Regulating DNA replication in eukarya.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Cold Spring Harbor Perspectives in Biology

• Publication date

  2013-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1101/cshperspect.a012930PMID 23838438PMCID PMC3753713
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Correction: Methylation of Histone H3 on Lysine 79 Associates with a Group of Replication Origins and Helps Limit DNA Replication Once per Cell Cycle

  2013cited by this paper
• DNA replication origins.

  2013cited by this paper
• Phosphorylation of ORC2 Protein Dissociates Origin Recognition Complex from Chromatin and Replication Origins*

  2012cited by this paper
• How dormant origins promote complete genome replication.

  2011cited by this paper
• MCM2-7 Form Double Hexamers at Licensed Origins in Xenopus Egg Extract

  2011influential reference
• Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase

  2011cited by this paper
• CDK promotes interactions of Sld3 and Drc1 with Cut5 for initiation of DNA replication in fission yeast

  2011cited by this paper
• Schizosaccharomyces pombe Minichromosome Maintenance-binding Protein (MCM-BP) Antagonizes MCM Helicase*

  2011cited by this paper
• MCM-BP regulates unloading of the MCM2-7 helicase in late S phase.

  2011cited by this paper
• Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication

  2011cited by this paper
• Origin association of Sld3, Sld7, and Cdc45 proteins is a key step for determination of origin-firing timing.

  2011cited by this paper
• CDK prevents Mcm2-7 helicase loading by inhibiting Cdt1 interaction with Orc6.

  2011cited by this paper
• Stalled fork rescue via dormant replication origins in unchallenged S phase promotes proper chromosome segregation and tumor suppression.

  2011cited by this paper
• Commitment to a cellular transition precedes genome-wide transcriptional change.

  2011cited by this paper
• Regulation of DNA replication through Sld3-Dpb11 interaction is conserved from yeast to humans.

  2011cited by this paper
• Different roles of the human Orc6 protein in the replication initiation process

  2011cited by this paper
• Dynamics of Cdk1 Substrate Specificity during the Cell Cycle

  2011cited by this paper
• Quality control in the initiation of eukaryotic DNA replication

  2011cited by this paper
• Sld7, an Sld3‐associated protein required for efficient chromosomal DNA replication in budding yeast

  2011influential reference
• Cdt1 proteolysis is promoted by dual PIP degrons and is modulated by PCNA ubiquitylation

  2011cited by this paper
• Bubble-chip analysis of human origin distributions demonstrates on a genomic scale significant clustering into zones and significant association with transcription.

  2011cited by this paper
• Inter‐origin cooperativity of geminin action establishes an all‐or‐none switch for replication origin licensing

  2011cited by this paper
• The histone H4 Lys 20 methyltransferase PR-Set7 regulates replication origins in mammalian cells

  2010cited by this paper
• Drosophila ORC localizes to open chromatin and marks sites of cohesin complex loading.

  2010cited by this paper
• A vertebrate gene, ticrr, is an essential checkpoint and replication regulator.

  2010cited by this paper
• Loss of DNA Replication Control Is a Potent Inducer of Gene Amplification

  2010cited by this paper
• Treslin collaborates with TopBP1 in triggering the initiation of DNA replication.

  2010cited by this paper
• Homology explains the functional similarities of Treslin/Ticrr and Sld3.

  2010cited by this paper
• Human origin recognition complex is essential for HP1 binding to chromatin and heterochromatin organization

  2010cited by this paper
• Crystal structure of the N-terminal region of human Topoisomerase IIβ binding protein 1.

  2010cited by this paper
• Genomic Study of Replication Initiation in Human Chromosomes Reveals the Influence of Transcription Regulation and Chromatin Structure on Origin Selection

  2010cited by this paper
• Study of DNA replication in Drosophila using cell free in vitro system

  2010cited by this paper
• CDK-dependent complex formation between replication proteins Dpb11, Sld2, Pol (epsilon}, and GINS in budding yeast.

  2010cited by this paper
• HBO1 histone acetylase activity is essential for DNA replication licensing and inhibited by Geminin.

