Transactivation of the PPAR-Responsive Enhancer Module in Chemopreventive Glutathione S-Transferase Gene by the Peroxisome Proliferator-Activated Receptor-γ and Retinoid X Receptor Heterodimer

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Cancer Research

• Publication date

  2004-05-15

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1158/0008-5472.CAN-03-3924PMID 15150131
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• [Liver regeneration after hepatectomy].

  2004cited by this paper
• The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity.

  2004cited by this paper
• The retinoid X receptor and its ligands: versatile regulators of metabolic function, cell differentiation and cell death.

  2003cited by this paper
• Essential role of phosphatidylinositol 3-kinase-dependent CCAAT/enhancer binding protein beta activation in the induction of glutathione S-transferase by oltipraz.

  2003cited by this paper
• Identification of beta‐carotene 15,15′‐monooxygenase as a peroxisome proliferator‐activated receptor target gene

  2003cited by this paper
• Activation of CCAAT/enhancer-binding protein beta by 2'-amino-3'-methoxyflavone (PD98059) leads to the induction of glutathione S-transferase A2.

  2003cited by this paper
• Retinoids and their receptors in cancer development and chemoprevention.

  2002cited by this paper
• Oltipraz regenerates cirrhotic liver through CCAAT/enhancer binding protein-mediated stellate cell inactivation.

  2002cited by this paper
• Regulation of peroxisome proliferator-activated receptor-gamma-mediated gene expression. A new mechanism of action for high density lipoprotein.

  2002cited by this paper
• Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.

  2002cited by this paper
• Role of peroxisome proliferator-activated receptor gamma and retinoid X receptor heterodimer in hepatogastroenterological diseases.

  2002influential reference
• Phosphatidylinositol 3-kinase regulates nuclear translocation of NF-E2-related factor 2 through actin rearrangement in response to oxidative stress.

  2002cited by this paper
• Liver regeneration after hepatectomy.

  2001cited by this paper
• Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

  2001cited by this paper
• Prospects for prevention and treatment of cancer with selective PPARgamma modulators (SPARMs).

  2001cited by this paper
• Activation of phosphatidylinositol 3-kinase and Akt by tert-butylhydroquinone is responsible for antioxidant response element-mediated rGSTA2 induction in H4IIE cells.

  2001cited by this paper
• Induction of catalase, alpha, and microsomal glutathione S‐transferase in CYP2E1 overexpressing HepG2 cells and protection against short‐term oxidative stress

  2001cited by this paper
• Peroxisome Proliferator-activated Receptor γ-mediated Transcriptional Up-regulation of the Hepatocyte Growth Factor Gene Promoter via a Novel Composite cis-Acting Element*

  2001cited by this paper
• High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes.

  2001cited by this paper
• Suppression of Rat Thromboxane Synthase Gene Transcription by Peroxisome Proliferator-activated Receptor γ in Macrophages via an Interaction with NRF2*

  2000cited by this paper
• Ligand type-specific Interactions of Peroxisome Proliferator-activated Receptor γ with Transcriptional Coactivators*

  2000cited by this paper
• Retinoids in chemoprevention and differentiation therapy.

  2000cited by this paper
• The essential role of phosphatidylinositol 3-kinase and of p38 mitogen-activated protein kinase activation in the antioxidant response element-mediated rGSTA2 induction by decreased glutathione in H4IIE hepatoma cells.

  2000cited by this paper
• Transcription Factor Nrf2 Coordinately Regulates a Group of Oxidative Stress-inducible Genes in Macrophages*

  2000cited by this paper
• Peroxisome proliferator-activated receptor gamma transcriptional regulation is involved in platelet-derived growth factor-induced proliferation of human hepatic stellate cells.

  2000cited by this paper
• Control of gene expression by growth hormone in liver: key role of a network of transcription factors.

  2000cited by this paper
• Identification and functional characterization of the peroxisomal proliferator response element in rat GLUT2 promoter.

  2000cited by this paper
• Peroxisome proliferator‐activated receptor γ transcriptional regulation is involved in platelet‐derived growth factor–induced proliferation of human hepatic stellate cells

  2000cited by this paper
• Peroxisome proliferator-activated receptors: nuclear control of metabolism.

  1999cited by this paper
• Loss-of-Function Mutations in PPARγ Associated with Human Colon Cancer

  1999cited by this paper
• Loss-of-function mutations in PPAR gamma associated with human colon cancer.

  1999cited by this paper
• Regulatory mechanisms of cellular response to oxidative stress.

