A-Subclass ATP-Binding Cassette Proteins in Brain Lipid Homeostasis and Neurodegeneration

The A-subclass of ATP-binding cassette (ABC) transporters comprises 12 structurally related members of the evolutionarily highly conserved superfamily of ABC transporters. ABCA transporters represent a subgroup of “full-size” multispan transporters of which several members have been shown to mediate the transport of a variety of physiologic lipid compounds across membrane barriers. The importance of ABCA transporters in human disease is documented by the observations that so far four members of this protein family (ABCA1, ABCA3, ABCA4, ABCA12) have been causatively linked to monogenetic disorders including familial high-density lipoprotein deficiency, neonatal surfactant deficiency, degenerative retinopathies, and congenital keratinization disorders. Recent research also point to a significant contribution of several A-subfamily ABC transporters to neurodegenerative diseases, in particular Alzheimer’s disease (AD). This review will give a summary of our current knowledge of the A-subclass of ABC transporters with a special focus on brain lipid homeostasis and their involvement in AD.

• Publication year

  2012

• Venue

  Frontiers in Psychiatry

• Publication date

  2012-01-17

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3389/fpsyt.2012.00017PMID 22403555PMCID 3293240
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• ATP hydrolysis-dependent conformational changes in the extracellular domain of ABCA1 are associated with apoA-I binding[S]

  2012cited by this paper
• Role of the evolutionarily conserved starvation response in anorexia nervosa

  2011cited by this paper
• Helical apolipoproteins of high-density lipoprotein enhance phagocytosis by stabilizing ATP-binding cassette transporter A7

  2011influential reference
• The roles of ABCA12 in keratinocyte differentiation and lipid barrier formation in the epidermis

  2011cited by this paper
• Roles of ATP-binding cassette transporter A7 in cholesterol homeostasis and host defense system.

  2011influential reference
• Function and regulation of ABCA1 – membrane meso‐domain organization and reorganization

  2011cited by this paper
• Pharmacological differentiation of opioid receptor antagonists by molecular and functional imaging of target occupancy and food reward-related brain activation in humans

  2011cited by this paper
• A TNF-Regulated Recombinatorial Macrophage Immune Receptor Implicated in Granuloma Formation in Tuberculosis

  2011cited by this paper
• The role of the ATP-binding cassette transporter P-glycoprotein in the transport of β-amyloid across the blood-brain barrier.

  2011cited by this paper
• The ATP-binding cassette transporter-2 (ABCA2) regulates cholesterol homeostasis and low-density lipoprotein receptor metabolism in N2a neuroblastoma cells.

  2011cited by this paper
• Genetic alterations in oral squamous cell carcinoma progression detected by combining array-based comparative genomic hybridization and multiplex ligation-dependent probe amplification.

  2011cited by this paper
• ATP-Binding Cassette Transporters and Their Roles in Protecting the Brain

  2011cited by this paper
• Genetic alterations in oral squamous cell carcinoma progression detected by combining array-based comparative genomic hybridization and multiplex ligation-dependent probe amplification

  2011cited by this paper
• HMG-CoA reductase inhibitors enhance phagocytosis by upregulating ATP-binding cassette transporter A7.

  2011influential reference
• Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels.

  2011cited by this paper
• Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice.

  2011cited by this paper
• Common variants in ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer’s disease

  2011cited by this paper
• Serum levels of thiobarbituric acid-reactive substances are associated with risk of coronary heart disease.

  2011cited by this paper
• Lipid metabolism and glial lipoproteins in the central nervous system.

  2011influential reference
• Individual metabolic capacity evaluation of cytochrome P450 2C19 by protein and activity in the small intestinal mucosa of Japanese pancreatoduodenectomy patients.

  2011cited by this paper
• Down-regulation of the ATP-binding Cassette Transporter 2 (Abca2) Reduces Amyloid-β Production by Altering Nicastrin Maturation and Intracellular Localization*

  2011influential reference
• Wild Type and Tangier Disease ABCA1 Mutants Modulate Cellular Amyloid-β Production Independent of Cholesterol Efflux Activity

  2011cited by this paper
• Cholesterol Efflux Potential and Antiinflammatory Properties of High-Density Lipoprotein After Treatment With Niacin or Anacetrapib

  2010cited by this paper
• Influence of Apolipoprotein (Apo) A-I Structure on Nascent High Density Lipoprotein (HDL) Particle Size Distribution*

  2010cited by this paper
• Blocking of ERK1 and ERK2 sensitizes human mesothelioma cells to doxorubicin

  2010cited by this paper
• Adenosine-triphosphate-binding cassette transporter-1 trafficking and function.

