Dihydrotestosterone upregulates the expression of epidermal growth factor receptor and ERBB2 in androgen receptor-positive bladder cancer cells.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Endocrine-Related Cancer

• Publication date

  2011-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1530/ERC-11-0010PMID 21613411
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Loss of androgen receptor expression is not associated with pathological stage, grade, gender or outcome in bladder cancer: a large multi‐institutional study

  2011cited by this paper
• Sex-specific hormone receptors in urothelial carcinomas of the human urinary bladder: a comparative analysis of clinicopathological features and survival outcomes according to receptor expression.

  2011cited by this paper
• Expression of semenogelins I and II and its prognostic significance in human prostate cancer

  2011cited by this paper
• Androgen receptor is a potential therapeutic target for bladder cancer.

  2010cited by this paper
• Cancer Statistics, 2010

  2010cited by this paper
• Expression status and prognostic significance of mammalian target of rapamycin pathway members in urothelial carcinoma of urinary bladder after cystectomy

  2010cited by this paper
• Androgen receptor is frequently expressed in HER2-positive, ER/PR-negative breast cancers

  2010cited by this paper
• Expression of androgen receptors in primary breast cancer.

  2010cited by this paper
• Epidermal growth factor receptor expression escapes androgen regulation in prostate cancer: a potential molecular switch for tumour growth

  2009cited by this paper
• Phosphatidylinositol 3-kinase (PI3K) pathway activation in bladder cancer

  2009cited by this paper
• Androgen receptor controls EGFR and ERBB2 gene expression at different levels in prostate cancer cell lines.

  2009influential reference
• Targeting EGFR with photodynamic therapy in combination with Erbitux enhances in vivo bladder tumor response

  2009cited by this paper
• Activation of extracellular regulated kinases (ERK1/2) predicts poor prognosis in urothelial bladder carcinoma and is not associated with B‐Raf gene mutations

  2009cited by this paper
• Effect of interleukin-8 gene silencing with liposome-encapsulated small interfering RNA on ovarian cancer cell growth.

  2008influential reference
• Dihydrotestosterone interacts with EGFR/MAPK signalling and modulates EGFR levels in androgen receptor-positive LNCaP prostate cancer cells.

  2008cited by this paper
• Androgenic dependence of exophytic tumor growth in a transgenic mouse model of bladder cancer: a role for thrombospondin-1

  2008cited by this paper
• Expression and significance of androgen receptor coactivators in urothelial carcinoma of the bladder.

  2008influential reference
• A functionally significant cross-talk between androgen receptor and ErbB2 pathways in estrogen receptor negative breast cancer.

  2008cited by this paper
• Sensitivity of Normal, Paramalignant, and Malignant Human Urothelial Cells to Inhibitors of the Epidermal Growth Factor Receptor Signaling Pathway

  2008cited by this paper
• Promotion of bladder cancer development and progression by androgen receptor signals.

  2007cited by this paper
• Targeted therapies in bladder cancer--an update.

  2007cited by this paper
• Androgen-dependent regulation of Her-2/neu in prostate cancer cells.

  2006cited by this paper
• Inhibition of HER-2/neu kinase impairs androgen receptor recruitment to the androgen responsive enhancer.

  2005cited by this paper
• Androgen receptor versus erbB-1 and erbB-2 expression in human prostate neoplasms.

  2004cited by this paper
• Androgen receptor expression is inversely correlated with pathologic tumor stage in bladder cancer.

  2004cited by this paper
• The phosphatidylinositol‐3 kinase pathway regulates bladder cancer cell invasion

  2004cited by this paper
• HER2/neu kinase-dependent modulation of androgen receptor function through effects on DNA binding and stability.

  2004cited by this paper
• Epidermal Growth Factor Increases Coactivation of the Androgen Receptor in Recurrent Prostate Cancer*

  2004cited by this paper
• HER2/neu gene amplification and protein overexpression in G3 pT2 transitional cell carcinoma of the bladder: a role for anti-HER2 therapy?

  2004influential reference
• A decade of tyrosine kinases: from gene discovery to therapeutics.

