Chronic carbamazepine selectively downregulates cytosolic phospholipase A2 expression and cyclooxygenase activity in rat brain.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Biological Psychiatry

• Publication date

  2004-08-15

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/J.BIOPSYCH.2004.05.012PMID 15312812
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The effect of chronic lithium on arachidonic acid release and metabolism in rat brain does not involve secretory phospholipase A2 or lipoxygenase/cytochrome P450 pathways.

  2004cited by this paper
• Valproic acid down‐regulates the conversion of arachidonic acid to eicosanoids via cyclooxygenase‐1 and ‐2 in rat brain

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• Long-term therapy of bipolar illness.

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• The expression of brain cyclooxygenase‐2 is down‐regulated in the cytosolic phospholipase A2 knockout mouse

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• Treatment of bipolar disorder.

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• Antiepileptic drugs and agents that inhibit voltage-gated sodium channels prevent NMDA antagonist neurotoxicity

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• Chronic lithium downregulates cyclooxygenase-2 activity and prostaglandin E2 concentration in rat brain

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• Synaptic, intracellular, and neuroprotective mechanisms of anticonvulsants: are they relevant for the treatment and course of bipolar disorders?

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• Phospholipase A2 enzymes.

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• Do lithium and anticonvulsants target the brain arachidonic acid cascade in bipolar disorder?

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• Effects of antiepileptic drugs on rat platelet aggregation: ex vivo and in vitro study.

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• Simultaneous high-performance liquid chromatography determination of carbamazepine and five of its metabolites in plasma of epileptic patients.

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• Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.

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• Chronic valproate treatment decreases the in vivo turnover of arachidonic acid in brain phospholipids: a possible common effect of mood stabilizers

  2001cited by this paper
• Regulation of phosphoinositide-specific phospholipase C.

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• Effectiveness of First Antiepileptic Drug

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• Inhibitory effect of carbamazepine on inflammatory mediators produced by stimulated glial cells.

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• Monitoring of carbamazepine and carbamazepine 10,11-epoxide in breast milk and plasma by high-performance liquid chromatography

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• An ever-increasing pharmacopoeia for the management of patients with bipolar disorder.

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• Effects of carbamazepine on acetylcholine release and metabolism.

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• Localization of cytosolic phospholipase A2 messenger RNA mainly in neurons in the rat brain.

  1999cited by this paper
• 85 kDa cytosolic phospholipase A2 is a target for chronic lithium in rat brain.

  1999cited by this paper
• Modulation of CNS signal transduction pathways and gene expression by mood-stabilizing agents: therapeutic implications.

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• Does carbamazepine have a narrow therapeutic plasma concentration range?

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• Chronic Lithium Treatment Decreases Brain Phospholipase A2 Activity

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• Effects of carbamazepine on hippocampal serotonergic system.

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• A History of the Use of Anticonvulsants as Mood Stabilizers in the Last Two Decades of the 20th Century

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• Attenuation of Cyclic AMP Production by Carbamazepine

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• Lithium decreases turnover of arachidonate in several brain phospholipids.

  1996cited by this paper
• Cytosolic phospholipase A2.

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• Carbamazepine exerts anti-inflammatory effects in the rat.

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• Arachidonic acid as a neurotoxic and neurotrophic substance.

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• Alterations in monoamine levels in discrete regions of rat brain after chronic administration of carbamazepine

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• 1-Hexadecyl-2-arachidonoylthio-2-deoxy-sn-glycero-3-phosphorylcholine as a substrate for the microtiterplate assay of human cytosolic phospholipase A2.

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• Arachidonic Acid in Cell Signaling

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• Substrate specificities and properties of human phospholipases A2 in a mixed vesicle model.

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• Bidirectional control of phospholipase A2 activity by Ca2+/calmodulin-dependent protein kinase II, cAMP-dependent protein kinase, and casein kinase II.

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• Effects of chronic treatment with trihexyphenidyl and carbamazepine alone or in combination with haloperidol on substance P content in rat brain: a possible implication of substance P in affective disorders.

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• Modulatory effects of prostaglandin D2, E2 and F2 alpha on the postsynaptic actions of inhibitory and excitatory amino acids in cerebellar Purkinje cell dendrites in vitro.

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• Carbamazepine in bipolar illness.

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• Carbamazepine in bipolar illness.

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  1983cited by this paper
• Extraction of tissue lipids with a solvent of low toxicity.

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• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

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• Assessment of hepatic prostaglandin E2 level in carbamazepine induced liver injury

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• Valnoctamide, which reduces rat brain arachidonic acid turnover, is a potential non-teratogenic valproate substitute to treat bipolar disorder.

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• Retraction note to: Chronic fluoxetine increases cytosolic phospholipase A2 activity and arachidonic acid turnover in brain phospholipids of the unanesthetized rat

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