Cardiac ATP-sensitive K+ channels: regulation by intracellular nucleotides and K+ channel-opening drugs.

No abstract is available for this paper.

• Publication year

  1995

• Venue

  American Journal of Physiology

• Publication date

  1995-09-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1152/AJPCELL.1995.269.3.C525PMID 7573382
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effects of ADP upon the ATP-sensitive K+ channel in rat ventricular myocytes

  2005cited by this paper
• ATP-sensitive inward rectifier and voltage- and calcium-activated K+ channels in cultured pancreatic islet cells

  2005cited by this paper
• Characterization of the G protein coupling of a somatostatin receptor to the K+ATP channel in insulin‐secreting mammalian HIT and RIN cell lines.

  1995cited by this paper
• Exercise‐Induced Enhancement of Immune Function in the Rat

  1994cited by this paper
• The ATP sensitive potassium channel of cardiac muscle and action potential shortening during metabolic stress.

  1994cited by this paper
• G-protein control of cardiac potassium channels.

  1994cited by this paper
• Inactivating ‘ball’ peptide from Shaker B blocks Ca(2+)‐activated but not ATP‐dependent K+ channels of rat skeletal muscle.

  1994cited by this paper
• KATP channels and basal coronary vascular tone.

  1994cited by this paper
• Activation of the cloned muscarinic potassium channel by G protein beta gamma subunits.

  1994cited by this paper
• Do potassium channel openers compete with ATP to activate ATP sensitive potassium channels?

  1994cited by this paper
• Direct G protein activation of ion channels?

  1994cited by this paper
• Cellular pharmacology of potassium channel openers in vascular smooth muscle.

  1994cited by this paper
• Electrophysiological effects of ATP sensitive potassium channel modulation: implications for arrhythmogenesis.

  1994cited by this paper
• Protective effects of ATP sensitive potassium channel openers in models of myocardial ischaemia.

  1994cited by this paper
• Activation of the cloned muscarinic potassium channel by G protein βγ subunits

  1994cited by this paper
• Intracellular acidification and ADP enhance nicorandil induction of ATP sensitive potassium channel current in cardiomyocytes.

  1994cited by this paper
• Recombinant G-protein βγ-subunits activate the muscarinic-gated atrial potassium channel

  1994cited by this paper
• Cloning and functional expression of a rat heart KATP channel

  1994cited by this paper
• KATP channels in ischaemic preconditioning.

  1994cited by this paper
• HOE-234, a second generation K+ channel opener, antagonizes the ATP-dependent gating of cardiac ATP-sensitive K+ channels.

  1994cited by this paper
• Muscarinic K+ Channels Are Activated by βγ Subunits and Inhibited by the GDP-Bound Form of α Subunit of Transducin

  1994cited by this paper
• G proteins activate ATP-sensitive K+ channels by antagonizing ATP-dependent gating.

  1994cited by this paper
• Dualistic behavior of ATP-sensitive K+ channels toward intracellular nucleoside diphosphates.

  1994cited by this paper
• Nucleotide regulation of ATP sensitive potassium channels.

  1994cited by this paper
• KATP channels in vascular smooth muscle.

  1994cited by this paper
• Molecular cloning and functional expression of cDNA encoding a second class of inward rectifier potassium channels in the mouse brain.

  1994cited by this paper
• Calcitonin gene‐related peptide activated ATP‐sensitive K+ currents in rabbit arterial smooth muscle via protein kinase A.

  1994cited by this paper
• Recombinant G-protein beta gamma-subunits activate the muscarinic-gated atrial potassium channel.

  1994cited by this paper
• Muscarinic K+ channels are activated by beta gamma subunits and inhibited by the GDP-bound form of alpha subunit of transducin.

  1994cited by this paper
• Mode of regulation by G protein of the ATP‐sensitive K+ channel in guinea‐pig ventricular cell membrane.

  1994cited by this paper
• Diverse effects of pinacidil on KATP channels in mouse skeletal muscle in the presence of different nucleotides.

  1994cited by this paper
• Effects of trypsin on cardiac ATP-sensitive K+ channels.

  1994cited by this paper
• Activation of cardiac KATP channels: an endogenous protective mechanism during repetitive ischemia.

