Hepatitis C virus mutation affects proteasomal epitope processing.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Journal of Clinical Investigation

• Publication date

  2004-07-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1172/JCI20985PMID 15254592PMCID PMC449747
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Reversion of CTL escape–variant immunodeficiency viruses in vivo

  2004cited by this paper
• Memory CD8+ T Cells Are Required for Protection from Persistent Hepatitis C Virus Infection

  2003cited by this paper
• HCV Persistence and Immune Evasion in the Absence of Memory T Cell Help

  2003cited by this paper
• An essential role for tripeptidyl peptidase in the generation of an MHC class I epitope

  2003cited by this paper
• Novel CD4+ and CD8+ T‐cell determinants within the NS3 protein in subjects with spontaneously resolved HCV infection

  2003cited by this paper
• Impaired Effector Function of Hepatitis C Virus-Specific CD8+ T Cells in Chronic Hepatitis C Virus Infection1

  2002cited by this paper
• Identification of vaccinia virus epitope-specific HLA-A*0201-restricted T cells and comparative analysis of smallpox vaccines

  2002cited by this paper
• Evidence of HIV-1 Adaptation to HLA-Restricted Immune Responses at a Population Level

  2002cited by this paper
• Link between Organ-specific Antigen Processing by 20S Proteasomes and CD8+ T Cell–mediated Autoimmunity

  2002cited by this paper
• Molecular Cloning: A Laboratory Manual

  2001cited by this paper
• Interferon-γ inducible exchanges of 20S proteasome active site subunits: Why?

  2001cited by this paper
• Immunoproteasomes Largely Replace Constitutive Proteasomes During an Antiviral and Antibacterial Immune Response in the Liver1

  2001cited by this paper
• Ubiquitin and proteasomes: Antigen processing by the proteasome

  2001cited by this paper
• Determinants of Viral Clearance and Persistence during Acute Hepatitis C Virus Infection

  2001cited by this paper
• Interferon-gamma inducible exchanges of 20S proteasome active site subunits: why?

  2001cited by this paper
• Oral immunization with HCV-NS3-transformed Salmonella: induction of HCV-specific CTL in a transgenic mouse model.

  2001cited by this paper
• The outcome of hepatitis C virus infection is predicted by escape mutations in epitopes targeted by cytotoxic T lymphocytes.

  2001cited by this paper
• Virus‐specific CD8+ T cells with type 1 or type 2 cytokine profile are related to different disease activity in chronic hepatitis C virus infection

  2001cited by this paper
• Overexpression of the Proteasome Subunits LMP2, LMP7, and MECL-1, But Not PA28α/β, Enhances the Presentation of an Immunodominant Lymphocytic Choriomeningitis Virus T Cell Epitope1

  2000cited by this paper
• The outcome of acute hepatitis C predicted by the evolution of the viral quasispecies.

  2000cited by this paper
• Two new proteases in the MHC class I processing pathway

  2000cited by this paper
• Association of hepatitis C virus-specific CD8+ T cells with viral clearance in acute hepatitis C.

  2000cited by this paper
• Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis C

  2000influential reference
• Abrogation of CTL Epitope Processing by Single Amino Acid Substitution Flanking the C-Terminal Proteasome Cleavage Site1

  2000cited by this paper
• Analysis of Successful Immune Responses in Persons Infected with Hepatitis C Virus

  2000cited by this paper
• Efficient Generation of a Hepatitis B Virus Cytotoxic T Lymphocyte Epitope Requires the Structural Features of Immunoproteasomes

  2000cited by this paper
• CD8+ T lymphocyte responses are induced during acute hepatitis C virus infection but are not sustained

  2000cited by this paper
• Low frequency of cirrhosis in a hepatitis C (genotype 1b) single‐source outbreak in germany: A 20‐year multicenter study

  2000cited by this paper
• MHC Class I Antigen Processing of an Adenovirus CTL Epitope Is Linked to the Levels of Immunoproteasomes in Infected Cells1

  2000cited by this paper
• Vigorous peripheral blood cytotoxic T cell response during the acute phase of hepatitis C virus infection.

