Chromosome Replication and Segregation

Microorganisms accurately position newly replicated chromosomes within genetically identical daughters prior to cell division. New DNA synthesis initiates from specialized chromosomal sites, termed replication origins, and regulation of ordered interactions with initiator proteins ensures replication forks are properly timed and assembled only once per-cycle. In eukaryotic microbes, movement of newly replicated chromosomes requires a microtubule-based mitotic spindle, but chromosomal segregation during the cell cycle is less well understood in bacteria. The rapid separation of replication origins and active remodeling of chromosome structure suggest an intimate relationship between segregation mechanisms and the DNA replication machinery.

• Publication year

  2019

• Venue

  Reference Module in Biomedical Sciences

• Publication date

  Unknown publication date

• Fields of study

  Biology

• Identifiers
  DOI 10.1016/B978-012373944-5.00263-7
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Centromeres License the Mitotic Condensation of Yeast Chromosome Arms

  2018cited by this paper
• Origin recognition is the predominant role for DnaA-ATP in initiation of chromosome replication

  2018cited by this paper
• The DnaA Cycle in Escherichia coli: Activation, Function and Inactivation of the Initiator Protein

  2017cited by this paper
• Mechanisms for initiating cellular DNA replication

  2017cited by this paper
• From structure to mechanism—understanding initiation of DNA replication

  2017cited by this paper
• The bacterial DnaA-trio replication origin element specifies ssDNA initiator binding

  2016cited by this paper
• The orisome: structure and function

  2015cited by this paper
• Bacterial chromosome organization and segregation.

  2015cited by this paper
• Chromosome Segregation in Budding Yeast: Sister Chromatid Cohesion and Related Mechanisms

  2014cited by this paper
• Archaeal DNA replication.

  2014cited by this paper
• DNA replication origins.

  2013cited by this paper
• Regulating DNA replication in eukarya.

  2013cited by this paper
• Regulating DNA replication in bacteria.

  2013cited by this paper
• The bacterial chromosome: architecture and action of bacterial SMC and SMC-like complexes

  2013cited by this paper
• Escherichia coli sister chromosome separation includes an abrupt global transition with concomitant release of late-splitting intersister snaps

  2011cited by this paper
• Cell biology: A switch for S phase

  2007cited by this paper
• DnaA: controlling the initiation of bacterial DNA replication and more.

  2006cited by this paper
• DNA Replication in the Archaea

  2006cited by this paper
• Mechanisms for chromosome and plasmid segregation.

  2006cited by this paper
• Helical proteins initiate replication of DNA helices

  2006cited by this paper
• The structure and function of the bacterial chromosome.

  2005cited by this paper
• The chromosome cycle: coordinating replication and segregation

  2005cited by this paper
• Origin recognition and the chromosome cycle

  2005cited by this paper
• Regulatory Network of the Initiation of Chromosomal Replication in Escherichia coli

  2005cited by this paper
• Building a bacterial orisome: emergence of new regulatory features for replication origin unwinding

  2004cited by this paper
• From a single double helix to paired double helices and back.

  2004cited by this paper
• Regulation of early events in chromosome replication.

  2004cited by this paper
• Bacterial Chromosome Dynamics

  2003cited by this paper
• Introduction to chromosome dynamics in mitosis

  2003cited by this paper
• An analysis of the factory model for chromosome replication and segregation in bacteria

  2001cited by this paper

• Machine Learning-Based Characterization of Bacillus anthracis Phenotypes from pXO1 Plasmid Proteins

  2025cites this paper
• The contribution of asymmetric cell division to phenotypic heterogeneity in cancer.

  2024cites this paper
• DNA replication is not a limiting factor for rapid growth of Vibrio natriegens

  2023cites this paper
• Chromosome Unipolar Division and Low Expression of Tws May Cause Parthenogenesis of Rice Water Weevil (Lissorhoptrus oryzophilus Kuschel)

  2021cites this paper
• DNA replication and replication termination in Escherichia coli

  2019cites this paper
• Dynamique de la réplication chez l'archée Haloferax volcanii

  2019cites this paper