Recent advances in molecular biology and physiology of the prostaglandin E2-biosynthetic pathway.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Progress in lipid research

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/S0163-7827(03)00037-7PMID 14636669
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Arachidonate release and prostaglandin production by group IVC phospholipase A2 (cytosolic phospholipase A2gamma).

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• Potential Role of Microsomal Prostaglandin E Synthase-1 in Tumorigenesis*

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• Cellular Arachidonate-releasing Function of Novel Classes of Secretory Phospholipase A2s (Groups III and XII)*

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• Regulation of cytosolic prostaglandin E2 synthase by 90-kDa heat shock protein.

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• Human Group IVC Phospholipase A2(cPLA2γ)

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• Arachidonate release and eicosanoid generation by group IIE phospholipase A(2).

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• Cyclooxygenase isozymes and their gene structures and expression.

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• Distinct functions of COX-1 and COX-2.

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• Cyclo‐Oxygenase 2 Function Is Essential for Bone Fracture Healing

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• Differential Expression of Microsomal Prostaglandin E Synthase at Implantation Sites and in Decidual Cells of Mouse Uterus1

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• Cyclooxygenase-2 Differentially Directs Uterine Angiogenesis during Implantation in Mice*

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• Susceptibility of cyclooxygenase-2-deficient mice to pulmonary fibrogenesis.

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• Protection against diet-induced obesity and obesity- related insulin resistance in Group 1B PLA2-deficient mice.

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• Phospholipase A2 enzymes.

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• Cytosolic phospholipase A2 in hypoxic pulmonary vasoconstriction

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• Phospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis

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• Transcriptional Regulation of the Membrane-associated Prostaglandin E2 Synthase Gene

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• Cytosolic phospholipase A(2) in hypoxic pulmonary vasoconstriction.

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• Function of prostanoid receptors: studies on knockout mice.

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• Lipopolysaccharide-Dependent Prostaglandin E2 Production Is Regulated by the Glutathione-Dependent Prostaglandin E2 Synthase Gene Induced by the Toll-Like Receptor 4/MyD88/NF-IL6 Pathway1

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• Prostaglandin E synthase.

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• The structures of prostaglandin endoperoxide H synthases-1 and -2.

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• Discrete role for cytosolic phospholipase A(2)alpha in platelets: studies using single and double mutant mice of cytosolic and group IIA secretory phospholipase A(2).

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• Autocrine/Paracrine Prostaglandin E2 Production by Non-small Cell Lung Cancer Cells Regulates Matrix Metalloproteinase-2 and CD44 in Cyclooxygenase-2-dependent Invasion*

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• Discrete Role for Cytosolic Phospholipase A2α in Platelets

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• Cytosolic phospholipase A2alpha is crucial [correction of A2alpha deficiency is crucial] for 'on-time' embryo implantation that directs subsequent development.

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• Cellular Arachidonate-releasing Function and Inflammation-associated Expression of Group IIF Secretory Phospholipase A2 *

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• Augmentation of allergic inflammation in prostanoid IP receptor deficient mice

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• Potent Modification of Low Density Lipoprotein by Group X Secretory Phospholipase A2 Is Linked to Macrophage Foam Cell Formation*

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• Roles of Catalytic Domain Residues in Interfacial Binding and Activation of Group IV Cytosolic Phospholipase A2 *

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• The Assembly and Intermolecular Properties of the hsp70-Hop-hsp90 Molecular Chaperone Complex*

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• Enzymatic Properties of Human Cytosolic Phospholipase A2γ*

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• Cytosolic phospholipase A2α deficiency is crucial for 'on-time' embryo implantation that directs subsequent development

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• A pivotal role of cytosolic phospholipase A2 in bleomycin-induced pulmonary fibrosis

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• Bactericidal Properties of Human and Murine Groups I, II, V, X, and XII Secreted Phospholipases A2 *

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• Immunohistochemical localization of microsomal PGE synthase-1 and cyclooxygenases in male mouse reproductive organs.

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• Platelet-activating factor acetylhydrolase.

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• Identification and characterization of a novel type of membrane-associated prostaglandin E synthase.

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• Enzymatic properties of human cytosolic phospholipase A(2)gamma.

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• Distinct Arachidonate-releasing Functions of Mammalian Secreted Phospholipase A2s in Human Embryonic Kidney 293 and Rat Mastocytoma RBL-2H3 Cells through Heparan Sulfate Shuttling and External Plasma Membrane Mechanisms*

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• Inducible microsomal prostaglandin E synthase is overexpressed in colorectal adenomas and cancer.

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• PLIP, a Novel Splice Variant of Tip60, Interacts with Group IV Cytosolic Phospholipase A2, Induces Apoptosis, and Potentiates Prostaglandin Production

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• Role of the Cytosolic Phospholipase A2-linked Cascade in Signaling by an Oncogenic, Constitutively Active Ha-Ras Isoform*

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• Induction of Cytosolic Phospholipase A2 by Oncogenic Ras Is Mediated through the JNK and ERK Pathways in Rat Epithelial Cells*

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• Functional Interaction of Calcium-/Calmodulin-dependent Protein Kinase II and Cytosolic Phospholipase A2 *

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• Diversity and regulatory functions of mammalian secretory phospholipase A2s.