  2003cited by this paper
• Novel approaches with targeted therapies in bladder cancer. Therapy of bladder cancer by blockade of the epidermal growth factor receptor family.

  2003cited by this paper
• Suppression Versus Induction of Androgen Receptor Functions by the Phosphatidylinositol 3-Kinase/Akt Pathway in Prostate Cancer LNCaP Cells with Different Passage Numbers*

  2003cited by this paper
• 3β-Acetoxyandrost-1,5-diene-17-ethylene ketal functions as a potent antiandrogen with marginal agonist activity

  2003influential reference
• Potential action of IGF-1 and EGF on androgen receptor nuclear transfer and transactivation in normal and cancer human prostate cell lines.

  2002cited by this paper
• The program of androgen-responsive genes in neoplastic prostate epithelium

  2002cited by this paper
• Expression of epidermal growth factor receptor correlates with disease relapse and progression to androgen-independence in human prostate cancer.

  2002cited by this paper
• Her-2/neu overexpression in muscle-invasive urothelial carcinoma of the bladder: prognostic significance and comparative analysis in primary and metastatic tumors.

  2001cited by this paper
• C-ERBB-2 gene amplification as a prognostic marker in human bladder cancer.

  2000cited by this paper
• Her-2-neu expression and progression toward androgen independence in human prostate cancer.

  2000cited by this paper
• A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase

  1999cited by this paper
• Developmental and Hormonal Regulation of Transforming Growth Factor-α and Epidermal Growth Factor Receptor Gene Expression in Isolated Prostatic Epithelial and Stromal Cells.

  1998cited by this paper
• Developmental and hormonal regulation of transforming growth factor-alpha and epidermal growth factor receptor gene expression in isolated prostatic epithelial and stromal cells.

  1998cited by this paper
• Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor.

  1998cited by this paper
• Detection of c-erbB-2 amplification in transitional cell bladder carcinoma using competitive PCR technique.

  1996cited by this paper
• Androgens regulate the expression of proliferating cell nuclear antigen posttranscriptionally in the human prostate cancer cell line, LNCaP.

  1996cited by this paper
• Type 1 receptor tyrosine kinases are differentially phosphorylated in mammary carcinoma and differentially associated with steroid receptors.

  1996cited by this paper
• MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data.

  1995cited by this paper
• Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor and epidermal growth factor.

  1995cited by this paper
• Changing pattern of expression of the epidermal growth factor receptor and transforming growth factor alpha in the progression of prostatic neoplasms.

  1995cited by this paper
• Androgen up-regulates epidermal growth factor receptor expression and binding affinity in PC3 cell lines expressing the human androgen receptor.

  1995cited by this paper
• Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor.

  1994cited by this paper
• Expression of epidermal growth factor receptor in bladder cancer as related to established prognostic factors, oncoprotein (c-erbB-2, p53) expression and long-term prognosis.

  1994cited by this paper
• Phosphatidylinositol 3‐kinase

  1994cited by this paper
• The epidermal growth factor receptor and the prognosis of bladder cancer

  1990cited by this paper
• Unexplained excess risk of bladder cancer in men.

  1990cited by this paper
• Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors.

  1990cited by this paper
• Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor

  1987cited by this paper
• Cáncer

  1939cited by this paper

• Effects of dutasteride with Bacillus Calmette-Guérin therapy on recurrence, progression, metastasis, and survival in non-muscle invasive bladder cancer: a retrospective single-center study

  2026cites this paper
• Recent advances in understanding the role of sex hormone receptors in urothelial cancer

  2025influential citation
• Differential Androgen Receptor Expression Across Bladder Cancer Stages and Its Link to Poor Outcomes

  2025cites this paper
• Latrophilin-1 and latrophilin-2 as androgen receptor-responsive G protein-coupled receptors promote bladder cancer progression.

  2025cites this paper
• Androgen receptor signaling induces hemorrhage and angiogenesis in the irradiated bladder

  2025cites this paper
• Deciphering mechanisms of GPCR compounds against tuberculosis through ferroptosis inhibition using high-throughput screening and network pharmacology analysis.

