Progressive loss of phasic, but not tonic, GABAA receptor-mediated inhibition in dentate granule cells in a model of post-traumatic epilepsy in rats.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Neuroscience

• Publication date

  2011-10-27

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1016/j.neuroscience.2011.07.074PMID 21840377
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Synaptic Reorganization of Inhibitory Hilar Interneuron Circuitry after Traumatic Brain Injury in Mice

  2011cited by this paper
• Alterations of GABA(A) and glutamate receptor subunits and heat shock protein in rat hippocampus following traumatic brain injury and in posttraumatic epilepsy.

  2011cited by this paper
• Receptors with low affinity for neurosteroids and GABA contribute to tonic inhibition of granule cells in epileptic animals.

  2010cited by this paper
• Increase of GABAA receptor-mediated tonic inhibition in dentate granule cells after traumatic brain injury.

  2010influential reference
• Post-traumatic epilepsy: an overview.

  2010cited by this paper
• Continuous Electroencephalographic Monitoring with Radio-Telemetry in a Rat Model of Perinatal Hypoxia–Ischemia Reveals Progressive Post-Stroke Epilepsy

  2010cited by this paper
• Parvalbumin Deficiency and GABAergic Dysfunction in Mice Lacking PGC-1α

  2010cited by this paper
• Long-term risk of epilepsy after traumatic brain injury in children and young adults: a population-based cohort study.

  2009cited by this paper
• Enhanced tonic GABA current in normotopic and hilar ectopic dentate granule cells after pilocarpine-induced status epilepticus.

  2009influential reference
• Control of hippocampal gamma oscillation frequency by tonic inhibition and excitation of interneurons

  2009cited by this paper
• From traumatic brain injury to posttraumatic epilepsy: What animal models tell us about the process and treatment options

  2009cited by this paper
• Posttraumatic epilepsy after controlled cortical impact injury in mice.

  2009cited by this paper
• Enhanced tonic GABAA inhibition in typical absence epilepsy

  2009cited by this paper
• Outwardly Rectifying Tonically Active GABAA Receptors in Pyramidal Cells Modulate Neuronal Offset, Not Gain

  2009cited by this paper
• Surviving Hilar Somatostatin Interneurons Enlarge, Sprout Axons, and Form New Synapses with Granule Cells in a Mouse Model of Temporal Lobe Epilepsy

  2009cited by this paper
• Which GABAA Receptor Subunits Are Necessary for Tonic Inhibition in the Hippocampus?

  2008influential reference
• Altered Localization of GABAA Receptor Subunits on Dentate Granule Cell Dendrites Influences Tonic and Phasic Inhibition in a Mouse Model of Epilepsy

  2007influential reference
• Functional regulation of the dentate gyrus by GABA-mediated inhibition.

  2007cited by this paper
• Is Posttraumatic Epilepsy the Best Model of Posttraumatic Epilepsy?

  2006cited by this paper
• Post-traumatic epilepsy: an overview.

  2006cited by this paper
• Hippocampal Cell Loss in Posttraumatic Human Epilepsy

  2006cited by this paper
• Tonic GABAA receptor‐mediated currents in human brain

  2006cited by this paper
• Trafficking of GABAA Receptors, Loss of Inhibition, and a Mechanism for Pharmacoresistance in Status Epilepticus

  2005cited by this paper
• Multiple and Plastic Receptors Mediate Tonic GABAA Receptor Currents in the Hippocampus

  2005cited by this paper
• Tonic excitation and inhibition of neurons: ambient transmitter sources and computational consequences.

  2005cited by this paper
• Changes in mIPSCs and sIPSCs after kainate treatment: evidence for loss of inhibitory input to dentate granule cells and possible compensatory responses.

  2005influential reference
• Altered expression of GABA(A) and GABA(B) receptor subunit mRNAs in the hippocampus after kindling and electrically induced status epilepticus.

  2005cited by this paper
• Diversity of inhibitory neurotransmission through GABA(A) receptors.

  2004cited by this paper
• Altered expression of the delta subunit of the GABAA receptor in a mouse model of temporal lobe epilepsy.

  2004cited by this paper
• Post-traumatic epilepsy following fluid percussion injury in the rat.

  2004cited by this paper
• Shunting inhibition modulates neuronal gain during synaptic excitation.