  2010cited by this paper
• Driving the cell cycle with a minimal CDK control network

  2010cited by this paper
• The DNA Unwinding Element Binding Protein DUE-B Interacts with Cdc45 in Preinitiation Complex Formation

  2010cited by this paper
• Chromatin unfolding by Cdt1 regulates MCM loading via opposing functions of HBO1 and HDAC11-geminin

  2010cited by this paper
• Interaction of the Retinoblastoma Protein with Orc1 and Its Recruitment to Human Origins of DNA Replication

  2010cited by this paper
• GEMC1 is a TopBP1 interacting protein required for chromosomal DNA replication

  2010cited by this paper
• Redundant and differential regulation of multiple licensing factors ensures prevention of re-replication in normal human cells

  2009cited by this paper
• Transcription Initiation Activity Sets Replication Origin Efficiency in Mammalian Cells

  2009cited by this paper
• Orc1 Controls Centriole and Centrosome Copy Number in Human Cells

  2009cited by this paper
• Cell cycle, CDKs and cancer: a changing paradigm

  2009cited by this paper
• The human GINS complex associates with Cdc45 and MCM and is essential for DNA replication

  2009cited by this paper
• The Dbf4-Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4

  2009cited by this paper
• Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing

  2009cited by this paper
• Selective killing of cancer cells by suppression of geminin activity.

  2009cited by this paper
• Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells.

  2009cited by this paper
• Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing.

  2009influential reference
• Assembly of the Cdc45-Mcm2–7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins

  2009cited by this paper
• MCM10 mediates RECQ4 association with MCM2‐7 helicase complex during DNA replication

  2009cited by this paper
• Incorporation into the prereplicative complex activates the Mcm2-7 helicase for Cdc7-Dbf4 phosphorylation.

  2009cited by this paper
• A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication

  2009influential reference
• Dividing the workload at a eukaryotic replication fork.

  2008cited by this paper
• HBO1 histone acetylase is a coactivator of the replication licensing factor Cdt1.

  2008cited by this paper
• Involvement of human ORC and TRF2 in pre‐replication complex assembly at telomeres

  2008cited by this paper
• In Xenopus Egg Extracts, DNA Replication Initiates Preferentially at or near Asymmetric AT Sequences

  2008cited by this paper
• Positive feedback of G1 cyclins ensures coherent cell cycle entry

  2008cited by this paper
• Interaction between HMGA1a and the origin recognition complex creates site-specific replication origins

  2008cited by this paper
• Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast

  2007cited by this paper
• Cdt1 degradation to prevent DNA re-replication: conserved and non-conserved pathways

  2007cited by this paper
• Mcm10 and And-1/CTF4 recruit DNA polymerase α to chromatin for initiation of DNA replication

  2007cited by this paper
• The APC/C inhibitor, Emi1, is essential for prevention of rereplication.

  2007cited by this paper
• Emi1 is needed to couple DNA replication with mitosis but does not regulate activation of the mitotic APC/C

  2007cited by this paper
• Nascent transcription of MCM2-7 is important for nuclear localization of the minichromosome maintenance complex in G1.

  2007cited by this paper
• Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication.

  2007cited by this paper
• Role of the Orc6 Protein in Origin Recognition Complex-Dependent DNA Binding and Replication in Drosophila melanogaster

  2007cited by this paper
• Orc6 is required for dynamic recruitment of Cdt1 during repeated Mcm2-7 loading.

  2007cited by this paper
• The DNA damage response: ten years after.

  2007cited by this paper
• Geminin Prevents Rereplication during Xenopus Development*

  2007cited by this paper
• CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast

  2007influential reference
• Genome‐wide localization of pre‐RC sites and identification of replication origins in fission yeast

  2007cited by this paper
• ATP-dependent Assembly of the Human Origin Recognition Complex*♦

  2007cited by this paper
• Isolation of the Cdc45/Mcm2–7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase

  2006cited by this paper
• Two E3 ubiquitin ligases, SCF‐Skp2 and DDB1‐Cul4, target human Cdt1 for proteolysis

  2006cited by this paper
• Ubiquitin ligases: cell-cycle control and cancer

  2006cited by this paper
• Ordered assembly of Sld3, GINS and Cdc45 is distinctly regulated by DDK and CDK for activation of replication origins

  2006cited by this paper
• DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint.

  2006cited by this paper
• The N-Terminal Noncatalytic Region of Xenopus RecQ4 Is Required for Chromatin Binding of DNA Polymerase α in the Initiation of DNA Replication

  2006cited by this paper
• A structural role for ATP in the formation and stability of the human origin recognition complex.

  2006cited by this paper
• DDB1 Maintains Genome Integrity through Regulation of Cdt1

  2006cited by this paper
• An Evolutionarily Conserved Function of Proliferating Cell Nuclear Antigen for Cdt1 Degradation by the Cul4-Ddb1 Ubiquitin Ligase in Response to DNA Damage*

  2006cited by this paper
• Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1.

  2006cited by this paper
• A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1.

  2006cited by this paper
• Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression.

