Neurotensin receptor mechanisms and its modulation of glutamate transmission in the brain: relevance for neurodegenerative diseases and their treatment.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Progress in neurobiology

• Publication date

  2007-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.PNEUROBIO.2007.06.006PMID 17673354
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell death

  2007cited by this paper
• Adenosine A2A and dopamine D2 heteromeric receptor complexes and their function

  2007cited by this paper
• NTS2 modulates the intracellular distribution and trafficking of NTS1 via heterodimerization.

  2007cited by this paper
• Selective elimination of glutamatergic synapses on striatopallidal neurons in Parkinson disease models

  2006cited by this paper
• Novel treatments of schizophrenia: targeting the neurotensin system.

  2006cited by this paper
• Intramembrane receptor–receptor interactions: a novel principle in molecular medicine

  2006cited by this paper
• New targets for pharmacological intervention in the glutamatergic synapse.

  2006cited by this paper
• Receptor–receptor interactions as studied with microdialysis. Focus on NTR/D2 interactions in the basal ganglia

  2006cited by this paper
• Bidirectional regulation of dopamine D2 and neurotensin NTS1 receptors in dopamine neurons

  2006cited by this paper
• Amphetamine-elicited striatal Fos expression is attenuated in neurotensin null mutant mice.

  2006cited by this paper
• The role of neurotensin in central nervous system pathophysiology: what is the evidence?

  2006cited by this paper
• Neurotensin: role in psychiatric and neurological diseases.

  2006cited by this paper
• Neurotensin selectively facilitates glutamatergic transmission in globus pallidus.

  2006cited by this paper
• Neurotensin peptides antagonistically regulate postsynaptic dopamine D2 receptors in rat nucleus accumbens: a receptor binding and microdialysis study

  2005cited by this paper
• Neurotensin Activates GABAergic Interneurons in the Prefrontal Cortex

  2005cited by this paper
• L-DOPA reverses the MPTP-induced elevation of the arrestin2 and GRK6 expression and enhanced ERK activation in monkey brain.

  2005cited by this paper
• Concurrent Stimulation of Cannabinoid CB1 and Dopamine D2 Receptors Enhances Heterodimer Formation: A Mechanism for Receptor Cross-Talk?

  2005cited by this paper
• Homeostatic plasticity and NMDA receptor trafficking.

  2005cited by this paper
• Pathogenesis of nigral cell death in Parkinson's disease.

  2005cited by this paper
• Role of glutamate in neurodegeneration of dopamine neurons in several animal models of parkinsonism

  2005cited by this paper
• Neurokinin B, Neurotensin, and Cannabinoid Receptor Antagonists and Parkinson Disease

  2004cited by this paper
• Electron microscopic dual labeling of high‐affinity neurotensin and dopamine D2 receptors in the rat nucleus accumbens shell

  2004cited by this paper
• Neurotensin, schizophrenia, and antipsychotic drug action.

  2004cited by this paper
• Endogenous neurotensin attenuates dopamine-dependent locomotion and stereotypy.

  2004cited by this paper
• Neurotensin Receptor Antagonist SR 142948A Alters Fos Expression and Extrapyramidal Side Effect Profile of Typical and Atypical Antipsychotic Drugs

  2004cited by this paper
• Role of Calcium in Neurotensin-Evoked Enhancement in Firing in Mesencephalic Dopamine Neurons

  2004cited by this paper
• Blockade of neurotensin receptors affects differently hypo-locomotion and catalepsy induced by haloperidol in mice.

  2004cited by this paper
• Neurotensin enhances endogenous extracellular glutamate levels in primary cultures of rat cortical neurons: involvement of neurotensin receptor in NMDA induced excitotoxicity.

  2004cited by this paper
• Role of store-dependent influx of Ca2+ and efflux of K+ in apoptosis of CHO cells.

  2004cited by this paper
• Neurotensin: dual roles in psychostimulant and antipsychotic drug responses.

  2003cited by this paper
• Chronic activation of ERK and neurodegenerative diseases

  2003cited by this paper
• Changes in dialysate concentrations of glutamate and GABA in the brain: an index of volume transmission mediated actions?

