Tyrosine Phosphorylation of the β-Amyloid Precursor Protein Cytoplasmic Tail Promotes Interaction with Shc*

β-Amyloid precursor protein (APP) is a widely expressed transmembrane protein of unknown function that is involved in the pathogenesis of Alzheimer's disease. The cytoplasmic tail of APP interacts with phosphotyrosine binding (PTB) domain containing proteins (Fe65, X11, mDab-1, and JIP-1) and may modulate gene expression and apoptosis. We now identify Shc A and Shc C, PTB-containing adapter proteins that signal to cellular differentiation and survival pathways, as novel APP-interacting proteins. The APP cytoplasmic tail contains a PTB-binding motif (Y682ENPTY687) that, when phosphorylated on Tyr682, precipitated the PTB domain of Shc A and Shc C, as well as endogenous full-length Shc A. APP and Shc C were physically associated in adult mouse brain homogenates. Increase in phosphorylation of APP by overexpression of the nerve growth factor receptor Trk A in 293T cells promoted the interaction of transfected APP and endogenous Shc A. Pervanadate treatment of N2a neuroblastoma cells resulted in tyrosine phosphorylation and association of endogenous APP and Shc A. Thus, APP and Shc proteins interact in vitro, in cells, and in the mouse brain. Tyrosine phosphorylation of APP may promote the interaction with Shc proteins.

• Publication year

  2002

• Venue

  Journal of Biological Chemistry

• Publication date

  2002-05-10

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1074/jbc.M110286200PMID 11877420
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• APP and Shc C associated in adult mouse brain homogenates, and increased APP tyrosine phosphorylation promoted APP-Shc A association in cells.

  Confidence 0.94

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewjihoonc (k5vuy3tzcm) review
• Phosphorylation of the APP Y682ENPTY687 PTB-binding motif enabled precipitation of the Shc A and Shc C PTB domains and endogenous full-length Shc A.

  Confidence 0.96

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewjihoonc (k5vuy3tzcm) review
• Shc A and Shc C were identified as novel APP-interacting proteins.

  Confidence 0.98

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewjihoonc (k5vuy3tzcm) review

• app cytoplasmic tail

  protein region

  The intracellular C-terminal region of APP that contains the binding site tested for PTB-domain interactions.

  Aliases: cytoplasmic tail of APP

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewjihoonc (k5vuy3tzcm) review
• shc a

  protein

  An Shc family adapter protein isoform with a PTB domain that participates in signaling to differentiation and survival pathways.

  Aliases: ShcA

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewjihoonc (k5vuy3tzcm) review
• shc c

  protein

  An Shc family adapter protein isoform with a PTB domain that participates in signaling to differentiation and survival pathways.

  Aliases: ShcC

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewjihoonc (k5vuy3tzcm) review
• tyrosine phosphorylation of app

  post-translational modification

  Phosphorylation of APP on tyrosine residues, especially Tyr682, that is evaluated as a binding-relevant state.

  Aliases: phosphorylated APP, APP phosphorylation on Tyr682

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewjihoonc (k5vuy3tzcm) review
• y682enpty687 ptb-binding motif

  motif

  A tyrosine-centered sequence in the APP cytoplasmic tail that serves as a PTB-domain binding site.

  Aliases: Y682ENPTY687, ENPTY motif, Tyr682-containing motif

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewjihoonc (k5vuy3tzcm) review
• β-amyloid precursor protein (app)

  protein

  A widely expressed transmembrane precursor protein whose cytoplasmic tail is examined here for interactions with PTB-domain adapter proteins.