  1999cited by this paper
• CCAAT/Enhancer-binding Protein β (C/EBPβ) and C/EBPδ Contribute to Growth Hormone-regulated Transcription of c-fos *

  1999cited by this paper
• Glutathione S-transferases--a review.

  1999cited by this paper
• CCAAT/enhancer-binding protein beta (C/EBPbeta) and C/EBPdelta contribute to growth hormone-regulated transcription of c-fos.

  1999cited by this paper
• Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma.

  1999cited by this paper
• Identification of high-affinity binding sites for the insulin sensitizer rosiglitazone (BRL-49653) in rodent and human adipocytes using a radioiodinated ligand for peroxisomal proliferator-activated receptor gamma.

  1998cited by this paper
• Identification of High-Affinity Binding Sites for the Insulin Sensitizer Rosiglitazone (BRL-49653) in Rodent and Human Adipocytes Using a Radioiodinated Ligand for Peroxisomal Proliferator-Activated Receptor γ

  1998cited by this paper
• A Dominant-Negative Inhibitor of CREB Reveals that It Is a General Mediator of Stimulus-Dependent Transcription of c-fos

  1998cited by this paper
• Retinoid-induced apoptosis in normal and neoplastic tissues

  1998cited by this paper
• High-resolution solution structure of the retinoid X receptor DNA-binding domain.

  1998cited by this paper
• Differentiation and reversal of malignant changes in colon cancer through PPARγ

  1998cited by this paper
• Terminal differentiation of human breast cancer through PPAR gamma.

  1998cited by this paper
• Interaction and functional collaboration of p300 and C/EBPbeta

  1997cited by this paper
• Enhancement of radiation-inducible hepatic glutathione-S-transferases Ya, Yb1, Yb2, Yc1, and Yc2 gene expression by oltipraz: possible role in radioprotection.

  1997cited by this paper
• Functional antioxidant responsive elements.

  1997cited by this paper
• Identification, Characterization, and Tissue Distribution of Human Peroxisome Proliferator-activated Receptor (PPAR) Isoforms PPARγ2 versus PPARγ1 and Activation with Retinoid X Receptor Agonists and Antagonists*

  1997cited by this paper
• An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements.

  1997cited by this paper
• Adipogenesis and obesity: rounding out the big picture.

  1996cited by this paper
• Retinoids in cancer chemoprevention

  1996cited by this paper
• The rat liver glutathione S-transferase Ya subunit gene: characterization of the binding properties of a nuclear protein from HepG2 cells that has high affinity for the antioxidant response element.

  1996cited by this paper
• The organization of the human GSTP1-1 gene promoter and its response to retinoic acid and cellular redox status.

  1996cited by this paper
• Retinoids and apoptosis: implications for cancer chemoprevention and therapy.

  1995cited by this paper
• Endogenous Retinoic Acid Receptor (RAR)-Retinoid X Receptor (RXR) Heterodimers Are the Major Functional Forms Regulating Retinoid-responsive Elements in Adult Human Keratinocytes

  1995cited by this paper
• Peroxisome proliferator-activated receptor (PPAR) gamma: adipose-predominant expression and induction early in adipocyte differentiation.

  1994cited by this paper
• Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors

  1992cited by this paper
• Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors

  1992cited by this paper
• Regulation of rat glutathione S-transferase Ya subunit gene expression. DNA-protein interaction at the antioxidant responsive element.

  1992influential reference
• Expression of specific mRNAs during adipose differentiation: identification of an mRNA encoding a homologue of myelin P2 protein.

  1984influential reference

• Omega-3 PUFAs reduce inflammation by targeting NRF2 and NF-κB activity in an ex vivo model of cardiac mature adipocytes and adipose derived stem cells from atherosclerotic patients.

  2026cites this paper
• Oxidative stress in cancer: from tumor and microenvironment remodeling to therapeutic frontiers

  2025cites this paper
• Deciphering the quantitative relationship between NRF2 and SRXN1 through semi-mechanistic computational modeling.

  2025cites this paper
• Modulation of Lipid Metabolism and Keap1–Nrf2 Pathway Activation in Macrophages by Targeting PPARγ Affects NAFLD Progression

  2025cites this paper
• Involvement of Nrf2-PPAR-γ signaling in Coenzyme Q10 protecting effect against methotrexate-induced testicular oxidative damage.

  2024cites this paper
• Transcription Factor NRF2 in Shaping Myeloid Cell Differentiation and Function.