  1993cited by this paper
• On the Mechanism of Inhibition of KATP Channels by Glibenclamide in Rat Ventricular Myocytes

  1993cited by this paper
• Mechanosensitive gating of atrial ATP-sensitive potassium channels.

  1993cited by this paper
• ATP‐regulated K+ channels are modulated by intracellular H+ in guinea‐pig ventricular cells.

  1993cited by this paper
• ATP‐sensitive K+ channel modification by metabolic inhibition in isolated guinea‐pig ventricular myocytes.

  1993cited by this paper
• Haemodynamic and clinical effects of an intravenous potassium channel opener--a review.

  1993cited by this paper
• Single delayed rectifier channels in the membrane of rabbit ventricular myocytes.

  1993cited by this paper
• Ca(2+)-activated potassium channels and ATP-sensitive potassium channels as modulators of vascular tone.

  1993cited by this paper
• Mechanosensitive gating of atrial ATP-sensitive potassium channels.

  1993cited by this paper
• YM934, a novel K+ channel opener, activates ATP-sensitive K+ channels in cardiac myocytes.

  1993cited by this paper
• Cardiovascular Profile of E4080 and Its Analogue ER001533: Novel Potassium Channel Openers with Bradycardic Properties

  1993cited by this paper
• Stimulation of the KATP channel by ADP and diazoxide requires nucleotide hydrolysis in mouse pancreatic beta‐cells.

  1993cited by this paper
• GK* and brain G beta gamma activate muscarinic K+ channel through the same mechanism.

  1993cited by this paper
• The pharmacology of ATP-sensitive potassium channels.

  1993cited by this paper
• ATP‐sensitive K+ channels: Pharmacologic properties, regulation, and therapeutic potential

  1993cited by this paper
• Trypsin and alpha-chymotrypsin treatment abolishes glibenclamide sensitivity of KATP channels in rat ventricular myocytes.

  1993cited by this paper
• Intracellular protons control the affinity of skeletal muscle ATP‐sensitive K+ channels for potassium‐channel‐openers

  1993cited by this paper
• Potassium channels as pharmacological targets in cardiovascular medicine.

  1993cited by this paper
• ATP-modulated K+ channels sensitive to antidiabetic sulfonylureas are present in adenohypophysis and are involved in growth hormone release.

  1993cited by this paper
• Molecular and functional diversity of cloned cardiac potassium channels

  1993cited by this paper
• Modification of K-ATP channels in pancreatic beta-cells by trypsin.

  1993cited by this paper
• Do the K+ channel openers relax smooth muscle by opening K+ channels?

  1993cited by this paper
• Modification of the adenosine 5'‐triphosphate‐sensitive K+ channel by trypsin in guinea‐pig ventricular myocytes.

  1993cited by this paper
• Primary structure and functional expression of a mouse inward rectifier potassium channel

  1993cited by this paper
• Glibenclamide Antagonizes Adenosine A, Receptor‐Mediated Cardioprotection in Stunned Canine Myocardium

  1993cited by this paper
• Single-channel properties and regulation of pinacidil/glibenclamide-sensitive K+ channels in follicular cells from Xenopus oocyte

  1993cited by this paper
• Adenosine‐activated potassium current in smooth muscle cells isolated from the pig coronary artery.

  1993cited by this paper
• Cloning and expression of an inwardly rectifying ATP-regulated potassium channel

  1993cited by this paper
• Role of ATP-sensitive K+ channel current in ischemic arrhythmias

  1993cited by this paper
• Primary structure and functional expression of a rat G-protein-coupled muscarinic potassium channel

  1993cited by this paper
• Metabolic regulation of cardiac ATP-sensitive K+ channels

  1993cited by this paper
• The ATP-sensitive K+ channel.

  1993cited by this paper
• K channel activation by nucleotide diphosphates and its inhibition by glibenclamide in vascular smooth muscle cells

  1993cited by this paper
• Gating properties of ATP-sensitive K+ channels in the heart

  1993cited by this paper
• Expression of an atrial G-protein-activated potassium channel in Xenopus oocytes.

  1993cited by this paper
• K+ channel openers and 'natural' cardioprotection.

