ISLET TRANSPLANTATION : ADVANCES AND IMMUNOLOGICAL CHALLENGES

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• Regulatory T cells in transplantation tolerance.

  2005cited by this paper
• Critical Role of OX40 in CD28 and CD154-Independent Rejection1

  2004cited by this paper
• Targeted bone marrow radioablation with 153Samarium-lexidronam promotes allogeneic hematopoietic chimerism and donor-specific immunologic hyporesponsiveness

  2004cited by this paper
• Islet allograft survival in nonhuman primates immunosuppressed with basiliximab, RAD, and FTY7201

  2004cited by this paper
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  2003cited by this paper
• Islet transplantation: a brave new world.

  2003cited by this paper
• The role of the ICOS-B7h T cell costimulatory pathway in transplantation immunity.

  2003cited by this paper
• The Role of the CD134-CD134 Ligand Costimulatory Pathway in Alloimmune Responses In Vivo 1

  2003cited by this paper
• Altered Proximal T‐Cell Receptor Signalling Events in Mouse CD4+ T Cells in the Presence of Anti‐CD4 Monoclonal Antibodies: Evidence for Reduced Phosphorylation of Zap‐70 and LAT

  2003cited by this paper
• Favorably tipping the balance between cytopathic and regulatory T cells to create transplantation tolerance.

  2003cited by this paper
• TGF-β-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes

  2003cited by this paper
• Th1 cytokines, programmed cell death, and alloreactive T cell clone size in transplant tolerance.

  2002cited by this paper
• Succesful transplantation of human islets in recipients bearing a kidney graft

  2002cited by this paper
• Physiological Mechanisms of Regulating Alloimmunity: Cytokines, CTLA-4, CD25+ Cells, and the Alloreactive T Cell Clone Size1

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• Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus.

  2002cited by this paper
• Achievement of insulin independence in three consecutive type-1 diabetic patients via pancreatic islet transplantation using islets isolated at a remote islet isolation center

  2002cited by this paper
• CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2.

  2002cited by this paper
• Both CD4+CD25+ and CD4+CD25− Regulatory Cells Mediate Dominant Transplantation Tolerance1

  2002cited by this paper
• Calcineurin inhibitor-free CD28 blockade-based protocol protects allogeneic islets in nonhuman primates.

  2002cited by this paper
• Reprogramming the immune system

  2002cited by this paper
• Production of tissue factor by pancreatic islet cells as a trigger of detrimental thrombotic reactions in clinical islet transplantation.

  2002cited by this paper
• Modulation of Fas-Dependent Apoptosis: A Dynamic Process Controlling Both the Persistence and Death of CD4 Regulatory T Cells and Effector T Cells1

  2002cited by this paper
• Long-term islet allograft function in the absence of chronic immunosuppression: a case report of a nonhuman primate previously made tolerant to a renal allograft from the same donor.

  2001cited by this paper
• An Antagonist IL-15/Fc Protein Prevents Costimulation Blockade-Resistant Rejection1

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• Contrasting roles of IL-2 and IL-15 in the life and death of lymphocytes: implications for immunotherapy.

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• Mixed chimerism and transplant tolerance.

  2001cited by this paper
• T cell death and transplantation tolerance.

  2001cited by this paper
• Quantifying the Frequency of Alloreactive T Cells In Vivo: New Answers to an Old Question1

  2001cited by this paper
• IL-15 and IL-2: a matter of life and death for T cells in vivo

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• Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-Free Immunosuppressive Regimen

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• Control of homeostasis of CD8+ memory T cells by opposing cytokines.

  2000cited by this paper
• Homeostasis of αβ TCR+ T cells

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• IL-2 receptor-targeted cytolytic IL-2/Fc fusion protein treatment blocks diabetogenic autoimmunity in nonobese diabetic mice.

  1999cited by this paper
• Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance

  1999cited by this paper
• Incompatibility between human blood and isolated islets of Langerhans: a finding with implications for clinical intraportal islet transplantation?

  1999cited by this paper
• Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154.

  1999cited by this paper
• Long-term survival and function of intrahepatic islet allografts in baboons treated with humanized anti-CD154.

  1999cited by this paper
• Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death.

  1999cited by this paper
• Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance

  1999cited by this paper
• Induction of specific tolerance to allografts in rats by therapy with non-mitogenic, non-depleting anti-CD3 monoclonal antibody: association with TH2 cytokines not anergy.

