Regulation and coordination of nuclear envelope and nuclear pore complex assembly

In metazoans with “open” mitosis, cells undergo structural changes involving the complete disassembly of the nuclear envelope (NE). In post-mitosis, the dividing cell faces the difficulty to reassemble NE structures in a highly regulated fashion around separated chromosomes. The de novo formation of nuclear pore complexes (NPCs), which are gateways between the cytoplasm and nucleoplasm across the nuclear membrane, is an archetype of macromolecular assembly and is therefore of special interest. The reformation of a functional NE further involves the reassembly and organization of other NE components, the nuclear membrane and NE proteins, around chromosomes in late mitosis. Here, we discuss the function of NE components, such as lamins and INM proteins, in NE reformation and highlight recent results on coordination of NPC and NE assembly.

• Publication year

  2013

• Venue

  The Nucleus

• Publication date

  2013-02-14

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4161/nucl.23796PMID 23412657PMCID 3621742
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The human nuclear pore complex as revealed by cryo-electron tomography.

  2012cited by this paper
• Chromosomal regions associated with prostate cancer risk localize to lamin B‐deficient microdomains and exhibit reduced gene transcription

  2012cited by this paper
• Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis.

  2012cited by this paper
• Heat-shock stress activates a novel nuclear import pathway mediated by Hikeshi

  2012cited by this paper
• SnapShot: the nuclear envelope II.

  2012cited by this paper
• © 2012 Landes Bioscience. Do not distribute. The nucleoporin ELYS/Mel28 regulates nuclear envelope subdomain formation in HeLa cells

  2012cited by this paper
• The nuclear lamins: flexibility in function

  2012cited by this paper
• The nucleoporin ELYS/Mel28 regulates nuclear envelope subdomain formation in HeLa cells

  2012cited by this paper
• The Nup155-mediated organisation of inner nuclear membrane proteins is independent of Nup155 anchoring to the metazoan nuclear pore complex

  2012cited by this paper
• LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins.

  2012cited by this paper
• Nuclear lamins

  2012cited by this paper
• The structure of the nuclear pore complex.

  2011cited by this paper
• Formation of the postmitotic nuclear envelope from extended ER cisternae precedes nuclear pore assembly

  2011cited by this paper
• Mouse B-Type Lamins Are Required for Proper Organogenesis But Not by Embryonic Stem Cells

  2011cited by this paper
• The role of nuclear lamin B1 in cell proliferation and senescence.

  2011cited by this paper
• Nuclear size, nuclear pore number and cell cycle

  2011cited by this paper
• POM121 and Sun1 play a role in early steps of interphase NPC assembly

  2011cited by this paper
• Temporal control of nuclear envelope assembly by phosphorylation of lamin B receptor

  2011cited by this paper
• Phosphorylation of Nup98 by multiple kinases is crucial for NPC disassembly during mitotic entry.

  2011cited by this paper
• Localization of Pom121 to the inner nuclear membrane is required for an early step of interphase nuclear pore complex assembly

  2011cited by this paper
• Requirement for Lamin B Receptor and Its Regulation by Importin β and Phosphorylation in Nuclear Envelope Assembly during Mitotic Exit*

  2010cited by this paper
• Nuclear lamins.

  2010cited by this paper
• Structural analysis of a metazoan nuclear pore complex reveals a fused concentric ring architecture.

  2010cited by this paper
• Defects in nuclear pore assembly lead to activation of an Aurora B–mediated abscission checkpoint

  2010cited by this paper
• An in vitro model for Pelger-Huët anomaly

  2010cited by this paper
• The nuclear pore complex and nuclear transport.

  2010cited by this paper
• Cell cycle-dependent differences in nuclear pore complex assembly in metazoa.

  2010cited by this paper
• Lamin B receptor

  2010cited by this paper
• NLS‐mediated NPC functions of the nucleoporin Pom121

  2010cited by this paper
• Nuclear pore formation but not nuclear growth is governed by cyclin-dependent kinases (Cdks) during interphase

  2010cited by this paper
• Self-organization of intracellular gradients during mitosis

  2010cited by this paper
• Lamin-binding Proteins.

  2010cited by this paper
• Pom121 links two essential subcomplexes of the nuclear pore complex core to the membrane

  2010cited by this paper
• Nuclear pore biogenesis into an intact nuclear envelope

  2010cited by this paper
• The nuclear envelope at a glance

  2010cited by this paper
• Interactions between nuclei and the cytoskeleton are mediated by SUN-KASH nuclear-envelope bridges.

  2010cited by this paper
• Diseases of the nuclear envelope.

