Regulation of apoptosis by PML and the PML-NBs

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Oncogene

• Publication date

  2008-10-20

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/onc.2008.305PMID 18931695
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• PML targeting eradicates quiescent leukaemia-initiating cells

  2009influential reference
• Marked for death

  2008influential reference
• Phosphorylation of PML is essential for activation of C/EBP epsilon and PU.1 to accelerate granulocytic differentiation.

  2008cited by this paper
• RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

  2008influential reference
• PML targeting eradicates quiescent leukaemia-initiating cells

  2008cited by this paper
• An Oncogene-Induced DNA Damage Model for Cancer Development

  2008cited by this paper
• SUMOylation of HMGA2: selective destabilization of promyelocytic leukemia protein via proteasome

  2008influential reference
• Arsenic degrades PML or PML–RARα through a SUMO-triggered RNF4/ubiquitin-mediated pathway

  2008influential reference
• Faculty Opinions recommendation of Arsenic degrades PML or PML-RARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathway.

  2008influential reference
• PML enhances the regulation of p53 by CK1 in response to DNA damage

  2008cited by this paper
• Significance of PML and p53 protein as molecular prognostic markers of gallbladder carcinomas

  2008influential reference
• A Role for Cytoplasmic PML in Cellular Resistance to Viral Infection

  2008influential reference
• SUMO Conjugation to the Matrix Attachment Region-binding Protein, Special AT-rich Sequence-binding Protein-1 (SATB1), Targets SATB1 to Promyelocytic Nuclear Bodies Where It Undergoes Caspase Cleavage*

  2008cited by this paper
• PML-Retinoic Acid Receptor α Inhibits PML IV Enhancement of PU.1-Induced C/EBPε Expression in Myeloid Differentiation

  2007cited by this paper
• Modification of nuclear PML protein by SUMO-1 regulates Fas-induced apoptosis in rheumatoid arthritis synovial fibroblasts

  2007cited by this paper
• Are promyelocytic leukaemia protein nuclear bodies a scaffold for caspase-2 programmed cell death?

  2007cited by this paper
• FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies

  2007influential reference
• FLASH Meets Nuclear Bodies: CD95 Receptor Signals via a Nuclear Pathway

  2007influential reference
• Degradation of the Tumor Suppressor PML by Pin1 Contributes to the Cancer Phenotype of Breast Cancer MDA-MB-231 Cells

  2007influential reference
• Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies

  2007cited by this paper
• PML4 induces differentiation by Myc destabilization

  2007cited by this paper
• Tyrosine kinase inhibitor, methyl 2,5-dihydromethylcinnimate, induces PML nuclear body formation and apoptosis in tumor cells.

  2007cited by this paper
• Daxx represses expression of a subset of antiapoptotic genes regulated by nuclear factor-kappaB.

  2006cited by this paper
• Identification of a tumour suppressor network opposing nuclear Akt function

  2006cited by this paper
• Promyelocytic Leukemia Activates Chk2 by Mediating Chk2 Autophosphorylation*

  2006cited by this paper
• Relationship between SUMO-1 modification of caspase-7 and its nuclear localization in human neuronal cells.

  2006cited by this paper
• The mechanisms of PML-nuclear body formation.

  2006cited by this paper
• SUSP1 antagonizes formation of highly SUMO2/3-conjugated species

  2006cited by this paper
• A CK2-dependent mechanism for degradation of the PML tumor suppressor.

  2006influential reference
• Promyelocytic leukemia nuclear bodies behave as DNA damage sensors whose response to DNA double-strand breaks is regulated by NBS1 and the kinases ATM, Chk2, and ATR

  2006cited by this paper
• A Cytoplasmic PML Mutant Inhibits p53 Function

  2006cited by this paper
• Characterization of endogenous human promyelocytic leukemia isoforms.

  2006influential reference
• Stabilization of PML nuclear localization by conjugation and oligomerization of SUMO-3

  2005cited by this paper
• The promyelocytic leukemia protein PML regulates c-Jun function in response to DNA damage.

  2005influential reference
• Physical and functional link of the leukemia-associated factors AML1 and PML.

  2005cited by this paper
• Mitochondria are the primary target in isothiocyanate-induced apoptosis in human bladder cancer cells

  2005cited by this paper
• Association of caspase-2 with the promyelocytic leukemia protein nuclear bodies

  2005influential reference
• PML is a direct p53 target that modulates p53 effector functions.

  2004cited by this paper
• Mutations of the PML tumor suppressor gene in acute promyelocytic leukemia.

  2004influential reference
• Cytoplasmic PML function in TGF-β signalling

  2004cited by this paper
• PML nuclear bodies and apoptosis

  2004cited by this paper
• Loss of the tumor suppressor PML in human cancers of multiple histologic origins.

  2004influential reference
• PML nuclear bodies: dynamic sensors of DNA damage and cellular stress

  2004cited by this paper
• PML regulates p53 stability by sequestering Mdm2 to the nucleolus

  2004influential reference
• Phosphorylation of PML by mitogen-activated protein kinases plays a key role in arsenic trioxide-mediated apoptosis.

  2004cited by this paper
• Cytoplasmic PML function in TGF-beta signalling.

  2004cited by this paper
• Nuclear and unclear functions of SUMO

  2003cited by this paper
• Promyelocytic leukemia protein sensitizes tumor necrosis factor alpha-induced apoptosis by inhibiting the NF-kappaB survival pathway.

