Inside the mammalian telomere interactome: regulation and regulatory activities of telomeres.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Critical Reviews in Eukaryotic Gene Expression

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1615/CRITREVEUKARGENEEXPR.V16.I2.10PMID 16749892
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  year unknowncites this paper