IL23R R381Q and ATG16L1 T300A Are Strongly Associated With Crohn's Disease in a Study of New Zealand Caucasians With Inflammatory Bowel Disease

No abstract is available for this paper.

• Publication year

  2007

• Venue

  American Journal of Gastroenterology

• Publication date

  2007-12-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1111/j.1572-0241.2007.01525.xPMID 17894849
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Wellcome Trust Case Control Consortium, U.K.

  2008cited by this paper
• IL23R Variation Determines Susceptibility But Not Disease Phenotype in Inflammatory Bowel Disease

  2007cited by this paper
• Confirmation of the role of ATG16l1 as a Crohn's disease susceptibility gene

  2007influential reference
• Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

  2007cited by this paper
• Effect of inflammatory bowel disease classification changes on NOD2 genotype–phenotype associations in a population‐based cohort

  2007cited by this paper
• Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

  2007influential reference
• Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis

  2007cited by this paper
• A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5.

  2007cited by this paper
• Contribution of the novel inflammatory bowel disease gene IL23R to disease susceptibility and phenotype

  2007cited by this paper
• IL23R Arg381Gln is associated with childhood onset inflammatory bowel disease in Scotland

  2007cited by this paper
• The PTPN22 C1858T functional polymorphism and autoimmune diseases--a meta-analysis.

  2007cited by this paper
• A critical role for the autophagy gene Atg5 in T cell survival and proliferation

  2007cited by this paper
• A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

  2007influential reference
• Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

  2007cited by this paper
• IL‐23 receptor (IL‐23R) gene protects against pediatric Crohn's disease

  2007cited by this paper
• IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6.

  2006cited by this paper
• Autophagy as an immune defense mechanism.

  2006cited by this paper
• High incidence of Crohn's disease in Canterbury, New Zealand: Results of an epidemiologic study

  2006cited by this paper
• A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene

  2006influential reference
• New genes in inflammatory bowel disease: lessons for complex diseases?

  2006cited by this paper
• Endogenous MHC Class II Processing of a Viral Nuclear Antigen After Autophagy

  2005cited by this paper
• IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

  2005cited by this paper
• Escape of Intracellular Shigella from Autophagy

  2005cited by this paper
• Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology.

  2005cited by this paper
• Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease.

  2005cited by this paper
• Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

  2005cited by this paper
• Association of the PTPN22 locus with rheumatoid arthritis in a New Zealand Caucasian cohort.

  2005cited by this paper
• A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

  2005cited by this paper
• Inflammatory bowel disease susceptibility loci defined by genome scan meta-analysis of 1952 affected relative pairs.

  2004cited by this paper
• Cloning and Analysis of Human Apg16L

  2004cited by this paper
• Autophagy Defends Cells Against Invading Group A Streptococcus

  2004cited by this paper
• Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages.

  2004cited by this paper
• IBD: a family affair.

  2004cited by this paper
• Differential Effects of NOD2 Variants on Crohn's Disease Risk and Phenotype in Diverse Populations: A Metaanalysis

  2004cited by this paper
• Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

  2003cited by this paper
• Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation

  2003cited by this paper
• Host Recognition of Bacterial Muramyl Dipeptide Mediated through NOD2

  2003cited by this paper
• Suppression of Immune Induction of Collagen-Induced Arthritis in IL-17-Deficient Mice 1

  2003cited by this paper
• Nod2 Is a General Sensor of Peptidoglycan through Muramyl Dipeptide (MDP) Detection*

  2003cited by this paper
• Defining Complex Contributions of NOD2/CARD15 Gene Mutations, Age at Onset, and Tobacco Use On Crohn's Disease Phenotypes

  2003cited by this paper
• mimR - A package for graphical modelling in R

  2003cited by this paper
• The immunological and genetic basis of inflammatory bowel disease

  2003cited by this paper
• A Receptor for the Heterodimeric Cytokine IL-23 Is Composed of IL-12Rβ1 and a Novel Cytokine Receptor Subunit, IL-23R1

  2002cited by this paper
• The immunology of mucosal models of inflammation.

  2002cited by this paper
• CARD15 genetic variation in a Quebec population: prevalence, genotype-phenotype relationship, and haplotype structure.

  2002cited by this paper
• Ubiquitin and proteasomes: Molecular dissection of autophagy: two ubiquitin-like systems

  2001cited by this paper
• Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease

  2001cited by this paper
• A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

  2001cited by this paper
• Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations.

  2001cited by this paper
• Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

  2001cited by this paper
• Concordance of Inflammatory Bowel Disease among Danish Twins: Results of a Nationwide Study

  2000cited by this paper
• Autophagy as a regulated pathway of cellular degradation.

  2000cited by this paper
• The molecular basis of T helper 1 and T helper 2 cell differentiation.