  2000cited by this paper
• Efficient Processing of the Immunodominant, HLA-A*0201-Restricted Human Immunodeficiency Virus Type 1 Cytotoxic T-Lymphocyte Epitope despite Multiple Variations in the Epitope Flanking Sequences

  1999cited by this paper
• Distinct proteolytic processes generate the C and N termini of MHC class I-binding peptides.

  1999cited by this paper
• Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy.

  1998cited by this paper
• Hepatitis C Viral Dynamics in Vivo and the Antiviral Efficacy of Interferon-α Therapy

  1998cited by this paper
• The Sequence Alteration Associated with a Mutational Hotspot in p53 Protects Cells From Lysis by Cytotoxic T Lymphocytes Specific for a Flanking Peptide Epitope

  1998cited by this paper
• Hepatitis C virus variants circumventing cytotoxic T lymphocyte activity as a mechanism of chronicity.

  1998cited by this paper
• Mechanisms of MHC class I--restricted antigen processing.

  1998cited by this paper
• Interferon-γ Can Stimulate Post-proteasomal Trimming of the N Terminus of an Antigenic Peptide by Inducing Leucine Aminopeptidase*

  1998cited by this paper
• Immunological significance of cytotoxic T lymphocyte epitope variants in patients chronically infected by the hepatitis C virus.

  1997influential reference
• Two distinct proteolytic processes in the generation of a major histocompatibility complex class I-presented peptide.

  1997cited by this paper
• Cloning and characterization of a complete open reading frame of the hepatitis C virus genome in only two cDNA fragments.

  1997cited by this paper
• Quantitative analysis of the peripheral blood cytotoxic T lymphocyte response in patients with chronic hepatitis C virus infection.

  1996cited by this paper
• Importance of MHC class 1 alpha2 and alpha3 domains in the recognition of self and non-self MHC molecules.

  1996cited by this paper
• Differential cytotoxic T-lymphocyte responsiveness to the hepatitis B and C viruses in chronically infected patients

  1996cited by this paper
• HLA class I-restricted cytotoxic T lymphocytes specific for hepatitis C virus. Identification of multiple epitopes and characterization of patterns of cytokine release.

  1995cited by this paper
• Contribution of proteasome-mediated proteolysis to the hierarchy of epitopes presented by major histocompatibility complex class I molecules.

  1995cited by this paper
• Persistent hepatitis C virus infection in a chimpanzee is associated with emergence of a cytotoxic T lymphocyte escape variant.

  1995cited by this paper
• The Interferon-γ-inducible 11 S Regulator (PA28) and the LMP2/LMP7 Subunits Govern the Peptide Production by the 20 S Proteasome in Vitro(*)

  1995cited by this paper
• Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection.

  1995cited by this paper
• Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLA A2.1 binding motif.

  1995cited by this paper
• Cytotoxic T-cell activity antagonized by naturally occurring HIV-1 Gag variants

  1994cited by this paper
• Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells

  1994cited by this paper
• Efficient processing of an antigenic sequence for presentation by MHC class I molecules depends on its neighboring residues in the protein.

  1991cited by this paper
• The secretory core protein of human hepatitis B virus is expressed on the cell surface

  1989cited by this paper

• Brain endothelial cells exposure to malaria parasites links type I interferon signalling to antigen presentation, immunoproteasome activation, endothelium disruption, and cellular metabolism

  2023cites this paper
• Integrated Clinical, Molecular and Immunological Characterization of Pulmonary Sarcomatoid Carcinomas Reveals an Immune Escape Mechanism That May Influence Therapeutic Strategies

  2023cites this paper
• Brain endothelial cells exposure to malaria parasites links Type I interferon signalling to antigen presentation, immunoproteasome activation, endothelium disruption and cell metabolic adaptation

  2022cites this paper
• CD8+ T-Cell Exhaustion Phenotype in Chronic Hepatitis C Virus Infection Is Associated With Epitope Sequence Variation

