Haemodynamics-Driven Developmental Pruning of Brain Vasculature in Zebrafish

Qi Chen,Luan Jiang,Chun Xing Li,Dan Hu,Ji-wen Bu,D. Cai,Jiu-Lin Du

Published 2012 in PLoS Biology

ABSTRACT

This in vivo time-lapse imaging study in zebrafish reveals how changes to brain blood flow drive vessel pruning via endothelial cell migration, and how pruning leads to the simplification of the brain vasculature during development.

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