Mechanisms of Mitochondrial Free Radical Production and their Relationship to the Aging Process

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Unknown venue

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/B978-0-12-378638-8.00003-8
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Low complex I content explains the low hydrogen peroxide production rate of heart mitochondria from the long‐lived pigeon, Columba livia

  2010cited by this paper
• Mice expressing an error-prone DNA polymerase in mitochondria display elevated replication pausing and chromosomal breakage at fragile sites of mitochondrial DNA

  2009cited by this paper
• Differential effects of mitochondrial Complex I inhibitors on production of reactive oxygen species.

  2009cited by this paper
• Overexpression of Mn superoxide dismutase does not increase life span in mice.

  2009cited by this paper
• Architecture of complex I and its implications for electron transfer and proton pumping.

  2009cited by this paper
• Overexpression of Catalase Targeted to Mitochondria Attenuates Murine Cardiac Aging

  2009cited by this paper
• Reactive oxygen species regulation by AIF- and complex I-depleted brain mitochondria.

  2009cited by this paper
• Structure of glycerol-3-phosphate dehydrogenase, an essential monotopic membrane enzyme involved in respiration and metabolism

  2008cited by this paper
• Involvement of thio-, peroxi-, and glutaredoxins in cellular redox-dependent processes

  2008cited by this paper
• The Dual Functions of Thiol-Based Peroxidases in H2O2 Scavenging and Signaling

  2008cited by this paper
• Movement of the iron-sulfur head domain of cytochrome bc(1) transiently opens the catalytic Q(o) site for reaction with oxygen.

  2008cited by this paper
• Breaking the Q-cycle: finding new ways to study Qo through thermodynamic manipulations

  2008cited by this paper
• How mitochondria produce reactive oxygen species

  2008cited by this paper
• The overexpression of major antioxidant enzymes does not extend the lifespan of mice

  2008cited by this paper
• The role of mitochondrial DNA mutations in aging and sarcopenia: implications for the mitochondrial vicious cycle theory of aging.

  2008cited by this paper
• Reduction of age-associated pathology in old mice by overexpression of catalase in mitochondria.

  2008cited by this paper
• Dissociation of superoxide production by mitochondrial complex I from NAD(P)H redox state

  2008cited by this paper
• Diphenyleneiodonium acutely inhibits reactive oxygen species production by mitochondrial complex I during reverse, but not forward electron transport.

  2008cited by this paper
• Thioredoxin 2 haploinsufficiency in mice results in impaired mitochondrial function and increased oxidative stress.

  2008cited by this paper
• Were there any "misassignments" among iron-sulfur clusters N4, N5 and N6b in NADH-quinone oxidoreductase (complex I)?

  2008cited by this paper
• The Mechanism of Mitochondrial Superoxide Production by the Cytochrome bc1 Complex*

  2008cited by this paper
• Thiol Chemistry in Peroxidase Catalysis and Redox Signaling

  2008cited by this paper
• Trends in oxidative aging theories.

  2007cited by this paper
• Hippocampal long-term potentiation, memory, and longevity in mice that overexpress mitochondrial superoxide dismutase.

  2007cited by this paper
• Fluorescent and luminescent probes for measurement of oxidative and nitrosative species in cells and tissues: progress, pitfalls, and prospects.

  2007cited by this paper
• Reevaluating the relationship between EPR spectra and enzyme structure for the iron–sulfur clusters in NADH:quinone oxidoreductase

  2007cited by this paper
• Catalase Takes Part in Rat Liver Mitochondria Oxidative Stress Defense*

  2007cited by this paper
• Simultaneous detection of apoptosis and mitochondrial superoxide production in live cells by flow cytometry and confocal microscopy

  2007cited by this paper
• Diabetic Cardiomyopathy in OVE26 Mice Shows Mitochondrial ROS Production and Divergence Between In Vivo and In Vitro Contractility.

  2007cited by this paper
• Respiratory chain components involved in the glycerophosphate dehydrogenase-dependent ROS production by brown adipose tissue mitochondria.

  2007cited by this paper
• The Important Role of Lipid Peroxidation Processes in Aging and Age Dependent Diseases

  2007cited by this paper
• Oxidative stress and mitochondrial impairment can be separated from lipofuscin accumulation in aged human skeletal muscle

  2007cited by this paper
• Lipofuscin

  2007cited by this paper
• Characteristics of α‐glycerophosphate‐evoked H2O2 generation in brain mitochondria

  2007cited by this paper
• Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeotherms

  2007cited by this paper
• Protein oxidation and aging

  2006cited by this paper
• Mitochondrial NADPH, transhydrogenase and disease.

