Antimitotic drugs in the treatment of cancer

Cancer is a complex disease since it is adaptive in such a way that it can promote proliferation and invasion by means of an overactive cell cycle and in turn cellular division which is targeted by antimitotic drugs that are highly validated chemotherapy agents. However, antimitotic drug cytotoxicity to non-tumorigenic cells and multiple cancer resistance developed in response to drugs such as taxanes and vinca alkaloids are obstacles faced in both the clinical and basic research field to date. In this review, the classes of antimitotic compounds, their mechanisms of action and cancer cell resistance to chemotherapy and other limitations of current antimitotic compounds are highlighted, as well as the potential of novel 17-β estradiol analogs as cancer treatment.

• Publication year

  2015

• Venue

  Cancer Chemotherapy and Pharmacology

• Publication date

  2015-11-12

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00280-015-2903-8PMID 26563258PMCID 4648954
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cancer statistics, 2015

  2015cited by this paper
• Neuroprotective effects of exendin-4 in rat model of spinal cord injury via inhibiting mitochondrial apoptotic pathway.

  2015cited by this paper
• Cyclin dependent kinase (CDK) inhibitors as anticancer drugs.

  2015influential reference
• The tubulysin analogue KEMTUB10 induces apoptosis in breast cancer cells via p53, Bim and Bcl-2

  2015cited by this paper
• Peloruside A Inhibits Growth of Human Lung and Breast Tumor Xenografts in an Athymic nu/nu Mouse Model

  2015cited by this paper
• Aneuploidy and chromosomal instability in cancer: a jackpot to chaos

  2015cited by this paper
• p53 orchestrates calcium signaling in vivo

  2015cited by this paper
• Evaluation of 2',4'-dihydroxy-3,4,5-trimethoxychalcone as antimitotic agent that induces mitotic catastrophe in MCF-7 breast cancer cells.

  2014cited by this paper
• Novel estradiol analogue induces apoptosis and autophagy in esophageal carcinoma cells

  2014cited by this paper
• Folate-vinca alkaloid conjugates for cancer therapy: a structure-activity relationship.

  2014cited by this paper
• Tubulin inhibitors: a patent review

  2014influential reference
• 17‐beta‐estradiol analog inhibits cell proliferation by induction of apoptosis in breast cell lines

  2014cited by this paper
• In vitro changes in mitochondrial potential, aggresome formation and caspase activity by a novel 17‐β‐estradiol analogue in breast adenocarcinoma cells

  2013cited by this paper
• The chemotherapeutic agent paclitaxel inhibits autophagy through two distinct mechanisms that regulate apoptosis

  2013cited by this paper
• PRECEDENT: a randomized phase II trial comparing vintafolide (EC145) and pegylated liposomal doxorubicin (PLD) in combination versus PLD alone in patients with platinum-resistant ovarian cancer.

  2013cited by this paper
• Drugs Used for Chemotherapy

  2013cited by this paper
• Induction of apoptosis in human ovarian cancer cells by new anticancer compounds, epothilone A and B.

  2013influential reference
• MicroRNAs: novel mediators of resistance to microtubule-targeting agents.

  2013influential reference
• Molecular aspects of cancer cell resistance to chemotherapy.

  2013influential reference
• Synthesis and biological activity of 3-N-substituted estrogen derivatives as breast cancer agents.

  2013influential reference
• Signaling Pathways of ESE-16, an Antimitotic and Anticarbonic Anhydrase Estradiol Analog, in Breast Cancer Cells

  2013cited by this paper
• Intrinsic and acquired resistance to HER2-targeted therapies in HER2 gene-amplified breast cancer: mechanisms and clinical implications.

  2012cited by this paper
• The European Medicines Agency review of cabazitaxel (Jevtana®) for the treatment of hormone-refractory metastatic prostate cancer: summary of the scientific assessment of the committee for medicinal products for human use.

  2012cited by this paper
• US Food and Drug Administration approval overview in metastatic breast cancer.

  2012cited by this paper
• In Vitro Evaluation of ESE-15-ol, an Estradiol Analogue with Nanomolar Antimitotic and Carbonic Anhydrase Inhibitory Activity

  2012cited by this paper
• Eribulin -- a review of preclinical and clinical studies.

  2012cited by this paper
• Immunotherapy of Cancer

  2012cited by this paper
• Taxane resistance in breast cancer: a closed HER2 circuit?

