Acute methamphetamine intoxication: brain hyperthermia, blood-brain barrier, brain edema, and morphological cell abnormalities.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  International review of neurobiology

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/S0074-7742(09)88004-5PMID 19897075PMCID PMC3145326
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Rapid morphological brain abnormalities during acute methamphetamine intoxication in the rat: an experimental study using light and electron microscopy.

  2009cited by this paper
• The blood-brain barrier in health and chronic neurodegenerative disorders.

  2008cited by this paper
• Methods to produce hyperthermia-induced brain dysfunction.

  2007cited by this paper
• Brain edema and breakdown of the blood–brain barrier during methamphetamine intoxication: critical role of brain hyperthermia

  2007cited by this paper
• Neurotoxicity of substituted amphetamines: Molecular and cellular mechanisms

  2007cited by this paper
• Spinal nerve lesion alters blood–spinal cord barrier function and activates astrocytes in the rat

  2006cited by this paper
• Review of "The Blood-Cerebrospinal Fluid Barrier" by Wei Zheng and Adam Chodobski (editors)

  2006cited by this paper
• High doses of methamphetamine that cause disruption of the blood‐brain barrier in limbic regions produce extensive neuronal degeneration in mouse hippocampus

  2006cited by this paper
• Mechanisms of methamphetamine-induced dopaminergic neurotoxicity

  2006cited by this paper
• Alterations in Blood–Brain Barrier Function by Morphine and Methamphetamine

  2006cited by this paper
• Brain hyperthermia as physiological and pathological phenomena.

  2005cited by this paper
• Blood-brain barrier integrity may be threatened by exercise in a warm environment.

  2005cited by this paper
• Pathophysiology of blood-spinal cord barrier in traumatic injury and repair.

  2005cited by this paper
• Techniques for Measuring the Blood–Brain Barrier Integrity

  2005cited by this paper
• Brain hyperthermia induced by MDMA (‘ecstasy’): modulation by environmental conditions

  2004cited by this paper
• Do fever and anapyrexia exist? Analysis of set point-based definitions.

  2004cited by this paper
• How does the blood leave the brain? A systematic ultrasound analysis of cerebral venous drainage patterns

  2004cited by this paper
• Modulation of physiological brain hyperthermia by environmental temperature and impaired blood outflow in rats.

  2004cited by this paper
• Hyperthermia induced pathophysiology of the central nervous system

  2003cited by this paper
• [Effect of hyperthermia on tight junctions between endothelial cells of the blood-brain barrier model in vitro].

  2003cited by this paper
• Elevated environmental temperature and methamphetamine neurotoxicity.

  2003cited by this paper
• Brain Hyperthermia Is Induced by Methamphetamine and Exacerbated by Social Interaction

  2003cited by this paper
• Post-traumatic inflammation following spinal cord injury

  2003cited by this paper
• Induction of Hsp27 and Hsp32 Stress Proteins and Vimentin in Glial Cells of the Rat Hippocampus Following Hyperthermia

  2003cited by this paper
• Neurons, glia, and plasticity in normal brain aging.

  2003cited by this paper
• Cellular effects of hyperthermia: relevance to the minimum dose for thermal damage

  2003cited by this paper
• Selected contribution: ambient temperature for experiments in rats: a new method for determining the zone of thermal neutrality.

  2002cited by this paper
• The pharmacology and toxicology of "ecstasy" (MDMA) and related drugs.

  2001cited by this paper
• Evaluation of the effect of stress on the blood--brain barrier: critical role of the brain perfusion time.

  2001cited by this paper
• Acute stress increases permeability of the blood-brain-barrier through activation of brain mast cells.

  2001cited by this paper
• Rapid astrocyte death induced by transient hypoxia, acidosis, and extracellular ion shifts

  2001cited by this paper
• Hyperthermia impairs liver mitochondrial function in vitro.

  2000cited by this paper
• Methamphetamine decreases mouse striatal dopamine transporter activity: roles of hyperthermia and dopamine.

  2000cited by this paper
• Acute histological effects of interstitial hyperthermia on normal rat brain

  2000cited by this paper
• Molecular Footprints of Neurotoxic Amphetamine Action

  2000cited by this paper
• The Effects of Methamphetamine on the Production of Free Radicals and Oxidative Stress 1

  1998cited by this paper
• Glial reactions in the central nervous system following heat stress.