  2003cited by this paper
• Aging alters dendritic morphology, input resistance, and inhibitory signaling in dentate granule cells of the rhesus monkey

  2003cited by this paper
• Reduced Inhibition of Dentate Granule Cells in a Model of Temporal Lobe Epilepsy

  2003cited by this paper
• Analyzing risk factors for late posttraumatic seizures: a prospective, multicenter investigation.

  2003cited by this paper
• “Dormant basket cell” hypothesis revisited: Relative vulnerabilities of dentate gyrus mossy cells and inhibitory interneurons after hippocampal status epilepticus in the rat

  2003cited by this paper
• Long‐term hyperexcitability in the hippocampus after experimental head trauma

  2001influential reference
• GABAA Receptor Phosphorylation and Functional Modulation in Cortical Neurons by a Protein Kinase C-dependent Pathway*

  2000cited by this paper
• GABAergic neurons and GABA(A)-receptors in temporal lobe epilepsy.

  1999cited by this paper
• Increased number of synaptic GABAA receptors underlies potentiation at hippocampal inhibitory synapses

  1998cited by this paper
• A population-based study of seizures after traumatic brain injuries.

  1998cited by this paper
• Selective changes in single cell GABAA receptor subunit expression and function in temporal lobe epilepsy

  1998cited by this paper
• Instantaneous Perturbation of Dentate Interneuronal Networks by a Pressure Wave-Transient Delivered to the Neocortex

  1997cited by this paper
• The effects of traumatic brain injury on inhibition in the hippocampus and dentate gyrus.

  1997cited by this paper
• GABA(A) receptor subunits in the rat hippocampus III: altered messenger RNA expression in kainic acid-induced epilepsy.

  1997influential reference
• GABA(A) receptor subunits in the rat hippocampus II: altered distribution in kainic acid-induced temporal lobe epilepsy.

  1997influential reference
• Perineuronal nets--a specialized form of extracellular matrix in the adult nervous system.

  1994cited by this paper
• Epileptogenic Effects of Status Epilepticus

  1993cited by this paper
• Wisteria floribunda agglutinin-labelled nets surround parvalbumin-containing neurons.

  1992cited by this paper
• Selective vulnerability of dentate hilar neurons following traumatic brain injury: a potential mechanistic link between head trauma and disorders of the hippocampus

  1992cited by this paper
• Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator

  1991cited by this paper
• Afferent and efferent synaptic conncetions sof somatostatin‐immunoreactive neurons in the rat fascia dentata

  1990cited by this paper
• Traumatic brain injury in the rat: characterization of a lateral fluid-percussion model.

  1989cited by this paper
• Ultrastructural localization of somatostatin‐like immunoreactivity in the rat dentate gyrus

  1989cited by this paper
• Decreased hippocampal inhibition and a selective loss of interneurons in experimental epilepsy.

  1987cited by this paper
• An immunohistochemical characterization of somatostatin‐28 and somatostatin‐281–12 in monkey prefrontal cortex

  1986cited by this paper
• Functional anatomy of limbic seizures: focal discharges from medial entorhinal cortex in rat.

  1983cited by this paper

• Medial ganglionic eminence transplantation restores inhibition after central visual system brain injury

  2025cites this paper
• Post-traumatic epilepsy: Insights from human cortical contused tissue.

  2025cites this paper
• WONOEP XVII appraisal: Targeting network excitability beyond the synapse ‐Neurotransmitter, ionic, and electro ‐diffusions

  2025cites this paper
• The effects of traumatic brain Injury, post-traumatic stress disorder on Amyloid-β associated network hyperconnectivity and progression of gray matter atrophy

  2025cites this paper
• Hippocampal Interneurons Shape Spatial Coding Alterations in Neurological Disorders

  2025cites this paper
• Case Report: Anti-SOX1 antibody-associated limbic encephalitis with hippocampal sclerosis: the first autopsy case

  2025cites this paper
• Tonic activation of GABAB receptors via GAT-3 mediated GABA release reduces network activity in the developing somatosensory cortex in GAD67-GFP mice

  2023cites this paper
• Potential role of creatine as an anticonvulsant agent: evidence from preclinical studies

  2023cites this paper
• E2730, an uncompetitive γ‐aminobutyric acid transporter‐1 inhibitor, suppresses epileptic seizures in a rat model of chronic mesial temporal lobe epilepsy