  2012cited by this paper
• Overcoming tumor multidrug resistance using drugs able to evade P‐glycoprotein or to exploit its expression

  2012cited by this paper
• Cabazitaxel: More Than a New Taxane for Metastatic Castrate-Resistant Prostate Cancer?

  2012influential reference
• Minireview: G protein-coupled estrogen receptor-1, GPER-1: its mechanism of action and role in female reproductive cancer, renal and vascular physiology.

  2012cited by this paper
• Hypoxia decreased chemosensitivity of breast cancer cell line MCF-7 to paclitaxel through cyclin B1.

  2012influential reference
• Microtubules as a Target in Cancer Therapy

  2012influential reference
• Multicenter Trial of EC145 in Advanced, Folate-Receptor Positive Adenocarcinoma of the Lung

  2012cited by this paper
• Review of hormonal treatment of breast cancer.

  2012cited by this paper
• The proliferation rate paradox in antimitotic chemotherapy

  2012influential reference
• Regulation of cancer cell metabolism

  2011cited by this paper
• Ixabepilone, a Novel Microtubule-Targeting Agent for Breast Cancer, Is a Substrate for P-Glycoprotein (P-gp/MDR1/ABCB1) but not Breast Cancer Resistance Protein (BCRP/ABCG2)

  2011influential reference
• Synergistic effect of folate-mediated targeting and verapamil-mediated P-gp inhibition with paclitaxel -polymer micelles to overcome multi-drug resistance.

  2011cited by this paper
• Principles and Current Strategies for Targeting Autophagy for Cancer Treatment

  2011influential reference
• Docking, Synthesis, and in vitro Evaluation of Antimitotic Estrone Analogs

  2011cited by this paper
• Hallmarks of cancer: the next generation.

  2011influential reference
• Cooperative phosphorylation of FADD by Aur-A and Plk1 in response to taxol triggers both apoptotic and necrotic cell death.

  2011influential reference
• Recent Developments in Cancer Vaccines

  2011cited by this paper
• βII-Tubulin and βIII-Tubulin Mediate Sensitivity to Peloruside A and Laulimalide, but not Paclitaxel or Vinblastine, in Human Ovarian Carcinoma Cells

  2011cited by this paper
• Carbonic anhydrase IX (CA9) modulates tumor-associated cell migration and invasion

  2011cited by this paper
• The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy

  2011cited by this paper
• MicroRNA-125b Confers the Resistance of Breast Cancer Cells to Paclitaxel through Suppression of Pro-apoptotic Bcl-2 Antagonist Killer 1 (Bak1) Expression*

  2010cited by this paper
• Microtubule-binding agents: a dynamic field of cancer therapeutics

  2010influential reference
• Microtubules and resistance to tubulin-binding agents

  2010influential reference
• Multiple Drug Resistance Mechanisms in Cancer

  2010influential reference
• Taxanes: optimizing adjuvant chemotherapy for early-stage breast cancer

  2010influential reference
• Microtubules and resistance to tubulin-binding agents

  2010cited by this paper
• Tumor self-seeding by circulating cancer cells.

  2009cited by this paper
• Cancer cell apoptotic pathways mediated by PEDF: prospects for therapy.

  2009cited by this paper
• Awakening guardian angels: drugging the p53 pathway

  2009cited by this paper
• Separase is recruited to mitotic chromosomes to dissolve sister chromatid cohesion in a DNA-dependent manner.

  2009cited by this paper
• Targeting Y-box binding protein-1 (YB-1) in Her-2 over-expressing breast cancer cells induces apoptosis via the signal transducer and activator or transcription-3 (STAT3) pathway and suppresses tumor growth.

  2008cited by this paper
• Targeting YB-1 in HER-2 overexpressing breast cancer cells induces apoptosis via the mTOR/STAT3 pathway and suppresses tumor growth in mice.

  2008cited by this paper
• Cardiac Toxicity in Breast Cancer Survivors: Review of Potential Cardiac Problems

  2008cited by this paper
• Folate-targeted drug strategies for the treatment of cancer.

  2008cited by this paper
• Linking kinetochore-microtubule binding to the spindle checkpoint.

  2008cited by this paper
• Apoptosis: A Review of Programmed Cell Death

  2007influential reference
• Y-box binding protein-1 (YB-1) is essential for the growth and survival of HER-2 over-expressing breast cancer cells

  2007cited by this paper
• In vitro and in vivo anticancer activities of synthetic (-)-laulimalide, a marine natural product microtubule stabilizing agent.

