Animal models of wound repair: Are they cutting it?

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Experimental Dermatology

• Publication date

  2012-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1600-0625.2012.01540.xPMID 22775993
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• First inducible transgene expression in porcine large animal models

  2012cited by this paper
• Skin organ culture as a model to study oxidative stress, inflammation and structural alterations associated with UVB‐induced photodamage

  2011cited by this paper
• Germ-layer and lineage-restricted stem/progenitors regenerate the mouse digit tip

  2011cited by this paper
• Burn injury dampens erythroid cell production through reprioritizing bone marrow hematopoietic response.

  2011cited by this paper
• Granzyme B contributes to extracellular matrix remodeling and skin aging in apolipoprotein E knockout mice.

  2011cited by this paper
• Previous chronic exogenous glucocorticoid administration in vivo does not affect functional characteristics and cellular lifespan of human skin fibroblasts in vitro

  2011cited by this paper
• Myosin II activity is required for functional leading-edge cells and closure of epidermal sheets in fish skin ex vivo

  2011cited by this paper
• Development of a Nongenetic Mouse Model of Type 2 Diabetes

  2011cited by this paper
• Wound Healing in Mice with High-Fat Diet- or ob Gene-Induced Diabetes-Obesity Syndromes: A Comparative Study

  2011cited by this paper
• Acceleration of diabetic‐wound healing with PEGylated rhaFGF in healing‐impaired streptozocin diabetic rats

  2011cited by this paper
• The effect of dextrin-rhEGF on the healing of full-thickness, excisional wounds in the (db/db) diabetic mouse.

  2011cited by this paper
• Estrogen promotes cutaneous wound healing via estrogen receptor β independent of its antiinflammatory activities

  2010cited by this paper
• Differential Roles of Macrophages in Diverse Phases of Skin Repair

  2010cited by this paper
• Scarless fetal wound healing: a basic science review.

  2010cited by this paper
• Surgical Approaches to Create Murine Models of Human Wound Healing

  2010cited by this paper
• Healing and healing rates of chronic wounds in the age of molecular pathogen diagnostics.

  2010cited by this paper
• Ex vivo generation of a functional and regenerative wound epithelium from axolotl (Ambystoma mexicanum) skin

  2010cited by this paper
• 3D-wound healing model: influence of morphine and solid lipid nanoparticles.

  2010cited by this paper
• Development of a Three-Dimensional Human Skin Equivalent Wound Model for Investigating Novel Wound Healing Therapies

  2010cited by this paper
• Vitamin C restores healthy aging in a mouse model for Werner syndrome

  2010cited by this paper
• Limitations of the db/db mouse in translational wound healing research: Is the NONcNZO10 polygenic mouse model superior?

  2010cited by this paper
• Wound repair at a glance

  2009cited by this paper
• Farnesyl Pyrophosphate Inhibits Epithelialization and Wound Healing through the Glucocorticoid Receptor*

  2009cited by this paper
• Differential Evaluation of Excisional Non-occluded Wound Healing in db/db Mice

  2009cited by this paper
• Poly-N-Acetyl Glucosamine Nanofibers: A New Bioactive Material to Enhance Diabetic Wound Healing by Cell Migration and Angiogenesis

  2009cited by this paper
• Human skin wounds: A major and snowballing threat to public health and the economy

  2009cited by this paper
• Staphylococcal biofilms impair wound healing by delaying reepithelialization in a murine cutaneous wound model

  2009cited by this paper
• A novel murine island skin flap for ischemic preconditioning.

  2009cited by this paper
• Angiopoietin-1 gene transfer improves impaired wound healing in genetically diabetic mice without increasing VEGF expression.

  2008cited by this paper
• The diabetic foot: grand overview, epidemiology and pathogenesis

  2008cited by this paper
• A murine living skin equivalent amenable to live-cell imaging: analysis of the roles of connexins in the epidermis.

  2008cited by this paper
• Animal models of wound healing: uility in transgenic mice

  2008cited by this paper
• Selective estrogen receptor modulators accelerate cutaneous wound healing in ovariectomized female mice.

  2008cited by this paper
• The burden of chronic wounds in the UK.

  2008cited by this paper
• Conditional transgenic mouse models: from the basics to genome-wide sets of knockouts and current studies of tissue regeneration.