  1999cited by this paper
• On histocompatibility barriers, Th1 to Th2 immune deviation, and the nature of the allograft responses.

  1998cited by this paper
• Transplantation of allogeneic islets of Langerhans in the rat liver: effects of macrophage depletion on graft survival and microenvironment activation.

  1998cited by this paper
• The use of antibodies against the IL-2 receptor in transplantation.

  1998cited by this paper
• Regulatory Cd4 T Cells: Expression of Il-2rα Chain, Resistance to Clonal Deletion and Il-2 Dependency

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• Impaired alloantigen-mediated T cell apoptosis and failure to induce long-term allograft survival in IL-2-deficient mice.

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• Targeting the IL-15 receptor with an antagonist IL-15 mutant/Fc gamma2a protein blocks delayed-type hypersensitivity.

  1998cited by this paper
• The effects of maintenance doses of FK506 versus cyclosporin A on glucose and lipid metabolism after orthotopic liver transplantation.

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• Improved Human Islet Isolation Using a New Enzyme Blend, Liberase

  1997cited by this paper
• Nonmitogenic Anti-CD3 Monoclonal Antibodies Deliver a Partial T Cell Receptor Signal and Induce Clonal Anergy

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• Long-Term Function (6 Years) of Islet Allografts in Type 1 Diabetes

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• CD28/B7 system of T cell costimulation.

  1996cited by this paper
• [The discovery of insulin].

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• Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

  1996cited by this paper
• Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand.

  1995cited by this paper
• Effect of 15-Deoxyspergualin on Immediate Function and Long-Term Survival of Transplanted Islets in Murine Recipients of a Marginal Islet Mass

  1994cited by this paper
• Acceleration of chronic failure of intrahepatic canine islet autografts by a short course of prednisone.

  1994cited by this paper
• Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice.

  1994cited by this paper
• Interleukin-2 receptor-directed therapies: antibody-or cytokine-based targeting molecules.

  1993cited by this paper
• Islet cell allotransplantation in diabetic patients. Histologic findings in four adults simultaneously receiving kidney or liver transplants.

  1992cited by this paper
• HUMAN ISLET ISOLATION AND ALLOTRANSPLANTATION IN 22 CONSECUTIVE CASES 1, 2

  1992cited by this paper
• Immunologic tolerance to renal allografts after bone marrow transplants from the same donors.

  1991cited by this paper
• Detection of pancreatic islet tissue following islet allotransplantation in man.

  1991cited by this paper
• Insulin Independence After Islet Transplantation Into Type I Diabetic Patient

  1990cited by this paper
• Pancreatic islet transplantation after upper abdominal exenteration and liver replacement.

  1990cited by this paper
• Differential roles of Mac-1+ cells, and CD4+ and CD8+ T lymphocytes in primary nonfunction and classic rejection of islet allografts

  1990cited by this paper
• New Answers to an Old Question

  1988cited by this paper
• Automated Method for Isolation of Human Pancreatic Islets

  1988cited by this paper
• Human tumor necrosis factor potentiates human interleukin 1-mediated rat pancreatic beta-cell cytotoxicity.

  1987cited by this paper
• Cytotoxicity of human pI 7 interleukin-1 for pancreatic islets of Langerhans.

  1986cited by this paper
• Transplantation of intact pancreatic islets in rats.

  1972cited by this paper
• Method for the Isolation of Intact Islets of Langerhans from the Rat Pancreas

  1967cited by this paper

• Co-expression of superoxide and peroxide scavenging antioxidant enzymes rescues β cells from hypoxia and hyperglycemia-induced oxidative damage

  2026cites this paper
• Subaqueous acoustic pressure system based one day heterotypic pseudo-islet spheroid formation with adipose derived stem cells for graft survival-related function enhancement

  2025cites this paper
• PEGylation-based surface engineering of islets with microparticles co-delivery for enhanced engraftment in streptozocin-induced hyperglycemic murine model

  2025cites this paper
• Polymerized laminin-modified microcapsules improve pancreatic islet resilience towards cytokine induced inflammatory stress and lower chemoattractant cytokine secretion

  2025cites this paper
• Improved conditioning for hematopoietic chimerism induces islet tolerance to cure diabetes

  2025cites this paper
• The efficacy and safety of ustekinumab in adolescents newly diagnosed with type 1 diabetes: the USTEK1D RCT

  2025cites this paper
• Establishment of subcutaneous transplantation platform for delivering induced pluripotent stem cell-derived insulin-producing cells

  2025cites this paper
• Islet organoids: a new hope for islet transplantation in diabetes

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• EndoC-βH3 pseudoislets are suitable for intraportal transplantation in diabetic mice

  2024cites this paper
• Encapsulated islet transplantation

  2024cites this paper
• Regulatory T cell-based therapy in type 1 diabetes: Latest breakthroughs and evidence.