  2025cites this paper
• Effects of androgen suppression therapy on the incidence and prognosis of bladder cancer: An updated systematic review and meta-analysis.

  2024cites this paper
• Prognostic feature based on androgen-responsive genes in bladder cancer and screening for potential targeted drugs

  2024cites this paper
• GULP1 as a Downstream Effector of the Estrogen Receptor-β Modulates Cisplatin Sensitivity in Bladder Cancer

  2024cites this paper
• Latrophilin-3 as a downstream effector of the androgen receptor induces bladder cancer progression

  2024cites this paper
• Sex differences in cancer and immunotherapy outcomes: the role of androgen receptor

  2024cites this paper
• Roles of Androgen Receptor Signaling in Urothelial Carcinoma

  2024cites this paper
• Androgen receptor transcriptionally inhibits programmed death ligand-1 (PD-L1) expression and influences immune escape in bladder cancer.

  2023cites this paper
• The urothelial gene regulatory network: understanding biology to improve bladder cancer management

  2023cites this paper
• GABBR2 as a Downstream Effector of the Androgen Receptor Induces Cisplatin Resistance in Bladder Cancer

  2023cites this paper
• Immunohistochemical expression of CD117/KIT, HER2, and Erβ in schistosomal and non-schistosomal urothelial carcinoma of Egyptian patients

  2023cites this paper
• Stranger Things: New Roles and Opportunities for Androgen Receptor in Oncology Beyond Prostate Cancer.

  2023cites this paper
• The androgen receptor in bladder cancer

  2023cites this paper
• Recent advances in the understanding of urothelial tumorigenesis

  2023cites this paper
• Non-muscle invasive bladder cancer biomarkers beyond morphology

  2022cites this paper
• Impact of Finasteride on Survival in Bladder Cancer: A Retrospective Multi-institutional Database Analysis.

  2022cites this paper
• Androgen Receptor Expression Is a Predictor of Poor Outcome in Urothelial Carcinoma

  2022cites this paper
• Prediction of recurrence of non-muscle invasive bladder cancer: The role of androgen receptor and miRNA-2909.

  2022cites this paper
• Comparative Metabolomics and Proteomics Reveal Vibrio parahaemolyticus Targets Hypoxia-Related Signaling Pathways of Takifugu obscurus

  2022cites this paper
• Dihydrotestosterone regulation of cyclooxygenase-2 expression in bovine endometrial epithelium cells by androgen receptor mediated EGFR/PI3K/Akt pathway.

  2021cites this paper
• The Clinical Significance and Prognostic Value of HER2 Expression in Bladder Cancer: A Meta-Analysis and a Bioinformatic Analysis

  2021cites this paper
• High expression of ERBB2 is an independent risk factor for reduced recurrence-free survival in patients with stage T1 non-muscle-invasive bladder cancer.

  2021cites this paper
• High Androgen Receptor mRNA Expression Is Associated with Improved Outcome in Patients with High-Risk Non-Muscle-Invasive Bladder Cancer

  2021cites this paper
• Sex Hormone Receptor Signaling in Bladder Cancer: A Potential Target for Enhancing the Efficacy of Conventional Non-Surgical Therapy

  2021cites this paper
• Androgen receptor signalling confers clonogenic and migratory advantages in urothelial cell carcinoma of the bladder

  2021cites this paper
• Identification of BXDC2 as a Key Downstream Effector of the Androgen Receptor in Modulating Cisplatin Sensitivity in Bladder Cancer

  2021cites this paper
• Androgen Receptor Signaling Induces Cisplatin Resistance via Down-Regulating GULP1 Expression in Bladder Cancer

  2021influential citation
• The correlation between EGFR and Androgen Receptor Pathways: A Novel Potential Prognostic Marker in Gastric Cancer.

  2020cites this paper
• The Clinical Signi cance and Prognostic Value of HER2 Expression in Bladder Cancer: a Systematic Review and Meta-analysis

  2020cites this paper
• Integrin αvβ3 in the Mediating Effects of Dihydrotestosterone and Resveratrol on Breast Cancer Cell Proliferation

  2020cites this paper
• Androgen receptor in bladder cancer: A promising therapeutic target

  2020influential citation
• The prognostic role of steroid hormone receptor signaling pathways in urothelial carcinoma

  2020influential citation
• Effects of α1-adrenergic receptor antagonists on the development and progression of urothelial cancer.

