Molecular and Cellular Aspects of Macrophage Aging

No abstract is available for this paper.

• Publication year

  2019

• Venue

  Handbook of Immunosenescence

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/978-1-4020-9063-9_46
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Ghrelin receptor regulates adipose tissue inflammation in aging

  2016cited by this paper
• Ageing and the telomere connection: An intimate relationship with inflammation.

  2016cited by this paper
• Attenuated phagocytosis of secondary necrotic neutrophils by macrophages in aged and SMP30 knockout mice

  2016cited by this paper
• Growth Hormone Receptor Deficiency Protects against Age-Related NLRP3 Inflammasome Activation and Immune Senescence

  2016cited by this paper
• Age-Dependent Susceptibility to Pulmonary Fibrosis Is Associated with NLRP3 Inflammasome Activation.

  2016cited by this paper
• Aging is associated with hypermethylation of autophagy genes in macrophages

  2016cited by this paper
• Macrophages in Tissue Repair, Regeneration, and Fibrosis.

  2016cited by this paper
• Phagocytosis: An Immunobiologic Process.

  2016cited by this paper
• Ex vivo foam cell formation is enhanced in monocytes from older individuals by both extrinsic and intrinsic mechanisms.

  2016cited by this paper
• G6PD protects from oxidative damage and improves healthspan in mice

  2016cited by this paper
• Generation of mice with longer and better preserved telomeres in the absence of genetic manipulations

  2016cited by this paper
• Increases of M2a macrophages and fibrosis in aging muscle are influenced by bone marrow aging and negatively regulated by muscle-derived nitric oxide

  2015cited by this paper
• NBS1 is required for macrophage homeostasis and functional activity in mice.

  2015cited by this paper
• Bone marrow-derived macrophages from aged rats are more responsive to inflammatory stimuli

  2015cited by this paper
• Elevated Endoplasmic Reticulum Stress Response Contributes to Adipose Tissue Inflammation in Aging.

  2015cited by this paper
• HSC Aging and Senescent Immune Remodeling.

  2015cited by this paper
• Ablation of XP-V gene causes adipose tissue senescence and metabolic abnormalities

  2015cited by this paper
• IL10-driven STAT3 signalling in senescent macrophages promotes pathological eye angiogenesis

  2015cited by this paper
• ROCK-isoform-specific polarization of macrophages associated with age-related macular degeneration.

  2015cited by this paper
• Age-associated inflammation connects RAS-induced senescence to stem cell dysfunction and epidermal malignancy

  2015cited by this paper
• Autophagy Controls Acquisition of Aging Features in Macrophages

  2015cited by this paper
• Most Tissue-Resident Macrophages Except Microglia Are Derived from Fetal Hematopoietic Stem Cells.

  2015cited by this paper
• Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination.

  2015cited by this paper
• University of Groningen Enhanced microglial pro-inflammatory response to lipopolysaccharide correlates with brain infiltration and blood-brain barrier dysregulation in a mouse model of telomere shortening

  2015cited by this paper
• Microglial K+ Channel Expression in Young Adult and Aged Mice

  2014cited by this paper
• Macrophage-derived IL-18 and increased fibrinogen deposition are age-related inflammatory signatures of vascular remodeling.

  2014cited by this paper
• IL-2/CD40-activated macrophages rescue age and tumor-induced T cell dysfunction in elderly mice

  2014cited by this paper
• Age-related clonal hematopoiesis associated with adverse outcomes.

  2014cited by this paper
• Origin and functions of tissue macrophages.

  2014cited by this paper
• Characterization of lung inflammation and its impact on macrophage function in aging

  2014cited by this paper
• Age-related changes in tissue macrophages precede cardiac functional impairment

  2014cited by this paper
• Effect of Age on Regulation of Human Osteoclast Differentiation

  2014cited by this paper
• Comparison of chosen activation markers of human monocytes/macrophages isolated from the peripheral blood of young and elderly volunteers

  2014cited by this paper
• Adiposity induces lethal cytokine storm after systemic administration of stimulatory immunotherapy regimens in aged mice

  2014cited by this paper
• Age-Enhanced Endoplasmic Reticulum Stress Contributes to Increased Atg9A Inhibition of STING-Mediated IFN-β Production during Streptococcus pneumoniae Infection

  2014cited by this paper
• Age-associated aberrations in mouse cellular and humoral immune responses

  2014cited by this paper
• Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny

  2014cited by this paper
• Elevated A20 contributes to age-dependent macrophage dysfunction in the lungs.