  1998cited by this paper
• Sympatho-adrenal involvement in methamphetamine-induced hyperthermia through skeletal muscle hypermetabolism.

  1998cited by this paper
• The effects of methamphetamine on the production of free radicals and oxidative stress.

  1998cited by this paper
• Heatstroke‐Induced Cerebral Ischemia and Neuronal Damage

  1997cited by this paper
• Methamphetamine and methylenedioxymethamphetamine neurotoxicity: possible mechanisms of cell destruction.

  1996cited by this paper
• Changes in the ultrastructure of human cells related to certain biological responses under hyperthermic culture conditions.

  1996cited by this paper
• Methamphetamine and methylenedioxymethamphetamine neurotoxicity: possible mechanisms of cell destruction.

  1996cited by this paper
• Role of hypothermia in the mechanism of protection against serotonergic toxicity. II. Experiments with methamphetamine, p-chloroamphetamine, fenfluramine, dizocilpine and dextromethorphan.

  1995cited by this paper
• Methamphetamine-induced hyperthermia and dopaminergic neurotoxicity in mice: pharmacological profile of protective and nonprotective agents.

  1995cited by this paper
• Neurotoxicity profiles of substituted amphetamines in the C57BL/6J mouse.

  1994cited by this paper
• Methamphetamine‐induced neurotoxicity: Roles for glutamate and dopamine efflux

  1994cited by this paper
• Low environmental temperatures or pharmacologic agents that produce hypothermia decrease methamphetamine neurotoxicity in mice.

  1994cited by this paper
• Environment-, drug- and stress-induced alterations in body temperature affect the neurotoxicity of substituted amphetamines in the C57BL/6J mouse.

  1994cited by this paper
• Effects of a cold environment or age on methamphetamine-induced dopamine release in the caudate putamen of female rats.

  1993cited by this paper
• Quantitative Features of Reactive Gliosis following Toxicant‐induced Damage of the CNS a

  1993cited by this paper
• Acute systemic heat stress increases glial fibrillary acidic protein immunoreactivity in brain: experimental observations in conscious normotensive young rats.

  1992cited by this paper
• Quantitative aspects of reactive gliosis: A review

  1992cited by this paper
• Hyperthermia enhances the cytotoxic effects of reactive oxygen species to Chinese hamster cells and bovine endothelial cells in vitro.

  1991cited by this paper
• A morphometric study on the development of the lateral ventricle choroid plexus, choroid plexus capillaries and ventricular ependyma in the rat.

  1990cited by this paper
• Methamphetamine-induced neuronal damage: a possible role for free radicals.

  1989cited by this paper
• Long-term effects of chronic methamphetamine administration in rhesus monkeys.

  1989cited by this paper
• Effects of vasoactive stimuli on blood flow to choroid plexus.

  1988cited by this paper
• Toxicity of MDA (3,4-methylenedioxyamphetamine) considered for relevance to hazards of MDMA (Ecstasy) abuse.

  1987cited by this paper
• Influence of long-term immobilization stress on regional blood-brain barrier permeability, cerebral blood flow and 5-HT level in conscious normotensive young rats.

  1986cited by this paper
• [Ultrastructural analysis of the phenomenon of acute neuronal swelling].

  1985cited by this paper
• Ultrastructural analysis of the phenomenon of acute neuronal swelling

  1985cited by this paper
• Long-term effects of repeated methylamphetamine administration on dopamine and serotonin neurons in the rat brain: a regional study.

  1980cited by this paper
• Experimental cerebral concussion. Part 1: An electron microscopic study.

  1977cited by this paper
• Blood-Brain Barrier in Physiology and Medicine

  1976cited by this paper
• Dependence on age of methamphetamine-produced changes in thermoregulation and metabolism

  1975cited by this paper
• Death in amphetamine users: causes and rates.

  1975cited by this paper
• THE CENTRAL EFFECTS OF XYLOPININE IN MICE.

  1963cited by this paper
• Gesammelte Arbeiten zur Immunitätsforschung

  year unknowncited by this paper

• AI/ML-based computational models for toxicity prediction.

