Celecoxib can suppress expression of genes associated with PGE2 pathway in chondrocytes under inflammatory conditions.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  International Journal of Clinical and Experimental Medicine

• Publication date

  2015-07-15

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 26379884PMCID PMC4565267
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Celecoxib exerts protective effects on extracellular matrix metabolism of mandibular condylar chondrocytes under excessive mechanical stress.

  2014cited by this paper
• Selective COX-2 inhibitor ameliorates osteoarthritis by repressing apoptosis of chondrocyte

  2012cited by this paper
• Celecoxib: considerations regarding its potential disease-modifying properties in osteoarthritis

  2011cited by this paper
• Prostaglandins and Inflammation

  2011cited by this paper
• Systematic analyses of genes associated with radiosensitizing effect by celecoxib, a specific cyclooxygenase-2 inhibitor.

  2011cited by this paper
• The chondroprotective effect of selective COX-2 inhibition in osteoarthritis: ex vivo evaluation of human cartilage tissue after in vivo treatment.

  2009cited by this paper
• IL-1β Stimulates the Expression of Prostaglandin Receptor EP4 in Human Chondrocytes by Increasing Production of Prostaglandin E2

  2009cited by this paper
• Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis.

  2008cited by this paper
• Prostaglandin E2 Exerts Catabolic Effects in Osteoarthritis Cartilage: Evidence for Signaling via the EP4 Receptor1

  2008cited by this paper
• Long-term NSAID treatment directly decreases COX-2 and mPGES-1 production in the articular cartilage of patients with osteoarthritis.

  2007cited by this paper
• Modern molecular analysis of a traditional disease: progression in osteoarthritis.

  2007cited by this paper
• Prostaglandin E Receptors*

  2007cited by this paper
• Pathobiology of osteoarthritis: pathomechanisms and potential therapeutic targets.

  2007cited by this paper
• Effects of celecoxib on human chondrocytes--enhanced production of chemokines.

  2007cited by this paper
• Global analyses of gene expression in early experimental osteoarthritis.

  2007cited by this paper
• Prostacyclin-IP signaling and prostaglandin E2-EP2/EP4 signaling both mediate joint inflammation in mouse collagen-induced arthritis

  2006cited by this paper
• Cyclooxygenases and prostaglandin E2 receptors in growth plate chondrocytes in vitro and in situ – prostaglandin E2 dependent proliferation of growth plate chondrocytes

  2006cited by this paper
• Prevalence of knee osteoarthritis in the United States: arthritis data from the Third National Health and Nutrition Examination Survey 1991-94.

  2006cited by this paper
• Prospects for disease modification in osteoarthritis

  2006cited by this paper
• Differential direct effects of cyclo-oxygenase-1/2 inhibition on proteoglycan turnover of human osteoarthritic cartilage: an in vitro study

  2005cited by this paper
• Cyclooxygenase (COX)-2 Inhibitor Celecoxib Abrogates TNF-Induced NF-κB Activation through Inhibition of Activation of IκBα Kinase and Akt in Human Non-Small Cell Lung Carcinoma: Correlation with Suppression of COX-2 Synthesis1

  2004cited by this paper
• Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-κB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation

  2004cited by this paper
• Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-kappa B activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synthesis.

  2004cited by this paper
• Recent advances in molecular biology and physiology of the prostaglandin E2-biosynthetic pathway.

  2004cited by this paper
• Genomics of osteoarthritis

  2003cited by this paper
• Cyclooxygenase-2 and prostaglandins in articular tissues.

  2003cited by this paper
• Cyclooxygenase 2-dependent prostaglandin E2 modulates cartilage proteoglycan degradation in human osteoarthritis explants.

  2002cited by this paper
• Do NSAIDs Affect the Progression of Osteoarthritis?

  2002cited by this paper
• Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.

  2001cited by this paper

• Advances in the Regulation of Inflammatory Mediators in Nitric Oxide Synthase: Implications for Disease Modulation and Therapeutic Approaches

  2025cites this paper
• Identification of therapeutic targets in osteoarthritis by combining heterogeneous transcriptional datasets, drug-induced expression profiles, and known drug-target interactions

  2024cites this paper
• Knockdown of DAPK1 inhibits IL-1β-induced inflammation and cartilage degradation in human chondrocytes by modulating the PEDF-mediated NF-κB and NLRP3 inflammasome pathway

  2022cites this paper
• Celecoxib substituted biotinylated poly(amidoamine) G3 dendrimer as potential treatment for temozolomide resistant glioma therapy and anti-nematode agent.

  2020cites this paper
• Triazol-phenyl antipyretic derivatives inhibit mPGES-1 mRNA levels in LPS-Induced RAW 264.7 macrophage cells.

  2020cites this paper
• Determination of two fluoroquinolones and their combinations with hyaluronan effect in in vitro canine cartilage explants

  2019cites this paper
• COX-2 induces T cell accumulation and IFN-γ production during the development of chromium allergy

  2019cites this paper
• KLF-4 is a novel target of 99 Tc-MDP mediating chondrocytes inflammation via NF-κB / iNOS / VCAM 1 signaling

  2018cites this paper
• Disease-modifying effects of COX-2 selective inhibitors and non-selective NSAIDs in osteoarthritis: a systematic review.

  2018cites this paper
• Celecoxib in breast cancer prevention and therapy

  2018cites this paper
• ASSESSMENT OF THE ANTI-INFLAMMATORY AND ANTIOXIDANT ROLES OF RESVERATROL IN ARTHRITIC RATS

  2018cites this paper
• Chondroprotective Effects of Ginsenoside Rg1 in Human Osteoarthritis Chondrocytes and a Rat Model of Anterior Cruciate Ligament Transection

  2017cites this paper
• MODULAÇÃO DO EFEITO DO 5-FLUOROURACIL PELO CELECOXIBE NA LINHAGEM CELULAR DERIVADA DE CARCINOMA COLORRETAL HUMANO

  2017cites this paper
• Dose–Effect of Irbesartan on Cyclooxygenase-2 and Matrix Metalloproteinase-9 Expression in Rabbit Atherosclerosis

  2017cites this paper
• Two fluoroquinolones and their combinations with hyaluronan: comparison of effects on canine chondrocyte culture.

  2016cites this paper