  2006cited by this paper
• DNA damage induces Cdt1 proteolysis in fission yeast through a pathway dependent on Cdt2 and Ddb1

  2006cited by this paper
• The anaphase promoting complex/cyclosome: a machine designed to destroy

  2006cited by this paper
• PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication

  2006cited by this paper
• The functional role of Cdc6 in S–G2/M in mammalian cells

  2006cited by this paper
• Genome-wide mapping of DNA synthesis in Saccharomyces cerevisiae reveals that mechanisms preventing reinitiation of DNA replication are not redundant.

  2006cited by this paper
• PCNA Is a Cofactor for Cdt1 Degradation by CUL4/DDB1-mediated N-terminal Ubiquitination*

  2006cited by this paper
• Identification of New Human Origins of DNA Replication by an Origin-Trapping Assay

  2006cited by this paper
• A role for the anaphase-promoting complex inhibitor Emi2/XErp1, a homolog of early mitotic inhibitor 1, in cytostatic factor arrest of Xenopus eggs.

  2005cited by this paper
• CDK phosphorylation of a novel NLS-NES module distributed between two subunits of the Mcm2-7 complex prevents chromosomal rereplication.

  2005cited by this paper
• Initiation of DNA replication requires the RECQL4 protein mutated in Rothmund-Thomson syndrome.

  2005cited by this paper
• CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis.

  2005cited by this paper
• Human Orc2 localizes to centrosomes, centromeres and heterochromatin during chromosome inheritance

  2005cited by this paper
• p53-Dependent Regulation of Cdc6 Protein Stability Controls Cellular Proliferation

  2005cited by this paper
• Cdt1 downregulation by proteolysis and geminin inhibition prevents DNA re‐replication in Xenopus

  2005cited by this paper
• Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts.

  2005cited by this paper

• Replication Stress in Cancer: Mechanistic Insights and Therapeutic Opportunities for Radiosensitization

  2026cites this paper
• Computational Insights into SIRT1: Elucidating Mutational Impact on SIRT1-RECQL4 Structural Dynamics.

  2026cites this paper
• CDK-mediated phosphorylation of PNKP is required for end-processing of single-strand DNA gaps on Okazaki fragments and genome stability

  2025cites this paper
• Mechanisms for licensing origins of DNA replication in eukaryotic cells

  2025cites this paper
• Molecular impacts of Meier–Gorlin syndrome mutations on human origin licensing

  2025cites this paper
• Antiparasitic agent emodepside exerts cytotoxicity in human corneal stromal cells by blocking the interaction between mini-chromosome maintenance 6 protein (MCM6) and chromatin licensing and DNA replication factor 1 (CDT1).

  2025cites this paper
• Non-disruptive 3D profiling of combinations of epigenetic marks in single cells

  2025cites this paper
• License to Replicate: Mechanisms of Licensing Eukaryotic Origins for DNA Replication

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• G-quadruplex stabilization induces DNA breaks in pericentromeric repetitive DNA sequences in B lymphocytes

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• ResNet-Powered Multi-Class Identification of Sequence Patterns for Genome Replication Timing Analysis.

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• Pesticide avermectin B1a exerts cytotoxicity by blocking the interaction between mini-chromosome maintenance 6 protein (MCM6) and chromatin licensing and DNA replication factor 1 (CDT1).

  2024cites this paper
• Multiple pathways for licensing human replication origins

  2024cites this paper
• TopBP1 utilises a bipartite GINS binding mode to support genome replication

  2024cites this paper
• RNF4 prevents genomic instability caused by chronic DNA under-replication.

  2024cites this paper
• Reconstitution of human DNA licensing and the structural and functional analysis of key intermediates

  2024cites this paper
• USP37 prevents premature disassembly of stressed replisomes by TRAIP

  2024cites this paper
• Pioneer factors for DNA replication initiation in metazoans

  2024cites this paper
• Transcriptome Analysis of the Takifugu rubripes Swimbladder under Chronic Hypoxic Stress

  2023cites this paper
• Regulation of replication origin licensing by ORC phosphorylation reveals a two-step mechanism for Mcm2–7 ring closing

  2023cites this paper
• REPercussions: how geminiviruses recruit host factors for replication

  2023cites this paper
• Chromatin-based DNA replication initiation regulation in eukaryotes

  2023cites this paper
• Regulation of replication origin licensing by ORC phosphorylation reveals a two-step mechanism for Mcm2-7 ring closing

  2023cites this paper
• Characterization of the Interaction Between SARS-CoV-2 Membrane Protein (M) and Proliferating Cell Nuclear Antigen (PCNA) as a Potential Therapeutic Target

