Traumatic Brain Injuries during Development: Implications for Alcohol Abuse

Traumatic brain injuries are strongly related to alcohol intoxication as by some estimates half or more of all brain injuries involve at least one intoxicated individual. Additionally, there is mounting evidence that traumatic brain injuries can themselves serve as independent risk factors for the development of alcohol use disorders, particularly when injury occurs during juvenile or adolescent development. Here, we will review the epidemiological and experimental evidence for this phenomenon and discuss potential psychosocial mediators including attenuation of negative affect and impaired decision making as well as neurochemical mediators including disruption in the glutamatergic, GABAergic, and dopaminergic signaling pathways and increases in inflammation.

• Publication year

  2017

• Venue

  Frontiers in Behavioral Neuroscience

• Publication date

  2017-07-20

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.3389/fnbeh.2017.00135PMID 28775682PMCID 5517445
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Glutamate Neurotransmission in Rodent Models of Traumatic Brain Injury

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• Adolescent Traumatic Brain Injury Induces Chronic Mesolimbic Neuroinflammation with Concurrent Enhancement in the Rewarding Effects of Cocaine in Mice during Adulthood

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• Traumatic brain injury and alcohol/substance abuse: A Bayesian meta-analysis comparing the outcomes of people with and without a history of abuse

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• Differential cytokine levels between early withdrawal and remission states in patients with alcohol dependence.

  2017cited by this paper
• Binge ethanol in adulthood exacerbates negative outcomes following juvenile traumatic brain injury.

  2017cited by this paper
• Factors affecting increased risk for substance use disorders following traumatic brain injury: What we can learn from animal models

  2017cited by this paper
• Relationships Between Traumatic Brain Injury and Illicit Drug Use and Their Association With Aggression in Inmates

  2016cited by this paper
• Neurobiology of addiction: a neurocircuitry analysis.

  2016cited by this paper
• Juvenile Traumatic Brain Injury Increases Alcohol Consumption and Reward in Female Mice

  2016influential reference
• Alcohol abuse after traumatic brain injury: Experimental and clinical evidence.

  2016influential reference
• Methylphenidate on Cognitive Improvement in Patients with Traumatic Brain Injury: A Meta-Analysis

  2016cited by this paper
• Voluntary Alcohol Intake following Blast Exposure in a Rat Model of Mild Traumatic Brain Injury

  2015cited by this paper
• Acute Inflammatory Biomarker Profiles Predict Depression Risk Following Moderate to Severe Traumatic Brain Injury

  2015cited by this paper
• Traumatic Brain Injury Increases Cortical Glutamate Network Activity by Compromising GABAergic Control.

  2015cited by this paper
• Substance Use and Related Harms Among Adolescents With and Without Traumatic Brain Injury

  2015cited by this paper
• Immune activation promotes depression one month after diffuse brain injury: a role for primed microglia

  2014cited by this paper
• raumatic brain injury induces neuroinflammation and neuronal egeneration that is associated with escalated alcohol elf-administration in rats

  2014cited by this paper
• Head trauma sustained under the influence of alcohol is a predictor for future traumatic brain injury: a long‐term follow‐up study

  2014cited by this paper
• Role of inflammatory pathways, blood mononuclear cells, and gut-derived bacterial products in alcohol dependence.

  2014cited by this paper
• Experimental Traumatic Brain Injury Alters Ethanol Consumption and Sensitivity

  2014cited by this paper
• Substance Abuse and Criminal Activities Following Traumatic Brain Injury in Childhood, Adolescence, and Early Adulthood

  2014influential reference
• Abusive Head Trauma

  2014cited by this paper
• Prior history of traumatic brain injury among persons in the Traumatic Brain Injury Model Systems National Database.