  2008cited by this paper
• Considerations for selecting the correct animal model for dermal wound-healing studies

  2008cited by this paper
• Proliferation and differentiation biomarkers in normal human breast skin organotypic cultures.

  2007cited by this paper
• db/db mice exhibit severe wound‐healing impairments compared with other murine diabetic strains in a silicone‐splinted excisional wound model

  2007cited by this paper
• Hyperglycemia, maturity-onset obesity, and insulin resistance in NONcNZO10/LtJ males, a new mouse model of type 2 diabetes.

  2007cited by this paper
• Treatment with an estrogen receptor-beta-selective agonist is cardioprotective.

  2007cited by this paper
• Hypertrophic scar model in the rabbit ear: a reproducible model for studying scar tissue behavior with new observations on silicone gel sheeting for scar reduction

  2007cited by this paper
• Phenotypic characterization of polygenic type 2 diabetes in TALLYHO/JngJ mice.

  2006cited by this paper
• Location of injury influences the mechanisms of both regeneration and repair within the MRL/MpJ mouse

  2006cited by this paper
• An In Vivo Mouse Excisional Wound Model of Scarless Healing

  2006cited by this paper
• Models of wound healing.

  2005cited by this paper
• Wound healing ability of Xenopus laevis embryos. I. Rapid wound closure achieved by bisectional half embryos

  2005cited by this paper
• Wound-healing studies in transgenic and knockout mice

  2004cited by this paper
• Development of a Simple, Noninvasive, Clinically Relevant Model of Pressure Ulcers in the Mouse

  2004cited by this paper
• Adenoviral mediated gene transfer of PDGF‐B enhances wound healing in type I and type II diabetic wounds

  2004cited by this paper
• Bacteria and wound healing

  2004cited by this paper
• Diverse and potent activities of HGF/SF in skin wound repair

  2004cited by this paper
• Quantitative and reproducible murine model of excisional wound healing

  2004cited by this paper
• The M16 mouse: an outbred animal model of early onset polygenic obesity and diabesity.

  2004cited by this paper
• Regulation of wound healing by growth factors and cytokines.

  2003cited by this paper
• Effect of hyperthermic preconditioning on the survival of ischemia-reperfused skin flaps: a new skin-flap model in the mouse.

  2002cited by this paper
• Neuroprotective effects of estradiol in middle-aged female rats.

  2001cited by this paper
• Time and Dose-related Ultraviolet B Damage in Viable Pig Skin Explants Held in a Newly Developed Organ Culture System¶

  2001cited by this paper
• Pretreatment with topical all-trans-retinoic acid is beneficial for wound healing in genetically diabetic mice

  2001cited by this paper
• Systemically and topically administered leptin both accelerate wound healing in diabetic ob/ob mice.

  2000cited by this paper
• Role of elevated plasma transforming growth factor-beta1 levels in wound healing.

  1999cited by this paper
• Role of Elevated Plasma Transforming Growth Factor-β1 Levels in Wound Healing

  1999cited by this paper
• The effect of leukocyte infiltration on apoptosis in an in vitro thermal injury bioartificial living skin equivalent model.

  1999cited by this paper
• Topical estrogen accelerates cutaneous wound healing in aged humans associated with an altered inflammatory response.

  1999cited by this paper
• Differences in cellular infiltrate and extracellular matrix of chronic diabetic and venous ulcers versus acute wounds.

  1998cited by this paper
• Animal models for wound repair

  1998cited by this paper
• The effects of ageing on wound healing: immunolocalisation of growth factors and their receptors in a murine incisional model

  1997cited by this paper
• A large deformation biomechanical model for pressure ulcers.

  1997cited by this paper
• Novel predictive assay for contact allergens using human skin explant cultures.

  1996cited by this paper
• A zebrafish retinoic acid receptor expressed in the regenerating caudal fin.

  1994cited by this paper
• 17 beta estradiol stimulation of endosteal bone formation in the ovariectomized mouse: an animal model for the evaluation of bone-targeted estrogens.

  1992cited by this paper
• Foetal wound healing in a large animal model: the deposition of collagen is confirmed.

  1990cited by this paper
• PDGF and FGF stimulate wound healing in the genetically diabetic mouse.

