Acute Prosocial Effects of Oxytocin and Vasopressin When Given Alone or in Combination with 3,4-Methylenedioxymethamphetamine in Rats: Involvement of the V1A Receptor

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Neuropsychopharmacology

• Publication date

  2013-10-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1038/npp.2013.125PMID 23676791PMCID PMC3773675
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Long-Term Administration of Intranasal Oxytocin Is a Safe and Promising Therapy for Early Adolescent Boys with Autism Spectrum Disorders

  2013cited by this paper
• Oxytocin and vasopressin in rodent behaviors related to social dysfunctions in autism spectrum disorders.

  2013cited by this paper
• Chronic intranasal oxytocin causes long-term impairments in partner preference formation in male prairie voles.

  2013cited by this paper
• Proconvulsive effects of oxytocin in the generalized pentylenetetrazol mouse model are mediated by vasopressin 1a receptors.

  2012cited by this paper
• The Nonpeptide Oxytocin Receptor Agonist WAY 267,464: Receptor‐Binding Profile, Prosocial Effects and Distribution of c‐Fos Expression in Adolescent Rats

  2012cited by this paper
• Oxytocin and Vasopressin Agonists and Antagonists as Research Tools and Potential Therapeutics

  2012cited by this paper
• Vasopressin regulates social recognition in juvenile and adult rats of both sexes, but in sex- and age-specific ways.

  2012cited by this paper
• Adjunctive intranasal oxytocin improves verbal memory in people with schizophrenia.

  2012cited by this paper
• Examining the role of oxytocin in the interoceptive effects of 3,4‐methylenedioxymethamphetamine (MDMA, ‘ecstasy’) using a drug discrimination paradigm in the rat

  2011cited by this paper
• Vasotocin neurons and septal V1a-like receptors potently modulate songbird flocking and responses to novelty.

  2011cited by this paper
• Pharmacologic rescue of impaired cognitive flexibility, social deficits, increased aggression, and seizure susceptibility in oxytocin receptor null mice: a neurobehavioral model of autism.

  2011cited by this paper
• The Neuropeptide Oxytocin Facilitates Pro-Social Behavior and Prevents Social Avoidance in Rats and Mice

  2011cited by this paper
• Sex differences in the effects of MDMA (ecstasy) on plasma copeptin in healthy subjects.

  2011cited by this paper
• The safety and efficacy of ±3,4-methylenedioxymethamphetamine-assisted psychotherapy in subjects with chronic, treatment-resistant posttraumatic stress disorder: the first randomized controlled pilot study

  2011cited by this paper
• MDMA-induced c-Fos expression in oxytocin-containing neurons is blocked by pretreatment with the 5-HT-1A receptor antagonist WAY 100635.

  2011cited by this paper
• Adolescent Oxytocin Exposure Causes Persistent Reductions in Anxiety and Alcohol Consumption and Enhances Sociability in Rats

  2011cited by this paper
• Oxytocin-Induced Analgesia and Scratching Are Mediated by the Vasopressin-1A Receptor in the Mouse

  2010cited by this paper
• An intrinsic vasopressin system in the olfactory bulb is involved in social recognition

  2010cited by this paper
• Triazole oxytocin antagonists: Identification of an aryloxyazetidine replacement for a biaryl substituent.

  2010cited by this paper
• Chronic icv oxytocin attenuates the pathological high anxiety state of selectively bred Wistar rats.

  2010cited by this paper
• A randomized controlled trial of intranasal oxytocin as an adjunct to exposure therapy for social anxiety disorder.

  2009cited by this paper
• Increased oxytocin concentrations and prosocial feelings in humans after ecstasy (3,4-methylenedioxymethamphetamine) administration

  2009cited by this paper
• Oxytocin protects against negative behavioral and autonomic consequences of long-term social isolation.

  2009cited by this paper
• Oxytocin: the great facilitator of life.

  2009cited by this paper
• Neural correlates of MDMA (“Ecstasy”)-induced social interaction in rats

  2009cited by this paper
• Peptide and non-peptide agonists and antagonists for the vasopressin and oxytocin V1a, V1b, V2 and OT receptors: research tools and potential therapeutic agents.

  2008cited by this paper
• Oxytocin shapes the neural circuitry of trust and trust adaptation in humans.

  2008cited by this paper
• Reduced sensitivity to MDMA-induced facilitation of social behaviour in MDMA pre-exposed rats.

  2008cited by this paper
• Vasopressin: behavioral roles of an "original" neuropeptide.

  2008cited by this paper
• Oxytocin increases retention of social cognition in autism.

