Gadolinium(III) complexes have been widely utilised as magnetic resonance imaging (MRI) contrast agents for decades. In recent years however, concerns have developed about their toxicity, believed to derive from demetallation of the complexes in vivo, and the relatively large quantities of compound required for a successful scan. Recent efforts have sought to enhance the relaxivity of trivalent gadolinium complexes without sacrificing their stability. This review aims to examine the strategic design of ligands synthesised for this purpose, provide an overview of recent successes in gadolinium-based contrast agent development and assess the requirements for clinical translation. Gadolinium(III) complexes are strong enhancers of magnetic resonance imaging (MRI) signals, thus are widely used as contrast agents despite their potential toxicity. Here, the authors review ligand design approaches aimed at improving the stability of Gd(III)-based MRI contrast agents.
Ligand design strategies to increase stability of gadolinium-based magnetic resonance imaging contrast agents
T. J. Clough,Lijun Jiang,Ka‐Leung Wong,N. Long
Published 2019 in Nature Communications
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- Publication year
2019
- Venue
Nature Communications
- Publication date
2019-03-29
- Fields of study
Medicine, Chemistry
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Semantic Scholar, PubMed
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