  2007cited by this paper
• The spindle-assembly checkpoint in space and time

  2007influential reference
• How do microtubule-targeted drugs work? An overview.

  2007cited by this paper
• Targeting tumor-associated carbonic anhydrase IX in cancer therapy.

  2006influential reference
• Bcl-w promotes gastric cancer cell invasion by inducing matrix metalloproteinase-2 expression via phosphoinositide 3-kinase, Akt, and Sp1.

  2006cited by this paper
• Paradoxical roles of the immune system during cancer development

  2006cited by this paper
• Update on tubulin-binding agents.

  2006cited by this paper
• What's wrong with our cancer models?

  2005cited by this paper
• beta-Tubulin mutations are associated with resistance to 2-methoxyestradiol in MDA-MB-435 cancer cells.

  2005cited by this paper
• Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay.

  2005cited by this paper
• Microtubules as a target for anticancer drugs

  2004cited by this paper
• Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain

  2004cited by this paper
• The selective estrogen enzyme modulators in breast cancer: a review.

  2004cited by this paper
• Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs

  2004cited by this paper
• Peloruside A Does Not Bind to the Taxoid Site on β-Tubulin and Retains Its Activity in Multidrug-Resistant Cell Lines

  2004cited by this paper
• Nanoparticle and targeted systems for cancer therapy.

  2004cited by this paper
• AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol.

  2003cited by this paper
• Dolastatin 15 binds in the vinca domain of tubulin as demonstrated by Hummel-Dreyer chromatography.

  2003cited by this paper
• 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF.

  2003cited by this paper
• The BCL2-family of protein ligands as cancer drugs: the next generation of therapeutics.

  2003cited by this paper
• Measuring the side effects of taxane therapy in oncology

  2003cited by this paper
• Immune evasion in human papillomavirus-associated cervical cancer

  2002cited by this paper
• The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to paclitaxel and epothilones, and may not require its epoxide moiety for activity.

  2002cited by this paper
• Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1

  2002cited by this paper
• Mad2 and BubR1 function in a single checkpoint pathway that responds to a loss of tension.

  2002cited by this paper
• Microtubule-stabilizing agents: a growing class of important anticancer drugs.

  2001cited by this paper
• Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2

  2001cited by this paper
• Spindle Checkpoint Protein Bub1 Is Required for Kinetochore Localization of Mad1, Mad2, Bub3, and Cenp-E, Independently of Its Kinase Activity

  2001cited by this paper
• Expression of hypoxia-inducible cell-surface transmembrane carbonic anhydrases in human cancer.

  2001cited by this paper
• TNF and TNFR biology in health and disease.

  2001cited by this paper
• Control of mitosis by changes in the subcellular location of cyclin-B1-Cdk1 and Cdc25C.

  2000influential reference
• Apoptosis control by death and decoy receptors.

  1999cited by this paper
• Paclitaxel resistance in non-small-cell lung cancer associated with beta-tubulin gene mutations.

  1999cited by this paper
• Inhibition of telomerase limits the growth of human cancer cells

  1999cited by this paper
• Spindle Checkpoint Protein Xmad1 Recruits Xmad2 to Unattached Kinetochores

  1998cited by this paper
• Concentrations of estrone, estradiol, and estrone sulfate and evaluation of sulfatase and aromatase activities in pre- and postmenopausal breast cancer patients.

  1996cited by this paper

• 2-Naphthyl tetrazoles are potent antiproliferative and apoptotic inducers with different tubulin polymerization dynamics inhibitory activity.

  2026cites this paper
• Evergreen Plants in Medicine: A Narrative Review of Their Therapeutic Potential and Pharmacological Applications

  2025cites this paper
• Novel Dihydropyrimidinones Synthesized through Modified Biginelli Reaction as Eg5 Kinesin Inhibitors with Potential Anti-cancer Effects: In vitro and In vivo Studies.

  2025cites this paper
• Time-Lapse Imaging to Analyze Cell Fate in Response to Antimitotics.

  2025cites this paper
• Meta-Analysis and Experimental Studies Reveal Mitotic Network Activity Index (MNAI) as Breast Cancer Metastasis and Treatment Biomarker

  2025cites this paper
• The Effect of Black Cumin (Nigella sativa) on Hypoxia-Inducible Factor (HIF-1), Vascular Endothelial Growth Factor (VEGF), Hemoglobin (Hb), and Neutrophil-Lymphocyte Ratio (NLR) Levels in Lung Cancer Patients

  2025cites this paper
• Structure based drug design and machine learning approaches for identifying natural inhibitors against the human αβIII tubulin isotype

  2025cites this paper
• Chemo-/sonodynamic/photothermal triune therapy in 2D and 3D models of MCF-7 cells using paclitaxel-loaded gold nanoparticles.