  2003cited by this paper
• Molecular Mechanisms and Therapeutical Implications of Intramembrane Receptor/Receptor Interactions among Heptahelical Receptors with Examples from the Striatopallidal GABA Neurons

  2003cited by this paper
• Central administration of the neurotensin receptor antagonist SR48692 attenuates vacuous chewing movements in a rodent model of tardive dyskinesia.

  2003cited by this paper
• Involvement of the Neurotensin Receptor-3 in the Neurotensin-Induced Migration of Human Microglia

  2003cited by this paper
• Neurotensin-induced modulation of dopamine D2 receptors and their function in rat striatum: Counteraction by a NTR1-like receptor antagonist

  2002cited by this paper
• The neuronal environment : brain homeostasis in health and disease

  2002cited by this paper
• An Endoplasmic Reticulum Stress-specific Caspase Cascade in Apoptosis

  2002cited by this paper
• Riluzole prolongs survival time and alters nuclear inclusion formation in a transgenic mouse model of Huntington's disease

  2002cited by this paper
• Presynaptic action of neurotensin on cultured ventral tegmental area dopaminergic neurones.

  2002cited by this paper
• Neurotensin regulates DARPP‐32 Thr34 phosphorylation in neostriatal neurons by activation of dopamine D1‐type receptors

  2002cited by this paper
• Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

  2002cited by this paper
• Neurotensin enhances glutamate excitotoxicity in mesencephalic neurons in primary culture

  2002cited by this paper
• Cytoplasmic aggregates of phosphorylated extracellular signal-regulated protein kinases in Lewy body diseases.

  2002cited by this paper
• Neurotensin receptor-1 and -3 complex modulates the cellular signaling of neurotensin in the HT29 cell line.

  2002cited by this paper
• The Developing Nervous System: A Series of Review Articles: Neurobiology of Hypoxic-Ischemic Injury in the Developing Brain

  2001cited by this paper
• Neurotensin and dopamine interactions.

  2001cited by this paper
• Neurotensin-deficient mice show altered responses to antipsychotic drugs

  2001cited by this paper
• Antiparkinson-like effects of a novel neurotensin analog in unilaterally 6-hydroxydopamine lesioned rats.

  2001cited by this paper
• Sustained extracellular signal‐regulated kinase activation by 6‐hydroxydopamine: implications for Parkinson's disease

  2001cited by this paper
• Pharmacological properties of the mouse neurotensin receptor 3. Maintenance of cell surface receptor during internalization of neurotensin

  2001cited by this paper
• Memory mechanisms: the yin and yang of protein phosphorylation.

  2001cited by this paper
• Protein kinase C modulates NMDA receptor trafficking and gating

  2001cited by this paper
• Sortilin/neurotensin receptor-3: a new tool to investigate neurotensin signaling and cellular trafficking?

  2001cited by this paper
• Activation and Functional Characterization of the Mosaic Receptor SorLA/LR11*

  2001cited by this paper
• mGluR1-mediated potentiation of NMDA receptors involves a rise in intracellular calcium and activation of protein kinase C.

  2001cited by this paper
• Transmitter-Receptor Mismatches in Central Dopamine, Serotonin, and Neuropeptide Systems: Further Evidence for Volume Transmission

  2001cited by this paper
• Agonism, inverse agonism, and neutral antagonism at the constitutively active human neurotensin receptor 2.

  2001cited by this paper
• Nigral neurotensin receptor regulation of nigral glutamate and nigroventral thalamic GABA transmission: a dual-probe microdialysis study in intact conscious rat brain.

  2001cited by this paper
• The neurotensin antagonist SR 48692 attenuates haloperidol-induced striatal Fos expression in the rat.

  2001cited by this paper
• Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

  2000cited by this paper
• NMDA receptors modulate dopamine loss due to energy impairment in the substantia nigra but not striatum.

  2000cited by this paper
• Control of apoptosis by IP(3) and ryanodine receptor driven calcium signals.

