A mutant telomerase defective in nuclear‐cytoplasmic shuttling fails to immortalize cells and is associated with mitochondrial dysfunction

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Aging Cell

• Publication date

  2010-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1474-9726.2010.00551.xPMID 20089117
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mitochondrial Telomerase Reverse Transcriptase Binds to and Protects Mitochondrial DNA and Function From Damage

  2009influential reference
• Analysis of Oxidative Damage by Gene‐Specific Quantitative PCR

  2009influential reference
• Ionizing Radiation Up-regulates Telomerase Activity in Cancer Cell Lines by Post-translational Mechanism via Ras/Phosphatidylinositol 3-Kinase/Akt Pathway

  2009influential reference
• Faculty Opinions recommendation of An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA.

  2009cited by this paper
• An RNA dependent RNA polymerase formed by hTERT and the RNase MRP RNA

  2009cited by this paper
• Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress

  2008influential reference
• Proteomic and oxidative stress analysis in human brain samples of Huntington disease.

  2008cited by this paper
• How mitochondria produce reactive oxygen species

  2008cited by this paper
• Nuclear Protein Tyrosine Phosphatase Shp-2 Is One Important Negative Regulator of Nuclear Export of Telomerase Reverse Transcriptase*

  2008influential reference
• Anecdotal, Historical and Critical Commentaries on Genetics: Mitochondria as Chi

  2008cited by this paper
• Homocysteine levels and leukocyte telomere length.

  2008cited by this paper
• Cellular senescence: when bad things happen to good cells

  2007cited by this paper
• Mitochondrial Dysfunction Accounts for the Stochastic Heterogeneity in Telomere-Dependent Senescence

  2007cited by this paper
• Oxidative Stress Overrides the Spindle Checkpoint

  2007cited by this paper
• Selective degradation of mitochondria by mitophagy.

  2007cited by this paper
• Oxidative stress induces the endoplasmic reticulum stress and facilitates inclusion formation in cultured cells.

  2007cited by this paper
• Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis.

  2006influential reference
• The structure and function of telomerase reverse transcriptase.

  2006cited by this paper
• Mitochondrial and nuclear DNA defects in Saccharomyces cerevisiae with mutations in DNA polymerase gamma associated with progressive external ophthalmoplegia.

  2006cited by this paper
• Regulation of Cellular Immortalization and Steady-State Levels of the Telomerase Reverse Transcriptase through Its Carboxy-Terminal Domain

  2006cited by this paper
• Isolation of mitochondria with high respiratory control from primary cultures of neurons and astrocytes using nitrogen cavitation.

  2006cited by this paper
• Role of mitochondrial DNA in toxic responses to oxidative stress.

  2006cited by this paper
• Quantitative PCR-based measurement of nuclear and mitochondrial DNA damage and repair in mammalian cells.

  2006cited by this paper
• Mitochondrial and nuclear DNA defects in Saccharomyces cerevisiae with mutations in DNA polymerase γ associated with progressive external ophthalmoplegia

  2006cited by this paper
• The telomerase reverse transcriptase regulates chromatin state and DNA damage responses.

  2005cited by this paper
• Senescence and immortalization: role of telomeres and telomerase.

  2005cited by this paper
• Induction of hTERT expression and phosphorylation by estrogen via Akt cascade in human ovarian cancer cell lines

  2004influential reference
• Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a).

  2004influential reference
• Telomere length mediates the effects of telomerase on the cellular response to genotoxic stress.

  2004cited by this paper
• Mitochondrial hTERT exacerbates free‐radical‐mediated mtDNA damage

  2004influential reference
• Antioxidants Inhibit Nuclear Export of Telomerase Reverse Transcriptase and Delay Replicative Senescence of Endothelial Cells

  2004cited by this paper
• Quantitative analysis of gene-specific DNA damage in human spermatozoa.

  2003cited by this paper
• A DNA damage checkpoint response in telomere-initiated senescence

  2003cited by this paper
• DNA damage foci at dysfunctional telomeres.

