Stopped at the border: boundaries and insulators.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Current Opinion in Genetics and Development

• Publication date

  1999-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0959-437X(99)80029-XPMID 10322134
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Featured Organism: Drosophila melanogaster

  2000cited by this paper
• Polycomb group repression is blocked by the Drosophila suppressor of Hairy-wing [su(Hw)] insulator.

  1998cited by this paper
• Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

  1998cited by this paper
• GAGA mediates the enhancer blocking activity of the eve promoter in the Drosophila embryo.

  1998cited by this paper
• A Nuclear Matrix/Scaffold Attachment Region Co-localizes with the Gypsy Retrotransposon Insulator Sequence*

  1998cited by this paper
• Genetic treatment of severe hemoglobinopathies: the combat against transgene variegation and transgene silencing.

  1998cited by this paper
• Human Matrix Attachment Regions Insulate Transgene Expression from Chromosomal Position Effects in Drosophila melanogaster

  1998cited by this paper
• Chromatin domain boundaries in the Bithorax complex

  1998cited by this paper
• Polycomb and trithorax group proteins mediate the function of a chromatin insulator.

  1998cited by this paper
• Identification of a Class of Chromatin Boundary Elements

  1998cited by this paper
• Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

  1998cited by this paper
• The scs and scs' insulator elements impart a cis requirement on enhancer-promoter interactions.

  1998cited by this paper
• Loss of transcriptional activity of a transgene is accompanied by DNA methylation and histone deacetylation and is prevented by insulators.

  1998cited by this paper
• Two modes of transvection: enhancer action in trans and bypass of a chromatin insulator in cis.

  1998cited by this paper
• The mouse H19 locus mediates a transition between imprinted and non-imprinted DNA replication patterns.

  1998cited by this paper
• Enhancer blocking activity located near the 3' end of the sea urchin early H2A histone gene.

  1997cited by this paper
• The repeat organizer, a specialized insulator element within the intergenic spacer of the Xenopus rRNA genes

  1997cited by this paper
• The scs' boundary element: characterization of boundary element-associated factors

  1997cited by this paper
• The gypsy insulator can function as a promoter‐specific silencer in the Drosophila embryo

  1997cited by this paper
• Co‐localization of Polycomb protein and GAGA factor on regulatory elements responsible for the maintenance of homeotic gene expression

  1997cited by this paper
• In situ dissection of the Fab-7 region of the bithorax complex into a chromatin domain boundary and a Polycomb-response element.

  1997cited by this paper
• Ligand-inducible and liver-specific target gene expression in transgenic mice

  1997cited by this paper
• Characterization of the chicken beta-globin insulator.

  1997cited by this paper
• Chip, a widely expressed chromosomal protein required for segmentation and activity of a remote wing margin enhancer in Drosophila.

  1997cited by this paper
• An enhancer-blocking element between alpha and delta gene segments within the human T cell receptor alpha/delta locus.

  1997cited by this paper
• The activity of the scs and scs' insulator elements is not dependent on chromosomal context

  1997cited by this paper
• A transcriptional insulator element, the su(Hw) binding site, protects a chromosomal DNA replication origin from position effects

  1997cited by this paper
• Stem cell gene therapy, position effects and chromatin insulators

  1997cited by this paper
• An enhancer-blocking element between α and δ gene segments within the human T cell receptor α/δ locus

  1997cited by this paper
• Genes regulating the remote wing margin enhancer in the Drosophila cut locus.

  1996cited by this paper
• The Fab-7 element of the bithorax complex attenuates enhancer-promoter interactions in the Drosophila embryo.

  1996cited by this paper
• Fab-7 functions as a chromatin domain boundary to ensure proper segment specification by the Drosophila bithorax complex.

  1996cited by this paper
• Disruption of imprinting caused by deletion of the H19 gene region in mice

  1995cited by this paper
• Action at a distance: DNA-looping and initiation of transcription.

  1995cited by this paper
• A Drosophila protein that imparts directionality on a chromatin insulator is an enhancer of position-effect variegation.

  1995cited by this paper
• Effects of the su(Hw) insulator protein on the expression of the divergently transcribed Drosophila yolk protein genes.

  1995cited by this paper
• Modulation of enhancer-promoter interactions by insulators in the Drosophila embryo.

  1995cited by this paper
• Modulation of enhancerá¤-promoter interactions by insulators in the Drosophilaembryo

  1995cited by this paper
• Visualization of chromosomal domains with boundary element-associated factor BEAF-32.