  2000cited by this paper
• Modulation of glutamate neurotoxicity on mesencephalic dopaminergic neurons in primary cultures by the presence of striatal target cells

  2000cited by this paper
• Effects of a novel neurotensin peptide analog given extracranially on CNS behaviors mediated by apomorphine and haloperidol.

  2000cited by this paper
• Persistent Activation of ERK Contributes to Glutamate-induced Oxidative Toxicity in a Neuronal Cell Line and Primary Cortical Neuron Cultures*

  2000cited by this paper
• Neurotensin increases endogenous glutamate release in rat cortical slices.

  2000cited by this paper
• Volume transmission revisited

  2000cited by this paper
• Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity.

  2000cited by this paper
• The role of excitotoxicity in neurodegenerative disease: implications for therapy.

  1999cited by this paper
• Neurotensin receptors and dopamine transporters: Effects of MPTP lesioning and chronic dopaminergic treatments in monkeys

  1999cited by this paper
• Pharmacological, molecular and functional characterization of glial neurotensin receptors.

  1999cited by this paper
• Alteration of neurotensin receptors in MPTP-treated mice.

  1999cited by this paper
• Neurotensin and neurotensin receptors.

  1999cited by this paper
• The role of excitotoxicity in neurodegenerative disease: implications for therapy.

  1999cited by this paper
• Atypical antipsychotic drugs selectively increase neurotensin efflux in dopamine terminal regions.

  1998cited by this paper
• Widespread expression in adult rat forebrain of mRNA encoding high‐affinity neurotensin receptor

  1998cited by this paper
• Stimulation by neurotensin of (3H)5-hydroxytryptamine (5HT) release from rat frontal cortex slices.

  1998cited by this paper
• Integrated events in central dopamine transmission as analyzed at multiple levels. Evidence for intramembrane adenosine A2A/dopamine D2 and adenosine A1/dopamine D1 receptor interactions in the basal ganglia.

  1998cited by this paper
• The Striatal Neurotensin Receptor Modulates Striatal and Pallidal Glutamate and GABA Release: Functional Evidence for a Pallidal Glutamate–GABA Interaction via the Pallidal–Subthalamic Nucleus Loop

  1998cited by this paper
• Dopamine D1 Receptors Facilitate GABAASynaptic Currents in the Rat Substantia Nigra Pars Reticulata

  1998cited by this paper
• Correlative Ultrastructural Distribution of Neurotensin Receptor Proteins and Binding Sites in the Rat Substantia Nigra

  1998cited by this paper
• Electrically evoked [3H]GABA release from cerebral cortical cultures: An in vitro approach for studying glutamate‐induced neurotoxicity

  1998cited by this paper
• Localization of ionotropic and metabotropic glutamate receptors in distinct neuronal elements of the rat substantia nigra.

  1998cited by this paper
• Glutamic acid and Alzheimer's disease.

  1998cited by this paper
• Increased contribution of NR2A subunit to synaptic NMDA receptors in developing rat cortical neurons

  1998cited by this paper
• Micromolar L-glutamate induces extensive apoptosis in an apoptotic-necrotic continuum of insult-dependent, excitotoxic injury in cultured cortical neurones.

  1998cited by this paper
• Electrophysiological evidence for putative subtypes of neurotensin receptors in guinea-pig mesencephalic dopaminergic neurons.

  1998cited by this paper
• Involvement of potentially distinct neurotensin receptors in neurotensin-induced stimulation of striatal [3H]dopamine release evoked by KCl versus electrical depolarization.

  1997cited by this paper
• Differential Effects of lntrastriatal Neurotensin(1–13) and Neurotensin(8–13) on Striatal Dopamine and Pallidal GABA Release. A Dual‐probe Microdialysis Study in the Awake Rat

  1997cited by this paper
• Biochemical and pharmacological activities of SR 142948A, a new potent neurotensin receptor antagonist.

  1997cited by this paper
• Use of Nonpeptide Antagonists to Explore the Physiological Roles of Neurotensin

  1997cited by this paper
• Differential Binding Profile and Internalization Process of Neurotensin via Neuronal and Glial Receptors

  1997cited by this paper
• Modulation of dopamine neuronal activity by glutamate receptor subtypes.