  2023cites this paper
• Long-Term Effects of Moderate Concussive Brain Injury During Adolescence on Synaptic and Tonic GABA Currents in Dentate Granule Cells and Semilunar Granule Cells

  2022cites this paper
• Repetitive mild traumatic brain injury induces persistent alterations in spontaneous synaptic activity of hippocampal CA1 pyramidal neurons

  2022cites this paper
• Identifying biomarkers for epilepsy after cerebral malaria in Zambian children: rationale and design of a prospective observational study

  2022cites this paper
• Zolpidem Profoundly Augments Spared Tonic GABAAR Signaling in Dentate Granule Cells Ipsilateral to Controlled Cortical Impact Brain Injury in Mice

  2022cites this paper
• Histopathological and Biochemical Assessment of Neuroprotective Effects of Sodium Valproate and Lutein on the Pilocarpine Albino Rat Model of Epilepsy

  2021cites this paper
• Knowledge atlas of post-traumatic epilepsy research: Based on citespace visualization analysis.

  2021cites this paper
• Traumatic brain injury to primary visual cortex produces long-lasting circuit dysfunction

  2021cites this paper
• Hippocampal-Dependent Cognitive Dysfunction following Repeated Diffuse Rotational Brain Injury in Male and Female Mice

  2021cites this paper
• Traumatic Brain Injury Broadly Affects GABAergic Signaling in Dentate Gyrus Granule Cells

  2021influential citation
• Mild traumatic brain injury is associated with dysregulated neural network functioning in children and adolescents

  2021cites this paper
• Long-term effects of moderate concussive brain injury during adolescence on synaptic and tonic GABA currents in dentate projection neurons

  2021influential citation
• Rodent models used in preclinical studies of deep brain stimulation to rescue memory deficits.

  2021cites this paper
• Regulation of parvalbumin interactome in the perilesional cortex after experimental traumatic brain injury.

  2021cites this paper
• Enhancement of intrinsic neuronal excitability‐mediated by a reduction in hyperpolarization‐activated cation current (Ih) in hippocampal CA1 neurons in a rat model of traumatic brain injury

  2020cites this paper
• Assessment of the response to antiepileptic drugs in epileptic patients with structural lesion(s) on neuroimaging

  2020cites this paper
• In vivo KPT-350 treatment decreases cortical hyperexcitability following traumatic brain injury

  2020cites this paper
• Interleukin-1 Beta Neutralization Attenuates Traumatic Brain Injury-Induced Microglia Activation and Neuronal Changes in the Globus Pallidus

  2020cites this paper
• Primary visual cortex injury produces loss of inhibitory neurons and long-term visual circuit dysfunction

  2020cites this paper
• Blast Exposure Impairs Sensory Gating: Evidence from Measures of Acoustic Startle and Auditory Event-Related Potentials

  2019cites this paper
• Inhibiting α5 Subunit-Containing γ-Aminobutyric Acid Type A Receptors Attenuates Cognitive Deficits After Traumatic Brain Injury.

  2019cites this paper
• Converging early responses to brain injury pave the road to epileptogenesis

  2019influential citation
• Selective vulnerability of hippocampal interneurons to graded traumatic brain injury.

  2019cites this paper
• Modulating neuroinflammation and oxidative stress to prevent epilepsy and improve outcomes after traumatic brain injury.

  2019cites this paper
• Impact of Traumatic Brain Injury on Neurogenesis

  2019cites this paper
• Delayed creatine supplementation counteracts reduction of GABAergic function and protects against seizures susceptibility after traumatic brain injury in rats

  2019cites this paper
• The Functional Role of Spontaneously Opening GABAA Receptors in Neural Transmission

  2019cites this paper
• Inhibitory neuronal changes following a mixed diffuse‐focal model of traumatic brain injury

  2019influential citation
• Sex differences in cued fear responses and parvalbumin cell density in the hippocampus following repetitive concussive brain injuries in C57BL/6J mice

  2019cites this paper
• Commonalities in epileptogenic processes from different acute brain insults: Do they translate?