  2003cited by this paper
• Reduction in frataxin causes progressive accumulation of mitochondrial damage.

  2003cited by this paper
• hTERT associates with human telomeres and enhances genomic stability and DNA repair

  2003cited by this paper
• Telomerase maintains telomere structure in normal human cells.

  2003cited by this paper
• The C terminus of the human telomerase reverse transcriptase is a determinant of enzyme processivity.

  2003cited by this paper
• Hydrogen Peroxide Triggers Nuclear Export of Telomerase Reverse Transcriptase via Src Kinase Family-Dependent Phosphorylation of Tyrosine 707

  2003cited by this paper
• Evidence That High Telomerase Activity May Induce a Senescent-like Growth Arrest in Human Fibroblasts*

  2003cited by this paper
• Nuclear factor-kappaB p65 mediates tumor necrosis factor alpha-induced nuclear translocation of telomerase reverse transcriptase protein.

  2003influential reference
• Asbestos induces mitochondrial DNA damage and dysfunction linked to the development of apoptosis.

  2003cited by this paper
• Cell Sorting Experiments Link Persistent Mitochondrial DNA Damage with Loss of Mitochondrial Membrane Potential and Apoptotic Cell Death*

  2003influential reference
• Nuclear Factor-κB p65 Mediates Tumor Necrosis Factor α-induced Nuclear Translocation of Telomerase Reverse Transcriptase Protein

  2003influential reference
• Measuring oxidative mtDNA damage and repair using quantitative PCR.

  2002influential reference
• Oxidative stress shortens telomeres.

  2002cited by this paper
• Telomerase contributes to tumorigenesis by a telomere length-independent mechanism

  2002cited by this paper
• Expression of Human Telomerase (hTERT) Does Not Prevent Stress-induced Senescence in Normal Human Fibroblasts but Protects the Cells from Stress-induced Apoptosis and Necrosis*

  2002cited by this paper
• Functional Analysis of the C-terminal Extension of Telomerase Reverse Transcriptase

  2002cited by this paper
• C-Terminal Regions of the Human Telomerase Catalytic Subunit Essential for In Vivo Enzyme Activity

  2002influential reference
• Mutations associated with base excision repair deficiency and methylation-induced genotoxic stress

  2002cited by this paper
• Cutting Edge: Telomerase Activation in Human T Lymphocytes Does Not Require Increase in Telomerase Reverse Transcriptase (hTERT) Protein But Is Associated with hTERT Phosphorylation and Nuclear Translocation

  2001influential reference
• Functional Multimerization of the Human Telomerase Reverse Transcriptase

  2001cited by this paper
• N-Terminal Domains of the Human Telomerase Catalytic Subunit Required for Enzyme Activity in Vivo

  2001influential reference
• Functional Regions of Human Telomerase Reverse Transcriptase and Human Telomerase RNA Required for Telomerase Activity and RNA-Protein Interactions

  2001cited by this paper
• Involvement of 14‐3‐3 proteins in nuclear localization of telomerase

  2000influential reference
• Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding.

  2000cited by this paper
• Sequence-specific DNA Cleavage by Fe2+-mediated Fenton Reactions Has Possible Biological Implications*

  1999cited by this paper
• Resistance to apoptosis in human cells conferred by telomerase function and telomere stability

  1999cited by this paper
• Expression profile of the putative catalytic subunit of the telomerase gene.

  1998cited by this paper
• Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization.

  1998cited by this paper
• Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types.

  1997cited by this paper
• Protein Phosphatase 2A Inhibits Nuclear Telomerase Activity in Human Breast Cancer Cells*

  1997influential reference
• Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress.

  1997cited by this paper

• Old Friends, New Faces in Endothelial Dysfunction and Senescence.

