Increased apoptotic peripheral blood neutrophils in systemic lupus erythematosus: relations with disease activity, antibodies to double stranded DNA, and neutropenia

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Annals of the Rheumatic Diseases

• Publication date

  1999-05-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1136/ard.58.5.309PMID 10225817PMCID PMC1752888
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2000cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
• A novel assay to measure loss of plasma membrane asymmetry during apoptosis of adherent cells in culture.

  1996cited by this paper
• Monocyte apoptosis in patients with active lupus.

  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1995cited by this paper
• Glucocorticoid treatment inhibits apoptosis in human neutrophils. Separation of survival and activation outcomes.

  1995cited by this paper
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  1995cited by this paper
• Glucocorticoids inhibit apoptosis of human neutrophils.

  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
• Accelerated in vitro apoptosis of lymphocytes from patients with systemic lupus erythematosus.

  1994cited by this paper
• The apoptosis-1/Fas protein in human systemic lupus erythematosus.

  1994cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1994cited by this paper
• Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule.

  1994cited by this paper
• Haematological manifestations of systemic lupus erythematosus.

  1993influential reference
• Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

  1992cited by this paper
• Prolongation of survival of human polymorphonuclear neutrophils by granulocyte-macrophage colony-stimulating factor is caused by inhibition of programmed cell death.

  1992cited by this paper
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  1992cited by this paper
• The spontaneous apoptotic cell death of normal human lymphocytes in vitro: the release of, and immunoproliferative response to, nucleosomes in vitro.

  1991cited by this paper
• Increased serum levels of granulocyte colony-stimulating factor in patients with severe congenital neutropenia.

  1991cited by this paper
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  1989cited by this paper
• A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor

  1989cited by this paper
• Bone marrow findings in connective tissue disease.

  1989cited by this paper
• Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages.

  1989cited by this paper
• Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.

  1984cited by this paper
• THE OCCURRENCE AND SIGNIFICANCE OF NEUTROPHIL ANTIBODIES

  1984cited by this paper
• The 1982 revised criteria for the classification of systemic lupus erythematosus.

  1982cited by this paper
• Single-step separation of red blood cells. Granulocytes and mononuclear leukocytes on discontinuous density gradients of Ficoll-Hypaque.

  1974cited by this paper
• Apoptosis: A Basic Biological Phenomenon with Wide-ranging Implications in Tissue Kinetics

  1972cited by this paper

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  2024cites this paper
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  2024cites this paper
• The role of neutrophils in autoimmune diseases.

  2024cites this paper
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  2022cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
• Cell death in the pathogenesis of systemic lupus erythematosus and lupus nephritis.

  2017cites this paper
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• Human neutrophils in auto-immunity.

  2016cites this paper
• Clearance Deficiency and Cell Death Pathways: A Model for the Pathogenesis of SLE

  2016cites this paper
• Impaired phagocytosis of apoptotic cell material in serologically active clinically quiescent patients with systemic lupus erythematosis

  2016cites this paper
• The role of autophagy in the pathogenesis of systemic lupus erythematosus.

  2016cites this paper
• Elucidation of the potential disease-promoting influence of IgM apoptotic cell-reactive antibodies in lupus

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• Involvement of high mobility group box 1 in the auto-inflammatory process in systemic lupus erythematosus

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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
• Diagnostic criteria for autoimmune neutropenia.

  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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