  2013influential reference
• TEMPORARY REMOVAL: Consensus Statement On Concussion In Sport - The 4th International Conference On Concussion In Sport Held In Zurich, November 2012

  2013cited by this paper
• Consensus statement on concussion in sport: the 4th International Conference on Concussion in Sport held in Zurich, November 2012

  2013cited by this paper
• Summary of evidence-based guideline update: Evaluation and management of concussion in sports

  2013cited by this paper
• Traumatic brain injury as a chronic health condition.

  2013cited by this paper
• Inflammation and white matter degeneration persist for years after a single traumatic brain injury.

  2013cited by this paper
• Cytokine effects on the basal ganglia and dopamine function: the subcortical source of inflammatory malaise.

  2012cited by this paper
• Decreased sensitivity of NMDA receptors on dopaminergic neurons from the posterior ventral tegmental area following chronic nondependent alcohol consumption.

  2012cited by this paper
• Neuroimmune regulation of alcohol consumption: behavioral validation of genes obtained from genomic studies

  2012cited by this paper
• Dopamine neurons in the ventral tegmental area fire faster in adolescent rats than in adults.

  2012cited by this paper
• Altered bidirectional plasticity and reduced implicit motor learning in concussed athletes.

  2012cited by this paper
• Alcohol use at time of injury and survival following traumatic brain injury: results from the National Trauma Data Bank.

  2012cited by this paper
• Substance Misuse Among Persons With Traumatic Brain Injury

  2012cited by this paper
• Minocycline reduces ethanol drinking.

  2011cited by this paper
• Alcoholism and inflammation: neuroimmunology of behavioral and mood disorders.

  2011cited by this paper
• Progressive loss of phasic, but not tonic, GABAA receptor-mediated inhibition in dentate granule cells in a model of post-traumatic epilepsy in rats.

  2011cited by this paper
• Role of TLR4 in ethanol effects on innate and adaptive immune responses in peritoneal macrophages

  2011cited by this paper
• Induction of innate immune genes in brain create the neurobiology of addiction.

  2011cited by this paper
• Traumatic Brain Injury in Adult Rats Causes Progressive Nigrostriatal Dopaminergic Cell Loss and Enhanced Vulnerability to the Pesticide Paraquat

  2011influential reference
• Activation of inflammatory signaling by lipopolysaccharide produces a prolonged increase of voluntary alcohol intake in mice.

  2011cited by this paper
• Involvement of pro- and anti-inflammatory cytokines and chemokines in the pathophysiology of traumatic brain injury

  2011cited by this paper
• Traumatic brain injury: a disease process, not an event.

  2010cited by this paper
• Delayed neural damage is induced by iNOS-expressing microglia in a brain injury model.

  2010cited by this paper
• Mechanisms involved in the neurotoxic, cognitive, and neurobehavioral effects of alcohol consumption during adolescence.

  2010cited by this paper
• Pivotal Role of TLR4 Receptors in Alcohol-Induced Neuroinflammation and Brain Damage

  2010cited by this paper
• Developmental changes in dopamine neurotransmission in adolescence: behavioral implications and issues in assessment.

  2010cited by this paper
• Substance abuse and psychosocial adaptation to physical disability: analysis of the literature and future directions

  2010cited by this paper
• Tetrahydrobiopterin: pleiotropic roles in cardiovascular pathophysiology

  2010cited by this paper
• Influence of alcohol on mortality in traumatic brain injury.

  2010cited by this paper
• Repeated ethanol exposure during adolescence alters the developmental trajectory of dopaminergic output from the nucleus accumbens septi

  2009cited by this paper
• Persistent cognitive dysfunction after traumatic brain injury: A dopamine hypothesis.

  2009influential reference
• Does Traumatic Brain Injury Increase Risk for Substance Abuse?

  2009influential reference
• Consensus statement on concussion.

  2009cited by this paper
• Early-Life Programming of Later-Life Brain and Behavior: A Critical Role for the Immune System

  2009cited by this paper
• Chronic methylphenidate treatment enhances striatal dopamine neurotransmission after experimental traumatic brain injury

  2009cited by this paper
• Self-medication of mood disorders with alcohol and drugs in the National Epidemiologic Survey on Alcohol and Related Conditions.

