Additional benefit of combined therapy with melatonin and apoptotic adipose‐derived mesenchymal stem cell against sepsis‐induced kidney injury

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Journal of Pineal Research

• Publication date

  2014-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/jpi.12140PMID 24761983
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2013influential reference
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  2013cited by this paper
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  2012influential reference
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  2012cited by this paper
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  2011influential reference
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  2011cited by this paper
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  2011influential reference
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  2010cited by this paper
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  2010cited by this paper
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  2008cited by this paper
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  2008cited by this paper
• Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008

  2007cited by this paper
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  2007cited by this paper
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  2004cited by this paper
• EPISEPSIS: a reappraisal of the epidemiology and outcome of severe sepsis in French intensive care units

  2004cited by this paper
• [Epidemiology of infection and sepsis in intensive care unit patients].

  2004cited by this paper
• Circulating endotoxin and antiendotoxin antibodies during severe sepsis and septic shock.

  2003cited by this paper
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