  2006cited by this paper
• The mechanism of superoxide production by NADH:ubiquinone oxidoreductase (complex I) from bovine heart mitochondria

  2006cited by this paper
• Differential Activation of Mitogenic Signaling Pathways in Aortic Smooth Muscle Cells Deficient in Superoxide Dismutase Isoforms

  2005cited by this paper
• Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging

  2005cited by this paper
• SOD2 overexpression: enhanced mitochondrial tolerance but absence of effect on UCP activity

  2005cited by this paper
• Correlations between physiology and lifespan – two widely ignored problems with comparative studies

  2005cited by this paper
• The topology of superoxide production by complex III and glycerol 3-phosphate dehydrogenase in Drosophila mitochondria.

  2005cited by this paper
• Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production.

  2005cited by this paper
• A Possible Site of Superoxide Generation in the Complex I Segment of Rat Heart Mitochondria

  2005cited by this paper
• Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria

  2005cited by this paper
• Fixing the Q cycle.

  2005cited by this paper
• Superoxide production by NADH:ubiquinone oxidoreductase (complex I) depends on the pH gradient across the mitochondrial inner membrane.

  2004cited by this paper
• Mitochondrial α-Ketoglutarate Dehydrogenase Complex Generates Reactive Oxygen Species

  2004cited by this paper
• Premature ageing in mice expressing defective mitochondrial DNA polymerase

  2004cited by this paper
• The cytochrome bc1 complex: function in the context of structure.

  2004cited by this paper
• Inhibitors of the Quinone-binding Site Allow Rapid Superoxide Production from Mitochondrial NADH:Ubiquinone Oxidoreductase (Complex I)*

  2004cited by this paper
• Pathology of skeletal muscle in mitochondrial disorders.

  2004cited by this paper
• Oxidative stress, toxicology, and pharmacology of CYP2E1.

  2004cited by this paper
• Mitochondrial Complex I Inhibitor Rotenone Induces Apoptosis through Enhancing Mitochondrial Reactive Oxygen Species Production*

  2003cited by this paper
• Superoxide anion generation by the cytochrome bc1 complex.

  2003cited by this paper
• Architecture of Succinate Dehydrogenase and Reactive Oxygen Species Generation

  2003cited by this paper
• The Absence of Mitochondrial Thioredoxin 2 Causes Massive Apoptosis, Exencephaly, and Early Embryonic Lethality in Homozygous Mice

  2003cited by this paper
• Synchronized Whole Cell Oscillations in Mitochondrial Metabolism Triggered by a Local Release of Reactive Oxygen Species in Cardiac Myocytes*

  2003cited by this paper
• Superoxide and hydrogen peroxide production by Drosophila mitochondria.

  2003cited by this paper
• Rate of generation of oxidative stress-related damage and animal longevity.

  2002cited by this paper
• The neutrophil NADPH oxidase.

  2002cited by this paper
• Glycerophosphate-Dependent Hydrogen Peroxide Production by Brown Adipose Tissue Mitochondria and Its Activation by Ferricyanide

  2002cited by this paper
• Overexpressed Human Mitochondrial Thioredoxin Confers Resistance to Oxidant-induced Apoptosis in Human Osteosarcoma Cells*

  2002cited by this paper
• Relative contributions of heart mitochondria glutathione peroxidase and catalase to H(2)O(2) detoxification in in vivo conditions.

  2002cited by this paper
• Multiple Q-cycle bypass reactions at the Qo site of the cytochrome bc1 complex.

  2002cited by this paper
• Succinate dehydrogenase and fumarate reductase from Escherichia coli.

  2002cited by this paper
• Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation-reduction state.

  2002cited by this paper
• Mitochondrial abnormalities are more frequent in muscles undergoing sarcopenia.

  2002cited by this paper
• Mechanism of Superoxide and Hydrogen Peroxide Formation by Fumarate Reductase, Succinate Dehydrogenase, and Aspartate Oxidase*

  2002cited by this paper
• Topology of Superoxide Production from Different Sites in the Mitochondrial Electron Transport Chain*

  2002cited by this paper
• Inactivation of the 2-oxo acid dehydrogenase complexes upon generation of intrinsic radical species.

  2002cited by this paper
• Tetrahydrobiopterin Scavenges Superoxide in Dopaminergic Neurons*

  2001cited by this paper
• Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple.

  2001cited by this paper
• The site of production of superoxide radical in mitochondrial Complex I is not a bound ubisemiquinone but presumably iron–sulfur cluster N2

  2001cited by this paper
• Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals

  2000cited by this paper
• Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblast.