  2003cited by this paper
• Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization

  2003influential reference
• RNAi reveals anti-apoptotic and transcriptionally repressive activities of DAXX

  2003cited by this paper
• Promyelocytic Leukemia Protein Sensitizes Tumor Necrosis Factor α-Induced Apoptosis by Inhibiting the NF-κB Survival Pathway*

  2003cited by this paper
• Role of PML and the PML-nuclear body in the control of programmed cell death

  2003cited by this paper
• UV-C-induced DNA damage leads to p53-dependent nuclear trafficking of PML

  2003cited by this paper
• Chromosomal Translocation t ( l 5 ; 17 ) in Human Acute Promyelocytic Leukemia Fuses RARa with a Novel Putative Transcription Factor , PML

  2003cited by this paper
• MDM2 and Promyelocytic Leukemia Antagonize Each Other through Their Direct Interaction with p53*

  2003influential reference
• PML is required for homeodomain-interacting protein kinase 2 (HIPK2)-mediated p53 phosphorylation and cell cycle arrest but is dispensable for the formation of HIPK domains.

  2003cited by this paper
• The Promyelocytic Leukemia Protein Protects p53 from Mdm2-mediated Inhibition and Degradation*

  2003influential reference
• Physical and Functional Interactions between PML and MDM2*

  2003influential reference
• Body language: the function of PML nuclear bodies in apoptosis regulation

  2003cited by this paper
• PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2

  2002cited by this paper
• Caspase-2 Induces Apoptosis by Releasing Proapoptotic Proteins from Mitochondria*

  2002cited by this paper
• Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis

  2002cited by this paper
• Nuclear and cytoplasmic shuttling of TRADD induces apoptosis via different mechanisms

  2002influential reference
• Caspase-2 Can Trigger Cytochrome c Release and Apoptosis from the Nucleus*

  2002cited by this paper
• Requirement for Caspase-2 in Stress-Induced Apoptosis Before Mitochondrial Permeabilization

  2002cited by this paper
• The Interaction of Pax5 (BSAP) with Daxx Can Result in Transcriptional Activation in B Cells*

  2002cited by this paper
• Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2

  2002cited by this paper
• Pondering the Promyelocytic Leukemia Protein (PML) Puzzle: Possible Functions for PML Nuclear Bodies

  2002cited by this paper
• PML NBs associate with the hMre11 complex and p53 at sites of irradiation induced DNA damage

  2002cited by this paper
• SUMO-1 protease-1 regulates gene transcription through PML.

  2002cited by this paper
• Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

  2002cited by this paper
• PML protein isoforms and the RBCC/TRIM motif

  2001influential reference
• The theory of APL

  2001influential reference
• Regulation of Pax3 transcriptional activity by SUMO-1-modified PML

  2001cited by this paper
• Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway.

  2000cited by this paper
• PML is induced by oncogenic ras and promotes premature senescence.

  2000influential reference
• Role of SUMO-1-modified PML in nuclear body formation.

  2000influential reference
• Primary mouse fibroblasts deficient for c-Fos, p53 or for both proteins are hypersensitive to UV light and alkylating agent-induced chromosomal breakage and apoptosis.

  2000cited by this paper
• PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

  2000influential reference
• The transcriptional role of PML and the nuclear body

  2000influential reference
• Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5.

  2000cited by this paper
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  2000influential reference
• Regulation of p53 activity in nuclear bodies by a specific PML isoform

  2000influential reference
• The function of PML in p53-dependent apoptosis

  2000influential reference
• Promyelocytic Leukemia (Pml) Nuclear Bodies Are Protein Structures That Do Not Accumulate RNA

  2000cited by this paper
• Promyelocytic Leukemia Protein (Pml) and Daxx Participate in a Novel Nuclear Pathway for Apoptosis

  2000influential reference
• Loss of Daxx, a promiscuously interacting protein, results in extensive apoptosis in early mouse development.

  1999cited by this paper
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  1999influential reference
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  1999cited by this paper
• Pml Is Critical for Nd10 Formation and Recruits the Pml-Interacting Protein Daxx to This Nuclear Structure When Modified by Sumo-1

  1999cited by this paper
• Deconstructing a disease: RARalpha, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia.

  1999cited by this paper
• Human Daxx regulates Fas‐induced apoptosis from nuclear PML oncogenic domains (PODs)

  1999influential reference
• Pml is essential for multiple apoptotic pathways

  1998influential reference
• p21-induced cycle arrest in G1 protects cells from apoptosis induced by UV-irradiation or RNA polymerase II blockage

  1998cited by this paper
• Recombinant PML adenovirus suppresses growth and tumorigenicity of human breast cancer cells by inducing G1 cell cycle arrest and apoptosis

  1998influential reference
• A novel nuclear substructure, ND10: distribution in normal and neoplastic human tissues.

  1998cited by this paper
• Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx.

  1998cited by this paper
• PML induces a novel caspase-independent death process

  1998cited by this paper
• A novel ubiquitin‐specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein

  1997cited by this paper
• A novel ubiquitin‐specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein

  1997cited by this paper

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  2024cites this paper
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  2024cites this paper
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  2024cites this paper
• The highly conserved region within exonuclease III-like in PML-I regulates the cytoplasmic localization of PML-NBs

  2024cites this paper
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  2024cites this paper
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  2020cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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