H+ pump-dependent changes in membrane voltage are an early mechanism necessary and sufficient to induce Xenopus tail regeneration

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Development

• Publication date

  2007-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/dev.02812PMID 17329365
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Apoptosis is required during early stages of tail regeneration in Xenopus laevis.

  2007influential reference
• Evidence for the regulation of left‐right asymmetry in Ciona intestinalis by ion flux

  2006cited by this paper
• Strategies and Techniques for Investigation of Biophysical Signals in Patterning

  2006influential reference
• Of Minds and Embryos: Left-Right Asymmetry and the Serotonergic Controls of Pre-Neural Morphogenesis

  2006cited by this paper
• Mathematical model of morphogen electrophoresis through gap junctions

  2006cited by this paper
• Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN.

  2006cited by this paper
• Early, H+-V-ATPase-dependent proton flux is necessary for consistent left-right patterning of non-mammalian vertebrates

  2006influential reference
• Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-γ and PTEN

  2006cited by this paper
• Analysis of growth factor signaling in embryos

  2006cited by this paper
• Effect of several uncouplers of cell-to-cell communication on gap junction morphology in mammalian heart

  2006cited by this paper
• Inverse drug screens: a rapid and inexpensive method for implicating molecular targets

  2006influential reference
• Ion flow regulates left–right asymmetry in sea urchin development

  2006cited by this paper
• Ouabain-induced endocytosis and signal transduction of the Na/K-ATPase.

  2005cited by this paper
• Left-right asymmetry in the sea urchin embryo is regulated by nodal signaling on the right side.

  2005influential reference
• Phosphoinositide phosphatase activity coupled to an intrinsic voltage sensor

  2005cited by this paper
• Human ether-a-go-go-related gene 1 channels are physically linked to beta1 integrins and modulate adhesion-dependent signaling.

  2005cited by this paper
• Controlling cell behavior electrically: current views and future potential.

  2005cited by this paper
• Ion Channels and Cancer

  2005cited by this paper
• Oscillating field stimulation for complete spinal cord injury in humans: a phase 1 trial.

  2005cited by this paper
• Shal and Shaker Differential Contribution to the K+ Currents in the Drosophila Mushroom Body Neurons

  2005cited by this paper
• Macroarray‐based analysis of tail regeneration in Xenopus laevis larvae

  2005cited by this paper
• Benzamil, a blocker of epithelial Na(+) channel-induced upregulation of artery oxygen pressure level in acute lung injury rabbit ventilated with high frequency oscillation.

  2005cited by this paper
• A novel immunohistochemical method for evaluation of antibody specificity and detection of labile targets in biological tissue.

  2004influential reference
• Involvement of V-ATPase in the regulation of cell size in the fly's visual system.

  2004cited by this paper
• Forelimb spike regeneration in Xenopus laevis: Testing for adaptiveness.

  2004cited by this paper
• Cell lineage tracing during Xenopus tail regeneration

  2004cited by this paper
• Treatment of the damaged rat hippocampus with a locally applied electric field

  2004cited by this paper
• Cellular and molecular mechanisms of regeneration in Xenopus.

  2004influential reference
• Differential gene expression between the embryonic tail bud and regenerating larval tail in Xenopus laevis

  2004cited by this paper
• Tagging muscle cell lineages in development and tail regeneration using Cre recombinase in transgenic Xenopus.

  2003cited by this paper
• Potassium Channel Blockers Tetraethylammonium and 4-Aminopyridine Fail to Prevent Microglial Activation Induced by Elevated Potassium Concentration

  2003cited by this paper
• Gadolinium, a mechano-sensitive channel blocker, inhibits osmosis-initiated motility of sea- and freshwater fish sperm, but does not affect human or ascidian sperm motility.

  2003cited by this paper
• Effects of palytoxin on cation occlusion and phosphorylation of the (Na+,K+)-ATPase

  2003cited by this paper
• From a pump to a pore: How palytoxin opens the gates

  2003cited by this paper
• Molecular pathways needed for regeneration of spinal cord and muscle in a vertebrate.

  2003influential reference
• Identification of genes induced in regenerating Xenopus tadpole tails by using the differential display method

  2003cited by this paper
• Bioelectromagnetics in morphogenesis

  2003cited by this paper
• Left/right, up/down: The role of endogenous electrical fields as directional signals in development, repair and invasion

  2003cited by this paper
• The freshwater planarian Schmidtea mediterranea: embryogenesis, stem cells and regeneration.

  2003cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
• The molecular basis of amphibian limb regeneration: integrating the old with the new.

  2002cited by this paper
• Calcium channel blockers inhibit galvanotaxis in human keratinocytes

  2002cited by this paper
• Concanamycin A, the Specific Inhibitor of V-ATPases, Binds to the Vo Subunit c*

  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
• Has electrical growth cone guidance found its potential?

  2002cited by this paper
• Spatial and temporal patterns of cell division during early Xenopus embryogenesis.

  2001cited by this paper
• Restriction of proliferation of primordial germ cells by the irradiation of Japanese quail embryos with soft X-rays.

  2001cited by this paper
• Nerve-independence of limb regeneration in larval Xenopus laevis is correlated to the level of fgf-2 mRNA expression in limb tissues.

  2001cited by this paper
• Cyclic AMP-dependent protein kinase A plays a role in the directed migration of human keratinocytes in a DC electric field.