  2007cited by this paper
• Oxytocin improves "mind-reading" in humans.

  2007cited by this paper
• A role for oxytocin and 5-HT(1A) receptors in the prosocial effects of 3,4 methylenedioxymethamphetamine ("ecstasy").

  2007cited by this paper
• Impaired social interaction and reduced anxiety-related behavior in vasopressin V1a receptor knockout mice.

  2007cited by this paper
• Sex-specific influences of vasopressin on human social communication

  2006cited by this paper
• Partial lesion of the serotonergic system by a single dose of MDMA results in behavioural disinhibition and enhances acute MDMA-induced social behaviour on the social interaction test.

  2006cited by this paper
• A review of acute effects of 3,4-methylenedioxymethamphetamine in healthy volunteers

  2006cited by this paper
• Anxiolytic-like activity of oxytocin in male mice: behavioral and autonomic evidence, therapeutic implications

  2006cited by this paper
• Peptides of love and fear: vasopressin and oxytocin modulate the integration of information in the amygdala.

  2005cited by this paper
• Vasopressin and Oxytocin Excite Distinct Neuronal Populations in the Central Amygdala

  2005cited by this paper
• The V1a vasopressin receptor is necessary and sufficient for normal social recognition: a gene replacement study.

  2005cited by this paper
• Oxytocin increases trust in humans

  2005cited by this paper
• Profound Impairment in Social Recognition and Reduction in Anxiety-Like Behavior in Vasopressin V1a Receptor Knockout Mice

  2004cited by this paper
• The effects of vasopressin on human facial responses related to social communication.

  2004cited by this paper
• Serotonin Receptors Involved in Vasopressin and Oxytocin Secretion

  2003cited by this paper
• Increased Anxiety 3 Months after Brief Exposure to MDMA (‘Ecstasy’) in Rats: Association with Altered 5-HT Transporter and Receptor Density

  2003cited by this paper
• Action of MDMA (Ecstasy) and Its Metabolites on Arginine Vasopressin Release

  2002cited by this paper
• MDMA ("ecstasy") exhibits an anxiogenic-like activity in social encounters between male mice.

  2001cited by this paper
• Oxytocin in the Medial Amygdala is Essential for Social Recognition in the Mouse

  2001cited by this paper
• Oxytocin modulates psychotomimetic-induced deficits in sensorimotor gating

  1999cited by this paper
• Binding of the Non-Peptide Vasopressin V1a Receptor Antagonist SR-49059 in the Rat Brain: An in vitro and in vivo Autoradiographic Study

  1999cited by this paper
• Low-dose MDMA ("ecstasy") induces vasopressin secretion.

  1998cited by this paper
• Vasopressin administration modulates anxiety-related behavior in rats.

  1998cited by this paper
• The effects of infusion of arginine vasopressin, oxytocin, or their antagonists into the olfactory bulb upon social recognition responses in male rats.

  1998cited by this paper
• Oxytocin, vasopressin, and the neuroendocrine basis of pair bond formation.

  1998cited by this paper
• Verbal memory after three months of intranasal vasopressin in healthy old humans.

  1997cited by this paper
• Aggressive behavior and jamming avoidance response in the weakly electric fish Gymnotus carapo: Effects of 3,4-methylenedioxymethamphetamine (MDMA)

  1997cited by this paper
• Brain potential changes after intranasal vs. intravenous administration of vasopressin: evidence for a direct nose-brain pathway for peptide effects in humans.

  1996cited by this paper
• Strain differences in fear-motivated behavior of rats.

  1996cited by this paper
• Simultaneous Monitoring of Intracerebral Release and Behavior: Endogenous Vasopressin Improves Social Recognition

  1994cited by this paper
• Microdialysis administration of vasopressin into the septum improves social recognition in Brattleboro rats.

  1994cited by this paper
• A role for central vasopressin in pair bonding in monogamous prairie voles

  1993cited by this paper
• Enhanced social interactions in rats following chronic, centrally infused oxytocin.

  1992cited by this paper
• Central administration of oxytocin modulates the infant rat's response to social isolation.

  1991cited by this paper
• Septal vasopressin modulates social memory in male rats.

  1988cited by this paper
• Identification and characterization of two classes of receptors for oxytocin and vasopressin in porcine tunica albuginea, epididymis, and vas deferens.

  1987cited by this paper
• Centrally injected arginine vasopressin (AVP) facilitates social memory in rats.

  1987cited by this paper
• Social interactions among rats housed in grouped and enriched conditions.