  2022cites this paper
• The Role of MTBP as a Replication Origin Firing Factor

  2022cites this paper
• Small Molecule Inhibitor Targeting CDT1/Geminin Protein Complex Promotes DNA Damage and Cell Death in Cancer Cells

  2022cites this paper
• Pyruvate kinase, a metabolic sensor powering glycolysis, drives the metabolic control of DNA replication

  2022cites this paper
• A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6

  2022cites this paper
• An autonomous mathematical model for the mammalian cell cycle

  2022cites this paper
• ZYP1-mediated recruitment of PCH2 to the synaptonemal complex remodels the chromosome axis leading to crossover restriction

  2022cites this paper
• RTEL1 and MCM10 overcome topological stress during vertebrate replication termination

  2022cites this paper
• Mobile origin-licensing factors confer resistance to conflicts with RNA polymerase

  2022cites this paper
• The consequences of differential origin licensing dynamics in distinct chromatin environments

  2022cites this paper
• Genetic instability from a single S phase after whole-genome duplication

  2022cites this paper
• Bipartite recruitment of PCH2 and COMET to the synaptonemal complex drives chromosome axis reconstruction leading to crossover restriction

  2022cites this paper
• A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6

  2022cites this paper
• Rad51-mediated replication of damaged templates relies on monoSUMOylated DDK kinase

  2022cites this paper
• Unscheduled DNA replication in G1 causes genome instability and damage signatures indicative of replication collisions

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• Measuring S-Phase Duration from Asynchronous Cells Using Dual EdU-BrdU Pulse-Chase Labeling Flow Cytometry

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• A PCNA-K164R mutation impinges on origin activation and mitotic DNA synthesis

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• CDT1 is the major functional regulatory subunit of the pre‐replication complex in zygotes

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• Dephosphorylation of the pre-initiation complex is critical for origin firing.

  2022cites this paper
• Rif1-Dependent Control of Replication Timing

  2022cites this paper
• Roles of phosphatases in eukaryotic DNA replication initiation control.

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• Rad51-mediated replication of damaged templates relies on monoSUMOylated DDK kinase

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• Replication timing analysis in polyploid cells reveals Rif1 uses multiple mechanisms to promote underreplication in Drosophila

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• Neural network and kinetic modelling of human genome replication reveal replication origin locations and strengths

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• Single-Molecule Dynamics at a Bacterial Replication Fork after Nutritional Downshift or Chemically Induced Block in Replication

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• The Contribution of Lysosomes to DNA Replication

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• Nucleosome-directed replication origin licensing independent of a consensus DNA sequence

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• Unscheduled DNA replication in G1 causes genome instability through head-to-tail replication fork collisions

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• The replicative CMG helicase: the ideal target for cancer therapy

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• Unscheduled origin building in S-phase upon tight CDK1 inhibition suppresses CFS instability

  2020cites this paper
• Staying true to yourself: mechanisms of DNA methylation maintenance in mammals

  2020cites this paper
• G-quadruplex binding protein Rif1, a key regulator of replication timing.

  2020cites this paper
• Topologically associating domain boundaries are enriched in early firing origins and restrict replication fork progression

  2020cites this paper
• TRF2 Mediates Replication Initiation within Human Telomeres to Prevent Telomere Dysfunction

  2020cites this paper
• Binding of the Treslin-MTBP Complex to Specific Regions of the Human Genome Promotes the Initiation of DNA Replication

  2020cites this paper
• Checkpoint inhibition of origin firing prevents inappropriate replication outside of S-phase

  2020cites this paper
• Spotlight on the Replisome: Aetiology of DNA Replication-Associated Genetic Diseases.

  2020cites this paper
• Bioinformatical dissection of fission yeast DNA replication origins

  2020cites this paper
• PCNA-K164 ubiquitination facilitates origin licensing and mitotic DNA synthesis

  2020cites this paper
• Limiting homologous recombination at stalled replication forks is essential for cell viability: DNA2 to the rescue

  2020cites this paper
• Replication origin location might contribute to genetic variability in Trypanosoma cruzi

  2020cites this paper
• In silico analysis of DNA re-replication across a complete genome reveals cell-to-cell heterogeneity and genome plasticity

  2020cites this paper
• Chromatin replication and epigenetic cell memory

  2020cites this paper
• The evolutionary plasticity of chromosome metabolism allows adaptation to constitutive DNA replication stress

  2020cites this paper
• Inhibition of transcription leads to rewiring of locus-specific chromatin proteomes

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• Sonic hedgehog accelerates DNA replication to cause replication stress promoting cancer initiation in medulloblastoma

  2020cites this paper
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  2019cites this paper
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• On the Interplay of the DNA Replication Program and the Intra-S Phase Checkpoint Pathway

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