Chk2 Is a Tumor Suppressor That Regulates Apoptosis in both an Ataxia Telangiectasia Mutated (ATM)-Dependent and an ATM-Independent Manner

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Molecular and Cellular Biology

• Publication date

  2002-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.22.18.6521-6532.2002PMID 12192050PMCID PMC135625
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• DNA damage-induced activation of p53 by the checkpoint kinase Chk2.

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• A role for ATR in the DNA damage-induced phosphorylation of p53.

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• Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

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• Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage.

  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
• Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks.

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• Regulation of p53 downstream genes.

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• The complexity of p53 modulation: emerging patterns from divergent signals.

  1998cited by this paper
• Overexpression of a kinase‐inactive ATR protein causes sensitivity to DNA‐damaging agents and defects in cell cycle checkpoints

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• Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathways

  1998influential reference
• Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system.

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  1998cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
• Atm-deficient mice: a paradigm of ataxia telangiectasia.

  1996cited by this paper
• Pleiotropic defects in ataxia-telangiectasia protein-deficient mice.

  1996cited by this paper
• Cell Cycle Checkpoints: Preventing an Identity Crisis

  1996cited by this paper
• Ataxia-telangiectasia and cellular responses to DNA damage.

  1995cited by this paper
• Ataxia-Telangiectasia: Closer to Unraveling the Mystery

  1995cited by this paper
• Oncogene involvement in tumor regression: H-ras activation in the rabbit keratoacanthoma model.

  1991cited by this paper
• Genetic complementation analysis of ataxia telangiectasia and Nijmegen breakage syndrome: a survey of 50 patients.

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