  2026cites this paper
• TERT promoter methylation predicts overall survival, immune cell infiltration and response to immunotherapy in clear cell renal cell carcinoma

  2025cites this paper
• Beyond Telomeres: Unveiling the Extratelomeric Functions of TERT in B-Cell Malignancies

  2025cites this paper
• How to measure and model cardiovascular aging

  2025cites this paper
• Telomeres, telomerase, and cancer: mechanisms, biomarkers, and therapeutics

  2025cites this paper
• TERT translocation as a Novel condition in Intrauterine Growth Restriction rats with early catch-up growth

  2025cites this paper
• Analysis of TERT mRNA Levels and Clinicopathological Features in Patients with Peritoneal Mesothelioma

  2025cites this paper
• Long-range PCR as a tool for evaluating mitochondrial DNA damage: Principles, benefits, and limitations of the technique.

  2025cites this paper
• mTORC1‐USP30‐LEF1 Cascade Regulates Cancer Stemness and Malignant Progression Through Mitonuclear Crosstalk

  2025cites this paper
• Recent Advances in DNA Systems for In Situ Telomerase Activity Detection and Imaging

  2025cites this paper
• EXTRA-NUCLEAR TERT COUNTERACTS OXIDATIVE STRESS AND PROMOTES PROGRESSION IN PAPILLARY THYROID CARCINOMA.

  2024cites this paper
• SIRT1 regulates the localization and stability of telomerase protein by direct interaction.

  2024cites this paper
• Telomere-based treatment strategy of cardiovascular diseases: imagination comes to reality

  2024cites this paper
• Upregulation of mitochondrial telomerase reverse transcriptase mediates the preventive effect of physical exercise on pathological cardiac hypertrophy via improving mitochondrial function and inhibiting oxidative stress.

  2023cites this paper
• Accumulation of TERT in mitochondria exerts two opposing effects on apoptosis

  2023cites this paper
• Post-Transcriptional and Post-Translational Modifications in Telomerase Biogenesis and Recruitment to Telomeres

  2023cites this paper
• The neuro-protective role of telomerase via TERT/TERF-2 in the acute phase of spinal cord injury

  2023cites this paper
• Arabidopsis telomerase takes off by uncoupling enzyme activity from telomere length maintenance in space

  2023cites this paper
• Leukocyte telomere length and mitochondrial DNA copy number associate with endothelial function in aging-related cardiovascular disease

  2023cites this paper
• Many Functions of Telomerase Components: Certainties, Doubts, and Inconsistencies

  2022influential citation
• Differential immunohistochemical expression of hTERT in lung cancer patients with and without idiopathic pulmonary fibrosis.

  2022cites this paper
• Telomerase As a Therapeutic Target in Cardiovascular Disease.

  2021cites this paper
• Accumulation of TERT in Mitochondria Shows Two Opposing Effects on Apoptosis

  2021cites this paper
• Role of Mitochondrial Protein Import in Age-Related Neurodegenerative and Cardiovascular Diseases

  2021cites this paper
• Reciprocal Inhibition of Immunogenic Performance in Mice of Two Potent DNA Immunogens Targeting HCV-Related Liver Cancer

  2021cites this paper
• Non-canonical Functions of Telomerase Reverse Transcriptase: Emerging Roles and Biological Relevance.

  2020cites this paper
• The altered expression of telomerase components and telomere-linked proteins may associate with ovarian aging in mouse.

  2020cites this paper
• TERT—Regulation and Roles in Cancer Formation

  2020cites this paper
• Telomerase inhibition causes premature senescence of fetal guinea pig muscle cells

  2020cites this paper
• Developing Enzyme‐Responsive Nanomedicine for Inhibition of hTERT Mitochondrial Translocation

  2020cites this paper
• Telomerase Biogenesis and Activities from the Perspective of Its Direct Interacting Partners

  2020cites this paper
• Telomerase Impinges on the Cellular Response to Oxidative Stress Through Mitochondrial ROS-Mediated Regulation of Autophagy