  2000cited by this paper
• Concordance of inflammatory bowel disease among Danish twins. Results of a nationwide study.

  2000cited by this paper
• The IBD2 locus shows linkage heterogeneity between ulcerative colitis and Crohn disease.

  2000cited by this paper
• HLA-DR and -DQ phenotypes in inflammatory bowel disease: a meta-analysis

  1999cited by this paper
• Linkage of inflammatory bowel disease to human chromosome 6p.

  1999cited by this paper
• Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells.

  1997cited by this paper
• Type 1 T-helper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease.

  1997cited by this paper
• Mapping of a susceptibility locus for Crohn's disease on chromosome 16

  1996cited by this paper
• Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5.

  1996cited by this paper
• Contribution of genes of the major histocompatibility complex to susceptibility and disease phenotype in inflammatory bowel disease.

  1996cited by this paper
• Genetics versus environment in inflammatory bowel disease: results of a British twin study

  1996cited by this paper
• Introduction to graphical modelling

  1995cited by this paper
• Antibodies to interleukin 12 abrogate established experimental colitis in mice

  1995cited by this paper
• A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies.

  1991cited by this paper
• HLA-DR4 subtype frequencies in rheumatoid arthritis indicate that DRB1 is the major susceptibility locus within the HLA class II region.

  1989cited by this paper
• Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking.

  1988cited by this paper
• A simple method for DNA purification from peripheral blood.

  1988cited by this paper
• Mucosal subclass distribution of immunoglobulin G-producing cells is different in ulcerative colitis and Crohn's disease of the colon.

  1987cited by this paper
• EncephalomyelitisDevelopment of Experimental Autoimmune IL-17 Plays an Important Role in the

  year unknowncited by this paper

• ACG Clinical Guideline: Management of Crohn's Disease in Adults

  2025cites this paper
• Population stratified differences between ATG16L1 rs2241880 polymorphism with Crohn's disease risk: a systematic review and meta-analysis

  2025cites this paper
• ATG16L1 rs2241880/T300A increases susceptibility to perianal Crohn's disease: An updated meta‐analysis on inflammatory bowel disease risk and clinical outcomes

  2023cites this paper
• Autophagy and Apoptosis in Inflammatory Bowel Disease

  2023cites this paper
• Interleukin 23 receptor: Expression and regulation in immune cells

  2023cites this paper
• Association between Taxonomic Composition of Gut Microbiota and Host Single Nucleotide Polymorphisms in Crohn’s Disease Patients from Russia

  2023cites this paper
• Digestive Tract Disease

  2021cites this paper
• Genetic polymorphisms of ATG16L1 and IRGM genes in Malaysian patients with Crohn's disease

  2020cites this paper
• Non-autophagy role of Atg5 and NBR1 in unconventional secretion of IL-12 prevents gut dysbiosis and inflammation

  2020cites this paper
• Current Understanding of Autophagy in Pregnancy

  2019cites this paper
• Genetic association between IL23R rs11209026 and rs10889677 polymorphisms and risk of Crohn’s disease and ulcerative colitis: evidence from 41 studies

  2019influential citation
• Roles of Autophagy-Related Genes in the Pathogenesis of Inflammatory Bowel Disease

  2019cites this paper
• Genetic Variations at rs3129891 and rs77005575 are Associated With Reduced Expression of Enteric α-defensins in IBD Patients

  2019cites this paper
• IL23R-Protective Coding Variant Promotes Beneficial Bacteria and Diversity in the Ileal Microbiome in Healthy Individuals Without Inflammatory Bowel Disease

  2018cites this paper
• Effector T Helper Cell Subsets in Inflammatory Bowel Diseases

  2018cites this paper
• Modulating T Cell Responses via Autophagy: The Intrinsic Influence Controlling the Function of Both Antigen-Presenting Cells and T Cells

  2018cites this paper
• ACG Clinical Guideline: Management of Crohn’s Disease in Adults

  2018cites this paper
• Association of Autophagy Gene ATG16L1 Polymorphism with Human Prostate Cancer and Bladder Cancer in Turkish Population

  2018influential citation
• T300A variant of AT16L1 gene in a cohort of Algerian Crohn disease patients.

  2018cites this paper
• Management of Crohn's disease in Taiwan: consensus guideline of the Taiwan Society of Inflammatory Bowel Disease

  2017cites this paper
• Crohn's Colitis: Development of a multiplex gene expression assay comparing mRNA levels of susceptibility genes.

  2017cites this paper
• Chapter 17 – Nutrigenomics: Integrating Genomic Approaches Into Nutrition Research

  2017cites this paper
• Association of ATG16L1 gene haplotype with inflammatory bowel disease in Indians

  2017cites this paper
• MicroRNAs: how many in inflammatory bowel disease?