  1992cited by this paper
• Activation of the cardiac ATP-sensitive K+ channel by ER-001533, a newly synthesized vasorelaxant.

  1992cited by this paper
• Ischemic preconditioning Nature's own cardioprotective intervention.

  1992cited by this paper
• Modulation of ATP sensitive potassium channels.

  1992cited by this paper
• Two sites for adenine-nucleotide regulation of ATP-sensitive potassium channels in mouse pancreatic β-cells and HIT cells

  1992cited by this paper
• Activation of ATP-sensitive K+ channels by cromakalim. Effects on cellular K+ loss and cardiac function in ischemic and reperfused mammalian ventricle.

  1992cited by this paper
• The sulfonylurea receptor.

  1992cited by this paper
• On the mechanism of G protein beta gamma subunit activation of the muscarinic K+ channel in guinea pig atrial cell membrane. Comparison with the ATP-sensitive K+ channel

  1992cited by this paper
• Role of Myocardial ATP‐Sensitive Potassium Channels in Mediating Preconditioning in the Dog Heart and Their Possible Interaction With Adenosine A1‐Receptors

  1992cited by this paper
• Internal blockade of a Ca(2+)-activated K+ channel by Shaker B inactivating "ball" peptide.

  1992cited by this paper
• Potassium channel openers: pharmacological and clinical aspects

  1992cited by this paper
• Opening of glibenclamide-sensitive K+ channels in follicular cells promotes Xenopus oocyte maturation.

  1992cited by this paper
• Identification of an ATP-sensitive K+ channel in rat cultured cortical neurons

  1992cited by this paper
• ATP-sensitive K+ channels regulate resting potential of pulmonary arterial smooth muscle cells.

  1992cited by this paper
• Nucleotide diphosphates activate the ATP-sensitive potassium channel in mouse skeletal muscle

  1992cited by this paper
• ATP is a coupling modulator of parallel Na,K-ATPase-K-channel activity in the renal proximal tubule.

  1992cited by this paper
• Cytosolic nucleotides enhance the tolbutamide sensitivity of the ATP-dependent K+ channel in mouse pancreatic B cells by their combined actions at inhibitory and stimulatory receptors.

  1992cited by this paper
• ATP‐sensitive K+ channels and cellular K+ loss in hypoxic and ischaemic mammalian ventricle.

  1992cited by this paper
• Pancreatic and Extrapancreatic Sulfonylurea Receptors

  1992cited by this paper
• Effects of pH upon the inhibition by sulphonylurea drugs of ATP-sensitive K+ channels in cardiac muscle.

  1992cited by this paper
• Role of ATP dependent potassium channels in myocardial ischaemia.

  1992cited by this paper
• Blockade of the ATP-sensitive K+ channel by 5-hydroxydecanoate in guinea pig ventricular myocytes.

  1992cited by this paper
• G protein activation of cardiac muscarinic K+ channels

  1992cited by this paper
• Modulation of ATP sensitive potassium channels.

  1992cited by this paper
• Putative receptor for the cytoplasmic inactivation gate in the Shaker K+ channel

  1991cited by this paper
• Separate processes mediate nucleotide-induced inhibition and stimulation of the ATP-regulated K+-channels in mouse pancreatic β-cells

  1991cited by this paper
• ATP‐sensitive K channels in heart muscle Spare channels

  1991cited by this paper
• Action of nicorandil on ATP‐sensitive K+ channel in guinea‐pig ventricular myocytes

  1991cited by this paper
• ATP-dependent potassium channels of muscle cells: Their properties, regulation, and possible functions

  1991cited by this paper
• Effect of H+ on ATP-regulated K+ channels in feline ventricular myocytes.

  1991cited by this paper
• Cloning, expression, pharmacology and regulation of a delayed rectifier K+ channel in mouse heart.

  1991cited by this paper
• Essential role of nucleotide diphosphates in nicorandil-mediated activation of cardiac ATP-sensitive K+ channel. A comparison with pinacidil and lemakalim.

  1991cited by this paper
• Role of cardiac ATP-regulated potassium channels in differential responses of endocardial and epicardial cells to ischemia.