  2001cited by this paper
• Stimulation of gap junctional intercellular communication by thalidomide and thalidomide analogs in human fetal skin fibroblasts (HFFF2) and in rat liver epithelial cells (WB-F344).

  2001cited by this paper
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  2001cited by this paper
• Regeneration in vertebrates.

  2000cited by this paper
• Early development of Xenopus laevis : a laboratory manual

  2000influential reference
• An NH2-terminal deleted plasma membrane H+-ATPase is a dominant negative mutant and is sequestered in endoplasmic reticulum derived structures.

  2000cited by this paper
• Molecular cloning of the Notophthalmus viridescens radical fringe cDNA and characterization of its expression during forelimb development and adult forelimb regeneration

  1999cited by this paper
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  1999cited by this paper
• Pharmacological plasticity of cardiac ATP-sensitive potassium channels toward diazoxide revealed by ADP.

  1999cited by this paper
• Potent inhibition of the CFTR chloride channel by suramin

  1999cited by this paper
• Amiloride and the Na(+)/H(+) exchanger protein: mechanism and significance of inhibition of the Na(+)/H(+) exchanger (review).

  1999cited by this paper
• Animal plasma membrane energization by proton‐motive V‐ATPases

  1999cited by this paper
• Gap junctions are involved in the early generation of left-right asymmetry.

  1998cited by this paper
• Evidence for an early G1 ionic event necessary for cell cycle progression and survival in the MCF‐7 human breast carcinoma cell line

  1998cited by this paper
• ATP-sensitive and inwardly rectifying potassium channels in smooth muscle.

  1997cited by this paper
• Loperamide: a positive modulator for store-operated calcium channels?

  1997cited by this paper
• Interactions of Palytoxin with the Na, K‐ATPase Where Are Those Sites?

  1997cited by this paper
• Mutations of pma-1, the Gene Encoding the Plasma Membrane H+-ATPase of Neurospora crassa, Suppress Inhibition of Growth by Concanamycin A, a Specific Inhibitor of Vacuolar ATPases*

  1997cited by this paper
• Characterization of Na+/H+ exchange activity in cultured rat hippocampal astrocytes

  1996cited by this paper
• Concanamycin B, a vacuolar H(+)-ATPase specific inhibitor suppresses bone resorption in vitro.

  1996cited by this paper
• Tetrahydroberberine suppresses dopamine-induced potassium current in acutely dissociated CA1 pyramidal neurons from rat hippocampus.

  1996cited by this paper
• Reduction of the current of injury leaving the amputation inhibits limb regeneration in the red spotted newt.

  1996cited by this paper
• Electric fields at the plasma membrane level: a neglected element in the mechanisms of cell signalling.

  1996cited by this paper
• An indelible lineage marker for Xenopus using a mutated green fluorescent protein.

  1996influential reference
• Association of BCL‐2 with membrane hyperpolarization and radioresistance

  1996cited by this paper
• Quinidine preferentially blocks the slow delayed rectifier potassium channel in the rested state.

  1996cited by this paper
• Three‐dimensional gradients of voltage during development of the nervous system as invisible coordinates for the establishment of embryonic pattern

  1995cited by this paper
• Normal table of Xenopus laevis (Daudin)

  1995cited by this paper
• Inhibition of ATP‐sensitive potassium channels causes reversible cell‐cycle arrest of human breast cancer cells in tissue culture

  1995cited by this paper
• Normal table of Xenopus laevis.

  1994cited by this paper
• Dual effect of suramin on calcium fluxes across sarcoplasmic reticulum vesicle membranes.

  1994cited by this paper
• Regeneration of rat sciatic nerves in silicone tubes: characterization of the response to low intensity d.c. stimulation.

  1994cited by this paper
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  1994cited by this paper
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  1993cited by this paper
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• Mechanism of heptanol-induced uncoupling of cardiac gap junctions: a perforated patch-clamp study.

  1992cited by this paper
• Electrical field effects on crushed nerve regeneration.

  1992cited by this paper
• Potassium channels and regulation of proliferation of human melanoma cells.

  1992cited by this paper
• Neural crest cell galvanotaxis: new data and a novel approach to the analysis of both galvanotaxis and chemotaxis.

  1991cited by this paper
• In situ hybridization: an improved whole-mount method for Xenopus embryos.

  1991cited by this paper
• Xenopus laevis : practical uses in cell and molecular biology

  1991cited by this paper
• Functional recovery after spinal cord hemisection in guinea pigs: The effects of applied electric fields

  1990cited by this paper
• Ion channel blockers inhibit B cell activation at a precise stage of the G1 phase of the cell cycle. Possible involvement of K+ channels.

  1990cited by this paper
• Electric fields in vertebrate repair

  1989cited by this paper
• Voltage gradients and ionic currents in injured and regenerating axons.

  1988cited by this paper
• Voltage gradients and ionic currents in injured and regenerating axons.

  1988cited by this paper
• Selective block of calcium current by lanthanum in single bullfrog atrial cells

  1988cited by this paper
• Mammalian optic nerve regeneration following the application of electric fields.

  1988cited by this paper

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• Aging as a loss of morphostatic information: a developmental bioelectricity perspective.

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• Wireless control of nerve growth using bipolar electrodes: a new paradigm in electrostimulation.

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• Hallmarks of regeneration.

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• Embryos assist morphogenesis of others through calcium and ATP signaling mechanisms in collective teratogen resistance

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• Darwin’s agential materials: evolutionary implications of multiscale competency in developmental biology

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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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