  2016cites this paper
• IL-23R mutation is associated with ulcerative colitis: A systemic review and meta-analysis

  2016cites this paper
• Association between ATG16L1 gene polymorphism and the risk of Crohn’s disease

  2016cites this paper
• Systematic meta-analyses and field synopsis of genetic and epigenetic studies in paediatric inflammatory bowel disease

  2016cites this paper
• Protective role of R381Q (rs11209026) polymorphism in IL-23R gene in immune-mediated diseases: A comprehensive review

  2016influential citation
• Investigating differential T cell polarization in the two pathological forms of sheep paratuberculosis

  2016cites this paper
• Association of Interleukin-23 receptor gene polymorphisms with susceptibility to Crohn’s disease: A meta-analysis

  2015cites this paper
• Smoking behaviour modifies IL23r‐associated disease risk in patients with Crohn's disease

  2015cites this paper
• ATG16L1 and IL23R Variants and Genetic Susceptibility to Crohn's Disease: Mode of Inheritance Based on Meta-analysis of Genetic Association Studies

  2015cites this paper
• Interleukin-23 receptor genetic polymorphisms and ulcerative colitis susceptibility: A meta-analysis.

  2015cites this paper
• ATG16L1: A multifunctional susceptibility factor in Crohn disease

  2015cites this paper
• Susceptibility to ulcerative colitis in Hungarian patients determined by gene-gene interactions.

  2014cites this paper
• Association between nucleotide oligomerisation domain two (Nod2) gene polymorphisms and canine inflammatory bowel disease.

  2014cites this paper
• How will insights from genetics translate to clinical practice in inflammatory bowel disease?

  2014cites this paper
• IL23R and ATG16L1 variants in Moroccan patients with inflammatory bowel disease

  2014cites this paper
• Determination of autophagy gene ATG16L1 polymorphism in human colorectal cancer.

  2014cites this paper
• Veterinary Immunology and Immunopathology

  2014cites this paper
• Towards personalized care in IBD

  2014cites this paper
• Genetic variants in the IL12B gene are associated with inflammatory bowel diseases in the Korean population

  2013cites this paper
• Immunomodulators in Inflammatory Bowel Disease: An Emerging Role for Biologic Agents

  2013cites this paper
• The role of the innate immune system in microbially induced intestinal inflammation and neoplasia

  2013cites this paper
• Commentary: predicting complicated Crohn's disease and surgery – phenotypes, genetics, serology and psychological characteristics of a population‐based cohort

  2013cites this paper
• Predicting complicated Crohn's disease and surgery: phenotypes, genetics, serology and psychological characteristics of a population‐based cohort

  2013cites this paper
• Perianal Disease Combined With NOD2 Genotype Predicts Need for IBD-related Surgery in Crohn’s Disease Patients From a Population-based Cohort

  2013cites this paper
• Identifying Envirogenomic Signatures for Predicting the Clinical Outcomes of Crohn's Disease

  2013cites this paper
• Macrophage migration inhibitory factor gene polymorphisms in inflammatory bowel disease: an association study in New Zealand Caucasians and meta-analysis.

  2013cites this paper
• Polymorphisms of interleukin-23 receptor in patients with inflammatory bowel disease in a Croatian tertiary center.

  2013cites this paper
• Predictors for developing intestinal failure in patients with Crohn's disease

  2013cites this paper
• Association of Single Nucleotide Polymorphisms of IL23R and IL17 with Ulcerative Colitis Risk in a Chinese Han Population

  2012cites this paper
• Role of ATG16L, NOD2 and IL23R in Crohn's disease pathogenesis.

  2012cites this paper
• Nutrigenomics

  2012cites this paper
• Association of peroxisome proliferator‐activated receptor gamma polymorphisms with inflammatory bowel disease in a Hungarian cohort

  2012cites this paper
• The Natural History of Inflammatory Bowel Disease

  2012cites this paper
• Genotype/Phenotype Analyses for 53 Crohn’s Disease Associated Genetic Polymorphisms

  2012cites this paper
• A hospital-based study of clinical and genetic features of Crohn's disease.

  2011cites this paper
• An Investigation of Genome-Wide Studies Reported Susceptibility Loci for Ulcerative Colitis Shows Limited Replication in North Indians

  2011cites this paper
• NOD2 and ATG16L1 polymorphisms affect monocyte responses in Crohn's disease.