  2024cites this paper
• Electroacupuncture reduces oxidative stress response and improves secondary injury of intracerebral hemorrhage in rats by activating the peroxisome proliferator-activated receptor-γ/nuclear factor erythroid2-related factor 2/γ-glutamylcysteine synthetase pathway

  2024cites this paper
• Canagliflozin Regulates Ferroptosis, Potentially via Activating AMPK/PGC-1α/Nrf2 Signaling in HFpEF Rats

  2023cites this paper
• Functional and Structural Insights into the Human PPARα/δ/γ Targeting Preferences of Anti-NASH Investigational Drugs, Lanifibranor, Seladelpar, and Elafibranor

  2023cites this paper
• Association between insulin and Nrf2 signalling pathway in Alzheimer's disease: A molecular landscape.

  2023cites this paper
• PPAR-γ signaling in nonalcoholic fatty liver disease: Pathogenesis and therapeutic targets.

  2023cites this paper
• Reno-protective effect of mangiferin against methotrexate-induced kidney damage in male rats: PPARγ-mediated antioxidant activity

  2022cites this paper
• Is the peroxisome proliferator-activated receptor gamma a putative target for epilepsy treatment? Current evidence and future perspectives.

  2022cites this paper
• Pharmacological Treatment for Neuroinflammation in Stress-Related Disorder

  2022cites this paper
• The Antioxidant Transcription Factor Nrf2 in Cardiac Ischemia–Reperfusion Injury

  2021cites this paper
• Sodium arsenite induces spatial learning and memory impairment associated with oxidative stress and activates the Nrf2/PPARγ pathway against oxidative injury in mice hippocampus.

  2021cites this paper
• Expression and distribution of glutathione transferases in protoscoleces of Echinococcus granulosus sensu lato.

  2021cites this paper
• Tackling of Renal Carcinogenesis in Wistar Rats by Silybum marianum Total Extract, Silymarin, and Silibinin via Modulation of Oxidative Stress, Apoptosis, Nrf2, PPARγ, NF-κB, and PI3K/Akt Signaling Pathways

  2021cites this paper
• Peroxisome Proliferator-Activated Receptors (PPARs) and Oxidative Stress in Physiological Conditions and in Cancer

  2021cites this paper
• Mycobacterium tuberculosis Rv3034c regulates mTORC1 and PPAR-γ dependant pexophagy mechanism to control redox levels in macrophages.

  2020cites this paper
• Rosiglitazone Prevents Autophagy by Regulating Nrf2-Antioxidant Response Element in a Rat Model of Lithium-pilocarpine-induced Status Epilepticus.

  2020cites this paper
• Peroxisome Proliferator-Activated Receptors and Caloric Restriction—Common Pathways Affecting Metabolism, Health, and Longevity

  2020cites this paper
• Endothelial Dysfunction in Diabetic Retinopathy

  2020cites this paper
• Role of Peroxisome Proliferated Activated Receptor gamma (PPARγ) in Different Disease States: Recent Updates.

  2020cites this paper
• Silent information regulator 1 ameliorates oxidative stress injury via PGC-1α/PPARγ-Nrf2 pathway after ischemic stroke in rat.

  2020cites this paper
• Protective effects of PAMAM dendrimers against ANIT-induced cholestatic liver injury in mice

  2020cites this paper
• Peroxisome Proliferator-Activated Receptors as Molecular Links between Caloric Restriction and Circadian Rhythm

  2020cites this paper
• The Differentiation of Spinal Cord Motor Neurons is Associated with Changes of the Mitochondrial Phospholipid Cardiolipin.

  2019cites this paper
• LRH1-driven transcription factor circuitry for hepatocyte identity: Super-enhancer cistromic analysis

  2019cites this paper
• Serum 15-d-PGJ2 and PPARγ levels are reduced in manic episode of bipolar disorder while IL-4 levels are not affected

  2019cites this paper
• Effects of PPAR-γ agonist, pioglitazone on brain tissues oxidative damage and learning and memory impairment in juvenile hypothyroid rats

  2019cites this paper
• Anti-inflammatory and anti-oxidant mechanisms of an MMP-8 inhibitor in lipoteichoic acid-stimulated rat primary astrocytes: involvement of NF-κB, Nrf2, and PPAR-γ signaling pathways

  2018cites this paper
• Antioxidant response elements: Discovery, classes, regulation and potential applications

  2018cites this paper
• Scutellarin ameliorates nonalcoholic fatty liver disease through the PPARγ/PGC-1α-Nrf2 pathway