  Aliases: APP, beta-amyloid precursor protein

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewjihoonc (k5vuy3tzcm) review

• Jun NH2-terminal Kinase (JNK) Interacting Protein 1 (JIP1) Binds the Cytoplasmic Domain of the Alzheimer's β-Amyloid Precursor Protein (APP)*

  2002cited by this paper
• The β-Amyloid Precursor Protein Functions as a Cytosolic Anchoring Site That Prevents Fe65 Nuclear Translocation*

  2001cited by this paper
• c-Jun N-Terminal Kinase (JNK)-Interacting Protein-1b/Islet-Brain-1 Scaffolds Alzheimer's Amyloid Precursor Protein with JNK

  2001cited by this paper
• Kinesin-mediated axonal transport of a membrane compartment containing β-secretase and presenilin-1 requires APP

  2001cited by this paper
• The amyloid precursor protein (APP)‐cytoplasmic fragment generated by γ‐secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture

  2001cited by this paper
• Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid.

  2001cited by this paper
• Activation and redistribution of c‐Jun N‐terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease

  2001cited by this paper
• Shc signaling in differentiating neural progenitor cells

  2001cited by this paper
• Phosphorylated Map Kinase (ERK1, ERK2) Expression is Associated with Early Tau Deposition in Neurones and Glial Cells, but not with Increased Nuclear DNA Vulnerability and Cell Death, in Alzheimer Disease, Pick's Disease, Progressive Supranuclear Palsy and Corticobasal Degeneration

  2001cited by this paper
• A Portrait of Alzheimer Secretases--New Features and Familiar Faces

  2001cited by this paper
• A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60.

  2001cited by this paper
• The β-Amyloid Precursor Protein APP Is Tyrosine-phosphorylated in Cells Expressing a Constitutively Active Form of the Abl Protoncogene*

  2001cited by this paper
• Amino-terminal modification and tyrosine phosphorylation of [corrected] carboxy-terminal fragments of the amyloid precursor protein in Alzheimer's disease and Down's syndrome brain.

  2001cited by this paper
• Phosphorylation-induced structural changes in the amyloid precursor protein cytoplasmic tail detected by NMR.

  2001cited by this paper
• Effects of the β-Amyloid and Carboxyl-terminal Fragment of Alzheimer's Amyloid Precursor Protein on the Production of the Tumor Necrosis Factor-α and Matrix Metalloproteinase-9 by Human Monocytic THP-1*

  2001cited by this paper
• The mammalian ShcB and ShcC phosphotyrosine docking proteins function in the maturation of sensory and sympathetic neurons.

  2000cited by this paper
• Mice with Combined Gene Knock-Outs Reveal Essential and Partially Redundant Functions of Amyloid Precursor Protein Family Members

  2000cited by this paper
• Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I.

  2000cited by this paper
• New Role for Shc in Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway

  2000cited by this paper
• Proteolytic processing and cell biological functions of the amyloid precursor protein.

  2000cited by this paper
• Phosphorylation Sites on Tau Identified by Nanoelectrospray Mass Spectrometry

  2000cited by this paper
• Neuron‐Specific Phosphorylation of Alzheimer's β‐Amyloid Precursor Protein by Cyclin‐Dependent Kinase 5

  2000cited by this paper
• Generation of an Apoptotic Intracellular Peptide by γ-Secretase Cleavage of Alzheimer's Amyloid ß Protein Precursor

  2000cited by this paper
• Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation.

  1999cited by this paper
• Proteolytic Processing of the Alzheimer’s Disease Amyloid Precursor Protein within Its Cytoplasmic Domain by Caspase-like Proteases*

  1999cited by this paper
• Alternative, Non-secretase Processing of Alzheimer’s β-Amyloid Precursor Protein during Apoptosis by Caspase-6 and -8*

  1999cited by this paper
• A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

  1999cited by this paper
• The Disabled 1 Phosphotyrosine-Binding Domain Binds to the Internalization Signals of Transmembrane Glycoproteins and to Phospholipids

  1999cited by this paper
• Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation.

  1999cited by this paper
• Elevated expression of p21ras is an early event in Alzheimer's disease and precedes neurofibrillary degeneration.