  1995cited by this paper
• Core histone hyperacetylation co‐maps with generalized DNase I sensitivity in the chicken beta‐globin chromosomal domain.

  1994cited by this paper
• Replication fork barriers in the Xenopus rDNA.

  1994cited by this paper
• Hypersensitive site 5 of the human beta locus control region functions as a chromatin insulator.

  1994cited by this paper
• Hypersensitive site 5 of the human beta locus control region functions as a chromatin insulator

  1994cited by this paper
• Mcp and Fab-7: molecular analysis of putative boundaries of cis-regulatory domains in the bithorax complex of Drosophila melanogaster.

  1994cited by this paper
• The su(Hw) protein insulates expression of the Drosophila melanogaster white gene from chromosomal position‐effects.

  1993cited by this paper
• A 5′ element of the chicken β-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila

  1993cited by this paper
• A group of scs elements function as domain boundaries in an enhancer-blocking assay

  1992cited by this paper
• DNA position-specific repression of transcription by a Drosophila zinc finger protein.

  1992cited by this paper
• A position-effect assay for boundaries of higher order chromosomal domains.

  1991cited by this paper
• Repression of hsp70 heat shock gene transcription by the suppressor of hairy-wing protein of Drosophila melanogaster

  1991cited by this paper
• Developmental regulation of topoisomerase II sites and DNase I-hypersensitive sites in the chicken beta-globin locus.

  1990cited by this paper
• Transactivation of the Xenopus rRNA gene promoter by its enhancer

  1989cited by this paper
• The 87A7 chromomere. Identification of novel chromatin structures flanking the heat shock locus that may define the boundaries of higher order domains.

  1985cited by this paper

• Set1/COMPASS repels heterochromatin invasion at euchromatic sites by disrupting Suv39/Clr4 activity and nucleosome stability

  2019cites this paper
• Three‐dimensional genome architecture in health and disease

  2019cites this paper
• Visualization of Chromatin Decompaction and Break Site Extrusion as Predicted by Statistical Polymer Modeling of Single-Locus Trajectories.

  2017cites this paper
• Chromatin dynamics in DNA double-strand break repair

  2016cites this paper
• The role of MAR elements in DNA recombination

  2015cites this paper
• Characterization and RNA-seq analysis of underperformer, an activation-tagged potato mutant

  2014cites this paper
• Chapter 2 – Transcription, Translation, and Regulation of Eukaryotic DNA

  2013cites this paper
• Site‐directed zebrafish transgenesis into single landing sites with the phiC31 integrase system

  2013cites this paper
• Understanding the contribution of individual zinc fingers to a multi-functional, polydactyl transcription factor

  2013cites this paper
• necessary for consistent, high-level megakaryocyte expression IIb gene locus α Identification of distal regulatory regions in the human

  2013cites this paper
• Retina-specific gene excision by targeted expression of Cre recombinase.

  2013cites this paper
• Identification and characterization of an A-kinase anchoring domain in Chromodomain Helicase Binding Protein 8

  2012cites this paper
• Modulation of AUXIN-BINDING PROTEIN 1 gene expression in maize and the teosintes by transposon insertions in its promoter

  2012cites this paper
• Germline transformation of the diamondback moth, Plutella xylostella L., using the piggyBac transposable element

  2012cites this paper
• Therapeutic Hemoglobin Levels after Gene Transfer in β-Thalassemia Mice and in Hematopoietic Cells of β-Thalassemia and Sickle Cells Disease Patients

  2012cites this paper
• Nuclear envelope attachment sites of interphase chromosomes: Barrier elements but not insulators

  2012cites this paper
• Insulators in vertebrates: regulatory mechanisms and chromatin structure

  2012cites this paper
• Fidelity of a BAC-EGFP transgene in reporting dynamic expression of IL-7Rα in T cells

  2012cites this paper
• Identifing Insulators in Arabidopsis thaliana

  2012cites this paper
• Keeping the genome in shape : a role for protein and RNA

  2011cites this paper
• Human tRNA genes function as chromatin insulators

  2011cites this paper
• Designing Transgenes for Optimal Expression

  2011cites this paper
• High-level transgene expression by homologous recombination-mediated gene transfer

  2011cites this paper
• FLUCTUATION OF ESTROGEN RECEPTOR TRANSCRIPTIONAL ACTIVITY IN PHYSIOLOGICAL CONDITIONS: FUNCTIONAL CONSEQUENCES

  2010cites this paper
• UNIVERSITÀ DEGLI STUDI DI MILANO Facoltà di Farmacia

  2010cites this paper
• Production of retroviral vectors: review.

