PML induces a novel caspase-independent death process

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Nature Genetics

• Publication date

  1998-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/3068PMID 9806544
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• [Mitochondria and apoptosis].

  2000cited by this paper
• Herpes virus induced proteasome-dependent degradation of the nuclear bodies-associated PML and Sp100 proteins

  1999cited by this paper
• Arsenic trioxide and interferon-alpha synergize to induce cell cycle arrest and apoptosis in human T-cell lymphotropic virus type I-transformed cells.

  1999cited by this paper
• The PML / RAR a Fusion Protein Inhibits Tumor Necrosis Factor-a – induced Apoptosis in U 937 Cells and Acute Promyelocytic Leukemia Blasts

  1998cited by this paper
• The Promyelocytic Leukemia Gene Product (PML) Forms Stable Complexes with the Retinoblastoma Protein

  1998cited by this paper
• Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL.

  1998cited by this paper
• E4orf4, a Novel Adenovirus Death Factor That Induces p53-independent Apoptosis by a Pathway That Is Not Inhibited by zVAD-fmk

  1998cited by this paper
• Inhibition of Caspases Increases the Sensitivity of L929 Cells to Necrosis Mediated by Tumor Necrosis Factor

  1998cited by this paper
• Two RING Finger Proteins, the Oncoprotein PML and the Arenavirus Z Protein, Colocalize with the Nuclear Fraction of the Ribosomal P Proteins

  1998cited by this paper
• Differential SMN2 expression associated with SMA severity

  1998cited by this paper
• Combined arsenic and retinoic acid treatment enhances differentiation and apoptosis in arsenic-resistant NB4 cells.

  1998cited by this paper
• Arsenic trioxide and melarsoprol induce programmed cell death in myeloid leukemia cell lines and function in a PML and PML-RARalpha independent manner.

  1998cited by this paper
• Conjugation with the ubiquitin‐related modifier SUMO‐1 regulates the partitioning of PML within the nucleus

  1998cited by this paper
• Structure and function in the nucleus.

  1998cited by this paper
• The Disruption of ND10 during Herpes Simplex Virus Infection Correlates with the Vmw110- and Proteasome-Dependent Loss of Several PML Isoforms

  1998cited by this paper
• Defects in the Ubiquitin Pathway Induce Caspase-independent Apoptosis Blocked by Bcl-2*

  1998cited by this paper
• Role of the histone deacetylase complex in acute promyelocytic leukaemia

  1998cited by this paper
• Mitochondria and apoptosis.

  1998cited by this paper
• The Overexpression of Bax Produces Cell Death upon Induction of the Mitochondrial Permeability Transition*

  1998cited by this paper
• Fusion proteins of the retinoic acid receptor-α recruit histone deacetylase in promyelocytic leukaemia

  1998cited by this paper
• Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes.

  1998cited by this paper
• The PML/RARalpha fusion protein inhibits tumor necrosis factor-alpha-induced apoptosis in U937 cells and acute promyelocytic leukemia blasts.

  1998cited by this paper
• Recombinant PML adenovirus suppresses growth and tumorigenicity of human breast cancer cells by inducing G1 cell cycle arrest and apoptosis

  1998cited by this paper
• Nuclear targeting of Bax during apoptosis in human colorectal cancer cells

  1998cited by this paper
• Pml is essential for multiple apoptotic pathways

  1998cited by this paper
• Localization of nascent RNA and CREB binding protein with the PML-containing nuclear body.

  1998cited by this paper
• Distinct interactions of PML-RARα and PLZF-RARα with co-repressors determine differential responses to RA in APL

  1998cited by this paper
• Role of PML in cell growth and the retinoic acid pathway.

  1998cited by this paper
• Leukemia-associated retinoic acid receptor alpha fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies.

  1997cited by this paper
• Movement of Bax from the Cytosol to Mitochondria during Apoptosis

  1997cited by this paper
• The promyelocytic leukemia protein PML has a pro‐apoptotic activity mediated through its RING domain

  1997cited by this paper
• Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosis.