  1991cited by this paper

• Gating and modulation of an inward-rectifier potassium channel

  2022cites this paper
• ATP-sensitive potassium channels: a double-edged sword in neurodegenerative diseases.

  2022cites this paper
• Mitochondrial K+ channels and their implications for disease mechanisms.

  2021cites this paper
• Comparison of K+ Channel Families.

  2021cites this paper
• Association between ABCC8 Ala1369Ser Polymorphism (rs757110 T/G) and Type 2 Diabetes risk in an Iranian population: A Case-Control Study.

  2020cites this paper
• The Role of ATP-Sensitive Inward Rectifier Potassium Channels In The Regulation of Reactive Oxygen Species In The Western Honey Bee, APIS Mellifera L.

  2019cites this paper
• Functional Role of Mitochondria in Arrhythmogenesis

  2019cites this paper
• Physiology and Molecular Biology of Ion Channels Underlying Ventricular Repolarization of the Mammalian Heart

  2019cites this paper
• All-cause mortality in patients on sulphonylurea monotherapy compared to metformin monotherapy in a nation-wide cohort.

  2019cites this paper
• ATP-Sensitive Potassium Channels and Their Physiological and Pathophysiological Roles.

  2018cites this paper
• Protein complexes as psychiatric and neurological drug targets

  2018cites this paper
• Management of Diabetes and/or Hyperglycemia in Non‐Critical Care Hospital Settings

  2018cites this paper
• The impact of oral anti-diabetic medications on heart failure: lessons learned from preclinical studies

  2018cites this paper
• Functional protection against cardiac diseases depends on ATP‐sensitive potassium channels

  2018cites this paper
• Age-dependent ventricular arrhythmias risk, structural and molecular remodeling in systemic arterial hypertension.

  2017cites this paper
• Functional Role of Mitochondria in Arrhythmogenesis.

  2017cites this paper
• Existence of ATP sensitive potassium currents on human periodontal ligament cells.

  2017cites this paper
• The IK1/Kir2.1 channel agonist zacopride prevents and cures acute ischemic arrhythmias in the rat

  2017cites this paper
• The therapeutic agents that target ATP-sensitive potassium channels

  2016cites this paper
• Simulating the effect of global cardiac ischaemia on the dynamics of ventricular arrhythmias in the human heart

  2016cites this paper
• Isosteviol Sensitizes sarcKATP Channels towards Pinacidil and Potentiates Mitochondrial Uncoupling of Diazoxide in Guinea Pig Ventricular Myocytes

  2016cites this paper
• Ischemic preconditioning: Interruption of various disorders

  2016cites this paper
• KATP Channels in the Cardiovascular System.

  2016cites this paper
• Cardiac Arrhythmias Associated to Abnormalities in the Functionality of K + ATP-Sensitive Channels

  2016cites this paper
• Hyperinsulinemia and sulfonylurea use are independently associated with left ventricular diastolic dysfunction in patients with type 2 diabetes mellitus with suboptimal blood glucose control

  2016cites this paper
• The molecular mechanisms of sodium metabisulfite on the expression of K ATP and L-Ca2+ channels in rat hearts.

  2015cites this paper
• Electrocardiac effects associated with lithium toxicity in children: an illustrative case and review of the pathophysiology

  2015cites this paper
• Channels + Mice Lacking Kir6.2-Containing ATP-Sensitive K Enhanced Neuronal Damage After Ischemic Insults in

  2015cites this paper
• Effect of electronic stimulation at Neiguan (PC 6) acupoint on gene expression of adenosine triphosphate-sensitive potassium channel and protein kinases in rats with myocardial ischemia.

  2015cites this paper
• Role of KATP channels in angiogenesis

  2015cites this paper
• Effect of electronic stimulation at Neiguan (PC 6) acupoint on gene expression of adenosine triphosphate-sensitive potassium channel and protein kinases in rats with myocardial ischemia.

  2015cites this paper
• Management of Hyperglycemia and Diabetes in Noncritical Care Settings

  2014cites this paper
• Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non‐diabetic controls

  2014cites this paper
• Lack of the QTc physiologic decrease during cardiac stress test in patients with type 2 diabetes treated with secretagogues

  2014cites this paper
• Glycemic management in patients with coronary artery disease and prediabetes or type 2 diabetes mellitus.