  1999cited by this paper
• The p66shc adaptor protein controls oxidative stress response and life span in mammals

  1999cited by this paper
• Cloning of AIP1, a Novel Protein That Associates with the Apoptosis-linked Gene ALG-2 in a Ca2+-dependent Reaction*

  1999cited by this paper
• Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

  1998cited by this paper
• Phosphorylation of microtubule‐associated protein tau by stress‐activated protein kinases

  1997cited by this paper
• Reactivating kinase/p38 phosphorylates tau protein in vitro.

  1997cited by this paper
• Alzheimer’s Presenilin Mutation Sensitizes Neural Cells to Apoptosis Induced by Trophic Factor Withdrawal and Amyloid β-Peptide: Involvement of Calcium and Oxyradicals

  1997cited by this paper
• Expression of V642 APP mutant causes cellular apoptosis as Alzheimer trait‐linked phenotype.

  1996cited by this paper
• Requirement of the Familial Alzheimer's Disease Gene PS2 for Apoptosis

  1996cited by this paper
• The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein

  1996cited by this paper
• Participation of Presenilin 2 in Apoptosis: Enhanced Basal Activity Conferred by an Alzheimer Mutation

  1996cited by this paper
• A family of Shc related proteins with conserved PTB, CH1 and SH2 regions.

  1996cited by this paper
• Shc Binding to Nerve Growth Factor Receptor Is Mediated by the Phosphotyrosine Interaction Domain (*)

  1995cited by this paper
• Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation.

  1995cited by this paper
• Ligand-dependent G Protein Coupling Function of Amyloid Transmembrane Precursor (*)

  1995cited by this paper
• The Regions of the Fe65 Protein Homologous to the Phosphotyrosine Interaction/Phosphotyrosine Binding Domain of Shc Bind the Intracellular Domain of the Alzheimer's Amyloid Precursor Protein (*)

  1995cited by this paper
• A region in Shc distinct from the SH2 domain can bind tyrosine-phosphorylated growth factor receptors.

  1994cited by this paper
• An alternative to SH2 domains for binding tyrosine-phosphorylated proteins.

  1994cited by this paper
• A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction.

  1992cited by this paper
• Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

  1992cited by this paper
• Potentially amyloidogenic, carboxyl-terminal derivatives of the amyloid protein precursor.

  1992cited by this paper
• Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues.

  1988cited by this paper

• Therapeutic Options for Alzheimer’s Disease and Aging-Associated Cognitive Decline: State of the Art in the ACH2.0 Paradigm

  2026cites this paper
• Production of Amyloid-β in the Aβ-Protein-Precursor Proteolytic Pathway Is Discontinued or Severely Suppressed in Alzheimer’s Disease-Affected Neurons: Contesting the ‘Obvious’

  2025cites this paper
• Serum tyrosine associates with increased CSF Aβ42, reduced Aβ deposition, and cognitive improvement in MCI: modulation by confounding factors

  2025cites this paper
• Alzheimer’s Is a Multiform Disease of Sustained Neuronal Integrated Stress Response Driven by the C99 Fragment Generated Independently of AβPP; Proteolytic Production of Aβ Is Suppressed in AD-Affected Neurons: Evolution of a Theory

  2025cites this paper
• Quintessential Synergy: Concurrent Transient Administration of Integrated Stress Response Inhibitors and BACE1 and/or BACE2 Activators as the Optimal Therapeutic Strategy for Alzheimer’s Disease

  2024cites this paper
• Advances in the cell biology of the trafficking and processing of amyloid precursor protein: impact of familial Alzheimer's disease mutations

  2024cites this paper
• On the Inadequacy of the Current Transgenic Animal Models of Alzheimer’s Disease: The Path Forward

  2024cites this paper
• ACH2.0/E, the Consolidated Theory of Conventional and Unconventional Alzheimer’s Disease: Origins, Progression, and Therapeutic Strategies

  2024cites this paper
• The paradigm of amyloid precursor protein in amyotrophic lateral sclerosis: The potential role of the 682YENPTY687 motif

  2023cites this paper
• Next Generation Therapeutic Strategy for Treatment and Prevention of Alzheimer’s Disease and Aging-Associated Cognitive Decline: Transient, Once-in-a-Lifetime-Only Depletion of Intraneuronal Aβ (iAβ) by Its Targeted Degradation via Augmentation of Intra-iAβ-Cleaving Activities of BACE1 and/or BACE2