  2022cites this paper
• Proteasomal Processing Immune Escape Mechanisms in Platinum-Treated Advanced Bladder Cancer

  2022cites this paper
• Adaptive Immune Responses, Immune Escape and Immune-Mediated Pathogenesis during HDV Infection

  2022cites this paper
• Immune escape pathways from the HBV core18-27 CD8 T cell response are driven by individual HLA class I alleles

  2022cites this paper
• A Novel Epitope Quality-Based Immune Escape Mechanism Reveals Patient’s Suitability for Immune Checkpoint Inhibition

  2020cites this paper
• Sub-genomic analysis of Chikungunya virus E2 mutations in Pakistani isolates potentially modulating B-cell & T-Cell immune response

  2020cites this paper
• T-Cell Immunity against the Hepatitis C Virus: A Persistent Research Priority in an Era of Highly Effective Therapy.

  2020cites this paper
• Major Advances in Hepatitis C Treatment but Not Hepatitis B

  2020cites this paper
• Adaptive Immune Response against Hepatitis C Virus

  2020cites this paper
• Beyond Metabolism: Role of the Immune System in Hepatic Toxicity

  2020cites this paper
• CMAR_A_258396 7881..7890

  2020cites this paper
• Tuning antiviral CD8 T-cell response via proline-altered peptide ligand vaccination

  2019cites this paper
• Hepatitis C Virus Infection: Host–Virus Interaction and Mechanisms of Viral Persistence

  2019cites this paper
• Mutations in Hepatitis D Virus Allow It to Escape Detection by CD8+ T Cells and Evolve at the Population Level

  2019cites this paper
• HCV-Specific T Cell Responses During and After Chronic HCV Infection

  2018cites this paper
• Strategies for immune evasion by human tumor viruses.

  2018cites this paper
• Lost in the crowd: identifying targetable MHC class I neoepitopes for cancer immunotherapy

  2018cites this paper
• Processing Escape Mechanisms Through Altered Proteasomal Cleavage of Epitopes Affect Immune Response in Pulmonary Neuroendocrine Tumors

  2018cites this paper
• Mechanism of immune escape from CD8+ T cell response in hepatitis delta virus infection

  2017cites this paper
• Statistical analysis of sequence populations in virology and immunology (Statistische Analyse von Sequenzpopulationen in der Virologie und Immunologie)

  2017cites this paper
• Processing Escapes: A New Perspective on Immune Escape Mechanisms

  2017cites this paper
• Prediction of cleavage fragments generated by the proteasome

  2016influential citation
• Influenza Virus-specific CD8+ T Cells : -longevity, cross-reactivity and viral evasion-

  2016cites this paper
• Strategies to enhance immunogenicity of cDNA vaccine encoded antigens by modulation of antigen processing.

  2016cites this paper
• Exposure to Melan-A/MART-126-35 tumor epitope specific CD8+T cells reveals immune escape by affecting the ubiquitin-proteasome system (UPS)

  2016cites this paper
• CD8+ T-Cell Responses in Hepatitis B and C: The (HLA-) A, B, and C of Hepatitis B and C

  2016cites this paper
• Hepatitis C virus‐cross‐reactive TCR gene‐modified T cells: a model for immunotherapy against diseases with genomic instability

  2016cites this paper
• Proteasome and immunoproteasome function in cigarette smoke-mediated chronic lung disease

  2016cites this paper
• Molecular Epidemiology of Hepatitis C Virus and Predominant Genotype in India

  2015cites this paper
• Tumor Necrosis Factor-Alpha (TNF-α) Gene Expression in Chronic Hepatitis B Virus Infection

  2015cites this paper
• The presence of prolines in the flanking region of an immunodominant HIV‐2 gag epitope influences the quality and quantity of the epitope generated

  2015cites this paper
• Development and evaluation of new therapeutic interventions for chronic hepatitis C virus infection

  2015cites this paper
• T cell responses in hepatitis C virus infection: historical overview and goals for future research.