  1997cited by this paper
• Inhibition of Ced-3/ICE-related Proteases Does Not Prevent Cell Death Induced by Oncogenes, DNA Damage, or the Bcl-2 Homologue Bak

  1997cited by this paper
• Retinoic acid and arsenic: towards oncogene-targeted treatments of acute promyelocytic leukaemia.

  1997cited by this paper
• Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): I. As2O3 exerts dose-dependent dual effects on APL cells.

  1997cited by this paper
• A role for T-helper type-1 and type-2 cytokines in the regulation of human monocyte apoptosis.

  1997cited by this paper
• Altered distribution of the promyelocytic leukemia-associated protein is associated with cellular senescence.

  1997cited by this paper
• Arsenic-induced PML targeting onto nuclear bodies: implications for the treatment of acute promyelocytic leukemia.

  1997cited by this paper
• Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis.

  1997cited by this paper
• Bax Deletion Further Orders the Cell Death Pathway in Cerebellar Granule Cells and Suggests a Caspase-independent Pathway to Cell Death

  1997cited by this paper
• Molecular Cloning of a New Interferon-induced PML Nuclear Body-associated Protein*

  1997cited by this paper
• Cell-cycle regulation of DNA damage-induced expression of the suppressor gene PML.

  1997cited by this paper
• PML shuttles between nuclear bodies and the cytoplasm

  1997cited by this paper
• Leukemia-associated retinoic acid receptor a fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies (nuclear matrixyacute promyelocytic leukemiayinterferonytranslocationyyeast two-hybrid)

  1997cited by this paper
• The Interferon (IFN)-stimulated Gene Sp100 Promoter Contains an IFN-γ Activation Site and an Imperfect IFN-stimulated Response Element Which Mediate Type I IFN Inducibility*

  1996cited by this paper
• The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein.

  1996cited by this paper
• The Origin of Programmed Cell Death

  1996cited by this paper
• BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases.

  1996cited by this paper
• Protection against Fas/APO-1- and tumor necrosis factor-mediated cell death by a novel protein, sentrin.

  1996cited by this paper
• The 8 kD product of the putative oncogene MTCP-1 is a mitochondrial protein.

  1995cited by this paper
• Transcriptional induction of the PML growth suppressor gene by interferons is mediated through an ISRE and a GAS element.

  1995cited by this paper
• The PML growth-suppressor has an altered expression in human oncogenesis.

  1995cited by this paper
• A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein.

  1994cited by this paper
• The t(15;17) translocation alters a nuclear body in a retinoic acid‐reversible fashion.

  1994cited by this paper
• Retinoic acid regulates aberrant nuclear localization of PML-RAR alpha in acute promyelocytic leukemia cells.

  1994cited by this paper
• PML, a growth suppressor disrupted in acute promyelocytic leukemia

  1994cited by this paper
• The acute promyelocytic leukemia-specific PML-RAR alpha fusion protein inhibits differentiation and promotes survival of myeloid precursor cells.

  1993cited by this paper
• PML protein expression in hematopoietic and acute promyelocytic leukemia cells.

  1993cited by this paper
• The acute promyelocytic leukemia-specific PML-RARα fusion protein inhibits differentiation and promotes survival of myeloid precursor cells

  1993cited by this paper
• The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

  1991cited by this paper

• Single-nucleus multiomics reveals the gene regulatory networks underlying sex determination of murine primordial germ cells

  2025cites this paper
• Single-nucleus multiomics reveals the gene-regulatory networks underlying sex determination of murine primordial germ cells

  2024cites this paper
• The PML hub: An emerging actor of leukemia therapies

  2023cites this paper
• PML-II regulates ERK and AKT signal activation and IFNα-induced cell death