  2014cited by this paper
• Microglial priming in neurodegenerative disease

  2014cited by this paper
• Aging impairs peritoneal but not bone marrow-derived macrophage phagocytosis

  2014cited by this paper
• Non-canonical Wnt4 prevents skeletal aging and inflammation by inhibiting NF-κB

  2014cited by this paper
• Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction.

  2014cited by this paper
• IL-4 Signaling Drives a Unique Arginase+/IL-1β+ Microglia Phenotype and Recruits Macrophages to the Inflammatory CNS: Consequences of Age-Related Deficits in IL-4Rα after Traumatic Spinal Cord Injury

  2014cited by this paper
• Anti-pneumococcal deficits of monocyte-derived macrophages from the advanced-age, frail elderly and related impairments in PI3K-AKT signaling.

  2014cited by this paper
• Mitochondrial Aging: Focus on Mitochondrial DNA Damage in Atherosclerosis - A Mini-Review

  2014cited by this paper
• Aging enhances classical activation but mitigates alternative activation in the central nervous system.

  2013cited by this paper
• Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration.

  2013cited by this paper
• Microglia during development and aging.

  2013cited by this paper
• Elevated COX2 expression and PGE2 production by downregulation of RXRα in senescent macrophages.

  2013cited by this paper
• Aging predisposes to acute inflammatory induced pathology after tumor immunotherapy

  2013cited by this paper
• Accumulation of mtDNA variations in human single CD34+ cells from maternally related individuals: effects of aging and family genetic background.

  2013cited by this paper
• Arginine transport is impaired in C57Bl/6 mouse macrophages as a result of a deletion in the promoter of Slc7a2 (CAT2), and susceptibility to Leishmania infection is reduced.

  2013cited by this paper
• Homeostatic and injury-induced microglia behavior in the aging brain

  2013cited by this paper
• Targeting macrophages rescues age‐related immune deficiencies in C57BL/6J geriatric mice

  2013cited by this paper
• Inhibition of x‐box binding protein 1 reduces tunicamycin‐induced apoptosis in aged murine macrophages

  2013cited by this paper
• Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging.

  2013cited by this paper
• Macrophage activation and polarization as an adaptive component of innate immunity.

  2013cited by this paper
• Dysregulated expression of miR‐146a contributes to age‐related dysfunction of macrophages

  2012cited by this paper
• Advanced Age Impairs Macrophage Polarization

  2012cited by this paper
• Alterations in Marginal Zone Macrophages and Marginal Zone B Cells in Old Mice

  2011cited by this paper
• Th2 immune responses and alternatively activated macrophages (AAMacs) in helminth infection in aged mice.

  2011cited by this paper
• Role of phosphoinositide 3-kinase-Akt signaling pathway in the age-related cytokine dysregulation in splenic macrophages stimulated via TLR-2 or TLR-4 receptors.

  2011cited by this paper
• CpG-ODN+IFN-γ confer pro- and anti-inflammatory properties to peritoneal macrophages in aged mice.

  2011cited by this paper
• Aging enhances the production of reactive oxygen species and bactericidal activity in peritoneal macrophages by upregulating classical activation pathways.

  2011cited by this paper
• Aging Is Associated with an Increase in T Cells and Inflammatory Macrophages in Visceral Adipose Tissue

  2011cited by this paper
• Age-related loss of CpG methylation in the tumour necrosis factor promoter.

  2011cited by this paper
• Dysregulation of human Toll-like receptor function in aging.

  2011cited by this paper
• Nomenclature of monocytes and dendritic cells in blood.

  2010cited by this paper
• Impaired Functions of Peripheral Blood Monocyte Subpopulations in Aged Humans

  2010cited by this paper
• In Aged Mice, Outgrowth of Intraocular Melanoma Depends on Proangiogenic M2-Type Macrophages

  2010cited by this paper
• Interleukin-6 Contributes to Age-Related Alteration of Cytokine Production by Macrophages

  2010cited by this paper
• Age-dependent alterations of monocyte subsets and monocyte-related chemokine pathways in healthy adults

  2010cited by this paper
• Decreased TNF-α synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4+ T cells during aging

  2009cited by this paper
• Telomere Shortening and Oxidative Stress in Aged Macrophages Results in Impaired STAT5a Phosphorylation1

  2009cited by this paper
• DNA repair is limiting for haematopoietic stem cells during ageing

  2007cited by this paper
• Microglia derived from aging mice exhibit an altered inflammatory profile

  2007cited by this paper
• Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis

  2007cited by this paper
• An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations.

  2007cited by this paper
• Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age

  2007cited by this paper
• Chitin induces accumulation in tissue of innate immune cells associated with allergy

  2007cited by this paper
• Microglial senescence: does the brain's immune system have an expiration date?