  2010cites this paper
• A functional analysis of the epigenetic regulator CTCF

  2010cites this paper
• Procédé pour améliorer le profile de glycosylation d'un anticorps

  2010cites this paper
• Usefulness of a non-invasive reporter system for monitoring reprogramming state in pig cells: results of a cell fusion experiment.

  2010cites this paper
• Valproic Acid Enhances In Vitro Development and Oct-3/4 Expression of Miniature Pig Somatic Cell Nuclear Transfer Embryos

  2010influential citation
• The sea urchin sns5 insulator protects retroviral vectors from chromosomal position effects by maintaining active chromatin structure.

  2009cites this paper
• Genetic analysis of P-TEFb function via heterologous nucleic acid tethering systems.

  2009cites this paper
• Defeating Randomness – Targeted Integration as a Boost for Biotechnology

  2009cites this paper
• Development of a noninvasive monitoring system for evaluation of Oct-3/4 promoter status in miniature pig somatic cell nuclear transfer embryos.

  2009cites this paper
• Transcriptional regulators of seven yeast species: Comparative genome analysis — Review

  2008cites this paper
• Boundaries. Boundaries...Boundaries???

  2008cites this paper
• Short hairpin RNA targeted to dihydrofolate reductase enhances the immunoglobulin G expression in gene-amplified stable Chinese hamster ovary cells.

  2008cites this paper
• Efficient Selection of Stable Chinese Hamster Ovary (CHO) Cell Lines for Expression of Recombinant Proteins by Using Human Interferon β SAR Element

  2008cites this paper
• Harnessing the Heat Shock Response to Raise Refined Therapeutic Outcomes

  2008cites this paper
• A simple analysis system for the estimation of recombination efficiency using fluorescence-activated cell sorting.

  2007cites this paper
• Isolation of 151 mutants that have developmental defects from T-DNA tagging.

  2007cites this paper
• In vivo imaging of farnesoid X receptor activity reveals the ileum as the primary bile acid signaling tissue.

  2007cites this paper
• Structural organization of dynamic chromatin.

  2007cites this paper
• Analysis of the H19ICR Insulator (cid:1)

  2007cites this paper
• A novel RNA silencing vector to improve antigen expression and stability in Chinese hamster ovary cells.

  2007cites this paper
• Molekularbiologische Analysen zur Regulation des T-Zell-Rezeptor-β-Lokus

  2007cites this paper
• Analysis of the H19ICR Insulator

  2007cites this paper
• We gather together: insulators and genome organization.

  2007cites this paper
• Analysis of genetic variants in the 5’ regulatory region of the ALAS1 gene in South African patients with Variegate Porphyria (VP)

  2007cites this paper
• Regulation of the mouse alphaB-crystallin and MKBP/HspB2 promoter activities by shared and gene specific intergenic elements: the importance of context dependency.

  2007cites this paper
• Distal control of the pig whey acidic protein (WAP) locus in transgenic mice.

  2007cites this paper
• Molecular characterization of a fusarium graminearum lipase gene and its promoter

  2007cites this paper
• Testing transgenic regulatory elements through live mouse imaging

  2007cites this paper
• Analysis of the H 19 ICR Insulator

  2007cites this paper
• Flanking HS-62.5 and 3 (cid:1) HS1, and regions upstream of the LCR, are not required for (cid:2) -globin transcription

  2006cites this paper
• Isolation of 151 Mutants That Have Developmental Defects from T-dna Tagging

  2006cites this paper
• Flanking HS-62.5 and 3' HS1, and regions upstream of the LCR, are not required for beta-globin transcription.

  2006cites this paper
• Flanking HS-62.5 and 3’HS1, and regions upstream of the LCR are not required for β-globin transcription. Running title: Deletion of HS-62 & 3’HS1 from the β-globin locus Scientific section heading: red cells

  2006cites this paper
• Functional analysis of the sea urchin‐derived arylsulfatase (Ars)‐element in mammalian cells

  2006cites this paper
• BASES MOLECULAIRES DE LA VARIEGATION D'EFFET DE POSITION CHEZ DROSOPHILA MELANOGASTER

  2006cites this paper
• Insulators of higher eukaryotes: Properties, mechanisms of action, and role in transcriptional regulation

  2006cites this paper
• Identification, genome mapping, and CTCF binding of potential insulators within the FXYD5-COX7A1 locus of human Chromosome 19q13.12

  2006cites this paper
• Studying and manipulating chromatin motion in mammalian cells

  2006cites this paper
• Running title : Isolation of mutants having developmental defects Co-corresponding authors:

  2006cites this paper
• Use of the chicken lysozyme 5' matrix attachment region to generate high producer CHO cell lines.