  2026cites this paper
• Clinical Approach to Acute Recreational Drug Intoxication in the Emergency Setting: A Practical Guide Based on Swiss Experience

  2025cites this paper
• Evaluation of Some Biochemical Parameters in Iraqi Methamphetamine Addicts

  2025cites this paper
• Methamphetamine Overdose and Hyperthermia in a 41-Year-Old Man Found Unresponsive

  2025influential citation
• Analysis of the methamphetamine-related deaths in Eastern Saxony, Germany, between 2005 and 2019

  2025cites this paper
• The pharmacology and neurotoxicology of synthetic cathinones.

  2024cites this paper
• Cardiopathology in Methamphetamine Poisoning-Related Deaths in Chiang Mai Thailand

  2024cites this paper
• Fever burden within 24 h after hematoma evacuation predicts early neurological deterioration in patients with intracerebral hemorrhage: a retrospective analysis

  2023cites this paper
• Effect of aerobic exercise on brain metabolite profiles in the mouse models of methamphetamine addiction: LC-MS-based metabolomics study

  2023cites this paper
• Risk factors for heat-related illness resulting in death or hospitalization in the oil and gas extraction industry

  2023cites this paper
• Nanowired Delivery of Mesenchymal Stem Cells with Antioxidant Compound H-290/51 Reduces Exacerbation of Methamphetamine Neurotoxicity in Hot Environment.

  2023cites this paper
• Nanowired Delivery of Curcumin Attenuates Methamphetamine Neurotoxicity and Elevates Levels of Dopamine and Brain-Derived Neurotrophic Factor.

  2023cites this paper
• Co-administration of Nanowired Oxiracetam and Neprilysin with Monoclonal Antibodies to Amyloid Beta Peptide and p-Tau Thwarted Exacerbation of Brain Pathology in Concussive Head Injury at Hot Environment.

  2023cites this paper
• Overview of blood-brain barrier dysfunction in methamphetamine abuse.

  2023cites this paper
• The role of metabotropic glutamate receptors in neurobehavioral effects associated with methamphetamine use.

  2023cites this paper
• Dantrolene sodium fails to reverse robust brain hyperthermia induced by MDMA and methamphetamine in rats

  2023cites this paper
• Synthetic Cathinone-Induced Myocarditis and Psychosis: A Case Report.

  2022cites this paper
• Laminin as a Biomarker of Blood–Brain Barrier Disruption under Neuroinflammation: A Systematic Review

  2022cites this paper
• The psychoactive drug of abuse mephedrone differentially disrupts blood-brain barrier properties

  2021cites this paper
• Understanding the Basis of METH Mouth Using a Rodent Model of Methamphetamine Injection, Sugar Consumption, and Streptococcus mutans Infection

  2021cites this paper
• Assessment of aversive effects of methylone in male and female Sprague-Dawley rats: Conditioned taste avoidance, body temperature and activity/stereotypies.

  2021cites this paper
• Optic nerve sheath diameter as a predictor of altered mental status in drug intoxication patients

  2021cites this paper
• Investigation on μ-opioid receptor in Sera of Iraqi Male addiction Tramadol or Methamphetamine

  2021cites this paper
• Methamphetamine exacerbates pathophysiology of traumatic brain injury at high altitude. Neuroprotective effects of nanodelivery of a potent antioxidant compound H-290/51.

  2021cites this paper
• Toxic Effects of Methamphetamine on Perivascular Health: Co-morbid Effects of Stress and Alcohol Use Disorders

  2021cites this paper
• Alzheimer's disease neuropathology is exacerbated following traumatic brain injury. Neuroprotection by co-administration of nanowired mesenchymal stem cells and cerebrolysin with monoclonal antibodies to amyloid beta peptide.

  2021cites this paper
• Functional and structural alternations in the choroid plexus upon Methamphetamine exposure.

  2021cites this paper
• Methamphetamine mediates apoptosis of vascular smooth muscle cells via the Chop-related endoplasmic reticulum stress pathway.

  2021cites this paper
• Effect of Methamphetamine Addiction on Brain Chemistry Through the Adoption of Fractalkine as an Indicator

  2020influential citation
• Role of natural products in mitigation of toxic effects of methamphetamine: A review of in vitro and in vivo studies

  2020cites this paper
• Minocycline attenuates 3,4-methylenedioxymethamphetamine-induced hyperthermia in the rat brain.

  2019cites this paper
• Prediction of Human Lethality of Psychoactive Drugs From Rodent LD50 Values

  2019cites this paper
• Psychiatric Disorders: Methods and Protocols

  2019influential citation
• Adverse effect of catechol-O-methyltransferase (COMT) Val158Met met/met genotype in methamphetamine-related executive dysfunction.