  1990cited by this paper
• Recombinant basic fibroblast growth factor stimulates wound healing in healing-impaired db/db mice

  1990cited by this paper
• Comparison of the effects of moist and dry conditions on dermal repair.

  1988cited by this paper
• The reconstitution of living skin.

  1983cited by this paper
• Intrauterine wound healing in a 20 week human fetus

  1979cited by this paper
• Alteration of Islet Cell Populations in Spontaneously Diabetic Mice

  1978cited by this paper
• Nerves and angiogenesis in amphibian limb regeneration

  1975cited by this paper
• INFLUENCE OF THE MUTATION "DIABETES" ON INSULIN RELEASE AND ISLET MORPHOLOGY IN MICE OF DIFFERENT GENETIC BACKGROUNDS

  1974cited by this paper
• The Principles of Humane Experimental Technique

  1960cited by this paper

• Characterization of Cutaneous Wound Healing in Swine

  2026cites this paper
• Multicomponent nanofibrous electrospun dressings, evaluated for the healing of full-thickness excision wounds in a porcine model

  2025cites this paper
• A high-resolution temporal transcriptomic and imaging dataset of porcine wound healing

  2025cites this paper
• Development of translational murine soft tissue defect model for wound healing research

  2025cites this paper
• Innovative Strategies: Use of Stromal Cell-Derived Secretome for Chronic Wound Therapy

  2025cites this paper
• Assessing New Collagen Therapies for Wound Healing: A Murine Model Approach

  2025cites this paper
• Quantitative ultrasound augmented with machine learning to assess tissue microstructure during wound healing

  2025cites this paper
• The role of Latin America medicinal plants in wound healing

  2025cites this paper
• The Role of Fibroblasts in Skin Homeostasis and Repair

  2024cites this paper
• Replicating Dynamic Immune Responses at Single‐Cell Resolution within a Microfluidic Human Skin Equivalent

  2024cites this paper
• Skin wound healing effects of (+)-syringaresinol from ginseng berry

  2023cites this paper
• Comparison of digital and traditional skin wound closure assessment methods in mice

  2023cites this paper
• Electrostatically assembled wound dressings deliver pro-angiogenic anti-miRs preferentially to endothelial cells.

  2023cites this paper
• Recent advances of cellular stimulation with triboelectric nanogenerators

  2023cites this paper
• Estradiol-17β [E2] stimulates wound healing in a 3D in vitro tissue-engineered vaginal wound model

  2023cites this paper
• Risk factors for the development and evolution of deep tissue injuries: A systematic review.

  2022cites this paper
• Altered regulation of mesenchymal cell senescence in adipose tissue promotes pathological changes associated with diabetic wound healing

  2022cites this paper
• Wound dressing adherence: a review.

  2022cites this paper
• Effects and Progress of Photo-Crosslinking Hydrogels in Wound Healing Improvement

  2022cites this paper
• Challenges faced in developing an ideal chronic wound model

  2022cites this paper
• Denervation Affected Skin Wound Healing in a Modified Rat Model

  2022cites this paper
• Effect of exogenous lipase on subcutaneous adipose tissue in a porcine animal model

  2022cites this paper
• Skin wound healing assessment via an optimized wound array model in miniature pigs

  2022cites this paper
• Wound Healing Modulation through the Local Application of Powder Collagen-Derived Treatments in an Excisional Cutaneous Murine Model

  2022cites this paper
• Altered regulation of mesenchymal cell senescence promotes pathological changes associated with diabetic wound healing

  2021cites this paper
• A Pilot Study To Establish an Ovalbumin-induced Atopic Dermatitis Minipig Model

  2021cites this paper
• Antimicrobial Peptides: The Promising Therapeutics for Cutaneous Wound Healing.

  2021cites this paper
• Tissue Oxygen Profiling Using Electron Paramagnetic Resonance Oximetry to Improve Wound Healing After Radiation

  2021cites this paper
• Visible light-curable water-soluble chitosan derivative, chitosan hydrogel, and preparation method: a patent evaluation of US2019202998A1

  2021cites this paper
• Accelerated Wound Healing Using a Novel Far-Infrared Ceramic Blanket

  2021cites this paper
• Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair.

