y tumores hipofisarios no productores de GH

  2001cites this paper
• Somatostatin receptor (SSTR) expression and function in normal and leukaemic T‐cells. Evidence for selective effects on adhesion to extracellular matrix components via SSTR2 and/or 3

  2001cites this paper
• Thyroid hormone-responsive pituitary hyperplasia independent of somatostatin receptor 2.

  2001cites this paper