  2021cites this paper
• PML-Dependent Memory of Type I Interferon Treatment Results in a Restricted Form of HSV Latency

  2021cites this paper
• PML‐NB‐dependent type I interferon memory results in a restricted form of HSV latency

  2021cites this paper
• JAK2V617F myeloproliferative neoplasm eradication by a novel interferon/arsenic therapy involves PML

  2020cites this paper
• The Cell Nucleus and Its Compartments

  2020cites this paper
• Dissecting the role of PML-II in gene transcription and in IFN alpha-mediated apoptosis

  2018cites this paper
• Acute promyelocytic leukemia lacking t(15;17): molecular evidence of atypical PML/RAR- α transcriptional variant by gene sequencing Akutna promijelocitna leukemija bez t(15;17): molekularni dokazi atipi č ne PML/RAR- α transkripcione varijante genskim sekvenciranjem

  2018cites this paper
• Programmed cell death in plants in response to pathogen attack

  2018cites this paper
• Évaluation du traitement par trioxyde d’arsenic dans la prise en charge des leucémies aiguës promyélocytaires de l’enfant : tolérance et devenir

  2018cites this paper
• TRIM22-Mediated Apoptosis is Associated with Bak Oligomerization in Monocytes

  2017cites this paper
• The discovery of a novel, Ras-mediated NORE1A/PMLIV tumor suppressor complex.

  2016cites this paper
• Restoration of tumor suppression in prostate cancer by targeting the E3 ligase E6AP

  2016cites this paper
• Promyelocytic Leukemia (PML) and Its Biological Roles

  2016cites this paper
• PML regulates neuroprotective innate immunity and neuroblast commitment in a hypoxic–ischemic encephalopathy model

  2016cites this paper
• Fumonisin B₁ inhibits apoptosis in HepG2 cells by inducing Birc-8/ILP-2.

  2015cites this paper
• ATL response to arsenic/interferon therapy is triggered by SUMO/PML/RNF4-dependent Tax degradation.

  2015cites this paper
• p53 as an Effector or Inhibitor of Therapy Response.

  2015cites this paper
• Arsenic trioxide and all-trans retinoic acid target NPM1 mutant oncoprotein levels and induce apoptosis in NPM1-mutated AML cells.

  2015cites this paper
• Akute myeloische Leukämie

  2015cites this paper
• Translational control of PML contributes to TNFα-induced apoptosis of MCF7 breast cancer cells and decreased angiogenesis in HUVECs

  2015cites this paper
• p27 and Leukemia: Cell Cycle and Beyond

  2015cites this paper
• The function, regulation and therapeutic implications of the tumor suppressor protein, PML

  2015cites this paper
• Promyelocytic leukemia gene functions and roles in tumorigenesis.

  2014cites this paper
• PML-mediated signaling and its role in cancer stem cells

  2014cites this paper
• The role of PML and PML nuclear bodies in FADD-mediated apoptosis

  2014cites this paper
• A Review of Arsenic Trioxide and Acute Promyelocytic Leukemia

  2014cites this paper
• Novel Role of CHK2 in the Intrinsic and Extrinsic Apoptosis Pathway

  2014cites this paper
• Propagation of viruses infecting waterfowl on continuous cell lines of Muscovy duck (Cairina moschata) origin

  2014cites this paper
• PML nuclear bodies: Assembly and oxidative stress-sensitive sumoylation

  2014cites this paper
• An investigation into the biochemical, molecular and epigenetic effects of fumonisin B1 in liver (HEPG2) cells.

  2014cites this paper
• Dual effect of oxidative stress on leukemia cancer induction and treatment

  2014cites this paper
• The acute promyelocytic leukaemia success story: curing leukaemia through targeted therapies

  2014cites this paper
• Université de Montréal-Thèse numérique

  2013cites this paper
• Is PML a Tumor Suppressor?