  2018cites this paper
• ROS release by PPARβ/δ-null fibroblasts reduces tumor load through epithelial antioxidant response

  2018cites this paper
• JMJD5 links CRY1 function and proteasomal degradation

  2018cites this paper
• Haemoglobin scavenging in intracranial bleeding: biology and clinical implications

  2018cites this paper
• Roles of Peroxisome Proliferator-Activated Receptor Gamma on Brain and Peripheral Inflammation

  2017cites this paper
• Peroxisome proliferator-activated receptor γ (PPARγ): A master gatekeeper in CNS injury and repair

  2017cites this paper
• The role of nuclear factor-erythroid 2 related factor 2 (Nrf-2) in the protection against lung injury.

  2017cites this paper
• Gr upSM Functioning of the PPAR Gamma and its Effect on Cardiovascular and Metabolic Diseases

  2017influential citation
• The Injury and Therapy of Reactive Oxygen Species in Intracerebral Hemorrhage Looking at Mitochondria

  2016cites this paper
• Protective effects of retinoid x receptors on retina pigment epithelium cells.

  2016cites this paper
• The role of PPARgamma in cardiovascular diseases.

  2016influential citation
• Hormetic and regulatory effects of lipid peroxidation mediators in pancreatic beta cells.

  2016cites this paper
• Structure, function and disease relevance of Omega-class glutathione transferases

  2016cites this paper
• Transcriptome Analysis of K-877 (a Novel Selective PPARα Modulator (SPPARMα))-Regulated Genes in Primary Human Hepatocytes and the Mouse Liver.

  2015cites this paper
• The role of transcription factor Nrf2 in osteoarthritis

  2015cites this paper
• Pleiotropic Role of PPARγ in Intracerebral Hemorrhage: An Intricate System Involving Nrf2, RXR, and NF‐κB

  2015cites this paper
• Rosiglitazone Suppresses In Vitro Seizures in Hippocampal Slice by Inhibiting Presynaptic Glutamate Release in a Model of Temporal Lobe Epilepsy

  2015cites this paper
• The biological roles of glutathione transferase Omega 1

  2015influential citation
• The Role of PPARγ in Stroke

  2014cites this paper
• Metformin induces microRNA-34a to downregulate the Sirt1/Pgc-1α/Nrf2 pathway, leading to increased susceptibility of wild-type p53 cancer cells to oxidative stress and therapeutic agents.

  2014cites this paper
• Dietary feeding of flavokawain A, a Kava chalcone, exhibits a satisfactory safety profile and its association with enhancement of phase II enzymes in mice

  2014cites this paper
• Glutathione transferase omega 1 is required for the lipopolysaccharide-stimulated induction of NADPH oxidase 1 and the production of reactive oxygen species in macrophages.

  2014cites this paper
• Neuroprotective Properties of a Novel Non-Thiazoledinedione Partial PPAR-γ Agonist against MPTP

  2013cites this paper
• Green tea polyphenols prevent Parkinson's disease: in vitro and in vivo studies

  2013cites this paper
• Inhibitory effects of rosiglitazone on paraquat-induced acute lung injury in rats

  2013cites this paper
• E-cadherin inhibits nuclear accumulation of Nrf2: implications for chemoresistance of cancer cells

  2012cites this paper
• The Nitrated Fatty Acid 10-Nitro-oleate Diminishes Severity of LPS-Induced Acute Lung Injury in Mice

  2012cites this paper
• The Key to Unlocking the Chemotherapeutic Potential of PPARγ Ligands: Having the Right Combination

  2012cites this paper
• Pioglitazone attenuates the detrimental effects of advanced glycation end-products in the pancreatic beta cell line HIT-T15.

  2012cites this paper
• Synergistic effect of cyanidin and PPAR agonist against nonalcoholic steatohepatitis-mediated oxidative stress-induced cytotoxicity through MAPK and Nrf2 transduction pathways.

  2012cites this paper
• The retinoid X receptors and their ligands.

  2012cites this paper
• PPARγ and Oxidative Stress: Con(β) Catenating NRF2 and FOXO

  2012cites this paper
• Pharmacological and Toxicological Advances in PPAR-Related Medicines

  2012cites this paper
• Pharmacological manipulation of peroxisome proliferator-activated receptor γ (PPARγ) reveals a role for anti-oxidant protection in a model of Parkinson's disease

  2012influential citation
• Possible involvement of PPAR-gamma receptor and nitric oxide pathway in the anticonvulsant effect of acute pioglitazone on pentylenetetrazole-induced seizures in mice.