  2009cited by this paper
• An Update on Substance Use and Treatment following Traumatic Brain Injury

  2008cited by this paper
• Behavioral disinhibition and the development of early-onset addiction: common and specific influences.

  2008cited by this paper
• Increased MCP-1 and microglia in various regions of the human alcoholic brain.

  2008cited by this paper
• Childhood and adolescent predictors of alcohol use and problems in adolescence and adulthood in the National Child Development Study.

  2008cited by this paper
• Alcohol and drug use following traumatic brain injury: A prospective study

  2007cited by this paper
• Pathophysiology of traumatic brain injury.

  2007cited by this paper
• Novelty seeking involved in mediating the association between the dopamine D4 receptor gene exon III polymorphism and heavy drinking in male adolescents: results from a high-risk community sample.

  2007cited by this paper
• Neuroinflammatory Responses After Experimental Diffuse Traumatic Brain Injury

  2007cited by this paper
• Is Being Plastic Fantastic? Mechanisms of Altered Plasticity after Developmental Traumatic Brain Injury

  2006cited by this paper
• Guidelines for the Pharmacologic Treatment of Neurobehavioral Sequelae of Traumatic Brain Injury

  2006cited by this paper
• Epidemiology and Outcomes of Pediatric Traumatic Brain Injury

  2006cited by this paper
• Mechanisms underlying the inability to induce area CA1 LTP in the mouse after traumatic brain injury

  2006cited by this paper
• Alcohol dependence is associated with blunted dopamine transmission in the ventral striatum.

  2005cited by this paper
• Alcohol and Other Drugs

  2005cited by this paper
• Post-traumatic early epilepsy in pediatric age group with emphasis on influential factors

  2005cited by this paper
• Controlled cortical impact injury affects dopaminergic transmission in the rat striatum

  2005cited by this paper
• Reduction of affective lability and alcohol use following traumatic brain injury: A clinical pilot study of anti-convulsant medications

  2005cited by this paper
• Gender and environmental enrichment impact dopamine transporter expression after experimental traumatic brain injury.

  2005cited by this paper
• Major depression following traumatic brain injury.

  2004cited by this paper
• Childhood externalizing and internalizing psychopathology in the prediction of early substance use.

  2004cited by this paper
• Chronic Ethanol Treatment Enhances Inflammatory Mediators and Cell Death in the Brain and in Astrocytes

  2004cited by this paper
• Ethanol and brain plasticity: receptors and molecular networks of the postsynaptic density as targets of ethanol.

  2003cited by this paper
• Development of the Key Behaviors Change Inventory: a traumatic brain injury behavioral outcome assessment instrument.

  2003cited by this paper
• The natural history of drinking and alcohol-related problems after traumatic brain injury.

  2003cited by this paper
• The importance of a positive family history of alcoholism, parental rejection and emotional warmth, behavioral problems and peer substance use for alcohol problems in teenagers: a path analysis.

  2002influential reference
• Traumatic brain injury reduces dopamine transporter protein expression in the rat frontal cortex

  2002cited by this paper
• Tyrosine hydroxylase, but not dopamine beta-hydroxylase, is increased in rat frontal cortex after traumatic brain injury

  2001cited by this paper
• Impaired motor learning and diffuse axonal damage in motor and visual systems of the rat following traumatic brain injury

  2001cited by this paper
• Growing up with parental alcohol abuse: exposure to childhood abuse, neglect, and household dysfunction.

  2001influential reference
• Impaired dopaminergic neurotransmission in patients with traumatic brain injury: a SPECT study using 123I-beta-CIT and 123I-IBZM.