  2018cites this paper
• Blocking Tumor Necrosis Factor-Alpha Expression Prevents Blast-Induced Excitatory/Inhibitory Synaptic Imbalance and Parvalbumin-Positive Interneuron Loss in the Hippocampus

  2018influential citation
• Neurotransmitter changes after traumatic brain injury: an update for new treatment strategies

  2018cites this paper
• Spontaneously opening GABAA receptors play a significant role in neuronal signal filtering and integration

  2018cites this paper
• Traumatic Brain Injury

  2018cites this paper
• Immediate and Medium-term Changes in Cortical and Hippocampal Inhibitory Neuronal Populations after Diffuse TBI.

  2018cites this paper
• Brain Injury-Induced Synaptic Reorganization in Hilar Inhibitory Neurons Is Differentially Suppressed by Rapamycin

  2017cites this paper
• GABAA receptor subunit deregulation in the hippocampus of human foetuses with Down syndrome

  2017cites this paper
• Traumatic Brain Injuries during Development: Implications for Alcohol Abuse

  2017cites this paper
• Previous physical exercise alters the hepatic profile of oxidative‐inflammatory status and limits the secondary brain damage induced by severe traumatic brain injury in rats

  2017cites this paper
• Anticonvulsive evaluation of THIP in the murine pentylenetetrazole kindling model: lack of anticonvulsive effect of THIP despite functional δ‐subunit‐containing GABAA receptors in dentate gyrus granule cells

  2017cites this paper
• The Role of GABAergic Interneurons in the Cortex and Hippocampus in the Development of Epilepsy

  2017cites this paper
• Analgesic Effect of 17β-Estradiol on Nucleus Paragigantocellularis Lateralis of Male Rats Mediated Via GABAA Receptors

  2017cites this paper
• Pathophysiology and Treatment of Memory Dysfunction After Traumatic Brain Injury

  2017cites this paper
• Mild Traumatic Brain Injury Leads to Decreased Inhibition and a Differential Response of Calretinin Positive Interneurons in the Injured Cortex

  2017cites this paper
• Injury induced plasticity in primary neuronal culture and the mature brain

  2017cites this paper
• Differential effects of rapamycin treatment on tonic and phasic GABAergic inhibition in dentate granule cells after focal brain injury in mice.

  2016influential citation
• Enduring changes in tonic GABAA receptor signaling in dentate granule cells after controlled cortical impact brain injury in mice.

  2016cites this paper
• The α1, α2, α3, and γ2 subunits of GABAA receptors show characteristic spatial and temporal expression patterns in rhombencephalic structures during normal human brain development

  2016cites this paper
• Environmental Enrichment Attenuates Traumatic Brain Injury: Induced Neuronal Hyperexcitability in Supragranular Layers of Sensory Cortex

  2016cites this paper
• Ex Vivo Tracing of NMDA and GABA-A Receptors in Rat Brain After Traumatic Brain Injury Using 18F-GE-179 and 18F-GE-194 Autoradiography

  2016cites this paper
• The Impact of Previous Physical Training on Redox Signaling after Traumatic Brain Injury in Rats: A Behavioral and Neurochemical Approach

  2016cites this paper
• Effects of Mammalian Target of Rapamycin Inhibition on Circuitry Changes in the Dentate Gyrus of Mice after Focal Brain Injury

  2016cites this paper
• Traumatic Brain Injury and Neuronal Functionality Changes in Sensory Cortex

  2016cites this paper
• Progesterone Exacerbates Short-Term Effects of Traumatic Brain Injury on Supragranular Responses in Sensory Cortex and Over-Excites Infragranular Responses in the Long Term

  2016cites this paper
• Differential susceptibility of cortical and subcortical inhibitory neurons and astrocytes in the long term following diffuse traumatic brain injury

  2016cites this paper
• Astrocyte Hypertrophy Contributes to Aberrant Neurogenesis after Traumatic Brain Injury

  2016cites this paper
• Hippocampal Sclerosis: Causes and Prevention

  2015cites this paper
• Role of Delta Subunit-Containing GABAA Receptors in Hippocampus Tonic Inhibition and Epileptogenesis within Transgenic Mouse Models

  2015cites this paper
• The impact of previous physical training on redox signaling after traumatic brain injury in rats : a behavioral and neurochemical approach Exercise vs . TBI

  2015cites this paper
• Expression of GABA receptor subunits in the hippocampus and thalamus after experimental traumatic brain injury

  2015influential citation
• Traumatic Brain Injury Increases Cortical Glutamate Network Activity by Compromising GABAergic Control.