  2015cites this paper
• Development and evaluation of new therapeutic interventions for chronic hepatitis C virus infection

  2015cites this paper
• The T210M Substitution in the HLA-a*02:01 gp100 Epitope Strongly Affects Overall Proteasomal Cleavage Site Usage and Antigen Processing*

  2015cites this paper
• Distinct Escape Pathway by Hepatitis C Virus Genotype 1a from a Dominant CD8+ T Cell Response by Selection of Altered Epitope Processing

  2015cites this paper
• Differential Recognition of Influenza A Viruses by M158–66 Epitope-Specific CD8+ T Cells Is Determined by Extraepitopic Amino Acid Residues

  2015cites this paper
• Influence of the hepatitis C genotype on the antiviral immune response

  2014cites this paper
• New Insights Into the Relationships Among Alcohol Consumption, Hepatocellular Carcinoma and Hepatitis C Virus Infection

  2014cites this paper
• CD8+ T CELL RESPONSE IN ACUTE HCV INFECTION

  2014cites this paper
• Analysis of the role of p7 protein function in hepatitis C virus life cycle

  2014cites this paper
• Designing the epitope flanking regions for optimal generation of CTL epitopes.

  2014cites this paper
• Proteasome- and Ethanol-Dependent Regulation of HCV-Infection Pathogenesis

  2014cites this paper
• Mutational escape of CD8+ T cell epitopes: implications for prevention and therapy of persistent hepatitis virus infections

  2014cites this paper
• This information is current as Cognate Antigen during Chronic Infection Persistence and Require Preservation of Acute Infection Are Associated with Viral Hepatitis C Virus-Specific T Cells during High-Programmed Death-1 Levels on

  2013cites this paper
• Adaptive immune responses in hepatitis C virus infection.

  2013cites this paper
• Hepatitis C Virus: From Molecular Virology to Antiviral Therapy

  2013cites this paper
• Failure of innate and adaptive immune responses in controlling hepatitis C virus infection.

  2012cites this paper
• IndividualsImmune Escape Patterns in HIV-Infected HIV Epitope Presentation and Predicts Aminopeptidase Substrate Preference Affects

  2012cites this paper
• IL28B polymorphism is not associated with HCV protease diversity in patients co‐infected with HIV and HCV treated with pegylated interferon and ribavirin

  2012cites this paper
• Persistent Hepatitis B Viral Replication in a FVB/N Mouse Model: Impact of Host and Viral Factors

  2012cites this paper
• 1 HBV & HCV Immunopathogenesis

  2012cites this paper
• Hepatitis C virus – T‐cell responses and viral escape mutations

  2012cites this paper
• Genetic Variation of Host Immune Response Genes and Their Effect on Hepatitis C Infection and Treatment Outcome

  2012cites this paper
• Roles of the two distinct proteasome pathways in hepatitis C virus infection.

  2012cites this paper
• Hepatitis C Virus-Mediated Modulation of Cellular Immunity

  2012cites this paper
• Aminopeptidase Substrate Preference Affects HIV Epitope Presentation and Predicts Immune Escape Patterns in HIV-Infected Individuals

  2012cites this paper
• A 2 Amino Acid Shift in Position Leads to a Substantial Difference in the Pattern of Processing of 2 HIV-1 Epitopes

  2012cites this paper
• Generation of polyfunctional T cells against HCV by T cell redirection and vaccination

  2012cites this paper
• Computational immunology : analyses of viral escape, epitope binding and T cell receptor recognition

  2011cites this paper
• Bacteria Modulate the CD8+ T Cell Epitope Repertoire of Host Cytosol-Exposed Proteins to Manipulate the Host Immune Response

  2011cites this paper
• An overview of HCV molecular biology, replication and immune responses

  2011cites this paper
• T cell responses in hepatitis C: the good, the bad and the unconventional

  2011cites this paper
• Analysis of the CD8+ T cell response against hepatitis C virus in intravenous drug users

  2011cites this paper
• Characterization of Liver Damage Mechanisms Induced by Hepatitis C Virus