  2014cites this paper
• Mortality risk with sulphonylureas compared to metformin

  2014cites this paper
• ATP-sensitive potassium channel modulators and cardiac arrhythmias: an update.

  2014cites this paper
• Screening for Prediabetes and Diabetes Mellitus

  2014cites this paper
• Meta-analysis of association of common variants in the KCNJ 11-ABCC 8 region with type 2 diabetes

  2013cites this paper
• Selenium Attenuates Adriamycin-Induced Cardiac Dysfunction via Restoring Expression of ATP-Sensitive Potassium Channels in Rats

  2013cites this paper
• Benzopyran derivatives as cardio-selective ATP-sensitive potassium channel openers: a review.

  2013cites this paper
• Cardiac ATP-Sensitive Potassium Channels and Associated Channelopathies

  2013cites this paper
• Investigation into the ion channels and plasma membrane properties of white adipocytes

  2013cites this paper
• Cardiac KATP channels in health and diseases

  2013cites this paper
• Hyperkalemic cardioplegia for adult and pediatric surgery: end of an era?

  2013cites this paper
• Meta-analysis of association of common variants in the KCNJ11-ABCC8 region with type 2 diabetes.

  2013cites this paper
• Sulfonylureas and meglitinides: historical and contemporary issues.

  2013cites this paper
• NMR and fluorescence studies of drug binding to the first nucleotide binding domain of SUR2A.

  2012cites this paper
• Роль препаратов сульфонилмочевины в развитии сердечно-сосудистых осложнений при сахарном диабете 2 типа

  2012cites this paper
• Molecular determinants of different gating mechanisms in inwardly-rectifying potassium channels

  2012cites this paper
• The Role of Chloride Channels in Remote Ischemic Preconditioning of Ventricular Cardiomyocytes

  2012cites this paper
• Allosteric Information Transfer through Inter-subunit Contacts in ATP-sensitive Potassium Channels

  2012cites this paper
• Insulin therapy for the management of hyperglycemia in hospitalized patients.

  2012cites this paper
• Neuroprotective role of ATP-sensitive potassium channels in cerebral ischemia

  2012cites this paper
• The Molecular Genetics of Sulfonylurea Receptors in the Pathogenesis and Treatment of Insulin Secretory Disorders and Type 2 Diabetes

  2011cites this paper
• Effects of glucose-lowering drugs in patients with diabetes and myocardial infarction

  2011cites this paper
• Characterization of an ATP-sensitive K(+) channel in rat carotid body glomus cells.

  2011cites this paper
• Advances in Arrhythmia and Electrophysiology Advances in Cardiac ATP-Sensitive K Channelopathies From Molecules to Populations

  2011cites this paper
• Cerebral Blood Flow and Metabolism and Cerebral Ischemia

  2011cites this paper
• Глибенкламид - профиль эффективности

  2011cites this paper
• The ATP-Sensitive K+ Channel ABCC8 S1369A Type 2 Diabetes Risk Variant Increases MgATPase Activity

  2011cites this paper
• Upper intestine - New target for type-2 diabetes: A review

  2011cites this paper
• Current understanding of KATP channels in neonatal diseases: focus on insulin secretion disorders

  2011cites this paper
• Pinacidil-primed ATP-sensitive potassium channels mediate feedback control of mechanical power output in isolated myocardium of rats and guinea pigs.

  2010cites this paper
• Management of hyperglycemia in hospitalized patients

  2010cites this paper
• Inwardly rectifying potassium channels: their structure, function, and physiological roles.

  2010influential citation
• Cardiac mitochondria and arrhythmias.