  2025cites this paper
• Discovery of a novel potent tubulin inhibitor through virtual screening and target validation for cancer chemotherapy

  2025cites this paper
• A novel thiazole-sulfonamide hybrid molecule as a promising dual tubulin/carbonic anhydrase IX inhibitor with anticancer activity

  2025cites this paper
• Global inhibition of deadenylation stabilizes the transcriptome in mitotic cells

  2025cites this paper
• Two-Dimensional and Spheroid-Based Three-Dimensional Cell Culture Systems: Implications for Drug Discovery in Cancer

  2024cites this paper
• Monastrol suppresses invasion and metastasis in human colorectal cancer cells by targeting fascin independent of kinesin-Eg5 pathway.

  2024cites this paper
• Prevention of paclitaxel-induced peripheral neuropathy: literature review of potential pharmacological interventions

  2024cites this paper
• The potential effect of Tubulysin A on autophagy in a group of cancer cell lines

  2024cites this paper
• A study of the molecular interactions of hemoglobin with diverse classes of therapeutic agents

  2024cites this paper
• First total synthesis, antitumor evaluation and target identification of mornaphthoate E: A new tubulin inhibitor template acting on PI3K/Akt signaling pathway

  2024cites this paper
• Efficacy of Moxibustion for Cancer-Related Fatigue in Patients with Breast Cancer: A Systematic Review and Meta-Analysis

  2024cites this paper
• Cell cycle arrest induces lipid droplet formation and confers ferroptosis resistance

  2024cites this paper
• 2-Aminoethyl Dihydrogen Phosphate (2-AEH2P) Associated with Cell Metabolism-Modulating Drugs Presents a Synergistic and Pro-Apoptotic Effect in an In Vitro Model of the Ascitic Ehrlich Tumor

  2024cites this paper
• Resistance to antibody–drug conjugates: A review

  2024cites this paper
• Potential Strategies for Overcoming Drug Resistance Pathways Using Propolis and Its Polyphenolic/Flavonoid Compounds in Combination with Chemotherapy and Radiotherapy

  2024cites this paper
• Centromeres in cancer: Unraveling the link between chromosomal instability and tumorigenesis

  2024cites this paper
• Design and synthesis of ferrocenyl 1,4-dihydropyridines and their evaluation as kinesin-5 inhibitors.

  2024cites this paper
• Comparison of Multiple Machine Learning Models for the Classification of Cell States Based on Impedance Features

  2024cites this paper
• Anticancer, anti-inflammatory and analgesic activities of aminoalcohol-based quinoxaline small molecules

  2024cites this paper
• Osmotic Stress Influences Microtubule Drug Response Via WNK1 Kinase Signaling

  2024cites this paper
• Idiopathic Intracranial Hypertension in a Breast Cancer Patient Receiving Adjuvant Paclitaxel: A Case Report and a Review of the Liter

  2024cites this paper
• Promising anti-proliferative indolic benzenesulfonamides alter mechanisms with sulfonamide nitrogen substituents.

  2024cites this paper
• New uracil analog as inhibitor/modulator of ABC transporters or/and NF-κB in taxol-resistant MCF-7/Tx cell line

  2024cites this paper
• DNA Damage Response Inhibition-Based Combination Therapies

  2023cites this paper
• Illuminating phenotypic drug responses of sarcoma cells to kinase inhibitors by phosphoproteomics

  2023cites this paper
• RNA sequencing and target long-read sequencing reveal an intronic transposon insertion causing aberrant splicing

  2023cites this paper
• Caffeine Increased Antitumor Effects of Paclitaxel (PTX) in MCF-7 and MDA-MB-231 Breast Cancer Cells

  2023cites this paper
• The Future of Chemotherapy: The Mechanisms and Benefits of Exercise in Taxane-Induced Peripheral Neuropathy

  2023cites this paper
• Inducing Mitotic Catastrophe as a Therapeutic Approach to Improve Outcomes in Ewing Sarcoma

  2023cites this paper
• 1 Design , Synthesis and Biological Evaluation of 2-Alkoxycarbonyl-3-Anilinoindoles as a New Class of Potent Inhibitors of Tubulin Polymerization