  1986cited by this paper
• Can aversive properties of (peripherally-injected) vasopressin account for its putative role in memory?

  1983cited by this paper
• The effects of vasopressin on positively rewarded responding and on locomotor activity in rats.

  1983cited by this paper
• Arginine vasopressin and a vasopressin antagonist peptide: opposite effects on extinction of active avoidance in rats.

  1981cited by this paper
• Play as a reinforcer for maze-learning in juvenile rats

  1981cited by this paper
• The use of social interaction as a method for detecting anxiolytic activity of chlordiazepoxide-like drugs.

  1980cited by this paper
• Social interaction between drugged and undrugged rats

  1974cited by this paper
• Effects of vasopressin on active and passive avoidance behavior.

  1972cited by this paper
• Social deprivation, housing density, and gregariousness in rats.

  1970cited by this paper
• Dimethyl sulfoxide (DMSO). Toxicology, pharmacology, and clinical experience.

  1967cited by this paper

• Oxytocin and Vasopressin Cross Talk Within the Brain Increases Blood Pressure

  2026cites this paper
• Exploring the impact of MDMA and oxytocin ligands on anxiety and social responses: A comprehensive behavioural and molecular study in the zebrafish model

  2025cites this paper
• Effects of oxytocin receptor ligands on anxiogenic-like effect, social avoidance and changes on medial prefrontal cortex oxytocin receptor expression evoked by chronic social defeat stress in rats.

  2025cites this paper
• The impact of membrane receptors on modulating empathic pain.

  2025cites this paper
• Using a socially enriched environment test to evaluate the effects of different therapeutic approaches on social behavior in a mouse model of social anxiety disorder.

  2025cites this paper
• History, pharmacology and therapeutic mechanisms of 3,4-methylenedioxymethamphetamine (MDMA).

  2025cites this paper
• A transcriptomic analysis in mice following a single dose of ibogaine identifies new potential therapeutic targets

  2024influential citation
• Effects of oxytocin receptor agonism on acquisition and expression of pair bonding in male prairie voles

  2024cites this paper
• Licit use of illicit drugs for treating depression: the pill and the process

  2024cites this paper
• Effects of Oxytocin Receptor Agonism on Acquisition and Expression of Pair Bonding in Male Prairie Voles

  2024cites this paper
• Naloxone increases conditioned fear responses during social buffering in male rats

  2024cites this paper
• Physiological and behavioral contagion/buffering effects of chronic unpredictable stress in a socially enriched environment: A preliminary study

  2024cites this paper
• Body Weight Modulates the Impact of Oxytocin on Chronic Cold-Immobilization Stress Response.

  2024cites this paper
• The Role of Oxytocin and Vasopressin in Drug-Induced Reward—Implications for Social and Non-Social Factors

  2023influential citation
• Social rank-dependent effects of testosterone on huddling strategies in mice

  2023cites this paper
• Maternal immune activation affects socio-communicative behavior in adult rats

  2023cites this paper
• Observational learning in rats: Interplay between demonstrator and observer behavior.

  2023cites this paper
• The Effects of Drugs on Behavior Maintained by Social Contact: Role of Monoamines in Social Reinforcement

  2022cites this paper
• Contrasting central and systemic effects of arginine-vasopressin on urinary marking behavior as a social signal in male mice.

  2022cites this paper
• Oxytocin promotes social proximity and decreases vigilance in groups of African lions

  2022cites this paper
• Four hypothalamic peptides and their impact on drug-seeking behaviour: a prefrontal cortex view.

  2022cites this paper
• Long-lasting effects of postweaning sleep deprivation on cognitive function and social behaviors in adult mice.

  2022cites this paper
• A Systematic Review of the MDMA Model to Address Social Impairment in Autism

  2021cites this paper
• Roles of Oxytocin in Stress Responses, Allostasis and Resilience

  2021cites this paper
• Sucrose intake by rats affected by both intraperitoneal oxytocin administration and time of day

  2021cites this paper
• Vulnerability factors for mephedrone-induced conditioned place preference in rats—the impact of sex differences, social-conditioning and stress

  2021cites this paper
• Lack of evidence for positive reinforcing and prosocial effects of MDMA in pair-housed male and female rats.

  2021cites this paper
• P.083 Peripheral oxytocin administration increases social interaction in the rat through activity at nucleus accumbens oxytocin receptors

  2020cites this paper
• Divergent pathways mediate 5-HT1A receptor agonist effects on close social interaction, grooming and aggressive behaviour in mice: Exploring the involvement of the oxytocin and vasopressin systems

  2020influential citation
• The impact of early life stress on the central oxytocin system and susceptibility for drug addiction: Applicability of oxytocin as a pharmacotherapy.