  2012cites this paper
• THE ROLE OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS IN AMYOTROPHIC LATERAL SCLEROSIS: POTENTIAL MECHANISMS FOR NEUROPROTECTION

  2011cites this paper
• Nrf2-dependent gene expression is affected by the proatherogenic apoE4 genotype—studies in targeted gene replacement mice

  2011cites this paper
• The novel Nrf2-interacting factor KAP1 regulates susceptibility to oxidative stress by promoting the Nrf2-mediated cytoprotective response.

  2011cites this paper
• The anti-inflammatory prostaglandin 15d-PGJ2 and its nuclear receptor PPARgamma are decreased in schizophrenia.

  2011cites this paper
• ROS acts as a double-edged sword in the pathogenesis of type 2 diabetes mellitus: is Nrf2 a potential target for the treatment?

  2011cites this paper
• Mechanisms of induction of cytosolic and microsomal glutathione transferase (GST) genes by xenobiotics and pro-inflammatory agents

  2011cites this paper
• 15-Deoxy-Δ¹²,¹⁴-prostaglandin J₂, an electrophilic lipid mediator of anti-inflammatory and pro-resolving signaling.

  2011cites this paper
• Is there a role for the nuclear receptor PPARγ in neuropsychiatric diseases?

  2010cites this paper
• Involvement of PPARα and PPARγ in apoptosis and proliferation of human hepatocarcinoma HepG2 cells

  2010cites this paper
• Decreased detoxification genes and genome size make the human body louse an efficient model to study xenobiotic metabolism

  2010cites this paper
• Alzheimer's Disease: Fatty Acids We Eat may be Linked to a Specific Protection via Low-dose Aspirin.

  2010cites this paper
• Wnt/beta-catenin signaling activates and determines hepatic zonal expression of glutathione S-transferases in mouse liver.

  2010cites this paper
• Transactivation of Genes Encoding for Phase II Enzymes and Phase III Transporters by Phytochemical Antioxidants

  2010influential citation
• Nrf2-regulated PPAR{gamma} expression is critical to protection against acute lung injury in mice.

  2010cites this paper
• Expression, purification and identification of LBD domain of human PPARδ in E. coli

  2009cites this paper
• Enhancement of preneoplastic lesion yield by Chios Mastic Gum in a rat liver medium-term carcinogenesis bioassay.

  2009cites this paper
• Structural Alerts, Reactive Metabolites, and Protein Covalent Binding: How Reliable Are These Attributes as Predictors of Drug Toxicity?

  2009cites this paper
• Neuronal PPARγ Deficiency Increases Susceptibility to Brain Damage after Cerebral Ischemia

  2009cites this paper
• Activation of the Liver X Receptor Prevents Lipopolysaccharide-induced Lung Injury*

  2009cites this paper
• Peroxisome Proliferator-Activated Receptor γ Pathway Targeting in Carcinogenesis: Implications for Chemoprevention

  2009cites this paper
• Enhanced effects of PPARgamma ligands and RXR selective retinoids in combination to inhibit migration and invasiveness in cancer cells.

  2009cites this paper
• Chemical genomics of cancer chemopreventive dithiolethiones

  2009cites this paper
• Metadoxine, an ion-pair of pyridoxine and L-2-pyrrolidone-5-carboxylate, blocks adipocyte differentiation in association with inhibition of the PKA-CREB pathway.

  2009cites this paper
• Mechanisms of clofibrate-induced apoptosis in Yoshida AH-130 hepatoma cells.

  2009cites this paper
• Therapeutic potential of dithiolethiones for hepatic diseases.

  2009cites this paper
• Primers used for RT-PCR and RT-qPCR gene expression analysis Gene symbol Forward primer Reverse primer Abcc 2

  2009cites this paper
• Combination Therapy of PPARγ Ligands and Inhibitors of Arachidonic Acid in Lung Cancer

  2009cites this paper
• Mechanisms of anti-inflammatory and neuroprotective actions of PPAR-gamma agonists.

  2008cites this paper
• Toxicophores, reactive metabolites and drug safety: when is it a cause for concern?

  2008cites this paper
• Compound C inhibits clonal expansion of preadipocytes by increasing p21 level irrespectively of AMPK inhibition.

  2008cites this paper
• Synergistic Effects of PPARγ Ligands and Retinoids in Cancer Treatment

  2008cites this paper
• ReviewArticle Therapeutic Potential of PPARγ Activation in Stroke

  2008cites this paper