  2019cites this paper
• Rodent Models of Methamphetamine Misuse: Mechanisms of Methamphetamine Action and Comparison of Different Rodent Paradigms.

  2019cites this paper
• Conditional Effects of Lifetime Alcohol Consumption on Methamphetamine-Associated Neurocognitive Performance

  2019cites this paper
• Colon dysregulation in methamphetamine self-administering HIV-1 transgenic rats

  2018cites this paper
• Chronic oxycodone induces axonal degeneration in rat brain

  2018cites this paper
• The impact of methamphetamines in patients with traumatic brain injury, a retrospective review.

  2018cites this paper
• The effects of vitamin B12 on the brain damages caused by methamphetamine in mice

  2018cites this paper
• Risk Factors for Heat-Related Illness in U.S. Workers: An OSHA Case Series

  2018cites this paper
• Examining the survival benefit of radiation therapy on leptomeningeal carcinomatosis and identifying factors associated with survival benefit of whole‐brain radiation therapy

  2018cites this paper
• Exploring the effect of intravenous lipid emulsion in acute methamphetamine toxicity

  2017influential citation
• TBHQ Alleviated Endoplasmic Reticulum Stress-Apoptosis and Oxidative Stress by PERK-Nrf2 Crosstalk in Methamphetamine-Induced Chronic Pulmonary Toxicity

  2017cites this paper
• β-elemene regulates endoplasmic reticulum stress to induce the apoptosis of NSCLC cells through PERK/IRE1α/ATF6 pathway.

  2017cites this paper
• Repeated Forced Swim Exacerbates Methamphetamine-Induced Neurotoxicity: Neuroprotective Effects of Nanowired Delivery of 5-HT3-Receptor Antagonist Ondansetron

  2017cites this paper
• Methamphetamine induces hepatotoxicity via inhibiting cell division, arresting cell cycle and activating apoptosis: In vivo and in vitro studies.

  2017cites this paper
• Toll-Like Receptor 4 Mediates Methamphetamine-Induced Neuroinflammation through Caspase-11 Signaling Pathway in Astrocytes

  2017cites this paper
• Endoplasmic reticulum stress and apoptosis via PERK-eIF2α-CHOP signaling in the methamphetamine-induced chronic pulmonary injury.

  2017cites this paper
• Trace amine‐associated receptor 1 regulation of methamphetamine‐induced neurotoxicity

  2017cites this paper
• Breakdown of Blood-Brain and Blood-Spinal Cord Barriers During Acute Methamphetamine Intoxication: Role of Brain Temperature.

  2016cites this paper
• Nanowired Drug Delivery Across the Blood-Brain Barrier in Central Nervous System Injury and Repair.

  2016cites this paper
• Cocaine and methamphetamine induce opposing changes in BOLD signal response in rats.

  2016cites this paper
• Methamphetamine alters microglial immune function through P2X7R signaling

  2016cites this paper
• Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine

  2016cites this paper
• Exploring new possible targets in Methamphetamine exposure

  2016cites this paper
• Role for Reactive Oxygen Species in Methamphetamine Modulation of Dopamine Release in the Striatum

  2016cites this paper
• Inhibitory effect of melatonin on cerebral endothelial cells dysfunction induced by methamphetamine via NADPH oxidase-2.

  2016influential citation
• Neurotoxicology of Synthetic Cathinone Analogs.

  2016cites this paper
• Interactions of Cannabis and Amphetamine-Type Stimulants

  2015cites this paper
• Stimulant Use Disorders

  2015cites this paper
• Methamphetamin – Wissenswertes für den Notfall

  2015cites this paper
• Exacerbation of Methamphetamine Neurotoxicity in Cold and Hot Environments: Neuroprotective Effects of an Antioxidant Compound H-290/51

  2015cites this paper
• Chronic oxycodone induces integrated stress response in rat brain

  2015cites this paper
• Characterization of in vitro models for evaluation of molecular mechanisms involved in the action of Acetyl-L-Carnitine

  2014cites this paper
• Methamphetamine-induced toxicity: an updated review on issues related to hyperthermia.

  2014cites this paper
• Development of in vivo drug-induced neurotoxicity models

  2014influential citation
• Methamphetamine Neurotoxicity and Neuroinflammatory Processes

  2014cites this paper
• Current preclinical studies on neuroinflammation and changes in blood-brain barrier integrity by MDMA and methamphetamine.