  2024cites this paper
• Biomaterial-assisted strategies to improve islet graft revascularization and transplant outcomes.

  2024cites this paper
• Advanced therapy to cure diabetes: mission impossible is now possible?

  2024cites this paper
• Pancreatic Islet Transplantation into the Submandibular Gland: Our Experimental Experience and a Review of the Relevant Literature

  2023cites this paper
• Advances in alginate encapsulation of pancreatic islets for immunoprotection in type 1 diabetes

  2023cites this paper
• Recent progress in microneedle-based cell delivery and cell sampling for biomedical applications.

  2023cites this paper
• A Supportive Role of Mesenchymal Stem Cells on Insulin-Producing Langerhans Islets with a Specific Emphasis on The Secretome

  2023cites this paper
• A novel therapeutic combination of sitagliptin and melatonin regenerates pancreatic β-cells in mouse and human islets.

  2022cites this paper
• ResearchTissueEngineering—Review Macroencapsulation Devices for Cell Therapy

  2022cites this paper
• Freezing biological organisms for biomedical applications

  2022cites this paper
• A Worldwide Survey of Activities and Practices in Clinical Islet of Langerhans Transplantation

  2022cites this paper
• Advances in single-cell nanoencapsulation and applications in diseases

  2022cites this paper
• Co-transplantation of Islets-Laden Microgels and Biodegradable O2-Generating Microspheres for Diabetes Treatment.

  2022cites this paper
• Mesenchymal Stem Cells Secretions Enhanced ATP Generation on Isolated Islets during Transplantation

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• Macroencapsulation devices for cell therapy

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• efforts as driving forces of healthcare

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• Designing Biomaterials for the Modulation of Allogeneic and Autoimmune Responses to Cellular Implants in Type 1 Diabetes.

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• All-in-One Silk Fibroin Sponge as the Vitrification Cryodevice of Rat Pancreatic Islets and the VEGF-Embedded Scaffold for Subrenal Transplantation.

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• Decellularized Matrix Bioscaffolds

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• Enhancing islet transplantation using a biocompatible collagen-PDMS bioscaffold enriched with dexamethasone-microplates

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• Acellular matrix derived from rat liver improves the functionality of rat pancreatic islets before or after vitrification.

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• Islet Transplantation in the Subcutaneous Space Achieves Long-term Euglycemia in Preclinical Models of Type 1 Diabetes

  2020cites this paper
• The MEK Inhibitor Trametinib Suppresses Major Histocompatibility Antigen-mismatched Rejection Following Pancreatic Islet Transplantation

  2020cites this paper
• Protection of Pancreatic Islets Using Theranostic Silencing Nanoparticles in a Baboon Model of Islet Transplantation

  2020cites this paper
• Drug-integrating amphiphilic nanomaterial assemblies: 1. Spatiotemporal control of cyclosporine delivery and activity using nanomicelles and nanofibrils.

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• Progress toward islet transplantation tolerance

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• Carnosine, pancreatic protection, and oxidative stress in type 1 diabetes

  2020cites this paper
• Islet immunoisolation by microencapsulation

  2020cites this paper
• In Vitro Evaluation of a Novel Synthetic Bilirubin Analog as an Antioxidant and Cytoprotective Agent for Pancreatic Islet Transplantation

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• Large Mammalian Model for Extrahepatic Langerhans Transplantation for the Treatment of Type 1 Diabetes

  2020cites this paper
• Islet Transplantation Imaging in vivo

  2020cites this paper
• The Effect of Recovery Warm-up Time Following Cold Storage on the Dynamic Glucose-stimulated Insulin Secretion of Isolated Human Islets

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• Latest Therapies for Type 1 Diabetes: Exsisting Setup and “Post-Insulin” Standpoints

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  2019cites this paper
• Cotransplantation of preactivated mesenchymal stem cells improves intraportal engraftment of islets by inhibiting liver natural killer cells in mice

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• Polymeric Approaches to Reduce Tissue Responses Against Devices Applied for Islet-Cell Encapsulation

  2019cites this paper
• Long‐term outcome of islet transplantation on insulin‐dependent diabetes mellitus: An observational cohort study

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• Characterization of Polyethylene Glycol-Reinforced Alginate Microcapsules for Mechanically Stable Cell Immunoisolation.