  2020cites this paper
• Differential sensitivity to detect prosocial effects of 3,4‐methylenedioxymethamphetamine (MDMA) in different social approach paradigms in mice

  2020cites this paper
• Oxytocin has sex-specific effects on social behaviour and hypothalamic oxytocin immunoreactive cells but not hippocampal neurogenesis in adult rats

  2019cites this paper
• Childhood stress impairs social function through AVP-dependent mechanisms

  2019cites this paper
• Increased anxiety and decreased sociability induced by paternal deprivation involve the PVN-PrL OTergic pathway

  2019cites this paper
• Dose dependent effects of oxytocin on cognitive defects and anxiety disorders in adult rats following acute infantile maternal deprivation stress

  2019cites this paper
• Viral rescue of magnocellular vasopressin cells in adolescent Brattleboro rats ameliorates diabetes insipidus, but not the hypoaroused phenotype

  2019cites this paper
• Effects of oxytocin receptor antagonism on social function and corticosterone release after adolescent social instability in male rats.

  2019cites this paper
• Early life stress impairs social function through AVP-dependent mechanisms

  2019cites this paper
• Psychedelic agents : Changes induced in subjective experience and brain activity

  2019cites this paper
• The effect of chronic oxytocin treatment during abstinence from methamphetamine self-administration on incubation of craving, reinstatement, and anxiety

  2019cites this paper
• Distinct acute effects of LSD, MDMA, and d-amphetamine in healthy subjects

  2019cites this paper
• Reduced Consolation Behaviors in Physically Stressed Mandarin Voles: Involvement of Oxytocin, Dopamine D2, and Serotonin 1A Receptors Within the Anterior Cingulate Cortex

  2019cites this paper
• Oxytocin and Social Behaviour in Dogs and Other (Self-)Domesticated Species Methodological Caveats and Promising Perspectives

  2019cites this paper
• The vagus nerve mediates the suppressing effects of peripherally administered oxytocin on methamphetamine self-administration and seeking in rats

  2019cites this paper
• Prosocial effects of an oxytocin metabolite, but not synthetic oxytocin receptor agonists, in a mouse model of autism

  2019cites this paper
• Involvement of oxytocin and GABA in consolation behavior elicited by socially defeated individuals in mandarin voles.

  2019cites this paper
• Impaired innate and conditioned social behavior in adult C57Bl6/J mice prenatally exposed to chlorpyrifos

  2019cites this paper
• Oxytocin and vasopressin inhibit hyper-aggressive behaviour in socially isolated mice.

  2019cites this paper
• (±)-MDMA and its enantiomers: potential therapeutic advantages of R(−)-MDMA

  2018cites this paper
• The role of the vasopressin V1A receptor in oxytocin modulation of methamphetamine primed reinstatement

  2018influential citation
• New psychoactive substances—Synthetic stimulants

  2018cites this paper
• Effects of alcohol and psychostimulants on the vasopressin system: Behavioural implications

  2018cites this paper
• Oxytocin Modulation of Neural Circuits.

  2018cites this paper
• Dark Classics in Chemical Neuroscience: 3,4-Methylenedioxymethamphetamine.

  2018cites this paper
• Oxytocin attenuates phencyclidine hyperactivity and increases social interaction and nucleus accumben dopamine release in rats

  2018cites this paper
• Investigation of social, affective, and locomotor behavior of adolescent Brattleboro rats reveals a link between vasopressin's actions on arousal and social behavior

  2018cites this paper
• and V 1a receptors in oxytocin-induced LMA and hypothermia

  2018cites this paper
• Influencia del genotipo apoE en la expresión de efectos neuroconductuales derivados de la exposición postnatal a clorpirifós

  2017cites this paper
• Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery.

  2017cites this paper
• Endogenous Oxytocin, Vasopressin, and Aggression in Domestic Dogs

  2017cites this paper
• Early Intranasal Vasopressin Administration Impairs Partner Preference in Adult Male Prairie Voles (Microtus ochrogaster)

  2017cites this paper
• The Psychopharmacology of Novel Synthetic Cannabinoids

  2017cites this paper
• The Non-Peptide Arginine-Vasopressin v1a Selective Receptor Antagonist, SR49059, Blocks the Rewarding, Prosocial, and Anxiolytic Effects of 3,4-Methylenedioxymethamphetamine and Its Derivatives in Zebra Fish

  2017cites this paper
• The Oxytocin–Vasopressin Pathway in the Context of Love and Fear

  2017cites this paper
• Acute and residual effects in adolescent rats resulting from exposure to the novel synthetic cannabinoids AB-PINACA and AB-FUBINACA

  2017cites this paper
• An investigation of social cognition using psilocybin and MDMA

  2017cites this paper
• Corrigendum: Dose-Dependent and Lasting Influences of Intranasal Vasopressin on Face Processing in Men

  2017cites this paper
• Increased anxiety and decreased sociability in adulthood following paternal deprivation involve oxytocin in the mPFC

  2017cites this paper
• Conspecific Interactions in Adult Laboratory Rodents: Friends or Foes?