  2010cited by this paper
• Decreased Clearance of CNS β-Amyloid in Alzheimer’s Disease

  2010cited by this paper
• Helical apolipoproteins of high-density lipoprotein enhance phagocytosis by stabilizing ATP-binding cassette transporter A7[S]

  2010cited by this paper
• Restoring Blood-Brain Barrier P-Glycoprotein Reduces Brain Amyloid-β in a Mouse Model of Alzheimer's Disease

  2010cited by this paper
• Role of HDL, ABCA1, and ABCG1 transporters in cholesterol efflux and immune responses.

  2010cited by this paper
• The role of ATP-binding cassette transporter A1 in Alzheimer's disease and neurodegeneration.

  2010influential reference
• The ATP-binding cassette transporter-2 (ABCA2) increases endogenous amyloid precursor protein expression and Aβ fragment generation.

  2010cited by this paper
• Eight genes are highly associated with BMD variation in postmenopausal Caucasian women.

  2010cited by this paper
• Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer's Disease

  2010cited by this paper
• Macrophage ABCA5 deficiency influences cellular cholesterol efflux and increases susceptibility to atherosclerosis in female LDLr knockout mice.

  2010cited by this paper
• No association of DAPK1 and ABCA2 SNPs on chromosome 9 with Alzheimer's disease.

  2009cited by this paper
• A cytogenetic abnormality and rare coding variants identify ABCA13 as a candidate gene in schizophrenia, bipolar disorder, and depression.

  2009cited by this paper
• ABCG2 Is Upregulated in Alzheimer's Brain with Cerebral Amyloid Angiopathy and May Act as a Gatekeeper at the Blood–Brain Barrier for Aβ1–40 Peptides

  2009cited by this paper
• Comparative gene expression profiles of ABC transporters in brain microvessel endothelial cells and brain in five species including human.

  2009cited by this paper
• A survey of ABCA1 sequence variation confirms association with dementia

  2009cited by this paper
• Microglial clearance function in health and disease.

  2009cited by this paper
• Isolation and Identification of Cancer Stem-Like Cells in Esophageal Carcinoma Cell Lines

  2009cited by this paper
• Why lipids are important for Alzheimer disease?

  2009influential reference
• Hepatic cell-specific ATP-binding cassette (ABC) transporter profiling identifies putative novel candidates for lipid homeostasis in mice.

  2008cited by this paper
• ABCA2 as a therapeutic target in cancer and nervous system disorders

  2008cited by this paper
• The ins and outs of ABCA11 See referenced article., J. Lipid Res. 2008, 49: 1322–1332.

  2008cited by this paper
• ATP‐binding cassette transporter A7 regulates processing of amyloid precursor protein in vitro

  2008influential reference
• Heterozygous ABCA3 mutation associated with non-fatal evolution of respiratory distress

  2008cited by this paper
• Novel compound heterozygous nonsense and missense ABCA12 mutations lead to nonbullous congenital ichthyosiform erythroderma

  2008cited by this paper
• Effect of tacrolimus on activity and expression of P-glycoprotein and ATP-binding cassette transporter A5 (ABCA5) proteins in hematoencephalic barrier cells.

  2008cited by this paper
• Role of ATP‐binding cassette transporters in brain lipid transport and neurological disease

  2008influential reference
• Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease.

  2008influential reference
• The human ABC transporter pseudogene family: Evidence for transcription and gene-pseudogene interference

  2008influential reference
• Haplotype analysis of ABCA3: association with respiratory distress in very premature infants

  2008cited by this paper
• ABCA3 deficiency presenting as persistent pulmonary hypertension of the newborn.

  2007cited by this paper
• Mapping ATP-binding cassette transporter gene expression profiles in melanocytes and melanoma cells

  2007cited by this paper
• The ABCA5 Protein: A Urine Diagnostic Marker for Prostatic Intraepithelial Neoplasia

  2007cited by this paper
• Association of genetic variants of ABCA1 with Alzheimer's disease risk

  2007cited by this paper
• Localization of ABCA12 from Golgi apparatus to lamellar granules in human upper epidermal keratinocytes

  2007influential reference
• ATP Binding Cassette Transporters

  2007cited by this paper
• ABCA3 inactivation in mice causes respiratory failure, loss of pulmonary surfactant, and depletion of lung phosphatidylglycerols⃞ Published, JLR Papers in Press, December 1, 2006.