  2013cites this paper
• resistance of TPA-differentiated leukemic cells to apoptosis Mitochondria-targeting drugs arsenic trioxide and lonidamine bypass the

  2013cites this paper
• Promyelocytic Leukemia Reveals Systematic Post-Transcriptional Control Mechanisms in Acute Comparative Proteomic Analysis of All-trans-Retinoic Acid Treatment

  2013cites this paper
• expression in human cell lines The PML gene is not involved in the regulation of MHC class I

  2013cites this paper
• progenitor cells translocation products by increasing the self-renewal of very primitive -Catenin contributes to leukemogenesis induced by AML-associated γ

  2013cites this paper
• Transformed Cells - Apoptosis in Human T-Cell Lymphotropic Virus Type I Arsenic Trioxide and Interferon-? Synergize to Induce Cell Cycle Arrest and

  2013cites this paper
• TRIM16 inhibits neuroblastoma cell proliferation through cell cycle regulation and dynamic nuclear localization

  2013cites this paper
• Elm tree bark extract inhibits HepG2 hepatic cancer cell growth via pro-apoptotic activity

  2012cites this paper
• The cell biology of disease: Acute promyelocytic leukemia, arsenic, and PML bodies.

  2012cites this paper
• Role of the promyelocytic leukaemia protein in cell death regulation

  2012cites this paper
• Investigation of the FAT10 conjugation pathway

  2012cites this paper
• PML as a potential predictive factor of oxaliplatin/fluoropyrimidine‐based first line chemotherapy efficacy in colorectal cancer patients

  2012cites this paper
• HIV-1 subtype B and C GP120-mediated apoptosis of bystander CD4+ T lymphocytes

  2012cites this paper
• The Role of PML in the Nervous System

  2011cites this paper
• Caractérisation du domaine de liaison à l'ARN de p54nrb

  2011cites this paper
• Molecular Diagnosis of Hematopoietic Neoplasms

  2011cites this paper
• Mitocans as Novel Agents for Anticancer Therapy: An Overview

  2011cites this paper
• TRIM32 Protein Sensitizes Cells to Tumor Necrosis Factor (TNFα)-induced Apoptosis via Its RING Domain-dependent E3 Ligase Activity against X-linked Inhibitor of Apoptosis (XIAP)*

  2011cites this paper
• PRAS40 and TSC2 regulate apoptosis during early development of embryoid bodies via mTOR

  2011cites this paper
• AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activation

  2011cites this paper
• Nuclear proteins acting on mitochondria.

  2011cites this paper
• Caspase Dependent Programmed Cell Death in Developing Embryos: A Potential Target for Therapeutic Intervention against Pathogenic Nematodes

  2011cites this paper
• SENP3-mediated De-conjugation of SUMO2/3 from Promyelocytic Leukemia Is Correlated with Accelerated Cell Proliferation under Mild Oxidative Stress*

  2010cites this paper
• Antiviral activity of resveratrol.

  2010cites this paper
• FOXO3A as a key molecule for all-trans retinoic acid-induced granulocytic differentiation and apoptosis in acute promyelocytic leukemia.

  2010cites this paper
• Regulation of stress-induced nuclear protein redistribution: a new function of Bax and Bak uncoupled from Bcl-xL

  2010cites this paper
• ROLE OF FANCM IN TELOMERE MAINTENANCE IN ALTERNATIVE LENGTHENING OF TELOMERES (ALT) HUMAN CELLS

  2010cites this paper
• Puzzled by PML

  2010cites this paper
• FOXO 3 A as a key molecule for all-trans retinoic acid – induced granulocytic differentiation and apoptosis in acute promyelocytic leukemia

  2010cites this paper
• Promyelocytic leukemia protein induces apoptosis due to caspase-8 activation via the repression of NFkappaB activation in glioblastoma.

  2009cites this paper
• Kaposi's Sarcoma-Associated Herpesvirus Protein LANA2 Disrupts PML Oncogenic Domains and Inhibits PML-Mediated Transcriptional Repression of the Survivin Gene

  2009cites this paper
• BAR the door: cancer suppression by amphiphysin-like genes.