  2020cites this paper
• Implications of androgen receptor and FUS expression on tumor progression in urothelial carcinoma.

  2020cites this paper
• 5α-Reductase Inhibitors Do Not Prevent the Development and Progression of Urothelial Cancer: In Vitro Evidence

  2020cites this paper
• Activation of Glucocorticoid Receptor Inhibits the Stem-Like Properties of Bladder Cancer via Inactivating the β-Catenin Pathway

  2020influential citation
• Androgen Receptor Signaling Reduces the Efficacy of Bacillus Calmette-Guérin Therapy for Bladder Cancer via Modulating Rab27b-Induced Exocytosis

  2020cites this paper
• The role of adipocytokines and their receptors in bladder cancer: expression of adiponectin or leptin is an independent prognosticator.

  2020cites this paper
• Targeting Angiogenesis in Prostate Cancer

  2019cites this paper
• Androgen Receptor mRNA Expression in Urothelial Carcinoma of the Bladder: A Retrospective Analysis of Two Independent Cohorts

  2019cites this paper
• The long non-coding RNA LINC00460 predicts the prognosis and promotes the proliferation and migration of cells in bladder urothelial carcinoma

  2019cites this paper
• Combination of androgen receptor inhibitor and cisplatin, an effective treatment strategy for urothelial carcinoma of the bladder.

  2019cites this paper
• Inhibition of autophagy enhances the anticancer effect of enzalutamide on bladder cancer.

  2019cites this paper
• Role of androgen receptor expression in non-muscle-invasive bladder cancer: a systematic review and meta-analysis.

  2019cites this paper
• Possible role of 5-alpha reductase inhibitors in non-invasive bladder urothelial neoplasm: multicentre study.

  2019cites this paper
• Androgen Receptor Signaling Reduces Radiosensitivity in Bladder Cancer

  2018cites this paper
• Nuclear Factor-κB Promotes Urothelial Tumorigenesis and Cancer Progression via Cooperation with Androgen Receptor Signaling

  2018cites this paper
• ATF2 promotes urothelial cancer outgrowth via cooperation with androgen receptor signaling

  2018cites this paper
• Analysis of the prognostic relevance of sex-steroid hormonal receptor mRNA expression in muscle-invasive urothelial carcinoma of the urinary bladder

  2018cites this paper
• Down‐regulation of PKM2 decreases FASN expression in bladder cancer cells through AKT/mTOR/SREBP‐1c axis

  2018cites this paper
• High expression of enhancer RNA MARC1 or its activation by DHT is associated with the malignant behavior in bladder cancer

  2018cites this paper
• CYP27A1 inhibits bladder cancer cells proliferation by regulating cholesterol homeostasis

  2018cites this paper
• Expression of AR, 5&agr;R1 and 5&agr;R2 in bladder urothelial carcinoma and relationship to clinicopathological factors

  2017cites this paper
• Expression and clinical significance of androgen receptor in bladder cancer: A meta-analysis.

  2017cites this paper
• Androgen Receptor Signaling in Bladder Cancer

  2017cites this paper
• Role of the androgen receptor in urothelial cancer.

  2017cites this paper
• AR-Signaling in Human Malignancies: Prostate Cancer and Beyond

  2017cites this paper
• Prostaglandin receptors induce urothelial tumourigenesis as well as bladder cancer progression and cisplatin resistance presumably via modulating PTEN expression

  2017cites this paper
• Dioscorea esculenta‐induced increase in muscle sex steroid hormones is associated with enhanced insulin sensitivity in a type 2 diabetes rat model

  2017cites this paper
• Androgen receptor activation: a prospective therapeutic target for bladder cancer?