  2010cited by this paper
• Nuclear transport and the mitotic apparatus: an evolving relationship

  2010cited by this paper
• Nesprin 4 is an outer nuclear membrane protein that can induce kinesin-mediated cell polarization

  2009cited by this paper
• Early embryonic requirement for nucleoporin Nup35/NPP-19 in nuclear assembly.

  2009cited by this paper
• Barrier-to-autointegration factor (BAF) condenses DNA by looping

  2009cited by this paper
• Transportin regulates major mitotic assembly events: from spindle to nuclear pore assembly.

  2009cited by this paper
• A-type and B-type lamins initiate layer assembly at distinct areas of the nuclear envelope in living cells.

  2009cited by this paper
• The Nup107-160 nucleoporin complex promotes mitotic events via control of the localization state of the chromosome passenger complex.

  2009cited by this paper
• Recruitment of functionally distinct membrane proteins to chromatin mediates nuclear envelope formation in vivo

  2009cited by this paper
• Spatial and temporal coordination of mitosis by Ran GTPase

  2008cited by this paper
• A new model for nuclear lamina organization.

  2008cited by this paper
• Kid-mediated chromosome compaction ensures proper nuclear envelope formation.

  2008influential reference
• Mutation in nuclear pore component NUP155 leads to atrial fibrillation and early sudden cardiac death.

  2008cited by this paper
• Capture of AT-rich chromatin by ELYS recruits POM121 and NDC1 to initiate nuclear pore assembly.

  2008cited by this paper
• Nup53 is required for nuclear envelope and nuclear pore complex assembly.

  2008cited by this paper
• Live cell imaging and electron microscopy reveal dynamic processes of BAF-directed nuclear envelope assembly

  2008cited by this paper
• The A- and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcription.

  2008cited by this paper
• Systematic kinetic analysis of mitotic dis- and reassembly of the nuclear pore in living cells

  2008cited by this paper
• Two distinct human POM121 genes: Requirement for the formation of nuclear pore complexes

  2007cited by this paper
• Functional association of Sun1 with nuclear pore complexes

  2007cited by this paper
• Snapshots of nuclear pore complexes in action captured by cryo-electron tomography

  2007cited by this paper
• A general amphipathic α-helical motif for sensing membrane curvature

  2007cited by this paper
• ELYS/MEL-28 Chromatin Association Coordinates Nuclear Pore Complex Assembly and Replication Licensing

  2007cited by this paper
• Lamin B receptor plays a role in stimulating nuclear envelope production and targeting membrane vesicles to chromatin during nuclear envelope assembly through direct interaction with importin β

  2007cited by this paper
• Chromosomal passengers: conducting cell division

  2007cited by this paper
• Nuclear envelope formation by chromatin-mediated reorganization of the endoplasmic reticulum

  2007cited by this paper
• LEM-Domain proteins: new insights into lamin-interacting proteins.

  2007cited by this paper
• A general amphipathic alpha-helical motif for sensing membrane curvature.

  2007cited by this paper
• MEL‐28/ELYS is required for the recruitment of nucleoporins to chromatin and postmitotic nuclear pore complex assembly

  2007cited by this paper
• Natively unfolded nucleoporins gate protein diffusion across the nuclear pore complex.

  2007cited by this paper
• FG-Rich Repeats of Nuclear Pore Proteins Form a Three-Dimensional Meshwork with Hydrogel-Like Properties

  2006cited by this paper
• ELYS is a dual nucleoporin/kinetochore protein required for nuclear pore assembly and proper cell division

  2006cited by this paper
• A Mitotic Lamin B Matrix Induced by RanGTP Required for Spindle Assembly

  2006cited by this paper
• Cell-cycle-dependent dynamics of nuclear pores: pore-free islands and lamins

  2006cited by this paper
• Nuclear Pores Form de Novo from Both Sides of the Nuclear Envelope

  2006cited by this paper
• The conserved transmembrane nucleoporin NDC1 is required for nuclear pore complex assembly in vertebrate cells.

  2006cited by this paper
• MEL-28, a novel nuclear-envelope and kinetochore protein essential for zygotic nuclear-envelope assembly in C. elegans.

  2006cited by this paper
• MEL-28 is downstream of the Ran cycle and is required for nuclear-envelope function and chromatin maintenance.

  2006cited by this paper
• The laminopathies: the functional architecture of the nucleus and its contribution to disease.

  2006cited by this paper
• Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex.

  2005cited by this paper
• Ran-GTP regulates Kinetochore Attachment in Somatic Cells

  2005cited by this paper
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  2005cited by this paper
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  2005cited by this paper
• The integral membrane nucleoporin pom121 functionally links nuclear pore complex assembly and nuclear envelope formation.

