Dissection of the proliferative and differentiative signals controlling murine cytotoxic T lymphocyte responses

Evidence is presented that interleukin 2 (IL-2) is not sufficient to cause the differentiation of primary cytotoxic T lymphocytes (CTL). Sources of IL-2 were compared for their ability to cause proliferation as well as differentiation into CTL. Whereas all factors caused proliferation, only the crude Con A supernatant had cytotoxic T cell differentiation factor (CTDF) activity. Furthermore, factors absorbed with an IL-2-dependent cell line to remove IL-2 still retained CTDF activity. Thus, IL-2 functions to cause clonal expansion of CTL precursors preactivated by antigen or mitogen, but for their differentiation into CTL, an additional factor is required, here called CTDF.

• Publication year

  1982

• Venue

  Journal of Experimental Medicine

• Publication date

  1982-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/0008-8749(82)90380-XPMID 6978927PMCID 2186696
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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