  2007cited by this paper
• ATP-binding cassette transporter ABCA4: Molecular properties and role in vision and macular degeneration

  2007influential reference
• ABCA2 Deficiency Results in Abnormal Sphingolipid Metabolism in Mouse Brain*

  2007influential reference
• The ABCA subfamily—gene and protein structures, functions and associated hereditary diseases

  2007cited by this paper
• ABC A-subclass proteins: gatekeepers of cellular phospho- and sphingolipid transport.

  2007cited by this paper
• Targeted inactivation of the murine Abca3 gene leads to respiratory failure in newborns with defective lamellar bodies.

  2007cited by this paper
• Correlation of induction of ATP binding cassette transporter A5 (ABCA5) and ABCB1 mRNAs with differentiation state of human colon tumor.

  2007cited by this paper
• Physiologically regulated transgenic ABCA1 does not reduce amyloid burden or amyloid-beta peptide levels in vivo.

  2007cited by this paper
• Clinical significance of ABCA2' a possible molecular marker for oligodendrogliomas.

  2007cited by this paper
• Role of gangliosides in Alzheimer's disease.

  2007cited by this paper
• Gender-specific association of ATP-binding cassette transporter 1 (ABCA1) polymorphisms with the risk of late-onset Alzheimer's disease.

  2007cited by this paper
• ABCA3 as a Lipid Transporter in Pulmonary Surfactant Biogenesis*

  2007cited by this paper
• ABCA1-Induced Cell Surface Binding Sites for ApoA-I

  2007cited by this paper
• MDR1‐P‐Glycoprotein (ABCB1) Mediates Transport of Alzheimer’s Amyloid‐β Peptides—Implications for the Mechanisms of Aβ Clearance at the Blood–Brain Barrier

  2007cited by this paper
• Structural and Functional Basis for (S)-Allantoin Formation in the Ureide Pathway*

  2007cited by this paper
• Retinoic acid in the development, regeneration and maintenance of the nervous system

  2007cited by this paper
• Expression of ABCA3 in Developing Lung and Other Tissues

  2007cited by this paper
• Expression of ABCA2 protein in both non-myelin-forming and myelin-forming Schwann cells in the rodent peripheral nerve.

  2007cited by this paper
• ABCA1 polymorphisms and Alzheimer's disease.

  2007cited by this paper
• Role of ABCG1 and ABCA1 in Regulation of Neuronal Cholesterol Efflux to Apolipoprotein E Discs and Suppression of Amyloid-β Peptide Generation*

  2007cited by this paper
• ABCA3 Is Critical for Lamellar Body Biogenesis in Vivo*

  2007cited by this paper
• Mechanism of ATP-binding Cassette Transporter A1-mediated Cellular Lipid Efflux to Apolipoprotein A-I and Formation of High Density Lipoprotein Particles*

  2007cited by this paper
• Novel ABCA12 mutations identified in two cases of non-bullous congenital ichthyosiform erythroderma associated with multiple skin malignant neoplasia.

  2007cited by this paper
• Polymorphisms of cholesterol metabolism genes CYP46 and ABCA1 and the risk of sporadic Alzheimer's disease in Chinese.

  2007cited by this paper
• ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages

  2006cited by this paper
• Intestinal ABCA1 directly contributes to HDL biogenesis in vivo.

  2006cited by this paper
• “Skittish” Abca2 Knockout Mice Display Tremor, Hyperactivity, and Abnormal Myelin Ultrastructure in the Central Nervous System

  2006cited by this paper
• Membrane topology of human ABC proteins

  2006cited by this paper
• ABC A-subfamily transporters: structure, function and disease.

  2006influential reference
• ABCA2 is a marker of neural progenitors and neuronal subsets in the adult rodent brain

  2006cited by this paper
• Ethnicity‐dependent genetic association of ABCA2 with sporadic Alzheimer's disease

  2006cited by this paper
• Polymorphism in ABCA1 influences CSF 24S-hydroxycholesterol levels but is not a major risk factor of Alzheimer's disease.