  2005cited by this paper
• The nuclear lamina comes of age

  2005cited by this paper
• Nup155 regulates nuclear envelope and nuclear pore complex formation in nematodes and vertebrates

  2005cited by this paper
• Vertebrate Nup 53 Interacts with the Nuclear Lamina and Is Required for the Assembly of a Nup 93-containing Complex □

  2005cited by this paper
• Targeted disruption of the mouse ELYS gene results in embryonic death at peri‐implantation development

  2004cited by this paper
• LAP2α and BAF transiently localize to telomeres and specific regions on chromatin during nuclear assembly

  2004cited by this paper
• Regulation of Binding of Lamin B Receptor to Chromatin by SR Protein Kinase and cdc2 Kinase in Xenopus Egg Extracts*

  2004cited by this paper
• Disorder in the nuclear pore complex: The FG repeat regions of nucleoporins are natively unfolded

  2003cited by this paper
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  2003cited by this paper
• Barrier-to-autointegration factor plays crucial roles in cell cycle progression and nuclear organization in Drosophila

  2003cited by this paper
• Autosomal recessive HEM/Greenberg skeletal dysplasia is caused by 3 beta-hydroxysterol delta 14-reductase deficiency due to mutations in the lamin B receptor gene.

  2003cited by this paper
• RanGTP mediates nuclear pore complex assembly

  2003cited by this paper
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  2003cited by this paper
• Autosomal recessive HEM/greenberg skeletal dysplasia is caused by 3 beta-hydroxysterol Delta(14)-reductase deficiency due to mutations in the lamin B receptor gene

  2003cited by this paper
• The C. elegans hook protein, ZYG-12, mediates the essential attachment between the centrosome and nucleus.

  2003cited by this paper
• The conserved Nup107-160 complex is critical for nuclear pore complex assembly.

  2003cited by this paper
• Genomic organization and characterization of the mouse ELYS gene.

  2003cited by this paper
• Mutations in the gene encoding the lamin B receptor produce an altered nuclear morphology in granulocytes (Pelger–Huët anomaly)

  2002cited by this paper
• Identification of a novel transcription factor, ELYS, expressed predominantly in mouse foetal haematopoietic tissues

  2002cited by this paper
• Barrier-to-autointegration factor

  2002cited by this paper
• Nuclear lamins: building blocks of nuclear architecture.

  2002cited by this paper

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  2025cites this paper
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  2025cites this paper
• Reconstitution of nuclear envelope subdomain formation on mitotic chromosomes in semi-intact cells

  2024cites this paper
• A role for Nup153 in nuclear assembly reveals differential requirements for targeting of nuclear envelope constituents

  2022cites this paper
• TEM Imaging of Membrane Choreography During Mitosis of Drosophila Tissue Culture Cells.

  2022cites this paper
• Micronuclei in Kif18a mutant mice form stable micronuclear envelopes and do not promote tumorigenesis

  2021cites this paper
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  2021cites this paper
• Small but mighty: the causes and consequences of micronucleus rupture

  2020cites this paper
• Micronuclei arising due to loss of KIF18A form stable micronuclear envelopes and do not promote tumorigenesis

  2020influential citation
• The coordination of nuclear envelope assembly and chromosome segregation in metazoans

  2020influential citation
• Guiding Drugs to Target- Harboring Organelles: Stretching Drug-Delivery to a Higher Level of Resolution.

  2019cites this paper
• Intracellular Pressure: A Driver of Cell Morphology and Movement.

  2018cites this paper
• Nuclear Envelope Regulation of Oncogenic Processes: Roles in Pancreatic Cancer

  2018cites this paper
• A statistical image analysis framework for pore-free islands derived from heterogeneity distribution of nuclear pore complexes

  2017cites this paper
• Proteome Profiling and Ultrastructural Characterization of the Human RCMH Cell Line: Myoblastic Properties and Suitability for Myopathological Studies.

  2016cites this paper
• Lamin A reassembly at the end of mitosis is regulated by its SUMO-interacting motif.

  2016cites this paper
• New Insights into Mechanisms and Functions of Nuclear Size Regulation.

  2016cites this paper
• A case of conjoined twins after a transfer of a multinuclear embryo

  2015cites this paper
• Molecular Characterization and Functional Analysis of Annulate Lamellae Pore Complexes in Nuclear Transport in Mammalian Cells

  2015cites this paper
• Centrosome maturation requires YB-1 to regulate dynamic instability of microtubules for nucleus reassembly

  2015cites this paper
• Phosphoinositide 3-Kinase Beta Protects Nuclear Envelope Integrity by Controlling RCC1 Localization and Ran Activity

  2014cites this paper
• Cancer Biology and the Nuclear Envelope

  2014cites this paper
• Control of nuclear size by NPC proteins.

  2014cites this paper