  2023cites this paper
• Biological Evaluation of Xanthene and Thioxanthene Derivatives as Antioxidant, Anticancer, and COX Inhibitors

  2023cites this paper
• Identification of Novel β-Tubulin Inhibitors Using a Combined In Silico/In Vitro Approach

  2023cites this paper
• Antiproliferative Activity and Inhibition of Tubulin Polymerization

  2023cites this paper
• Conventional DNA-Damaging Cancer Therapies and Emerging cGAS-STING Activation: A Review and Perspectives Regarding Immunotherapeutic Potential

  2023cites this paper
• Microtubules and Cell Division: Potential Pharmacological Targets in Cancer Therapy.

  2023cites this paper
• Determination of Active Ingredients, Mineral Composition and Antioxidant Properties of Hydroalcoholic Macerates of Vinca minor L. Plant from the Dobrogea Area

  2023cites this paper
• Role of forkhead box proteins in regulation of doxorubicin and paclitaxel responses in tumor cells: A comprehensive review.

  2023cites this paper
• Di-indenopyridines as topoisomerase II-selective anticancer agents: Design, synthesis, and structure-activity relationships.

  2023cites this paper
• Understanding the Artemia Salina (Brine Shrimp) Test: Pharmacological Significance and Global Impact.

  2023cites this paper
• Combination Therapy as a Promising Way to Fight Oral Cancer

  2023cites this paper
• Exploring the Potential of Metal‐Based Candidate Drugs as Modulators of the Cytoskeleton

  2023cites this paper
• Design, Synthesis and Evaluation of Biological Activity of Ferrocene-Ispinesib Hybrids - Impact of a Ferrocenyl Group on the Antiproliferative and KSP Inhibitory Activity.

  2023cites this paper
• Antimitotic Activity of Samanea saman Leaf Extract in the In Vitro Development of Tripneustes gratilla Embryo

  2023cites this paper
• Molecular mechanisms protecting centromeres from self-sabotage and implications for cancer therapy

  2023cites this paper
• Cellular resistance mechanisms in cancer and the new approaches to overcome resistance mechanisms chemotherapy

  2023cites this paper
• Deregulated Gene Expression Profiles and Regulatory Networks in Adult and Pediatric RUNX1/RUNX1T1-Positive AML Patients

  2023cites this paper
• Radiosensitization of Breast Cancer Cells with a 2-Methoxyestradiol Analogue Affects DNA Damage and Repair Signaling In Vitro

  2023cites this paper
• DDX11-AS1 modulates DNA damage repair to enhance paclitaxel resistance of lung adenocarcinoma cells.

  2023cites this paper
• Exploring pradimicin-IRD antineoplastic mechanisms and related DNA repair pathways.

  2023cites this paper
• A fitness trade-off explains the early fate of yeast aneuploids with chromosome gains

  2023cites this paper
• Microtubules Destabilizing Agents Binding Sites in Tubulin

  2022cites this paper
• Recent Advances of Tubulin Inhibitors Targeting the Colchicine Binding Site for Cancer Therapy

  2022cites this paper
• 1 Design , Synthesis , in Vitro and in Vivo Biological Evaluation of 2-Amino-3-Aroylbenzo [ b ] furan Derivatives as Highly Potent Tubulin Polymerization Inhibitors

  2022cites this paper
• PQM-75: A N-benzyl-piperidine Acyl-hydrazone Derivative with Inhibitory Effects on Clonogenic Capacity and Cell Cycle Progression of HepG2 Cells

  2022cites this paper
• Overview of Nanoparticle-Based Approaches for the Combination of Photodynamic Therapy (PDT) and Chemotherapy at the Preclinical Stage

  2022cites this paper
• Synthesis, Characterisation and Mechanism of Action of Anticancer 3-Fluoroazetidin-2-ones

  2022cites this paper
• IMB5476, a novel microtubule inhibitor, induces mitotic catastrophe and overcomes multidrug resistance in tumors.

  2022cites this paper
• Design, Synthesis and Biological Investigation of 2-Anilino Triazolopyrimidines as Tubulin Polymerization Inhibitors with Anticancer Activities

  2022cites this paper
• Therapeutic Potential of Marine Peptides in Prostate Cancer: Mechanistic Insights

  2022cites this paper
• The effects of estrogen on targeted cancer therapy drugs.