  2000cited by this paper
• Epidemiology of Concussion in Collegiate and High School Football Players

  2000cited by this paper
• Impaired dopaminergic neurotransmission in patients with traumatic brain injury: a SPET study using 123I-β-CIT and 123I-IBZM

  2000cited by this paper
• Development of psychiatric comorbidity with substance abuse in adolescents: effects of timing and sex.

  1999cited by this paper
• Age of onset of drug use and its association with DSM-IV drug abuse and dependence: results from the National Longitudinal Alcohol Epidemiologic Survey.

  1998cited by this paper
• Factors affecting excitatory amino acid release following severe human head injury.

  1998cited by this paper
• Educational outcome for secondary and postsecondary students following traumatic brain injury.

  1998cited by this paper
• Age at onset of alcohol use and its association with DSM-IV alcohol abuse and dependence: results from the National Longitudinal Alcohol Epidemiologic Survey.

  1997cited by this paper
• Histological markers of neuronal, axonal and astrocytic changes after lateral rigid impact traumatic brain injury.

  1997cited by this paper
• Systematic bias in outcome studies of persons with traumatic brain injury.

  1997cited by this paper
• Building social networks for children and adolescents with traumatic brain injury: A school-based intervention.

  1997cited by this paper
• Psychiatric sequelae of posttraumatic stress disorder in women.

  1997cited by this paper
• Alcohol and Drug Use Among Young Persons with Traumatic Brain Injury

  1996cited by this paper

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• Assessment of the relationship between anhedonia, sleep quality and alcohol craving in patients with alcohol dependence and comorbid depression

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• Patterns of Alcohol Use in Hispanic Individuals with TBI over the Ten Years Post-Injury: A Model Systems Study

  2024cites this paper
• Reducing the incidence and mortality of traumatic brain injury in Latin America

  2023cites this paper
• The negative influence of chronic alcohol abuse on acute cognitive recovery after a traumatic brain injury

  2022cites this paper
• The Role of Neuroinflammation in Neuropsychiatric Disorders Following Traumatic Brain Injury: A Systematic Review

  2022cites this paper
• Pathophysiology of Pediatric Traumatic Brain Injury

  2021cites this paper
• Traumatic Brain Injury and Treatment of Behavioral Health Conditions.

  2021cites this paper
• Investigating cannabis use and associated symptoms among university students with and without a history of concussion

  2020cites this paper
• The Diagnostic Value of Neuron-Specific Enolase in Children with Mild Blunt Trauma Requiring Cranial CT Scan

  2020cites this paper
• Is Pediatric Traumatic Brain Injury Associated with Adult Alcohol Misuse?

  2020cites this paper
• Alcohol Use Disorder Increases Risk of Traumatic Brain Injury-Related Hospitalization: Insights From 3.8 Million Children and Adolescent Inpatients

  2020cites this paper
• Sex, Drugs, and TBI: The Role of Sex in Substance Abuse Related to Traumatic Brain Injuries

  2020cites this paper
• Intoxication: Alcohol

  2019cites this paper
• Translational modelling of traumatic axonal and vascular injury using CHIMERA (Closed Head Impact Model of Engineered Rotational Acceleration)

  2019cites this paper
• Alcohol misuse and traumatic brain injury: a review of the potential roles of dopaminergic dysfunction and physiological underarousal post-injury

  2019cites this paper
• Repetitive closed-head impact model of engineered rotational acceleration (CHIMERA) injury in rats increases impulsivity, decreases dopaminergic innervation in the olfactory tubercle and generates white matter inflammation, tau phosphorylation and degeneration.

  2019cites this paper
• Alcohol Use Disorder and Traumatic Brain Injury

  2018cites this paper
• Minocycline blocks traumatic brain injury-induced alcohol consumption and nucleus accumbens inflammation in adolescent male mice.

  2018cites this paper
• An Examination of Behavioral and Neuronal Effects of Comorbid Traumatic Brain Injury and Alcohol Use.

  2017cites this paper