  2000cited by this paper
• Titrating the Effects of Mitochondrial Complex I Impairment in the Cell Physiology*

  1999cited by this paper
• The regeneration of reduced glutathione in rat forebrain mitochondria identifies metabolic pathways providing the NADPH required.

  1999cited by this paper
• Mitochondrial reactive oxygen species trigger hypoxia-induced transcription.

  1998cited by this paper
• Substrate and site specificity of hydrogen peroxide generation in mouse mitochondria.

  1998cited by this paper
• The free radical theory of aging matures.

  1998cited by this paper
• Structure and function of the cytochrome bc1 complex of mitochondria and photosynthetic bacteria.

  1998cited by this paper
• Oxidative Stress and Mitochondrial DNA Mutations in Human Aging

  1998cited by this paper
• Electron transfer by domain movement in cytochrome bc1

  1998cited by this paper
• Sites and mechanisms responsible for the low rate of free radical production of heart mitochondria in the long-lived pigeon.

  1997cited by this paper
• Dependence of H2O2 Formation by Rat Heart Mitochondria on Substrate Availability and Donor Age

  1997cited by this paper
• Superoxide Production by the Mitochondrial Respiratory Chain

  1997cited by this paper
• Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice.

  1996cited by this paper
• The specificity of mitochondrial complex I for ubiquinones.

  1996cited by this paper
• Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death

  1995cited by this paper
• Diphenyleneiodonium inhibits reduction of iron-sulfur clusters in the mitochondrial NADH-ubiquinone oxidoreductase (Complex I).

  1994cited by this paper
• Complex I and complex III of mitochondria have common inhibitors acting as ubiquinone antagonists.

  1993cited by this paper
• Relationship between mitochondrial superoxide and hydrogen peroxide production and longevity of mammalian species.

  1993cited by this paper
• Comparison of mitochondrial pro-oxidant generation and anti-oxidant defenses between rat and pigeon: possible basis of variation in longevity and metabolic potential.

  1993cited by this paper
• Age-associated oxygen damage and mutations in mitochondrial DNA in human hearts.

  1992cited by this paper
• The measurement and mechanism of lipid peroxidation in biological systems.

  1990cited by this paper
• Mitochondrial mutations may increase oxidative stress: implications for carcinogenesis and aging?

  1990cited by this paper
• Physiological roles of nicotinamide nucleotide transhydrogenase.

  1988cited by this paper
• Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria.

  1985cited by this paper

• Targeting Mitochondrial Metabolism as a Strategy to Treat Senescence

  2021cites this paper
• Oxidative carbonilation of liver tissue proteins under the influence of pesticide based on glyphosate in a subchronic experiment

  2020cites this paper
• A Mechanistic Evaluation of Antioxidant Nutraceuticals on Their Potential against Age-Associated Neurodegenerative Diseases

  2020cites this paper
• Pregnancy-associated plasma protein-aa supports hair cell survival by regulating mitochondrial function

  2019cites this paper
• Pregnancy-associated plasma protein-aa promotes neuron survival by regulating mitochondrial function

  2018cites this paper
• Mild aerobic training with blood flow restriction increases the hypertrophy index and MuSK in both slow and fast muscles of old rats: Role of PGC‐1&agr;

  2018cites this paper
• The 2-Oxoacid Dehydrogenase Complexes in Mitochondria Can Produce Superoxide/Hydrogen Peroxide at Much Higher Rates Than Complex I*

  2014cites this paper
• Higher Rates Than Complex I Superoxide / Hydrogen Peroxide at Much in Mitochondria Can Produce The 2-Oxoacid Dehydrogenase Complexes Bioenergetics :

  2014cites this paper
• The pH sensitivity of H2O2 metabolism in skeletal muscle mitochondria

  2013cites this paper
• PGC1&agr; and mitochondrial metabolism – emerging concepts and relevance in ageing and neurodegenerative disorders

  2012influential citation
• Native rates of superoxide production from multiple sites in isolated mitochondria measured using endogenous reporters.

  2012cites this paper
• Mitochondrial Complex II Can Generate Reactive Oxygen Species at High Rates in Both the Forward and Reverse Reactions*

  2012cites this paper
• 1 EVIDENCE FOR TWO SITES OF SUPEROXIDE PRODUCTION BY MITOCHONDRIAL NADH-Q OXIDOREDUCTASE ( COMPLEX I ) *

  2011cites this paper
• Evidence for Two Sites of Superoxide Production by Mitochondrial NADH-Ubiquinone Oxidoreductase (Complex I)*

  2011cites this paper
• ScholarWorks@UARK ScholarWorks@UARK

  year unknowncites this paper