  2009cites this paper
• Arsenic trioxide is highly cytotoxic to small cell lung carcinoma cells

  2009cites this paper
• Perspectives in PML: a unifying framework for PML function.

  2009cites this paper
• Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy

  2009cites this paper
• Acute promyelocytic leukemia and differentiation therapy: molecular mechanisms of differentiation, retinoic acid resistance and novel treatments.

  2009cites this paper
• Promyelocytic leukemia protein is required for gain of function by mutant p53.

  2009cites this paper
• PML nuclear bodies in the pathogenesis of acute promyelocytic leukemia: active players or innocent bystanders?

  2009influential citation
• Differential Expression of PML in 60 Co γ-ray and γ-IFN- Induced Apoptosis in B-lymphocytes

  2008cites this paper
• High concentration simvastatin induces apoptosis in fibroblast-like synoviocytes from patients with rheumatoid arthritis.

  2008cites this paper
• Modulation of M2‐type pyruvate kinase activity by the cytoplasmic PML tumor suppressor protein

  2008cites this paper
• Regulation of apoptosis by PML and the PML-NBs

  2008cites this paper
• Pondering the puzzle of PML (promyelocytic leukemia) nuclear bodies: can we fit the pieces together using an RNA regulon?

  2008cites this paper
• Arsenic Trioxide and Acute Promyelocytic Leukemia: A Drug for All Stages of Disease

  2008cites this paper
• The eIF4E RNA regulon promotes the Akt signaling pathway

  2008cites this paper
• New insights into the role of PML in tumour suppression

  2008cites this paper
• HIV-1 viral genes and mitochondrial apoptosis

  2008cites this paper
• The eIF 4 E RNA regulon promotes the Akt signaling pathway

  2008cites this paper
• Increased Expression of PML Protein in Lymphocytes Induced by Serum from Patients with Severe Aplastic Anemia

  2008cites this paper
• Redox status of thioredoxin-1 (TRX1) determines the sensitivity of human liver carcinoma cells (HepG2) to arsenic trioxide-induced cell death

  2008cites this paper
• Mitochondria play a role in the development of non-apoptotic programmed cell death of neutrophils induced by ONO-AE-248.

  2007cites this paper
• Hypoxia-induced cell death of HepG2 cells involves a necrotic cell death mediated by calpain

  2007cites this paper
• TRIM22/Staf50 - a novel target gene of the tumor suppressor p53

  2007cites this paper
• Treatment of acute promyelocytic leukaemia with all-trans retinoic acid and arsenic trioxide: a paradigm of synergistic molecular targeting therapy

  2007cites this paper
• Arsenic trioxide and acute promyelocytic leukemia: clinical and biological.

  2007cites this paper
• Identification of IRF-8 and IRF-1 target genes in activated macrophages.

  2007cites this paper
• Direct transcriptional activation of promyelocytic leukemia protein by IFN regulatory factor 3 induces the p53-dependent growth inhibition of cancer cells.

  2007cites this paper
• Are promyelocytic leukaemia protein nuclear bodies a scaffold for caspase-2 programmed cell death?

  2007cites this paper
• Staf 50-a novel target gene of the tumor suppressor p 53

  2007cites this paper
• Control of virus infection by tumour suppressors.

  2007cites this paper
• UvA-DARE ( Digital Academic Repository ) CD 20 monoclonal antibody therapy for B-cell lymphona

  2007cites this paper
• Nuclear expression of E 2 F 4 induces cell death via multiple pathways in normal human intestinal epithelial crypt cells but not in colon cancer cells

  2007cites this paper
• The theory of APL revisited.

  2007cites this paper
• Nuclear Architecture: Topology and Function of Chromatin- and Non-Chromatin Nuclear Domains

  2007cites this paper