  2019cites this paper
• Back to the future: The intimate and evolving connection between telomere-related factors and genotoxic stress

  2019cites this paper
• Nucleoside and Nucleotide Reverse Transcriptase Inhibitors Induce Aging by Inhibiting Telomerase Function

  2019cites this paper
• Telomerase Does Not Improve DNA Repair in Mitochondria upon Stress but Increases MnSOD Protein under Serum-Free Conditions

  2019cites this paper
• Mitochondrial Dysfunction in Aging and Cancer

  2019cites this paper
• Mitochondria, Telomeres and Telomerase Subunits

  2019cites this paper
• Mitochondrial DNA content of peripheral blood mononuclear cells in ART untreated & stavudine/zidovudine treated HIV-1-infected patients

  2018cites this paper
• Exercise, telomerase activity, and cardiovascular disease prevention

  2018cites this paper
• TERT regulates telomere-related senescence and apoptosis through DNA damage response in male germ cells exposed to BPDE in vitro and to B[a]P in vivo.

  2018cites this paper
• Exploiting TERT dependency as a therapeutic strategy for NRAS-mutant melanoma

  2018cites this paper
• The non-canonical functions of telomerase: to turn off or not to turn off

  2018cites this paper
• Transcriptional consequences of XPA disruption in human cell lines

  2017cites this paper
• Investigating the Protective Effects of Telomerase Reverse Transcriptase on Neuronal Metabolism and Resistance to Amyloid-beta

  2017cites this paper
• Current Insights to Regulation and Role of Telomerase in Human Diseases

  2017cites this paper
• Mitochondrial genetic variation and gout in Māori and Pacific people living in Aotearoa New Zealand

  2017cites this paper
• 37 kDa LRP::FLAG enhances telomerase activity and reduces senescent markers in vitro

  2017cites this paper
• ZBTB48 is both a vertebrate telomere‐binding protein and a transcriptional activator

  2017cites this paper
• Excitotoxic and Radiation Stress Increase TERT Levels in the Mitochondria and Cytosol of Cerebellar Purkinje Neurons

  2016cites this paper
• Stem cell mitochondria during aging.

  2016cites this paper
• Critical Role for Telomerase in the Mechanism of Flow-Mediated Dilation in the Human Microcirculation

  2016cites this paper
• Differential Protein Distribution between the Nucleus and Mitochondria: Implications in Aging

  2016cites this paper
• Role of XPD in cellular functions: To TFIIH and beyond.

  2016cites this paper
• Does telomerase protein protect our neurons

  2016cites this paper
• The Role of Telomere Maintenance in Adult Mammalian Acute Central Nervous System Injury and Retinal Ganglion Cell Apoptosis

  2016cites this paper
• Pacific People, Metabolic Disease and Evolutionary Processes: a mitochondrial DNA study

  2016cites this paper
• Contributions of Telomere Biology to Human Age-Related Disease

  2016cites this paper
• Metabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis?

  2015cites this paper
• Effects of Mitochondrial Translocation of Telomerase on Drug Resistance in Hepatocellular Carcinoma Cells

  2015cites this paper
• Tissue formation and tissue engineering through host cell recruitment or a potential injectable cell-based biocomposite with replicative potential: Molecular mechanisms controlling cellular senescence and the involvement of controlled transient telomerase activation therapies.

  2015cites this paper
• Saccharomyces cerevisiae as a model for the study of extranuclear functions of mammalian telomerase

  2015cites this paper
• Mitochondrial Proteins Moonlighting in the Nucleus.

  2015cites this paper
• Biomolecular bases of the senescence process and cancer. A new approach to oncological treatment linked to ageing.

  2015cites this paper
• Inflammation, advancing age and nutrition

  2014cites this paper
• Telomerase reverse transcriptase in the regulation of gene expression

  2014cites this paper
• Extra-telomeric functions of human telomerase: cancer, mitochondria and oxidative stress.