  2006cited by this paper
• This information is current as Macrophages Role in Classical or Alternative Activation of Transporter 2 Plays a Critical Regulatory Arginine Transport via Cationic Amino Acid

  2006cited by this paper
• Effect of aging on the microglial response to peripheral nerve injury.

  2006cited by this paper
• Macrophages require distinct arginine catabolism and transport systems for proliferation and for activation

  2006cited by this paper
• Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.

  2006cited by this paper
• The IL-21 receptor augments Th2 effector function and alternative macrophage activation.

  2006cited by this paper
• Molecular basis of age‐associated cytokine dysregulation in LPS‐stimulated macrophages

  2006cited by this paper
• Activin A Functions as a Th2 Cytokine in the Promotion of the Alternative Activation of Macrophages1

  2006cited by this paper
• ATP mediates rapid microglial response to local brain injury in vivo

  2005cited by this paper
• Resting Microglial Cells Are Highly Dynamic Surveillants of Brain Parenchyma in Vivo

  2005cited by this paper
• Glia and their cytokines in progression of neurodegeneration.

  2005cited by this paper
• Major cutbacks at chromosome ends.

  2005cited by this paper
• The plasticity of aging: insights from long-lived mutants.

  2005cited by this paper
• Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress.

  2005cited by this paper
• LPS, TLR4 and infectious disease diversity

  2005cited by this paper
• Aging Increases Stromal/Osteoblastic Cell‐Induced Osteoclastogenesis and Alters the Osteoclast Precursor Pool in the Mouse

  2005cited by this paper
• Ageing, repetitive genomes and DNA damage

  2004cited by this paper
• Innate immunity in aging: impact on macrophage function

  2004cited by this paper
• Insulin Receptor Substrate-2-dependent Interleukin-4 Signaling in Macrophages Is Impaired in Two Models of Type 2 Diabetes Mellitus*

  2004cited by this paper
• Effects of Telomerase Modulation in Human Hematopoietic Progenitor Cells

  2004cited by this paper

• The interplay between the immune microenvironment and bone aging: From molecular mechanisms to therapeutic interventions.

  2025cites this paper
• Immunosenescence and the Geriatric Giants: Molecular Insights into Aging and Healthspan

  2025cites this paper
• Age-Related Impairments in Immune Cell Efferocytosis and Autophagy Hinder Atherosclerosis Regression

  2025cites this paper
• Bacteriophage derived dsRNA induces polarized activation of alveolar macrophages from Balb/c and C57Bl/6 mice in vitro in sex- and age-dependent manner.

  2025cites this paper
• Sustained exposure to high glucose induces differential expression of cellular senescence markers in murine macrophages but impairs immunosurveillance response to senescent cells secretome

  2024cites this paper
• CCR1 mediates Müller cell activation and photoreceptor cell death in macular and retinal degeneration

  2023cites this paper
• Modern Concepts in Cardiovascular Disease: Inflamm-Aging

  2022cites this paper
• A Novel Mechanism of Macrophage Activation by the Natural Yolkin Polypeptide Complex from Egg Yolk

  2022cites this paper
• The Aging of Adipocytes Increases Expression of Pro-Inflammatory Cytokines Chronologically

  2021cites this paper
• Aging versus youth: Endocrine aspects of vulnerability for COVID-19

  2021cites this paper
• Hallmarks of Aging in Macrophages: Consequences to Skin Inflammaging

  2021cites this paper
• The Role of Ageing and Parenchymal Senescence on Macrophage Function and Fibrosis

  2021cites this paper
• The NLRP3 Inflammasome as a Critical Actor in the Inflammaging Process

  2020cites this paper
• Distinct release strategies are required to modulate macrophage phenotype in young versus aged animals.

  2019cites this paper
• A Study of Macrophages in the Aging Liver and in the Host Response to Engineered Lung Scaffolds

  2019cites this paper
• Aging and Cardiovascular Diseases: The Role of Cellular Senescence

  2019cites this paper
• The Interaction of miR-378i-Skp2 Regulates Cell Senescence in Diabetic Nephropathy

  2018cites this paper
• DEVELOPMENT OF CYTOKINE ELUTING COATINGS TO MODULATE MACROPHAGE BEHAVIOUR AND MITIGATE THE FOREIGN BODY REACTION AGAINST IMPLANTABLE BIOMATERIALS

  2018cites this paper
• Effects of age-related shifts in cellular function and local microenvironment upon the innate immune response to implants.

  2017cites this paper
• Effects of aging upon the host response to implants.

  2017cites this paper
• Alzheimer's pathology: should peripheral monocytes and CCR2 take center stage?

  2013cites this paper
• Macrophage biology: The regulation of gene expression

  2009cites this paper