  2022cites this paper
• Novel insights on [1,2]oxazolo[5,4‐e]isoindoles on multidrug resistant acute myeloid leukemia cell line

  2022cites this paper
• Cell Fate following Irradiation of MDA-MB-231 and MCF-7 Breast Cancer Cells Pre-Exposed to the Tetrahydroisoquinoline Sulfamate Microtubule Disruptor STX3451

  2022cites this paper
• Vitamin D enhances the sensitivity of breast cancer cells to the combination therapy of photodynamic therapy and paclitaxel.

  2022cites this paper
• An empirical review on the risk factors, therapeutic strategies and materials at nanoscale for the treatment of oral malignancies

  2022cites this paper
• Mechanisms of Chemotherapy-Induced Neurotoxicity

  2022cites this paper
• Cyclodextrin-Based Nanosponges as Perse Antimicrobial Agents Increase the Activity of Natural Antimicrobial Peptide Nisin

  2022cites this paper
• Oxidative stress in breast cancer after chemotherapy

  2022cites this paper
• Dimethoxycurcumin reduces proliferation and induces apoptosis in renal tumor cells more efficiently than demethoxycurcumin and curcumin.

  2021cites this paper
• Synthesis and biological activity of ferrocenyl and ruthenocenyl analogues of etoposide - discovery of a novel dual inhibitor of topoisomerase II activity and tubulin polymerization.

  2021cites this paper
• Molecular Delivery of Cytotoxic Agents via Integrin Activation

  2021cites this paper
• Vocal Fold Motion Impairment Following Chemotherapy Administration: Case Reports and Review of the Literature

  2021cites this paper
• Molecular mechanism of a parasite kinesin motor and implications for its inhibition

  2021cites this paper
• KIF11 promotes cell proliferation via ERBB2/PI3K/AKT signaling pathway in gallbladder cancer

  2021cites this paper
• Pancreatic Cancer: Recent Progress of Drugs in Clinical Trials

  2021cites this paper
• Design, synthesis and biological evaluation of benz‐fused five‐membered heterocyclic compounds as tubulin polymerization inhibitors with anticancer activities

  2021cites this paper
• Synthesis and Biological Evaluation of 1-(Diarylmethyl)-1H-1,2,4-triazoles and 1-(Diarylmethyl)-1H-imidazoles as a Novel Class of Anti-Mitotic Agent for Activity in Breast Cancer

  2021cites this paper
• Role of protein S-Glutathionylation in cancer progression and development of resistance to anti-cancer drugs.

  2021cites this paper
• Multifunctional Role of Astrocyte Elevated Gene-1 (AEG-1) in Cancer: Focus on Drug Resistance

  2021cites this paper
• Covalent cell surface recruitment of chemotherapeutic polymers enhances selectivity and activity†

  2021cites this paper
• Mdivi-1 induces spindle abnormalities and augments taxol cytotoxicity in MDA-MB-231 cells

  2021cites this paper
• Neutropenic Enterocolitis and Sepsis: Towards the Definition of a Pathologic Profile

  2021cites this paper
• Second-Generation Antimitotics in Cancer Clinical Trials

  2021cites this paper
• Cryo-EM structure of a microtubule-bound parasite kinesin motor and implications for its mechanism and inhibition

  2021influential citation
• Design, synthesis, biological evaluation, and molecular docking of new benzofuran and indole derivatives as tubulin polymerization inhibitors

  2021cites this paper
• Targeting Mps1 in combination with paclitaxel inhibits osteosarcoma progression by modulating spindle assembly checkpoint and Akt/mTOR signaling

  2021cites this paper
• Pyrimidyn‐Based Dynamin Inhibitors as Novel Cytotoxic Agents

  2021cites this paper
• Dietary Phytochemicals: As a Natural Source of Antioxidants

  2021cites this paper
• Heptamethine Cyanine Dye MHI-148-Mediated Drug Delivery System to Enhance the Anticancer Efficiency of Paclitaxel

  2021cites this paper
• Design, Synthesis and Antitumoral Activity of New O ‐Alkylamidoximes

  2021cites this paper
• Pharmaceuticals in the Aquatic Environment and Their Endocrine Disruptive Effects in Fish

  2021cites this paper
• Therapeutic potential of marine peptides in cervical and ovarian cancers

  2021cites this paper
• Nanoscale characterization of drug-induced microtubule filament dysfunction using super-resolution microscopy

  2021cites this paper
• Therapeutic potential of marine peptides in cervical and ovarian cancers

  2021cites this paper