  2005cites this paper
• Cholesterogenic lanosterol 14alpha-demethylase (CYP51) is an immediate early response gene.

  2005cites this paper
• Cholesterogenic Lanosterol 14 (cid:1) -Demethylase ( CYP51 ) Is an Immediate Early Response Gene

  2005influential citation
• Transcriptional interference mediated by retrotransposons within the genome of their host: lessons from alleles of the white gene from Drosophila melanogaster

  2005cites this paper
• Insulators are fundamental components of the eukaryotic genomes

  2005influential citation
• Functional characterization of the sea urchin sns chromatin insulator in erythroid cells.

  2005cites this paper
• LeuO Protein Delimits the Transcriptionally Active and Repressive Domains on the Bacterial Chromosome*

  2005cites this paper
• Developmental Regulation of the β-Globin Gene Locus

  2005cites this paper
• Versatility of gene therapy vectors through viruses

  2005cites this paper
• Developmental regulation of the beta-globin gene locus.

  2005cites this paper
• A novel gene expression system: non-viral gene transfer for hemophilia as model systems.

  2005cites this paper
• Transgenic Xenopus laevis embryos can be generated using φC31 integrase

  2005cites this paper
• ACCELERATED PUBLICATION Use of the Chicken Lysozyme 5 0 Matrix Attachment Region to Generate High Producer CHO Cell Lines

  2005cites this paper
• CHOLESTEROGENIC LANOSTEROL 14 α-DEMETHYLASE ( CYP 51 ) IS AN IMMEDIATE EARLY RESPONSE GENE Running title : Immediate early response of CYP 51 to cAMP stimuli

  2005cites this paper
• Structure and Functions of Nuclear Matrix Associated Regions (S/MARs)

  2004cites this paper
• cis-Regulatory activity of randomly chosen genomic fragments from the sea urchin.

  2004cites this paper
• Bystander gene activation by a locus control region

  2004cites this paper
• Symmetry applied to nuclear microanatomy: a review of gene function and cell differentiation.

  2004cites this paper
• Potent stimulation of gene expression by histone deacetylase inhibitors on transiently transfected DNA.

  2004cites this paper
• Hair keratin associated proteins: characterization of a second high sulfur KAP gene domain on human chromosome 21.

  2004cites this paper
• The chromosomes of Drosophila melanogaster.

  2004cites this paper
• Progress towards the development of a transgenic strain of the Australian sheep blowfly (Lucilia cuprina) suitable for a male-only sterile release program.

  2004cites this paper
• The glioma-amplified sequence 41 gene (GAS41) is a direct Myb target gene.

  2004cites this paper
• Transgenic animal bioreactors

  2004cites this paper
• Cell Memory and Cancer – The Story of the Trithorax and Polycomb Group Genes

  2004cites this paper
• Down-regulation of early sea urchin histone H2A gene relies on cis regulative sequences located in the 5' and 3' regions and including the enhancer blocker sns.

  2004cites this paper
• Homogeneity and long-term stability of tetracycline-regulated gene expression with low basal activity by using the rtTA2S-M2 transactivator and insulator-flanked reporter vectors.

  2004cites this paper
• Comparative sequence and x-inactivation analyses of a domain of escape in human xp11.2 and the conserved segment in mouse.

  2004cites this paper
• The Functional Significance and Chromatin Organisation of the Imprinting Control Regions of the H19 and Kcnq1 Genes

  2004cites this paper
• The Promoter Targeting Sequence mediates epigenetically heritable transcription memory.

  2004cites this paper
• Partition of distinct chromosomal regions: negotiable border and fixed border

  2004cites this paper
• Genomic imprinting: CTCF protects the boundaries.

  2004cites this paper
• Flp-mediated integration of expression cassettes into FRT-tagged chromosomal loci in mammalian cells.

  2004cites this paper
• The many roles of the transcriptional regulator CTCF.

  2003cites this paper
• Replicating Adenoviral Vectors for Cancer Therapy

  2003cites this paper
• Putative FLJ20436 gene characterisation in goat. Observed ubiquitous expression in goat and transgenic mice allowed to restrict the location of an hypothesised insulator element.

  2003cites this paper