  2017cites this paper
• Oxytocin in the medial prefrontal cortex attenuates anxiety: Anatomical and receptor specificity and mechanism of action.

  2017cites this paper
• Dose-Dependent and Lasting Influences of Intranasal Vasopressin on Face Processing in Men

  2017cites this paper
• Oxytocin Mitigates the Negative Consequences of Chronic Social Isolation in Prairie Voles (Microtus ochrogaster)

  2017cites this paper
• Preference for novel faces in male infant monkeys predicts cerebrospinal fluid oxytocin concentrations later in life

  2017cites this paper
• Rebalancing the Addicted Brain: Oxytocin Interference with the Neural Substrates of Addiction.

  2017cites this paper
• Title : Strongly bonded family members in common 1 marmosets show synchronized fluctuations in oxytocin 2 3

  2017cites this paper
• The sex-specific effects of neuropeptide receptors in the bed nucleus of the stria terminalis on social behavior

  2017influential citation
• Novel Roles of Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) and its Receptors in Social Behaviors and Stress Responses in the Mouse

  2016cites this paper
• Model Roles of the Hypothalamo-Neurohypophysial System in Neuroscience Study

  2016cites this paper
• Role of the oxytocin system in amygdala subregions in the regulation of social interest in male and female rats.

  2016cites this paper
• Sex Differences in the Embryonic Development of the Central Oxytocin System in Mice

  2016cites this paper
• Inhibition of vasopressin V1a receptors in the medioventral bed nucleus of the stria terminalis has sex- and context-specific anxiogenic effects.

  2016influential citation
• The effects of MDMA on socio-emotional processing: Does MDMA differ from other stimulants?

  2016cites this paper
• Regional c-Fos expression induced by peripheral oxytocin administration is prevented by the vasopressin 1A receptor antagonist SR49059.

  2016cites this paper
• Effects of oxytocin on serotonin 1B agonist-induced autism-like behavior in mice.

  2016cites this paper
• MDMA ('Ecstasy'), oxytocin and vasopressin modulate social preference in rats: A role for handling and oxytocin receptors.

  2016cites this paper
• The neurocircuitry involved in oxytocin modulation of methamphetamine addiction.

  2016cites this paper
• Lysergic acid diethylamide: a drug of ‘use’?

  2016cites this paper
• [Synthetic Drugs - An Overview of Important and Newly Emerging Substances].

  2016cites this paper
• Alcohol acutely enhances decoding of positive emotions and emotional concern for positive stimuli and facilitates the viewing of sexual images

  2016cites this paper
• Moderate Stress-Induced Social Bonding and Oxytocin Signaling are Disrupted by Predator Odor in Male Rats

  2016cites this paper
• Involvement of the oxytocin system in the bed nucleus of the stria terminalis in the sex-specific regulation of social recognition.

  2016cites this paper
• Effects of intranasal and peripheral oxytocin or gastrin-releasing peptide administration on social interaction and corticosterone levels in rats.

  2016cites this paper
• Cross-talk between the Oxytocin and Vasopressin Systems in the Brian: Roles in Social Behavior

  2016cites this paper
• The Behavioral Effects of MDMA in Humans Under Controlled Laboratory Conditions

  2016cites this paper
• Neural mechanisms of oxytocin and serotonin interaction in non-human primates and patients with autism

  2016cites this paper
• Conducive Social Roles and Demographics Influencing Volunteering

  2016cites this paper
• Physiological Correlates of Volunteering

  2016cites this paper
• Oxytocin (OT) and arginine-vasopressin (AVP) act on OT receptors and not AVP V1a receptors to enhance social recognition in adult Syrian hamsters (Mesocricetus auratus).

  2016cites this paper
• The prosocial effects of 3,4-methylenedioxymethamphetamine (MDMA): Controlled studies in humans and laboratory animals.

  2015influential citation
• Strongly bonded family members in common marmosets show synchronized fluctuations in oxytocin.

  2015cites this paper