  2023cites this paper
• The Amyloid Cascade Hypothesis 2.0 for Alzheimer’s Disease and Aging-Associated Cognitive Decline: From Molecular Basis to Effective Therapy

  2023cites this paper
• The Influence of Copper Nanoparticles on Neurometabolism Marker Levels in the Brain and Intestine in a Rat Model

  2023cites this paper
• Amyloid Precursor Protein: A Regulatory Hub in Alzheimer's Disease

  2023cites this paper
• Vav2 is a novel APP-interacting protein that regulates APP protein level

  2022cites this paper
• Phosphorylation and Glycosylation of Amyloid-β Protein Precursor: The Relationship to Trafficking and Cleavage in Alzheimer’s Disease

  2021cites this paper
• TrkB receptor cleavage by delta-secretase abolishes its phosphorylation of APP, aggravating Alzheimer’s disease pathologies

  2020cites this paper
• Positive Association of Human SHC3 Gene with Schizophrenia in a Northeast Chinese Han Population

  2020cites this paper
• Phosphorylation Signaling in APP Processing in Alzheimer’s Disease

  2019cites this paper
• The Y682ENPTY687 motif of APP: Progress and insights toward a targeted therapy for Alzheimer's disease patients.

  2019cites this paper
• Effects of the Pentapeptide P33 on Memory and Synaptic Plasticity in APP/PS1 Transgenic Mice: A Novel Mechanism Presenting the Protein Fe65 as a Target

  2019cites this paper
• The amyloid-β precursor protein (APP)-binding protein Fe65 and APP processing

  2018influential citation
• Protein Phosphorylation is a Key Mechanism in Alzheimer’s Disease

  2017cites this paper
• Chapter 6 Pin 1 Protects Against Alzheimer ' s Disease : One Goal , Multiple Mechanisms

  2017influential citation
• Defining the function of Amyloid Precursor Protein dimerisation in neuritogenesis

  2017influential citation
• Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents

  2017cites this paper
• Small things matter: Implications of APP intracellular domain AICD nuclear signaling in the progression and pathogenesis of Alzheimer's disease

  2017cites this paper
• APP Receptor? To Be or Not To Be.

  2016cites this paper
• c-Abl links APP-BACE1 interaction promoting APP amyloidogenic processing in Niemann-Pick type C disease.

  2016cites this paper
• Implication du domaine intracellulaire du précurseur de la protéine amyloïde dans la modulation de la plasticité synaptique

  2016influential citation
• Multisite tyrosine phosphorylation of the N‐terminus of Mint1/X11α by Src kinase regulates the trafficking of amyloid precursor protein

  2016cites this paper
• Cathepsin Inhibition Prevents Autophagic Protein Turnover and Downregulates Insulin Growth Factor-1 Receptor–Mediated Signaling in Neuroblastoma

  2016cites this paper
• Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration*

  2016cites this paper
• Cellular functions of the amyloid precursor protein from development to dementia.

  2015cites this paper
• Y682G Mutation of Amyloid Precursor Protein Promotes Endo-Lysosomal Dysfunction by Disrupting APP–SorLA Interaction

  2015influential citation
• ShcC proteins: brain aging and beyond.

  2015cites this paper
• Altered Levels of Amyloid Precursor Protein Intracellular Domain-interacting Proteins in Alzheimer Disease

  2014cites this paper
• RanBP9 Modulates AICD Localization and Transcriptional Activity via Direct Interaction with Tip60

  2014cites this paper
• APP Is Cleaved by Bace1 in Pre-Synaptic Vesicles and Establishes a Pre-Synaptic Interactome, via Its Intracellular Domain, with Molecular Complexes that Regulate Pre-Synaptic Vesicles Functions

  2014cites this paper
• Investigating mechanisms of neuronal migration in the zebrafish embryo