  2006cited by this paper
• Involvement of transient receptor potential vanilloid-1 in calcium current inhibition by capsaicin

  2006cited by this paper
• ABCA7 expression is regulated by cellular cholesterol through the SREBP2 pathway and associated with phagocytosis Published, JLR Papers in Press, June 20, 2006.

  2006influential reference
• The human ortholog of the rodent testis-specific ABC transporter Abca17 is a ubiquitously expressed pseudogene (ABCA17P) and shares a common 5' end with ABCA3

  2006cited by this paper
• Quantitation of ATP-binding cassette subfamily-A transporter gene expression in primary human brain cells

  2006influential reference
• Pathomechanisms of harlequin ichthyosis and ABCA transporters in human diseases.

  2006cited by this paper
• Human multidrug resistance ABCB and ABCG transporters: participation in a chemoimmunity defense system.

  2006cited by this paper
• Subcellular localization of rat Abca5, a rat ATP-binding-cassette transporter expressed in Leydig cells, and characterization of its splice variant apparently encoding a half-transporter.

  2006cited by this paper
• Association studies of cholesterol metabolism genes (CH25H, ABCA1 and CH24H) in Alzheimer's disease.

  2006cited by this paper

• Unraveling novel mechanisms of ATP-Binding cassette (ABC) transporter in insulin Resistance-induced amyloidogenesis

  2025cites this paper
• Novel modelling approaches to elucidate the genetic architecture of resilience to Alzheimer's disease.

  2025cites this paper
• From Genetics to Function: the Role of ABCA12 in Autism Neurobiology

  2025cites this paper
• Comprehensive account of exosome isolation from rat substantia nigra for mass spectrometry-based proteomics study.

  2025cites this paper
• Multi-omics landscapes reveal heterogeneity in long COVID patients characterized with enhanced neutrophil activity

  2024cites this paper
• Phagocytosis-driven neurodegeneration through opposing roles of an ABC transporter in neurons and phagocytes

  2024cites this paper
• The association of ABC proteins with multidrug resistance in cancer.

  2024cites this paper
• Differential gene expression of blood-based ABCA9, CNOT8, SESN1, UCP3, MAP2K1 and DDIT4 in Alzheimer’s disease

  2023cites this paper
• Identification and characterization of ABC proteins in an important rice insect pest, Cnaphalocrocis medinalis unveil their response to Cry1C toxin.

  2023cites this paper
• ATP-binding cassette transporter expression is widely dysregulated in frontotemporal dementia with TDP-43 inclusions

  2022cites this paper
• ABCA7, a Genetic Risk Factor Associated with Alzheimer’s Disease Risk in African Americans

  2022cites this paper
• Structure and function of ABCA4 and its role in the visual cycle and Stargardt macular degeneration.

  2021cites this paper
• Binding mode analysis of ABCA7 for the prediction of novel Alzheimer's disease therapeutics

  2021cites this paper
• ATP binding cassette transporters and cancer: revisiting their controversial role.

  2021cites this paper
• Loss of ABCA8B decreases myelination by reducing oligodendrocyte precursor cells in mice

  2021cites this paper
• Overview of Beneficial Effects of (Poly)phenol Metabolites in the Context of Neurodegenerative Diseases on Model Organisms

  2021cites this paper
• Cryo-EM structures of the ABCA4 importer reveal mechanisms underlying substrate binding and Stargardt disease

  2021cites this paper
• ATP-binding cassette transporters and neurodegenerative diseases.

  2021cites this paper
• The Role of ABC Transporters in Lipid Metabolism and the Comorbid Course of Chronic Obstructive Pulmonary Disease and Atherosclerosis

  2021cites this paper
• Strategies to gain novel Alzheimer’s disease diagnostics and therapeutics using modulators of ABCA transporters

  2021cites this paper
• 5′ Untranslated Region Elements Show High Abundance and Great Variability in Homologous ABCA Subfamily Genes

  2020cites this paper
• Loss of CDC50A function drives Aβ/p3 production via increased β/α-secretase processing of APP

  2020cites this paper
• Discovering weaker genetic associations guided by known associations

  2020cites this paper
• Transcriptional Signatures of Tau and Amyloid Neuropathology

  2020cites this paper
• ABCA13 dysfunction associated with psychiatric disorders causes impaired cholesterol trafficking

  2020cites this paper
• The Role of Cholesterol in α‐Synuclein and Lewy Body Pathology in GBA1 Parkinson's Disease

  2020cites this paper
• ABCA13 dysfunction associated with psychiatric disorders causes impaired cholesterol trafficking.