  2017cites this paper
• Histopathological and prognostic significance of the expression of sex hormone receptors in bladder cancer: A meta-analysis of immunohistochemical studies

  2017cites this paper
• High Androgen Receptor mRNA Expression Is Independently Associated with Prolonged Cancer-Specific and Recurrence-Free Survival in Stage T1 Bladder Cancer

  2017cites this paper
• Enzalutamide as an androgen receptor inhibitor prevents urothelial tumorigenesis.

  2016cites this paper
• Expression of androgen receptor in non-muscle-invasive bladder cancer predicts the preventive effect of androgen deprivation therapy on tumor recurrence

  2016cites this paper
• Effects of Androgen and Estrogen Receptor Signaling Pathways on Bladder Cancer Initiation and Progression

  2016cites this paper
• Androgen receptor activity modulates responses to cisplatin treatment in bladder cancer

  2016cites this paper
• The Epidemiological, Mechanistic and Potential Clinical Role of Androgen Receptor (AR) in Urothelial Carcinoma.

  2016cites this paper
• Enzalutamide inhibits androgen receptor-positive bladder cancer cell growth.

  2016cites this paper
• Endocrine disruptor actions through receptor crosstalk

  2016cites this paper
• Infiltrating neutrophils increase bladder cancer cell invasion via modulation of androgen receptor (AR)/MMP13 signals

  2015cites this paper
• Compound A Inhibits Bladder Cancer Growth Predominantly via Glucocorticoid Receptor Transrepression.

  2015cites this paper
• ELK1 is up-regulated by androgen in bladder cancer cells and promotes tumor progression

  2015cites this paper
• Involvement of the Androgen and Glucocorticoid Receptors in Bladder Cancer

  2015cites this paper
• Steroid Hormone Receptor Signals as Prognosticators for Urothelial Tumor

  2015cites this paper
• The emerging role of the androgen receptor in bladder cancer.

  2015influential citation
• Dehydroepiandrosterone Derivatives as Potent Antiandrogens with Marginal Agonist Activity

  2015cites this paper
• Expression of UDP‐glucuronosyltransferase 1A in bladder cancer: Association with prognosis and regulation by estrogen

  2014cites this paper
• Loss of GATA3 in bladder cancer promotes cell migration and invasion

  2014cites this paper
• Activated androgen receptor promotes bladder cancer metastasis via Slug mediated epithelial-mesenchymal transition.

  2014cites this paper
• GATA3 in the urinary bladder: suppression of neoplastic transformation and down-regulation by androgens.

  2014cites this paper
• Androgen deprivation therapy prevents bladder cancer recurrence

  2014cites this paper
• Epidermal growth factor enhances androgen receptor‑mediated bladder cancer progression and invasion via potentiation of AR transactivation.

  2013cites this paper
• Higher expression of peroxisome proliferator-activated receptor γ or its activation by agonist thiazolidinedione-rosiglitazone promotes bladder cancer cell migration and invasion.

  2013cites this paper
• Androgen receptor signals regulate UDP‐glucuronosyltransferases in the urinary bladder: A potential mechanism of androgen‐induced bladder carcinogenesis

  2013cites this paper
• Androgen receptor may be responsible for gender disparity in gastric cancer.

  2013cites this paper
• Androgen activates b -catenin signaling in bladder cancer cells

  2013cites this paper
• The Crosstalk of c-MET with Related Receptor Tyrosine Kinases in Urothelial Bladder Cancer

  2013cites this paper
• Androgen activates β-catenin signaling in bladder cancer cells.

  2013influential citation
• Current world literature.

  2012cites this paper
• Epidermal growth factor induces bladder cancer cell proliferation through activation of the androgen receptor

  2012influential citation
• GATA binding protein 3 is down-regulated in bladder cancer yet strong expression is an independent predictor of poor prognosis in invasive tumor.

  2012cites this paper
• Contrary Regulation of Bladder Cancer Cell Proliferation and Invasion by Dexamethasone-Mediated Glucocorticoid Receptor Signals

  2012influential citation
• Nuclear hormone receptor signals as new therapeutic targets for urothelial carcinoma.

  2012cites this paper
• Androgen receptor in human health: a potential therapeutic target.

  2012cites this paper
• The role of the androgen receptor in the development and progression of bladder cancer.

  2012cites this paper