  2021cites this paper
• Dermal Drivers of Injury-Induced Inflammation: Contribution of Adipocytes and Fibroblasts

  2021cites this paper
• Toward Developing Immunocompetent Diabetic Foot Ulcer-on-a-Chip Models for Drug Testing

  2021cites this paper
• Deep tissue injury: a narrative review on the aetiology of a controversial wound.

  2021cites this paper
• Skin-brain axis signaling mediates behavioral changes after skin wounding

  2021cites this paper
• Spatiotemporal distribution and speciation of silver nanoparticles in the healing wound.

  2020cites this paper
• Advancements in the Delivery of Growth Factors and Cytokines for the Treatment of Cutaneous Wound Indications

  2020cites this paper
• Calotropis - A multi-potential plant to humankind: Special focus on its wound healing efficacy

  2020cites this paper
• Advances in Healthcare Electronics Enabled by Triboelectric Nanogenerators

  2020cites this paper
• Nrf2-activating Therapy Accelerates Wound Healing in a Model of Cutaneous Chronic Venous Insufficiency

  2020cites this paper
• Cellular benefits of single‐use negative pressure wound therapy demonstrated in a novel ex vivo human skin wound model

  2020cites this paper
• Transcriptomic Analysis of a Diabetic Skin-Humanized Mouse Model Dissects Molecular Pathways Underlying the Delayed Wound Healing Response

  2020cites this paper
• Understanding Transcriptional Networks Regulating Initiation of Cutaneous Wound Healing

  2020cites this paper
• Role of oxidants and antioxidants in diabetic wound healing

  2020cites this paper
• An mRNA sequencing analysis of the healing-promoting role of electroacupuncture a in rat skin wound model.

  2020cites this paper
• Microphysiological systems for the modeling of wound healing and evaluation of pro-healing therapies.

  2020cites this paper
• Nanotechnology-Based Medical Devices for the Treatment of Chronic Skin Lesions: From Research to the Clinic

  2020cites this paper
• Wound healing: cellular mechanisms and pathological outcomes

  2020cites this paper
• Current status and future outlook of nano-based systems for burn wound management.

  2019cites this paper
• Naringenin potentiated β-sitosterol healing effect on the scratch wound assay

  2019cites this paper
• Proinflammatory Cytokines and Skin Wound Healing in Mice

  2019cites this paper
• [Proinflammatory Cytokines and Skin Wound Healing in Mice].

  2019cites this paper
• Ozonated Oils and Cutaneous Wound Healing.

  2019cites this paper
• The Horse as a Model for the Study of Cutaneous Wound Healing

  2019cites this paper
• Nutraceuticals for Wound Healing: A Special Focus on Chromolaena odorata as Guardian of Health with Broad Spectrum of Biological Activities

  2019cites this paper
• Elevated Local Senescence in Diabetic Wound Healing Is Linked to Pathological Repair via CXCR2.

  2019cites this paper
• Ex vivo culture of keratinocytes on papillary and reticular dermal layers remodels skin explants differently: towards improved wound care

  2019cites this paper
• Biobehavioral Mechanisms Associated With Nonhealing Wounds and Psychoneurologic Symptoms (Pain, Cognitive Dysfunction, Fatigue, Depression, and Anxiety) in Older Individuals With Chronic Venous Leg Ulcers

  2019cites this paper
• Multimodal, in-situ imaging of ex-vivo human skin reveals decrease of cholesterol sulfate in the neoepithelium during acute wound healing.

  2019cites this paper
• Healing of Chronic Wounds: An Update of Recent Developments and Future Possibilities

  2019cites this paper
• A harlequin ichthyosis pig model with a novel ABCA12 mutation can be rescued by acitretin treatment

  2019cites this paper
• EFFECT OF LEVETIRACETAM ON HEALING OF EXCISION AND BURN WOUND MODELS IN WISTAR RATS

  2019cites this paper
• Modelling skin wound healing angiogenesis: A review.

  2018cites this paper
• Effects of Carvacrol, Thymol and essential oils containing such monoterpenes on wound healing: a systematic review

  2018cites this paper
• Antimicrobial endotoxin‐neutralizing peptides promote keratinocyte migration via P2X7 receptor activation and accelerate wound healing in vivo

  2018cites this paper
• Effectiveness of a monofilament wound debridement pad at removing biofilm and slough: ex vivo and clinical performance.