  2014influential citation
• Cellular functions of the dual-targeted catalytic subunit of telomerase, telomerase reverse transcriptase--potential role in senescence and aging.

  2014cites this paper
• EFFECT OF OXIDATIVE STRESS ON HUMAN TELOMERIC DNA STRUCTURAL DYNAMICS AND ACCESSIBILITY

  2014cites this paper
• Telomere Biology in Senescence and Aging

  2014cites this paper
• The mitochondrial genome in aging and senescence.

  2014cites this paper
• Telomeres-structure, function, and regulation.

  2013cites this paper
• Mitochondrial dysfunction and nuclear‐mitochondrial shuttling of TERT are involved in cell proliferation arrest induced by G‐quadruplex ligands

  2013cites this paper
• MULTIFACTORIAL MODULATION OF THE BLOOD-BRAIN BARRIER: RELATIONSHIP TO STROKE

  2013cites this paper
• Telomerase regulation and the intimate relationship with aging

  2013cites this paper
• Localization of RNA-binding Proteins in Mature and Aging Neurons

  2013cites this paper
• The role of telomere biology in cancer.

  2013cites this paper
• Telomerase inhibition may contribute to accelerated mitochondrial aging induced by anti-retroviral HIV treatment.

  2013cites this paper
• The neuroprotective role and mechanisms of TERT in neurons with oxygen-glucose deprivation.

  2013cites this paper
• Implications of telomere‐independent activities of telomerase reverse transcriptase in human cancer

  2013cites this paper
• Mitochondrial Telomerase Protects Cancer Cells from Nuclear DNA Damage and Apoptosis

  2013cites this paper
• Conflict of interests: Multiple signal peptides with diverging goals

  2013cites this paper
• The role of telomerase in brain during ageing and under dietary restriction

  2013cites this paper
• The Endothelium Abridges Insulin Resistance to Premature Aging

  2013cites this paper
• Mitochondrial localisation of hTERT protects against nuclear DNA damage and mitochondrial ROS production after endogenous and exogenous stress

  2013influential citation
• Endothelial Dysfunction : Consequence and Predictor of Insulin Resistance and Metabolic Diseases

  2013cites this paper
• Increased telomerase activity and vitamin D supplementation in overweight African Americans

  2012cites this paper
• The Effects of Telomerase Inhibition on Cellular Senescence in Fetal Guinea Pig Muscle Cells

  2012cites this paper
• Extra-Telomeric Roles of Telomeric Proteins

  2012cites this paper
• In Vitro and Ex Vivo Inhibition of Human Telomerase by Anti-HIV Nucleoside Reverse Transcriptase Inhibitors (NRTIs) but Not by Non-NRTIs

  2012cites this paper
• Axis of ageing: telomeres, p53 and mitochondria

  2012cites this paper
• Telomerase Biogenesis: RNA Processing, Trafficking, and Protein Interactions

  2012cites this paper
• Human telomerase represses ROS-dependent cellular responses to Tumor Necrosis Factor-α without affecting NF-κB activation.

  2012cites this paper
• Abnormalities in Growth Control, Telomerase Activity, Apoptosis, and Angiogenesis Linked to Mitochondrial Dysfunction

  2012cites this paper
• Nuclear import of hTERT requires a bipartite nuclear localization signal and Akt-mediated phosphorylation

  2012cites this paper
• Telomere Lengthening and Other Functions of Telomerase


  2012cites this paper
• Telomerase reverse transcriptase: A novel neuroprotective mechanism involved in neonatal hypoxic‐ischemic brain injury

  2011cites this paper
• Telomere length in cardiovascular disease: new challenges in measuring this marker of cardiovascular aging.

  2011cites this paper
• PinX1 the tail on the chromosome.

  2011cites this paper
• eview elomerase reverse transcriptase : A novel neuroprotective mechanism involved n neonatal hypoxic-ischemic brain injury

  2011cites this paper
• Non-telomeric activities of telomerase.

  2011cites this paper