  2020cites this paper
• Novel genetic link between the ATP-binding cassette subfamily A gene and hippo gene in Drosophila.

  2019cites this paper
• Leukocyte expression profiles reveal gene sets with prognostic value for seizure-free outcome following stereotactic laser amygdalohippocampotomy

  2019cites this paper
• Membrane transporters in traumatic brain injury: Pathological, pharmacotherapeutic, and developmental implications.

  2019influential citation
• Transcriptional signatures of progressive neuropathology in transgenic tau and amyloid mouse models

  2019cites this paper
• Autism Spectrum Disorder-Related Syndromes: Modeling with Drosophila and Rodents

  2019cites this paper
• Transcriptional Signatures of Progressive Neuropathology in Transgenic Models of Tau and Amyloid Pathology

  2019cites this paper
• ABC Family Transporters.

  2019cites this paper
• Gene expression of A6-like subgroup of ATP-binding cassette transporters in mouse brain parenchyma and microvessels

  2018cites this paper
• The neuropathological investigation of the brain in a monkey model of autism spectrum disorder with ABCA13 deletion

  2018cites this paper
• Novel Drosophila model for psychiatric disorders including autism spectrum disorder by targeting of ATP‐binding cassette protein A

  2018cites this paper
• Nutritional, hormonal and genetic factors in the development of overeating tendency toward food addiction

  2017cites this paper
• Identification of functional variants in the Alzheimer’s disease candidate gene ABCA7

  2017influential citation
• Novel Mutation in the ATP-Binding Cassette Transporter A3 (ABCA3) Encoding Gene Causes Respiratory Distress Syndrome in A Term Newborn in Southwest Iran

  2016cites this paper
• Expression and variability of lipid metabolism genes in intracranial aneurysm.

  2016cites this paper
• Frontal Cortex Stimulation Reduces Vigilance to Threat: Implications for the Treatment of Depression and Anxiety.

  2016cites this paper
• The ATP-Binding Cassette Transporter-2 (ABCA2) Overexpression Modulates Sphingosine Levels and Transcription of the Amyloid Precursor Protein (APP) Gene.

  2015cites this paper
• Gangliosides: glycosphingolipids essential for normal neural development and function.

  2015cites this paper
• Schistosome ABC multidrug transporters: From pharmacology to physiology

  2014cites this paper
• Expression, purification and structural properties of ABC transporter ABCA4 and its individual domains.

  2014cites this paper
• THE ROLE OF MDR1 IN IMMUNE SYSTEM AND NEURODEGENERATIVE DISORDERS

  2014cites this paper
• ABC multidrug transporters in schistosomes and other parasitic flatworms.

  2013cites this paper
• Análise de redes de interação transcricional na substância nigra, locus cerúleo e núcleo dorsal do nervo vago na Doença de Parkinson

  2013cites this paper
• Quantitative targeted absolute proteomic analysis of transporters, receptors and junction proteins for validation of human cerebral microvascular endothelial cell line hCMEC/D3 as a human blood-brain barrier model.

  2013cites this paper
• Impaired mitochondrial energy production and ABC transporter function-A crucial interconnection in dementing proteopathies of the brain.

  2013cites this paper
• ATP-Binding Cassette, Subfamily A (ABC1), Member 7 (ABCA7)

  2013cites this paper
• Differential Phospholipid Substrates and Directional Transport by ATP-binding Cassette Proteins ABCA1, ABCA7, and ABCA4 and Disease-causing Mutants*♦

  2013cites this paper
• Molecular organization and ATP-induced conformational changes of ABCA4, the photoreceptor-specific ABC transporter.

  2013cites this paper
• Lipid Transport Activity of ABCA Transporters 1 Differential Phospholipid Substrates and Directional Transport by ATP Binding Cassette Proteins ABCA 1 , ABCA 7 , and ABCA 4 and Disease-causing Mutants *

  2013cites this paper
• From Linkage to GWAS: A Multifaceted Exploration of the Genetic Risk for Alcohol Dependence

  2012cites this paper
• The Effects of Neurological Disorder-Related Codon Variations of ABCA13 on the Function of the ABC Protein

  2012cites this paper