  2014cites this paper
• Psychostimulants and brain dysfunction: a review of the relevant neurotoxic effects.

  2014cites this paper
• MRI assessment of brain iron content in methamphetamine users

  2014influential citation
• Co‐administration of betulinic acid and methamphetamine causes toxicity to dopaminergic and serotonergic nerve terminals in the striatum of late adolescent rats

  2014cites this paper
• Ammonia Mediates Methamphetamine-Induced Increases in Glutamate and Excitotoxicity

  2014cites this paper
• The Involvement of Sigma Receptor Modulation in the Antidepressant Effects of Ketamine and the Neurotoxic Actions of Methamphetamine

  2013cites this paper
• Progress Towards Understanding Of Mechanisms Of Action Of Potent Multifunctional Disease Modifying Therapeutics For Parkinson's Disease & Investigating The Methamphetamine-Induced Striatal Microglia Activation.

  2013cites this paper
• Mephedrone does not damage dopamine nerve endings of the striatum, but enhances the neurotoxicity of methamphetamine, amphetamine, and MDMA

  2013cites this paper
• Drug-induced hyperthermic syndromes: part I. Hyperthermia in overdose.

  2013cites this paper
• Characterization of in vitro models for evaluation of molecular mechanisms involved in the action of Acetyl-L-Carnitine

  2013cites this paper
• Latest trends in drugs of abuse - HIV infection and neuroAIDS.

  2013cites this paper
• Methamphetamine causes acute hyperthermia-dependent liver damage

  2013cites this paper
• Ultra-performance liquid chromatography tandem mass spectrometry method for the determination of AZ66, a sigma receptor ligand, in rat plasma and its application to in vivo pharmacokinetics.

  2013cites this paper
• Methamphetamine Enhances Cryptococcus neoformans Pulmonary Infection and Dissemination to the Brain

  2013cites this paper
• Part I. Hyperthermia in Overdose

  2013cites this paper
• A study on the effect of JNK inhibitor, SP600125, on the disruption of blood-brain barrier induced by methamphetamine.

  2013cites this paper
• The effects of methamphetamine self‐administration on cortical monoaminergic deficits induced by subsequent high‐dose methamphetamine administrations

  2013cites this paper
• σ Receptor antagonist attenuation of methamphetamine-induced neurotoxicity is correlated to body temperature modulation

  2013cites this paper
• Acute Bacterial Meningitis with Coincident Methamphetamine Use: A Case Report and Review of the Literature

  2013cites this paper
• The Contribution of Ammonia to Methamphetamine Neurotoxicity

  2013cites this paper
• The Effects of Psychostimulant Drugs on Blood Brain Barrier Function and Neuroinflammation

  2012cites this paper
• Plasma Proteomic Profiling in HIV-1 Infected Methamphetamine Abusers

  2012cites this paper
• Prior methamphetamine self-administration attenuates serotonergic deficits induced by subsequent high-dose methamphetamine administrations.

  2012cites this paper
• L-ascorbate attenuates methamphetamine neurotoxicity through enhancing the induction of endogenous heme oxygenase-1.

  2012cites this paper
• Bioenergetics Failure and Oxidative Stress in Brain Stem Mediates Cardiovascular Collapse Associated with Fatal Methamphetamine Intoxication

  2012cites this paper
• Persistent Neuroinflammatory Effects of Serial Exposure to Stress and Methamphetamine on the Blood-Brain Barrier

  2012cites this paper
• Molecular and cellular bases for the protective effects of dopamine D1 receptor antagonist, SCH23390, against methamphetamine-induced neurotoxicity in the rat brain

  2012cites this paper
• Diabetes exacerbates nanoparticles induced brain pathology.

  2012cites this paper
• Breaking down the barrier: the effects of HIV-1 on the blood-brain barrier.

  2011cites this paper
• Interacció dels derivats amfetamínics amb els receptors nicotínics: Aspectes moleculars i funcionals

  2011cites this paper
• Impairment of brain endothelial glucose transporter by methamphetamine causes blood-brain barrier dysfunction

  2011cites this paper
• Cerebrolysin Attenuates Heat Shock Protein (HSP 72 KD) Expression in the Rat Spinal Cord Following Morphine Dependence and Withdrawal: Possible New Therapy for Pain Management

  2011influential citation