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• Cell encapsulation: Overcoming barriers in cell transplantation in diabetes and beyond.

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• Rapid and Long‐Term Glycemic Regulation with a Balanced Charged Immune‐Evasive Hydrogel in T1DM Mice

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• Cold-Responsive Nanocapsules Enable the Sole-Cryoprotectant-Trehalose Cryopreservation of β Cell-Laden Hydrogels for Diabetes Treatment.

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• Modulation of the Apoptosis Gene Bcl-x Function Through Alternative Splicing

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• Cold-Responsive Nanocapsules Enable the Sole-Cryoprotectant-Trehalose Cryopreservation of β Cell-Laden Hydrogels for Diabetes Treatment.

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• Islet Encapsulation: A Long-Term Treatment for Type 1 Diabetes

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  2018cites this paper
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  2018cites this paper
• Enhanced survival and insulin secretion of insulinoma cell aggregates by incorporating gelatin hydrogel microspheres

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• Design of a vascularized synthetic poly(ethylene glycol) macroencapsulation device for islet transplantation.

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• Glucose‐stimulated insulin release: Parallel perifusion studies of free and hydrogel encapsulated human pancreatic islets

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• Mesenchymal stem cells in combination with low-dose rapamycin significantly prolong islet allograft survival through induction of regulatory T cells.

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• Systematic review of islet cryopreservation

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• Insulin secretion of mixed insulinoma aggregates-gelatin hydrogel microspheres after subcutaneous transplantation

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• Comparison of different compressed sensing algorithms for low SNR 19F MRI applications—Imaging of transplanted pancreatic islets and cells labeled with perfluorocarbons

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• Metabolomics Study of the Effects of Inflammation, Hypoxia, and High Glucose on Isolated Human Pancreatic Islets.

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• Efficacy of Autologous Bone Marrow-Derived Mesenchymal Stem Cell and Mononuclear Cell Transplantation in Type 2 Diabetes Mellitus: A Randomized, Placebo-Controlled Comparative Study

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• Combined Oral Administration of GABA and DPP-4 Inhibitor Prevents Beta Cell Damage and Promotes Beta Cell Regeneration in Mice

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• Multicenter Assessment of Animal-free Collagenase AF-1 for Human Islet Isolation

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• Clinical pancreatic islet transplantation

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• Generation of glucose-sensitive insulin-secreting beta-like cells from human embryonic stem cells by incorporating a synthetic lineage-control network.

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• Quantum dots labelling allows detection of the homing of mesenchymal stem cells administered as immunomodulatory therapy in an experimental model of pancreatic islets transplantation

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• Deformability-based microfluidic separation of pancreatic islets from exocrine acinar tissue for transplant applications.

  2017cites this paper
• C-C Chemokine Receptor Type 2–Dependent Migration of Myeloid-Derived Suppressor Cells in Protection of Islet Transplants

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• An in vitro study of mesenchyme–islet cell interactions in islet neogenesis: A model for tissue replacement therapy in diabetes mellitus

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• CD8+ Effector T Cell Migration to Pancreatic Islet Grafts Is Dependent on Cognate Antigen Presentation by Donor Graft Cells

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• [Real-time quantitative reverse transcription-polymerase chain reaction (PCR).

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• β‐Cell regeneration through the transdifferentiation of pancreatic cells: Pancreatic progenitor cells in the pancreas

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• The Different Faces of the Pancreatic Islet.

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• The Human Endocrine Pancreas: New Insights on Replacement and Regeneration.

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• A microfluidic array for real-time live-cell imaging of human and rodent pancreatic islets.

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• Instant Blood-Mediated Inflammatory Reaction in Hepatocyte Transplantation: Current Status and Future Perspectives

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• A programmable synthetic lineage-control network that differentiates human IPSCs into glucose-sensitive insulin-secreting beta-like cells

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  2016cites this paper