  2014cites this paper
• An Intracellular Threonine of Amyloid-β Precursor Protein Mediates Synaptic Plasticity Deficits and Memory Loss

  2013cites this paper
• Effect of Reserpine on the Behavioral Defects, Aβ-42 Deposition and NGF Metabolism in Tg2576 Transgenic Mouse Model for Alzheimer’s Disease

  2013cites this paper
• A new molecular explanation for age-related neurodegeneration: The Tyr682 residue of amyloid precursor protein

  2013cites this paper
• Intensive protein synthesis in neurons and phosphorylation of beta-amyloid precursor protein and tau-protein are triggering factors of neuronal amyloidosis and Alzheimer’s disease

  2013cites this paper
• NGF and APP Interplay: Focus on YENPTY Motif of Amyloid Precursor Protein and Y682 Residue

  2013cites this paper
• Pin1 Protects Against Alzheimer's Disease: One Goal, Multiple Mechanisms

  2013cites this paper
• The Contribution of the Amyloid Hypothesis to the Understanding of Alzheimer's Disease: A Critical Overview

  2012cites this paper
• Studies on the use of glycosaminoglycans for the treatment of Alzheimer's Disease

  2012cites this paper
• The Amyloid Precursor Protein Intracellular Domain-Fe65 Multiprotein Complexes: A Challenge to the Amyloid Hypothesis for Alzheimer's Disease?

  2012cites this paper
• Proteolytic processing of Alzheimer’s β‐amyloid precursor protein

  2012cites this paper
• Novel Adaptors of Amyloid Precursor Protein Intracellular Domain and Their Functional Implications

  2012cites this paper
• Studies on the use of glycosaminoglycans for the treatment of Alzheimer ’ s disease

  2012cites this paper
• Tyr682 in the Aβ‐precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance

  2012cites this paper
• Adaptor protein 2–mediated endocytosis of the β-secretase BACE1 is dispensable for amyloid precursor protein processing

  2012influential citation
• All in the Family: How the APPs Regulate Neurogenesis

  2012cites this paper
• Neurodegeneration in Alzheimer Disease: Role of Amyloid Precursor Protein and Presenilin 1 Intracellular Signaling

  2012cites this paper
• Interactome of the amyloid precursor protein APP in brain reveals a protein network involved in synaptic vesicle turnover and a close association with Synaptotagmin-1.

  2012cites this paper
• APP is Phosphorylated by TrkA and Regulates NGF/TrkA Signaling

  2011influential citation
• Dynamic Changes of the Phosphoproteome in Postmortem Mouse Brains

  2011cites this paper
• Activation of Amyloid Precursor Protein Processing by Growth Factors is Dependent on Ras GTPase Activity

  2011cites this paper
• The Intracellular Threonine of Amyloid Precursor Protein That Is Essential for Docking of Pin1 Is Dispensable for Developmental Function

  2011cites this paper
• APP physiological and pathophysiological functions: insights from animal models

  2011cites this paper
• Amyloid-β Protein Precursor Family Members: A Review from Homology to Biological Function

  2011cites this paper
• Functional implications of the conformational switch in AICD peptide upon binding to Grb2-SH2 domain.

  2011cites this paper
• A Single Tyrosine Residue in the Amyloid Precursor Protein Intracellular Domain Is Essential for Developmental Function*

  2011cites this paper
• Overexpression of TMP21 Could Induce not only Downregulation of TrkA/ERK Phosphorylation but also Upregulation of p75NTR/RhoA Expression on NGF Receptor Signaling Pathway

  2011cites this paper
• The Role of ShcA Phosphotyrosine Signaling in the Myocardium

  2011cites this paper
• Design, Synthesis and Biological Evaluation of 2,4-Disubstituted Pyrimidine Derivatives: Multifunctional Candidates as Potential Treatment Options for Alzheimer’s Disease

  2011cites this paper
• Rapamycin promotes β -amyloid production via ADAM-10 inhibition

  2011cites this paper
• EGCG functions through estrogen receptor‐mediated activation of ADAM10 in the promotion of non‐amyloidogenic processing of APP

  2010cites this paper
• Tyr682 in the Intracellular Domain of APP Regulates Amyloidogenic APP Processing In Vivo

  2010cites this paper
• Possible roles of amyloid intracellular domain of amyloid precursor protein.