  1997cited by this paper
• Molecular cloning of a levocabastine‐sensitive neurotensin binding site

  1996cited by this paper
• 6-Hydroxydopamine induces the loss of the dopaminergic phenotype in substantia nigra neurons of the rat

  1996cited by this paper
• Morphologically distinct subpopulations of neurotensin-immunoreactive striatal neurons observed in rat following dopamine depletions and D2 receptor blockade project to the globus pallidus.

  1996cited by this paper
• Alterations in peptide levels in Parkinson's disease and incidental Lewy body disease.

  1996cited by this paper
• Dual character, asynaptic and synaptic, of the dopamine innervation in adult rat neostriatum: A quantitative autoradiographic and immunocytochemical analysis

  1996cited by this paper
• The neurotensin receptor antagonist SR 48692 decreases extracellular striatal GABA in rats.

  1996cited by this paper

• Transcriptomic and Proteomic Changes in the Brain Along with Increasing Phenotypic Severity in a Rat Model of Neonatal Hyperbilirubinemia

  2025cites this paper
• Mechanisms underlying delirium in patients with critical illness

  2024cites this paper
• Demystifying the Neuroprotective Role of Neuropeptides in Parkinson’s Disease: A Newfangled and Eloquent Therapeutic Perspective

  2022cites this paper
• Plasma Proneurotensin and Prediction of Cause-Specific Mortality in a Middle-aged Cohort During Long-term Follow-up

  2021cites this paper
• The role of neurotensin receptor 1 on fear memory in mice

  2021cites this paper
• The Emerging Role of Neuropeptides in Parkinson’s Disease

  2021cites this paper
• Impact of polyphenols on receptor–ligand interactions by NMR: the case of neurotensin (NT)–neurotensin receptor fragment (NTS1) complex

  2020cites this paper
• The combination of opioid and neurotensin receptor agonists improves their analgesic/adverse effect ratio

  2019cites this paper
• Journal of Reproduction and Development

  2019cites this paper
• Brain Dopamine Transmission in Health and Parkinson's Disease: Modulation of Synaptic Transmission and Plasticity Through Volume Transmission and Dopamine Heteroreceptors

  2018cites this paper
• Ginsenoside Rb1 confers neuroprotection via promotion of glutamate transporters in a mouse model of Parkinson's disease

  2018cites this paper
• In vivo N-15 MRS study of glutamate metabolism in the rat brain.

  2017cites this paper
• Modulation of excitatory neurotransmission by neuronal/glial signalling molecules: interplay between purinergic and glutamatergic systems

  2016cites this paper
• Neurotensin: A role in substance use disorder?

  2016cites this paper
• Molecular characterization of Thy1 expressing fear-inhibiting neurons within the basolateral amygdala

  2016cites this paper
• Xenin-induced feeding suppression is not mediated through the activation of central extracellular signal-regulated kinase signaling in mice.

  2016cites this paper
• Neurotensinergic modulation of glutamatergic neurotransmission in VTA neurons

  2016cites this paper
• New extracellular factors in glioblastoma multiforme development: neurotensin, growth differentiation factor-15, sphingosine-1-phosphate and cytomegalovirus infection

  2015cites this paper
• Ventral Midbrain NTS1 Receptors Mediate Conditioned Reward Induced by the Neurotensin Analog, D-Tyr[11]neurotensin

  2015cites this paper
• Diferents estats d’oligomerització entre els receptors 5-HT1A, GALR1 I GPR39 com a noves dianes terapèutiques en depressió

  2015cites this paper
• Neurotensin enhances glutamatergic EPSCs in VTA neurons by acting on different neurotensin receptors.

  2015cites this paper
• INTRACRANIAL INFUSIONS OF NEUROTENSIN AGONISTS PRODUCE AN ANXIOLYTIC PROFILE IN A RAT ULTRASONIC VOCALIZATION MODEL

  2015cites this paper
• Neurotensin Enhances Sperm Capacitation and Acrosome Reaction in Mice

  2014cites this paper
• Neurotensin-Like Peptides as Potential Antipsychotics: Modulation of the Serotonin System

  2014cites this paper
• Microfluidics based techniques for electrophysiological studies of cells

  2014cites this paper
• Neurotensin NTS1-dopamine D2 receptor-receptor interactions in putative receptor heteromers: relevance for Parkinson's disease and schizophrenia.