  2015cites this paper
• Neuroproteome Dynamics in Modeled Brain Injury

  2015cites this paper
• GABAergic interneuronal loss and reduced inhibitory synaptic transmission in the hippocampal CA1 region after mild traumatic brain injury.

  2015influential citation
• Glutamate and GABA Imbalance Following Traumatic Brain Injury

  2015cites this paper
• Synaptic GABA release prevents GABA transporter type-1 reversal during excessive network activity

  2015cites this paper
• Perimenstrual-Like Hormonal Regulation of Extrasynaptic δ-Containing GABAA Receptors Mediating Tonic Inhibition and Neurosteroid Sensitivity

  2014cites this paper
• The GABAA Antagonist DPP-4-PIOL Selectively Antagonises Tonic over Phasic GABAergic Currents in Dentate Gyrus Granule Cells

  2014cites this paper
• Alteration of Hippocampal Cytokines and Astrocyte Morphology Observed in Rats 24 Hour after Fluid Percussion Injury

  2014cites this paper
• Parvalbumin immunoreactivity and expression of GABAA receptor subunits in the thalamus after experimental TBI.

  2014cites this paper
• Impairment of GABA release in the hippocampus at the time of the first spontaneous seizure in the pilocarpine model of temporal lobe epilepsy.

  2014cites this paper
• Pathophysiological mechanisms underlying increased anxiety after soman exposure: reduced GABAergic inhibition in the basolateral amygdala.

  2014cites this paper
• Extrasynaptic GABAA Receptors

  2014cites this paper
• What non-neuronal mechanisms should be studied to understand epileptic seizures?

  2014cites this paper
• The Role of Extrasynaptic GABAA Receptors in Focal Epilepsy

  2014cites this paper
• The Role of δ Subunit-containing γ-aminobutyric Acid Type A Receptors in Memory and Synaptic Plasticity

  2014cites this paper
• Alteration of Hippocampal Cytokines and Astrocyte Morphology Observed in Rats 24 Hour after Fluid Percussion

  2014cites this paper
• The parvalbumin-positive interneurons in the mouse dentate gyrus express GABAA receptor subunits α1, β2, and δ along their extrasynaptic cell membrane.

  2013cites this paper
• A functional role for both γ-aminobutyric acid (GABA) transporter-1 and GABA transporter-3 in the modulation of extracellular GABA and GABAergic tonic conductances in the rat hippocampus

  2013cites this paper
• Neocortical interneurons

  2013cites this paper
• Neural circuit mechanisms of post–traumatic epilepsy

  2013cites this paper
• Research advances in basic mechanisms of seizures and antiepileptic drug action

  2013cites this paper
• Cortical Hypoexcitation Defines Neuronal Responses in the Immediate Aftermath of Traumatic Brain Injury

  2013cites this paper
• Computational modelling of normal function and pathology in neural systems : new tools, techniques and results in cortex and basal ganglia

  2013cites this paper
• GABA transporter-1 and GABA transporter-3 in the modulation of extracellular GABA and GABAergic tonic conductances in the rat

  2013cites this paper
• Impulsive and episodic disorders of aggressive behaviour following traumatic brain injury

  2013cites this paper
• Tonic GABA inhibition in hippocampal dentate granule cells: its regulation and function in temporal lobe epilepsies

  2013cites this paper
• Traumatic Brain Injury Pathophysiology and Treatments: Early, Intermediate, and Late Phases Post-Injury

  2013cites this paper
• Neurosteroid interactions with synaptic and extrasynaptic GABAA receptors: regulation of subunit plasticity, phasic and tonic inhibition, and neuronal network excitability

  2013cites this paper
• Cortical inhibition, pH and cell excitability in epilepsy: what are optimal targets for antiepileptic interventions?

  2013cites this paper
• Loss of hippocampal interneurons and epileptogenesis: a comparison of two animal models of acquired epilepsy

  2013cites this paper
• Tonic GABA(A) receptor-mediated signalling in temporal lobe epilepsy.

  2013influential citation
• Restoration of Neuroendocrine Stress Response by Glucocorticoid Receptor or GABAA Receptor Antagonists after Experimental Traumatic Brain Injury

  2013cites this paper