  2011cites this paper
• Interaction between CTLA4 gene and IBD5 locus in Hungarian Crohn’s disease patients

  2011cites this paper
• Comparative Genetic Analysis of Type 1 Diabetes and Inflammatory Bowel Disease

  2011cites this paper
• Meta‐analysis of published studies identified eight additional common susceptibility loci for Crohn's disease and ulcerative colitis

  2011cites this paper
• Functional Studies on the IBD Susceptibility Gene IL23R Implicate Reduced Receptor Function in the Protective Genetic Variant R381Q

  2011cites this paper
• Genetic polymorphisms of IL-23R and IL-17A and novel insights into their associations with inflammatory bowel disease

  2011cites this paper
• Association of Interleukin 23 Receptor Gene with Sarcoidosis

  2011cites this paper
• Canine breeds at high risk of developing inflammatory bowel disease in the south-eastern UK

  2011cites this paper
• Inflammatory Bowel Disease Genetics

  2011cites this paper
• The CTLA4 variants may interact with the IL23R- and NOD2-conferred risk in development of Crohn's disease

  2010cites this paper
• Replication and meta-analysis of 13,000 cases defines the risk for interleukin-23 receptor and autophagy-related 16-like 1 variants in Crohn's disease.

  2010cites this paper
• Association of the interleukin‐23 receptor gene variant rs11209026 with Crohn’s disease in German children

  2010cites this paper
• Association of FcgR2a, but not FcgR3a, with inflammatory bowel diseases across three Caucasian populations†

  2010cites this paper
• Association between idiopathic achalasia and IL23R gene

  2010cites this paper
• Autophagy and Crohn's disease: at the crossroads of infection, inflammation, immunity, and cancer.

  2010cites this paper
• Interleukin-23 receptor genetic polymorphisms and Crohn’s disease susceptibility: a meta-analysis

  2010cites this paper
• IL23R and IL12B SNPs and Haplotypes Strongly Associate with Crohn's Disease Risk in a New Zealand Population

  2010cites this paper
• Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn's disease patients.

  2010cites this paper
• Polymorphisms of IL23R and Vogt-Koyanagi-Harada syndrome in a Chinese Han population.

  2010cites this paper
• Association of Higher DEFB4 Genomic Copy Number With Crohn's Disease

  2010cites this paper
• T300A polymorphism of ATG16L1 and susceptibility to inflammatory bowel diseases: a meta-analysis.

  2010cites this paper
• Clinical features and long-term prognosis of Crohn's disease in Korea

  2010cites this paper
• SLC11A1 polymorphisms in inflammatory bowel disease and Mycobacterium avium subspecies paratuberculosis status.

  2010cites this paper
• Evidence that glioma-associated oncogene homolog 1 is not a universal risk gene for inflammatory bowel disease in Caucasians

  2010cites this paper
• Food-derived bioactives as potential regulators of the IL-12/IL-23 pathway implicated in inflammatory bowel diseases.

  2010cites this paper
• Evidence of interaction of CARD8 rs2043211 with NALP3 rs35829419 in Crohn's disease

  2010cites this paper
• Genetic Association of Nonsynonymous Variants of the IL23R with Familial and Sporadic Inflammatory Bowel Disease in Women

  2010cites this paper
• Understanding Probiotic Treatment Strategies in Inflammatory Bowel Disease , with a Special Emphasis on the Intestinal Barrier Probiotics

  2010cites this paper
• Interleukin-23 receptor genetic polymorphisms and Crohn's disease susceptibility: a meta-analysis

  2010cites this paper
• KCNN4 Gene Variant Is Associated With Ileal Crohn's Disease in the Australian and New Zealand Population

  2010cites this paper
• Novel Association of the Interleukin 2–Interleukin 21 Region With Inflammatory Bowel Disease

  2009cites this paper
• Association of ATG16L1 and IRGM genes polymorphisms with inflammatory bowel disease: a meta-analysis approach

  2009cites this paper
• Study of the effects of dietary polyunsaturated fatty acids: Molecular mechanisms involved in intestinal inflammation

  2009cites this paper
• Role of ATG16L1 Thr300Ala polymorphism in inflammatory bowel disease: A Study in the Spanish population and a meta‐analysis

  2009cites this paper
• Contribution of rs11465788 in IL23R gene to Crohn’s disease susceptibility and phenotype in Chinese population

  2009cites this paper
• Genetic Variants in IL-23R and ATG16L1 Independently Predispose to Increased Susceptibility to Crohn's Disease in a Canadian Population

  2009cites this paper
• Charité Centrum 13 für Innere Medizin mit Kardiologie, Gastroenterologie und Nephrologie Medizinische Klinik mit Schwerpunkt Gastroenterologie, Hepatologie und

  2009cites this paper
• Autophagy gene ATG16L1 but not IRGM is associated with Crohn's disease in Canadian children

  2009cites this paper
• Tumor Necrosis Factor Receptor Superfamily, Member 1B Haplotypes Increase or Decrease the Risk of Inflammatory Bowel Diseases in a New Zealand Caucasian Population

  2009cites this paper
• The role of fatty acid hydrolase gene variants in inflammatory bowel disease

  2009cites this paper
• IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease

  2009cites this paper