  2010cites this paper
• Myocardial infarction and diabetes mellitus Studies on glucose lowering therapies and novel risk markers based on observations from the DIGAMI 2 trial

  2010cites this paper
• Management of Diabetes Mellitus in Patients With Cardiovascular Disease in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) Trial

  2010cites this paper
• KCNJ11 knockout morula re-engineered by stem cell diploid aggregation

  2009cites this paper
• A dual mechanism of cytoprotection afforded by M-LDH in embryonic heart H9C2 cells

  2009cites this paper
• Causes of Abnormal Ca2+ Transients in Guinea Pig Pathophysiological Ventricular Muscle Revealed by Ca2+ and Action Potential Imaging at Cellular Level

  2009cites this paper
• Modeling of cardiac ischemia in human myocytes and tissue including spatiotemporal electrophysiological variations / Modellierung kardialer Ischämie in menschlichen Myozyten und Gewebe

  2009cites this paper
• GLP-1 agonist-based therapies: An emerging new class of antidiabetic drug with potential cardioprotective effects

  2009cites this paper
• Preliminary Characterization of Mitochondrial ATP-sensitive Potassium Channel (MitoKATP) Activity in Mouse Heart Mitochondria

  2009cites this paper
• Sulfonylurea receptors and mechanism of sulfonylurea action.

  2009cites this paper
• Human KATP channelopathies: diseases of metabolic homeostasis

  2009cites this paper
• ATP-sensitive K+ channel knockout induces cardiac proteome remodeling predictive of heart disease susceptibility.

  2009cites this paper
• ATP regulation of a large conductance voltage-gated cation channel in rough endoplasmic reticulum of rat hepatocytes.

  2008cites this paper
• Aging and cardioprotection.

  2007cites this paper
• Mechanism of abnormal intestinal motility in inflammatory bowel disease: how smooth muscle contraction is reduced?

  2007cites this paper
• Hydrogen sulfide contributes to cardioprotection during ischemia-reperfusion injury by opening K ATP channels.

  2007cites this paper
• HIGHLIGHTED TOPIC Perspectives in Innate and Acquired Cardioprotection Aging and cardioprotection

  2007cites this paper
• Diabetes in very young children and mutations in the insulin-secreting cell potassium channel genes: therapeutic consequences.

  2007cites this paper
• Efficacy and Safety of Mitiglinide in Korean Type 2 Diabetic Patients: Prospective Randomised Multicenter Comparative Phase III Study

  2007cites this paper
• ATP-sensitive potassium channels: metabolic sensing and cardioprotection.

  2007cites this paper
• The Effects of Nicorandil and Nifekalant, Which Were Injected into the Pericardial Space, for Transmural Dispersion of Repolarization in the Pig

  2007cites this paper
• Effects of Nifekalant Injected into the Pericardial Space on the Transmural Dispersion of Repolarization in Pig

  2007cites this paper
• Efeitos da glibenclamida na função e histologia renais, em ratos submetidos à hemorragia aguda sob anestesia com sevoflurano

  2007cites this paper
• ATP-sensitive potassium currents reduce the PGE2-mediated enhancement of excitability in adult rat sensory neurons.

  2007cites this paper
• Cocaine-induced inhibition of ATP-sensitive K+ channels in rat ventricular myocytes and in heart-derived H9c2 cells.

  2006cites this paper
• Impact of In Vivo Preconditioning by Isoflurane on Adenosine Triphosphate–sensitive Potassium Channels in the Rat Heart: Lasting Modulation of Nucleotide Sensitivity during Early Memory Period

  2006influential citation
• Intestinal dysmotility in inflammatory bowel disease: Mechanisms of the reduced activity of smooth muscle contraction

  2006cites this paper
• Perioperative glucose control in the diabetic or nondiabetic patient.

  2006cites this paper
• Enhanced neuronal damage after ischemic insults in mice lacking Kir6.2-containing ATP-sensitive K+ channels.

  2006cites this paper
• Molecular basis of native inward rectifier currents : role of Kir2 subunits

  2006cites this paper
• Alarmone: Signalfaktoren in der lokalen Regulation

  2006cites this paper
• Protection conferred by myocardial ATP‐sensitive K+ channels in pressure overload‐induced congestive heart failure revealed in KCNJ11 Kir6.2‐null mutant

  2006cites this paper
• Cardiac and vascular KATP channels in rats are activated by endogenous epoxyeicosatrienoic acids through different mechanisms

  2006cites this paper
• KCNJ11 gene knockout of the Kir6.2 KATP channel causes maladaptive remodeling and heart failure in hypertension.

  2006cites this paper