  2014cites this paper
• G-protein-coupled receptors oligomerization: emerging signaling units and new opportunities for drug design.

  2014cites this paper
• Neurotensin Receptor 1 Gene Polymorphisms Are Associated with Personality Traits in Healthy Chinese Individuals

  2013cites this paper
• Association Between Neurotensin Receptor 1 (NTR1) Gene Polymorphisms and Schizophrenia in a Han Chinese Population

  2013cites this paper
• Diverse Roles of Neurotensin Agonists in the Central Nervous System

  2013cites this paper
• Exploring the Multifactorial Nature of Autism Through Computational Systems Biology: Calcium and the Rho GTPase RAC1 Under the Spotlight

  2013cites this paper
• Receptor to glutamate NMDA-type: the functional diversity of the nr1 isoforms and pharmacological properties.

  2013cites this paper
• Striatal NTS1, dopamine D2 and NMDA receptor regulation of pallidal GABA and glutamate release – a dual‐probe microdialysis study in the intranigral 6‐hydroxydopamine unilaterally lesioned rat

  2012cites this paper
• Nitrogen Metabolism In Vivo

  2012cites this paper
• Guide to Receptors and Channels (GRAC), 5th edition

  2011cites this paper
• Neurotensin regulates cortical glutamate transmission by modulating N‐methyl‐D‐aspartate receptor functional activity: An in vivo microdialysis study

  2011cites this paper
• NT69L blocks ethanol-induced increase of dopamine and glutamate levels in striatum of mouse.

  2011cites this paper
• Contribution of neurotensin in the immune and neuroendocrine modulation of normal and abnormal enteric function.

  2011cites this paper
• Effect of amphetamine on extracellular concentrations of amino acids in striatum in neurotensin subtype 1 and 2 receptor null mice: a possible interaction between neurotensin receptors and amino acid systems for study of schizophrenia.

  2010cites this paper
• The novel neurotensin analog NT69L blocks phencyclidine (PCP)-induced increases in locomotor activity and PCP-induced increases in monoamine and amino acids levels in the medial prefrontal cortex.

  2010cites this paper
• Similarities in the behavior and molecular deficits in the frontal cortex between the neurotensin receptor subtype 1 knockout mice and chronic phencyclidine-treated mice: relevance to schizophrenia.

  2010cites this paper
• Neurotensin promotes the dendrite elongation and the dendritic spine maturation of the cerebral cortex in vitro.

  2010cites this paper
• Dopamine Receptor Oligomerization

  2010cites this paper
• Ligand-based peptide design and combinatorial peptide libraries to target G protein-coupled receptors.

  2010cites this paper
• Piracetam and Piracetam-Like Drugs

  2010cites this paper
• Targeting neurotensin as a potential novel approach for the treatment of autism

  2010cites this paper
• Integrated signaling in heterodimers and receptor mosaics of different types of GPCRs of the forebrain: relevance for schizophrenia

  2009cites this paper
• Emerging evidence for neurotensin receptor 1 antagonists as novel pharmaceutics in neurodegenerative disorders.

  2009cites this paper
• Guide to Receptors and Channels (GRAC), 4th edition

  2009cites this paper
• Biology of Neurotensin: Revisited Study

  2008cites this paper
• Neurotensin receptor involvement in the rise of extracellular glutamate levels and apoptotic nerve cell death in primary cortical cultures after oxygen and glucose deprivation.

  2008cites this paper
• Novel insights into GPCR-peptide interactions: mutations in extracellular loop 1, ligand backbone methylations and molecular modeling of neurotensin receptor 1.

  2008cites this paper
• Piracetam and Piracetam-Like Drugs From Basic Science to Novel Clinical Applications to CNS Disorders

  year unknowncites this paper