Kiss1-/- mice exhibit more variable hypogonadism than Gpr54-/- mice.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Endocrinology

• Publication date

  2007-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1210/EN.2007-0078PMID 17595229
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2007influential reference
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  2001cited by this paper
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  1997cited by this paper
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  1981cited by this paper
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  1977cited by this paper
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  1962cited by this paper

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