  2011cites this paper
• HBV & HCV Immunopathogenesis

  2011cites this paper
• Success and Failure of Virus-Specific T Cell Responses in Hepatitis C Virus Infection

  2011cites this paper
• Escape from a Dominant HLA-B*15-Restricted CD8+ T Cell Response against Hepatitis C Virus Requires Compensatory Mutations outside the Epitope

  2011cites this paper
• Characterization of antigenic variants of hepatitis C virus in immune evasion

  2011cites this paper
• Cell Type-Specific Proteasomal Processing of HIV-1 Gag-p24 Results in an Altered Epitope Repertoire (cid:1)

  2011cites this paper
• The Antiviral Efficacy of HIV-Specific CD8+ T-Cells to a Conserved Epitope Is Heavily Dependent on the Infecting HIV-1 Isolate

  2011cites this paper
• The role of the proteasome in the generation of MHC class I ligands and immune responses

  2011cites this paper
• Etude phénotypique et fonctionnelle des lymphocytes intra-hépatiques dans l'hépatite chronique virale C et le carcinome hépatocellulaire

  2011cites this paper
• Hepatitis C virus evasion of adaptive immune responses: a model for viral persistence

  2010cites this paper
• Mutation or loss of Wilms' tumor gene 1 (WT1) are not major reasons for immune escape in patients with AML receiving WT1 peptide vaccination

  2010cites this paper
• Développement de lignées de poissons zébrés transgéniques pour l'étude du rôle de la protéine F dans la pathogenèse de l'hépatite C

  2010cites this paper
• HCV-related hepatocellular carcinoma: From chronic inflammation to cancer.

  2010cites this paper
• Cell Type-Specific Proteasomal Processing of HIV-1 Gag-p24 Results in an Altered Epitope Repertoire

  2010cites this paper
• Conflicting selection pressures target the NS3 protein in hepatitis C virus genotypes 1a and 1b.

  2010cites this paper
• Die Rolle von Proteasomen in der Antigenpräsentation in der Coxsackievirus B3 induzierten akuten und chronischen Myokarditis

  2010cites this paper
• Henry M Jackson Foundation for the Advancement of Military Medicine, 1600 East Gude Drive,

  2010cites this paper
• Transduction of Human T Cells with a Novel T-Cell Receptor Confers Anti-HCV Reactivity

  2010cites this paper
• Optimal epitope composition after antigen screening using a live bacterial delivery vector

  2010cites this paper
• MHC-I-restricted HIV epitope processing, immune control and immunogen design

  2010cites this paper
• Effects of HCV proteins in current HCV transgenic models

  2010cites this paper
• Natural epitope variants of the hepatitis C virus impair cytotoxic T lymphocyte activity.

  2010cites this paper
• Peripheral T-lymphocyte subpopulations in different clinical stages of chronic HBV infection correlate with HBV load.

  2009cites this paper
• P17-28 LB. The antiviral efficacy of HIV-specific CD8+ T-cells to a conserved epitope is heavily dependent on the infecting HIV-1 isolate

  2009cites this paper
• Characterization of the cellular immune response in hepatitis C virus infection

  2009cites this paper
• Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence.

  2009cites this paper
• Mechanisms of HCV survival in the host

  2009cites this paper
• State-of-the-Art Lecture: Immune responses and viral escape mechanisms in hepatitis C virus infection

  2009cites this paper
• Impact of viral selected mutations on T cell mediated immunity in chronically evolving and self limiting acute HCV infection.

  2009cites this paper
• Cognate Antigen during Chronic Infection Persistence and Require Preservation of Acute Infection Are Associated with Viral Hepatitis C Virus-Specific T Cells during High-Programmed Death-1 Levels on Sette

  2008cites this paper
• Remodelling of the ubiquitin-proteasome system in response to interferons.

  2008cites this paper
• Hepatitis C Virus Immune Escape via Exploitation of a Hole in the T Cell Repertoire1

  2008cites this paper
• Understanding the immunopathogenesis of chronic hepatitis B virus: An Asian prospective

  2008cites this paper