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• Failure of ductus arteriosus closure and remodeling in neonatal mice deficient in cyclooxygenase-1 and cyclooxygenase-2.

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• Deletion of cytosolic phospholipase A2 suppresses ApcMin-induced tumorigenesis

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• Inducible prostaglandin E synthase is overexpressed in non-small cell lung cancer.

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• Renal concentrating defect in mice lacking group IV cytosolic phospholipase A(2).

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• Molecular cloning and induction of bovine prostaglandin E synthase by gonadotropins in ovarian follicles prior to ovulation in vivo.

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• Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells.

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• A Novel Group of Phospholipase A2s Preferentially Expressed in Type 2 Helper T Cells*

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• Genetic deletion of COX-2 prevents increased renin expression in response to ACE inhibition.

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• Urogenital distribution of a mouse membrane-associated prostaglandin E(2) synthase.

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• Molecular Cloning and Induction of Bovine Prostaglandin E Synthase by Gonadotropins in Ovarian Follicles Prior to Ovulationin Vivo *

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• Overexpression of Cyclooxygenase-2 Is Sufficient to Induce Tumorigenesis in Transgenic Mice*

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• Acceleration of intestinal polyposis through prostaglandin receptor EP2 in ApcΔ716 knockout mice

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• Why there are two cyclooxygenase isozymes.

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• Coupling between Cyclooxygenase, Terminal Prostanoid Synthase, and Phospholipase A2 *

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• Microsomal Prostaglandin E Synthase Is Regulated by Proinflammatory Cytokines and Glucocorticoids in Primary Rheumatoid Synovial Cells1

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• Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice.

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• Characterization of EP receptor subtypes responsible for prostaglandin E2‐induced pain responses by use of EP1 and EP3 receptor knockout mice

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• Cloning, Expression, and Up-regulation of Inducible Rat Prostaglandin E Synthase during Lipopolysaccharide-induced Pyresis and Adjuvant-induced Arthritis*

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• Intracellular Calcium Signals Regulating Cytosolic Phospholipase A2 Translocation to Internal Membranes* 210

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• Compensatory phospholipid digestion is required for cholesterol absorption in pancreatic phospholipase A(2)-deficient mice.

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• Redundancy in the Signaling Pathways and Promoter Elements Regulating Cyclooxygenase-2 Gene Expression in Endotoxin-treated Macrophage/Monocytic Cells*

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• Prostaglandin E2 Increases Growth and Motility of Colorectal Carcinoma Cells*

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• Crystal Structure and Activity of Human p23, a Heat Shock Protein 90 Co-chaperone*

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• Human glutathione dependent prostaglandin E synthase: gene structure and regulation

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• Prostaglandin D2 as a mediator of allergic asthma.

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• Cloning and Recombinant Expression of a Structurally Novel Human Secreted Phospholipase A2 *

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• mRNA and Protein Stability Regulate the Differential Expression of Pro- and Anti-inflammatory Genes in Endotoxin-tolerant THP-1 Cells*

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• Mouse group X secretory phospholipase A2 induces a potent release of arachidonic acid from spleen cells and acts as a ligand for the phospholipase A2 receptor.

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• Structures, Enzymatic Properties, and Expression of Novel Human and Mouse Secretory Phospholipase A2s*

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• Distinct Roles of Two Intracellular Phospholipase A2s in Fatty Acid Release in the Cell Death Pathway

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• The genetic ablation of cyclooxygenase 2 prevents the development of autoimmune arthritis.

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• Identification of Mu-Class Glutathione Transferases M2-2 and M3-3 as Cytosolic Prostaglandin E Synthases in the Human Brain

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• Identification of a Cellular Protein That Functionally Interacts with the C2 Domain of Cytosolic Phospholipase A2α*

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• Regulation of Prostaglandin E2 Biosynthesis by Inducible Membrane-associated Prostaglandin E2 Synthase That Acts in Concert with Cyclooxygenase-2*

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• The Genomic Organization, Complete mRNA Sequence, Cloning, and Expression of a Novel Human Intracellular Membrane-associated Calcium-independent Phospholipase A2 *

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• Crucial Involvement of the EP4 Subtype of Prostaglandin E Receptor in Osteoclast Formation by Proinflammatory Cytokines and Lipopolysaccharide

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• Impaired Bone Resorption to Prostaglandin E2 in Prostaglandin E Receptor EP4-knockout Mice*

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• Renin expression in COX-2-knockout mice on normal or low-salt diets.

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• NSAID-induced gastric damage in rats: requirement for inhibition of both cyclooxygenase 1 and 2.

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• Cellular Regulation of Cytosolic Group IV Phospholipase A2 by Phosphatidylinositol Bisphosphate Levels1

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• Potential role of group X secretory phospholipase A2 in cyclooxygenase‐2‐dependent PGE2 formation during colon tumorigenesis

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• Novel Human Secreted Phospholipase A2 with Homology to the Group III Bee Venom Enzyme*

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• Bibliography Abdelrahim, M. and Safe, S. 2005. Cyclooxygenase-2 Inhibitors Decrease Vascular Endothelial Growth Factor Expression in Colon Cancer Cells by Enhanced Degradation of Sp 1 and Sp 4

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• Candida parapsilosis produces prostaglandins from exogenous arachidonic acid and OLE2 is not required for their synthesis

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