  2010cites this paper
• EDG3 and SHC3 on chromosome 9q22 are co-amplified in human ependymomas.

  2010cites this paper
• Phosphorylation of APP‐CTF‐AICD domains and interaction with adaptor proteins: signal transduction and/or transcriptional role – relevance for Alzheimer pathology

  2010cites this paper
• Rapamycin promotes beta-amyloid production via ADAM-10 inhibition.

  2010cites this paper
• Synaptic NMDA Receptor Activation Stimulates α-Secretase Amyloid Precursor Protein Processing and Inhibits Amyloid-β Production

  2009cites this paper
• UNIVERSITA' DEGLI STUDI DI NAPOLI FEDERICO II Ph.D. in Molecular Medicine - Ciclo VIII/XXVI Human Genetics

  2009cites this paper
• Proteolytic processing of the Alzheimer APP protein family during neuronal differentiation

  2009cites this paper
• Amyloid precursor protein and its homologues: a family of proteolysis-dependent receptors

  2009influential citation
• Amyloid precursor family proteins are expressed by thymic and lymph node stromal cells but are not required for lymphocyte development

  2009cites this paper
• Regulation of the Physiological Function and Metabolism of AβPP by AβPP Binding Proteins

  2009cites this paper
• The interactome of the amyloid β precursor protein family members is shaped by phosphorylation of their intracellular domains

  2009influential citation
• Interactions of the NPXY microdomains of the low density lipoprotein receptor‐related protein 1

  2009cites this paper
• Ligand-Dependent Activation of the Chimeric Tumor Necrosis Factor Receptor-Amyloid Precursor Protein (APP) Reveals Increased APP Processing and Suppressed Neuronal Differentiation

  2009cites this paper
• Monitoring ``De Novo'' APP Synthesis by Taking Advantage of the Reversible Effect of Cycloheximide

  2009cites this paper
• Phosphorylation of a Tyrosine in the Amyloid-β Protein Precursor Intracellular Domain Inhibits Fe65 Binding and Signaling

  2009influential citation
• Interaction of Mint2 with TrkA Is Involved in Regulation of Nerve Growth Factor-induced Neurite Outgrowth*

  2009cites this paper
• Substrate specificity of γ-secretase and other intramembrane proteases

  2008cites this paper
• Mechanisms of Microglial Activation by Amyloid Precursor Protein and its Proteolytic Fragments

  2008cites this paper
• Amyloid precursor protein with the Alzheimer´s disease 670/671 mutation : Animal and cellular models

  2008cites this paper
• Towards Non Invasive Nerve Growth Factor Therapies for Alzheimer's Disease

  2008cites this paper
• UC San Diego UC San Diego Electronic Theses and Dissertations Title

  2008cites this paper
• Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65‐PTB2

  2008cites this paper
• A putative role of the Amyloid Precursor Protein Intracellular Domain (AICD) in transcription.

  2008influential citation
• The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer's disease.

  2008cites this paper
• Activation of mitogen-activated protein kinase pathways by the granulocyte colony-stimulating factor receptor: mechanisms and functional consequences.

  2007cites this paper
• AICD and its Adaptors – In Search of New Players

  2007influential citation
• Gleevec increases levels of the amyloid precursor protein intracellular domain and of the amyloid-beta degrading enzyme neprilysin.

  2007cites this paper
• Amyloid Precursor Protein and Presenilin1 Interact with the Adaptor GRB2 and Modulate ERK 1,2 Signaling*

  2007cites this paper
• Amyloid beta as a regulator of lipid homeostasis.

  2007cites this paper
• Screening for PTB Domain Binding Partners and Ligand Specificity Using Proteome-Derived NPXY Peptide Arrays

  2007cites this paper