  2018cites this paper
• The earthworm Dendrobaena veneta (Annelida): A new experimental-organism for photobiomodulation and wound healing

  2018cites this paper
• Neuropeptides, Inflammation, and Diabetic Wound Healing: Lessons from Experimental Models and Human Subjects

  2018cites this paper
• Evaluation of in vivo wound healing and anti-inflammatory activity of crude extract of the fruits of Brucea antidysentrica in mice

  2018cites this paper
• Antimicrobial Peptides and Their Therapeutic Potential for Bacterial Skin Infections and Wounds

  2018cites this paper
• Investigations on the activity of synthetic anti-lipopolysaccharide peptidesagainst cytoplasmic lipopolysaccharide-induced responses and their anti-inflammatory and wound healing-promoting effect in the skin

  2018cites this paper
• Collagen Fibers in the Healing Process of Rat Achilles Tendon Rupture Using Different Times of Ultrasound Therapy

  2018cites this paper
• Microscopy Based Methods for the Assessment of Epithelial Cell Migration During In Vitro Wound Healing.

  2018cites this paper
• Review: Multimodal bioactive material approaches for wound healing

  2018cites this paper
• A mathematical model for the determination of mouse excisional wound healing parameters from photographic data

  2018cites this paper
• Nanopharmaceuticals for wound healing – Lost in translation?

  2018cites this paper
• A histologically hostile environment made more hospitable?

  2018cites this paper
• The potential of human induced pluripotent stem cells for modelling diabetic wound healing in vitro.

  2018cites this paper
• Regenerative medicine and war: a front-line focus for UK defence

  2018cites this paper
• Effects of incorporation of granule-lyophilised platelet-rich fibrin into polyvinyl alcohol hydrogel on wound healing

  2018cites this paper
• Effective Wound Healing Enabled by Discrete Alternative Electric Fields from Wearable Nanogenerators

  2018cites this paper
• EGF‐Loaded Hyaluronic Acid Based Microparticles as Effective Carriers in a Wound Model

  2017cites this paper
• Effect of high- and low- frequency transcutaneous electrical nerve stimulation (TENS) on angiogenesis and wound contraction in acute excisional wounds in rat skin

  2017cites this paper
• The efficacy of probiotics as pharmacological treatment of cutaneous wounds: Meta‐analysis of animal studies

  2017cites this paper
• Strategies for Optimizing the Soft Tissue Seal around Osseointegrated Implants

  2017cites this paper
• Laser-Generated Shockwaves as a Treatment to Reduce Bacterial Load and Disrupt Biofilm

  2017cites this paper
• The effect of color type on early wound healing in farmed mink (Neovison vison)

  2017cites this paper
• Burn wound healing: present concepts, treatment strategies and future directions.

  2017cites this paper
• Evaluating STZ-Induced Impaired Wound Healing in Rats.

  2017cites this paper
• Applications of bioresorbable polymers in skin and eardrum

  2017cites this paper
• Electrospun curcumin gelatin blended nanofibrous mats accelerate wound healing by Dkk-1 mediated fibroblast mobilization and MCP-1 mediated anti-inflammation

  2017cites this paper
• In vivo assessment of wound re-epithelialization by UV fluorescence excitation imaging

  2017cites this paper
• Working title: Evaluating STZ-induced impaired wound healing in rats

  2017cites this paper
• Model membrane systems, membrane-active peptides and application possibilities

  2017cites this paper
• Preparation and evaluation of visible-light cured glycol chitosan hydrogel dressing containing dual growth factors for accelerated wound healing

  2017cites this paper
• Comparative Degradomics of Porcine and Human Wound Exudates Unravels Biomarker Candidates for Assessment of Wound Healing Progression in Trauma Patients.

  2017cites this paper
• Wound healing : a multidisciplinary approach : combining mathematical models and biological experiments

  2016cites this paper
• Examination of endothelial cell‐induced epidermal regeneration in a mice‐based chimney wound model

  2016cites this paper
• Full-thickness wound healing using 3D bioprinted gelatin-alginate scaffolds in mice: A histopathological study

  2016cites this paper
• The refined biomimetic NeuroDigm GEL™ model of neuropathic pain in a mature rat

  2016cites this paper